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P12336

- GTR2_RAT

UniProt

P12336 - GTR2_RAT

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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

Slc2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei347 – 3471MonosaccharideBy similarity
Binding sitei418 – 4181MonosaccharideBy similarity

GO - Molecular functioni

  1. dehydroascorbic acid transporter activity Source: UniProtKB
  2. D-glucose transmembrane transporter activity Source: UniProtKB
  3. glucose transmembrane transporter activity Source: RGD
  4. insulin receptor binding Source: RGD

GO - Biological processi

  1. carbohydrate utilization Source: RGD
  2. dehydroascorbic acid transport Source: UniProtKB
  3. fructose transport Source: RGD
  4. glucose transport Source: UniProtKB
  5. response to glucose Source: RGD
  6. response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3705. Slc2a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini32 – 9665ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini118 – 1258CytoplasmicSequence Analysis
Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini147 – 15610ExtracellularSequence Analysis
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 1858CytoplasmicSequence Analysis
Transmembranei186 – 20621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini207 – 2159ExtracellularSequence Analysis
Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini237 – 30165CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini323 – 33715ExtracellularSequence AnalysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini359 – 3657CytoplasmicSequence Analysis
Transmembranei366 – 38621Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini387 – 40115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei402 – 42221Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini423 – 4319CytoplasmicSequence Analysis
Transmembranei432 – 45221Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini453 – 4597ExtracellularSequence Analysis
Transmembranei460 – 48021Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini481 – 52242CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. brush border Source: RGD
  3. brush border membrane Source: RGD
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: RGD
  6. endosome Source: RGD
  7. integral component of membrane Source: UniProtKB-KW
  8. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Solute carrier family 2, facilitated glucose transporter member 2PRO_0000050348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12336.
PRIDEiP12336.

PTM databases

PhosphoSiteiP12336.

Expressioni

Tissue specificityi

Present in liver, intestine, kidney and beta-pancreatic islet cells.

Gene expression databases

GenevestigatoriP12336.

Structurei

3D structure databases

ProteinModelPortaliP12336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 3187Monosaccharide bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP12336.
PhylomeDBiP12336.

Family and domain databases

InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12336-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL
60 70 80 90 100
DDRRATINYD INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS
110 120 130 140 150
SFAVGGMVAS FFGGWLGDKL GRIKAMLAAN SLSLTGALLM GCSKFGPAHA
160 170 180 190 200
LIIAGRSVSG LYCGLISGLV PMYIGEIAPT TLRGALGTLH QLALVTGILI
210 220 230 240 250
SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES PRYLYLNLEE
260 270 280 290 300
EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ
310 320 330 340 350
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF
360 370 380 390 400
TAVSVLLVEK AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT
410 420 430 440 450
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PTALALAAFS NWVCNFIIAL
460 470 480 490 500
CFQYIADFLG PYVFFLFAGV VLVFTLFTFF KVPETKGKSF DEIAAEFRKK
510 520
SGSAPPRKAT VQMEFLGSSE TV
Length:522
Mass (Da):57,086
Last modified:October 1, 1989 - v1
Checksum:i075AB81E56CF33F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03145 mRNA. Translation: AAA41298.1.
L28134 Genomic DNA. Translation: AAA99958.1.
PIRiA31556.
UniGeneiRn.89295.

Genome annotation databases

UCSCiRGD:3705. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03145 mRNA. Translation: AAA41298.1 .
L28134 Genomic DNA. Translation: AAA99958.1 .
PIRi A31556.
UniGenei Rn.89295.

3D structure databases

ProteinModelPortali P12336.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P12336.

Proteomic databases

PaxDbi P12336.
PRIDEi P12336.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3705. rat.

Organism-specific databases

RGDi 3705. Slc2a2.

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000202871.
HOVERGENi HBG014816.
InParanoidi P12336.
PhylomeDBi P12336.

Miscellaneous databases

PROi P12336.

Gene expression databases

Genevestigatori P12336.

Family and domain databases

InterProi IPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells."
    Thorens B., Sarkar H.K., Kaback H.R., Lodish H.F.
    Cell 55:281-290(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization."
    Ahn Y.H., Kim J.W., Han G.S., Lee B.G., Kim Y.S.
    Arch. Biochem. Biophys. 323:387-396(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 389-456.
    Strain: Holtzman.
    Tissue: Liver.

Entry informationi

Entry nameiGTR2_RAT
AccessioniPrimary (citable) accession number: P12336
Secondary accession number(s): Q6LE98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 1, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3