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P12341

- G6PI_KLULA

UniProt

P12341 - G6PI_KLULA

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Protein

Glucose-6-phosphate isomerase

Gene

RAG2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei368 – 3681Proton donorBy similarity
Active sitei399 – 3991By similarity
Active sitei521 – 5211By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:RAG2
Ordered Locus Names:KLLA0E23595g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome E

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Glucose-6-phosphate isomerasePRO_0000180575Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi28985.P12341.

Structurei

3D structure databases

ProteinModelPortaliP12341.
SMRiP12341. Positions 13-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
InParanoidiP12341.
KOiK01810.
OMAiNCHFVAN.
OrthoDBiEOG7N0CDV.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12341-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKNTYSDF KLATELPAWN QLQSLYEQKG KKLNVKDEFA KDNSRYEKFA
60 70 80 90 100
KTFVNYDGSK ILFDFSKNLV DDEILKSLIQ LAKEAKVTSL RDAMFNGEPI
110 120 130 140 150
NFTEGRAVYH VALRNRSLKP MYVDGTNVTP EVDAVLQHMK EFTEEVRSGA
160 170 180 190 200
WKGYTGKSIT DVVNIGIGGS DLGPVMVTEA LKHYATNLKV HFVSNIDGTH
210 220 230 240 250
IAETLKDLDH ETTLFLIASK TFTTAETITN ATSAKNWFLS KNGGDQSHIS
260 270 280 290 300
KHFAALSTNA TEVEKFGIDT KNMFGFENWV GGRYSVWSAI GLSVALYIGF
310 320 330 340 350
DNFEAFLKGA EAVDKHFVET PLEDNIPLLG GLLSVWYNNF FDAQTHLVAP
360 370 380 390 400
FDQYLHRFPA YLQQLSMESN GKSVTRGNVF ANYSTGSILF GEPATNAQHS
410 420 430 440 450
FFQLIHQGTK LIPSDFILAA QSHNPIENNL HQKMLASNFF AQAEALMVGK
460 470 480 490 500
DEEQVKSEGA TGGLVPHKVF SGNRPTTSIL AQKITPATLG ALIAYYEHVT
510 520 530 540 550
FTEGAIWNIN SFDQWGVELG KVLAKVIGSE LATDNKISSH DSSTNGLINQ

FKEWI
Length:555
Mass (Da):61,568
Last modified:September 27, 2004 - v2
Checksum:iF61A9F8806C1E2CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2342SA → QLEL in CAA30923. (PubMed:3419932)Curated
Sequence conflicti505 – 5051A → R in CAA30923. (PubMed:3419932)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12360 Genomic DNA. Translation: CAA30923.1.
CR382125 Genomic DNA. Translation: CAH00100.1.
PIRiS01414. NUVKL.
RefSeqiXP_455013.1. XM_455013.1.

Genome annotation databases

GeneIDi2894287.
KEGGikla:KLLA0E23519g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12360 Genomic DNA. Translation: CAA30923.1 .
CR382125 Genomic DNA. Translation: CAH00100.1 .
PIRi S01414. NUVKL.
RefSeqi XP_455013.1. XM_455013.1.

3D structure databases

ProteinModelPortali P12341.
SMRi P12341. Positions 13-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.P12341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2894287.
KEGGi kla:KLLA0E23519g.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261371.
InParanoidi P12341.
KOi K01810.
OMAi NCHFVAN.
OrthoDBi EOG7N0CDV.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The RAG2 gene of the yeast Kluyveromyces lactis codes for a putative phosphoglucose isomerase."
    Wesolowski-Louvel M., Goffrini P., Ferrero I.
    Nucleic Acids Res. 16:8714-8714(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
  3. "A phosphoglucose isomerase gene is involved in the Rag phenotype of the yeast Kluyveromyces lactis."
    Goffrini P., Wesolowski-Louvel M., Ferrero I.
    Mol. Gen. Genet. 228:401-409(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiG6PI_KLULA
AccessioniPrimary (citable) accession number: P12341
Secondary accession number(s): Q6CM26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3