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P12336

- GTR2_RAT

UniProt

P12336 - GTR2_RAT

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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene
Slc2a2, Glut-2, Glut2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei347 – 3471Monosaccharide By similarity
Binding sitei418 – 4181Monosaccharide By similarity

GO - Molecular functioni

  1. dehydroascorbic acid transporter activity Source: UniProtKB
  2. D-glucose transmembrane transporter activity Source: UniProtKB
  3. glucose transmembrane transporter activity Source: RGD
  4. insulin receptor binding Source: RGD

GO - Biological processi

  1. carbohydrate utilization Source: RGD
  2. dehydroascorbic acid transport Source: UniProtKB
  3. fructose transport Source: RGD
  4. glucose transport Source: UniProtKB
  5. response to glucose Source: RGD
  6. response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3705. Slc2a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini32 – 9665Extracellular Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini118 – 1258Cytoplasmic Reviewed prediction
Transmembranei126 – 14621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini147 – 15610Extracellular Reviewed prediction
Transmembranei157 – 17721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini178 – 1858Cytoplasmic Reviewed prediction
Transmembranei186 – 20621Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini207 – 2159Extracellular Reviewed prediction
Transmembranei216 – 23621Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini237 – 30165Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei302 – 32221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini323 – 33715Extracellular Reviewed predictionAdd
BLAST
Transmembranei338 – 35821Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini359 – 3657Cytoplasmic Reviewed prediction
Transmembranei366 – 38621Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini387 – 40115Extracellular Reviewed predictionAdd
BLAST
Transmembranei402 – 42221Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini423 – 4319Cytoplasmic Reviewed prediction
Transmembranei432 – 45221Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini453 – 4597Extracellular Reviewed prediction
Transmembranei460 – 48021Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini481 – 52242Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. brush border Source: RGD
  3. brush border membrane Source: RGD
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: RGD
  6. endosome Source: RGD
  7. integral component of membrane Source: UniProtKB-KW
  8. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Solute carrier family 2, facilitated glucose transporter member 2PRO_0000050348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12336.
PRIDEiP12336.

PTM databases

PhosphoSiteiP12336.

Expressioni

Tissue specificityi

Present in liver, intestine, kidney and beta-pancreatic islet cells.

Gene expression databases

GenevestigatoriP12336.

Structurei

3D structure databases

ProteinModelPortaliP12336.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 3187Monosaccharide binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP12336.
PhylomeDBiP12336.

Family and domain databases

InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12336-1 [UniParc]FASTAAdd to Basket

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MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL    50
DDRRATINYD INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS 100
SFAVGGMVAS FFGGWLGDKL GRIKAMLAAN SLSLTGALLM GCSKFGPAHA 150
LIIAGRSVSG LYCGLISGLV PMYIGEIAPT TLRGALGTLH QLALVTGILI 200
SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES PRYLYLNLEE 250
EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ 300
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF 350
TAVSVLLVEK AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT 400
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PTALALAAFS NWVCNFIIAL 450
CFQYIADFLG PYVFFLFAGV VLVFTLFTFF KVPETKGKSF DEIAAEFRKK 500
SGSAPPRKAT VQMEFLGSSE TV 522
Length:522
Mass (Da):57,086
Last modified:October 1, 1989 - v1
Checksum:i075AB81E56CF33F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03145 mRNA. Translation: AAA41298.1.
L28134 Genomic DNA. Translation: AAA99958.1.
PIRiA31556.
UniGeneiRn.89295.

Genome annotation databases

UCSCiRGD:3705. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03145 mRNA. Translation: AAA41298.1 .
L28134 Genomic DNA. Translation: AAA99958.1 .
PIRi A31556.
UniGenei Rn.89295.

3D structure databases

ProteinModelPortali P12336.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P12336.

Proteomic databases

PaxDbi P12336.
PRIDEi P12336.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3705. rat.

Organism-specific databases

RGDi 3705. Slc2a2.

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000202871.
HOVERGENi HBG014816.
InParanoidi P12336.
PhylomeDBi P12336.

Miscellaneous databases

PROi P12336.

Gene expression databases

Genevestigatori P12336.

Family and domain databases

InterProi IPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells."
    Thorens B., Sarkar H.K., Kaback H.R., Lodish H.F.
    Cell 55:281-290(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization."
    Ahn Y.H., Kim J.W., Han G.S., Lee B.G., Kim Y.S.
    Arch. Biochem. Biophys. 323:387-396(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 389-456.
    Strain: Holtzman.
    Tissue: Liver.

Entry informationi

Entry nameiGTR2_RAT
AccessioniPrimary (citable) accession number: P12336
Secondary accession number(s): Q6LE98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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