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P12336

- GTR2_RAT

UniProt

P12336 - GTR2_RAT

Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

Slc2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei347 – 3471MonosaccharideBy similarity
    Binding sitei418 – 4181MonosaccharideBy similarity

    GO - Molecular functioni

    1. dehydroascorbic acid transporter activity Source: UniProtKB
    2. D-glucose transmembrane transporter activity Source: UniProtKB
    3. glucose transmembrane transporter activity Source: RGD
    4. insulin receptor binding Source: RGD

    GO - Biological processi

    1. carbohydrate utilization Source: RGD
    2. dehydroascorbic acid transport Source: UniProtKB
    3. fructose transport Source: RGD
    4. glucose transport Source: UniProtKB
    5. response to glucose Source: RGD
    6. response to peptide hormone Source: RGD

    Keywords - Biological processi

    Sugar transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2
    Alternative name(s):
    Glucose transporter type 2, liver
    Short name:
    GLUT-2
    Gene namesi
    Name:Slc2a2
    Synonyms:Glut-2, Glut2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3705. Slc2a2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RGD
    2. brush border Source: RGD
    3. brush border membrane Source: RGD
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: RGD
    6. endosome Source: RGD
    7. integral component of membrane Source: UniProtKB-KW
    8. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Solute carrier family 2, facilitated glucose transporter member 2PRO_0000050348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP12336.
    PRIDEiP12336.

    PTM databases

    PhosphoSiteiP12336.

    Expressioni

    Tissue specificityi

    Present in liver, intestine, kidney and beta-pancreatic islet cells.

    Gene expression databases

    GenevestigatoriP12336.

    Structurei

    3D structure databases

    ProteinModelPortaliP12336.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 9665ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 1258CytoplasmicSequence Analysis
    Topological domaini147 – 15610ExtracellularSequence Analysis
    Topological domaini178 – 1858CytoplasmicSequence Analysis
    Topological domaini207 – 2159ExtracellularSequence Analysis
    Topological domaini237 – 30165CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini323 – 33715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 3657CytoplasmicSequence Analysis
    Topological domaini387 – 40115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini423 – 4319CytoplasmicSequence Analysis
    Topological domaini453 – 4597ExtracellularSequence Analysis
    Topological domaini481 – 52242CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni312 – 3187Monosaccharide bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000202871.
    HOVERGENiHBG014816.
    InParanoidiP12336.
    PhylomeDBiP12336.

    Family and domain databases

    InterProiIPR002440. Glc_transpt_2.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR01191. GLUCTRSPORT2.
    PR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12336-1 [UniParc]FASTAAdd to Basket

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    MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL    50
    DDRRATINYD INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS 100
    SFAVGGMVAS FFGGWLGDKL GRIKAMLAAN SLSLTGALLM GCSKFGPAHA 150
    LIIAGRSVSG LYCGLISGLV PMYIGEIAPT TLRGALGTLH QLALVTGILI 200
    SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES PRYLYLNLEE 250
    EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ 300
    PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF 350
    TAVSVLLVEK AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT 400
    AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PTALALAAFS NWVCNFIIAL 450
    CFQYIADFLG PYVFFLFAGV VLVFTLFTFF KVPETKGKSF DEIAAEFRKK 500
    SGSAPPRKAT VQMEFLGSSE TV 522
    Length:522
    Mass (Da):57,086
    Last modified:October 1, 1989 - v1
    Checksum:i075AB81E56CF33F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03145 mRNA. Translation: AAA41298.1.
    L28134 Genomic DNA. Translation: AAA99958.1.
    PIRiA31556.
    UniGeneiRn.89295.

    Genome annotation databases

    UCSCiRGD:3705. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03145 mRNA. Translation: AAA41298.1 .
    L28134 Genomic DNA. Translation: AAA99958.1 .
    PIRi A31556.
    UniGenei Rn.89295.

    3D structure databases

    ProteinModelPortali P12336.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P12336.

    Proteomic databases

    PaxDbi P12336.
    PRIDEi P12336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3705. rat.

    Organism-specific databases

    RGDi 3705. Slc2a2.

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000202871.
    HOVERGENi HBG014816.
    InParanoidi P12336.
    PhylomeDBi P12336.

    Miscellaneous databases

    PROi P12336.

    Gene expression databases

    Genevestigatori P12336.

    Family and domain databases

    InterProi IPR002440. Glc_transpt_2.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR01191. GLUCTRSPORT2.
    PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells."
      Thorens B., Sarkar H.K., Kaback H.R., Lodish H.F.
      Cell 55:281-290(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization."
      Ahn Y.H., Kim J.W., Han G.S., Lee B.G., Kim Y.S.
      Arch. Biochem. Biophys. 323:387-396(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 389-456.
      Strain: Holtzman.
      Tissue: Liver.

    Entry informationi

    Entry nameiGTR2_RAT
    AccessioniPrimary (citable) accession number: P12336
    Secondary accession number(s): Q6LE98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3