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P12341 (G6PI_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:RAG2
Ordered Locus Names:KLLA0E23595g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subunit structure

Homodimer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180575

Sites

Active site3681Proton donor By similarity
Active site3991 By similarity
Active site5211 By similarity

Experimental info

Sequence conflict233 – 2342SA → QLEL in CAA30923. Ref.1
Sequence conflict5051A → R in CAA30923. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P12341 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: F61A9F8806C1E2CB

FASTA55561,568
        10         20         30         40         50         60 
MASKNTYSDF KLATELPAWN QLQSLYEQKG KKLNVKDEFA KDNSRYEKFA KTFVNYDGSK 

        70         80         90        100        110        120 
ILFDFSKNLV DDEILKSLIQ LAKEAKVTSL RDAMFNGEPI NFTEGRAVYH VALRNRSLKP 

       130        140        150        160        170        180 
MYVDGTNVTP EVDAVLQHMK EFTEEVRSGA WKGYTGKSIT DVVNIGIGGS DLGPVMVTEA 

       190        200        210        220        230        240 
LKHYATNLKV HFVSNIDGTH IAETLKDLDH ETTLFLIASK TFTTAETITN ATSAKNWFLS 

       250        260        270        280        290        300 
KNGGDQSHIS KHFAALSTNA TEVEKFGIDT KNMFGFENWV GGRYSVWSAI GLSVALYIGF 

       310        320        330        340        350        360 
DNFEAFLKGA EAVDKHFVET PLEDNIPLLG GLLSVWYNNF FDAQTHLVAP FDQYLHRFPA 

       370        380        390        400        410        420 
YLQQLSMESN GKSVTRGNVF ANYSTGSILF GEPATNAQHS FFQLIHQGTK LIPSDFILAA 

       430        440        450        460        470        480 
QSHNPIENNL HQKMLASNFF AQAEALMVGK DEEQVKSEGA TGGLVPHKVF SGNRPTTSIL 

       490        500        510        520        530        540 
AQKITPATLG ALIAYYEHVT FTEGAIWNIN SFDQWGVELG KVLAKVIGSE LATDNKISSH 

       550 
DSSTNGLINQ FKEWI 

« Hide

References

« Hide 'large scale' references
[1]"The RAG2 gene of the yeast Kluyveromyces lactis codes for a putative phosphoglucose isomerase."
Wesolowski-Louvel M., Goffrini P., Ferrero I.
Nucleic Acids Res. 16:8714-8714(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
[2]"Genome evolution in yeasts."
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. expand/collapse author list , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
[3]"A phosphoglucose isomerase gene is involved in the Rag phenotype of the yeast Kluyveromyces lactis."
Goffrini P., Wesolowski-Louvel M., Ferrero I.
Mol. Gen. Genet. 228:401-409(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X12360 Genomic DNA. Translation: CAA30923.1.
CR382125 Genomic DNA. Translation: CAH00100.1.
PIRNUVKL. S01414.
RefSeqXP_455013.1. XM_455013.1.

3D structure databases

ProteinModelPortalP12341.
SMRP12341. Positions 13-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.P12341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2894287.
KEGGkla:KLLA0E23519g.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261371.
KOK01810.
OMALKMHFVS.
OrthoDBEOG7N0CDV.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_KLULA
AccessionPrimary (citable) accession number: P12341
Secondary accession number(s): Q6CM26
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 27, 2004
Last modified: February 19, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways