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P12341

- G6PI_KLULA

UniProt

P12341 - G6PI_KLULA

Protein

Glucose-6-phosphate isomerase

Gene

RAG2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei368 – 3681Proton donorBy similarity
    Active sitei399 – 3991By similarity
    Active sitei521 – 5211By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:RAG2
    Ordered Locus Names:KLLA0E23595g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome E

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Glucose-6-phosphate isomerasePRO_0000180575Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi28985.P12341.

    Structurei

    3D structure databases

    ProteinModelPortaliP12341.
    SMRiP12341. Positions 13-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG7N0CDV.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12341-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKNTYSDF KLATELPAWN QLQSLYEQKG KKLNVKDEFA KDNSRYEKFA    50
    KTFVNYDGSK ILFDFSKNLV DDEILKSLIQ LAKEAKVTSL RDAMFNGEPI 100
    NFTEGRAVYH VALRNRSLKP MYVDGTNVTP EVDAVLQHMK EFTEEVRSGA 150
    WKGYTGKSIT DVVNIGIGGS DLGPVMVTEA LKHYATNLKV HFVSNIDGTH 200
    IAETLKDLDH ETTLFLIASK TFTTAETITN ATSAKNWFLS KNGGDQSHIS 250
    KHFAALSTNA TEVEKFGIDT KNMFGFENWV GGRYSVWSAI GLSVALYIGF 300
    DNFEAFLKGA EAVDKHFVET PLEDNIPLLG GLLSVWYNNF FDAQTHLVAP 350
    FDQYLHRFPA YLQQLSMESN GKSVTRGNVF ANYSTGSILF GEPATNAQHS 400
    FFQLIHQGTK LIPSDFILAA QSHNPIENNL HQKMLASNFF AQAEALMVGK 450
    DEEQVKSEGA TGGLVPHKVF SGNRPTTSIL AQKITPATLG ALIAYYEHVT 500
    FTEGAIWNIN SFDQWGVELG KVLAKVIGSE LATDNKISSH DSSTNGLINQ 550
    FKEWI 555
    Length:555
    Mass (Da):61,568
    Last modified:September 27, 2004 - v2
    Checksum:iF61A9F8806C1E2CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti233 – 2342SA → QLEL in CAA30923. (PubMed:3419932)Curated
    Sequence conflicti505 – 5051A → R in CAA30923. (PubMed:3419932)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12360 Genomic DNA. Translation: CAA30923.1.
    CR382125 Genomic DNA. Translation: CAH00100.1.
    PIRiS01414. NUVKL.
    RefSeqiXP_455013.1. XM_455013.1.

    Genome annotation databases

    GeneIDi2894287.
    KEGGikla:KLLA0E23519g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12360 Genomic DNA. Translation: CAA30923.1 .
    CR382125 Genomic DNA. Translation: CAH00100.1 .
    PIRi S01414. NUVKL.
    RefSeqi XP_455013.1. XM_455013.1.

    3D structure databases

    ProteinModelPortali P12341.
    SMRi P12341. Positions 13-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.P12341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2894287.
    KEGGi kla:KLLA0E23519g.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG7N0CDV.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The RAG2 gene of the yeast Kluyveromyces lactis codes for a putative phosphoglucose isomerase."
      Wesolowski-Louvel M., Goffrini P., Ferrero I.
      Nucleic Acids Res. 16:8714-8714(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
    3. "A phosphoglucose isomerase gene is involved in the Rag phenotype of the yeast Kluyveromyces lactis."
      Goffrini P., Wesolowski-Louvel M., Ferrero I.
      Mol. Gen. Genet. 228:401-409(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiG6PI_KLULA
    AccessioniPrimary (citable) accession number: P12341
    Secondary accession number(s): Q6CM26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3