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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

Slc2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei347MonosaccharideBy similarity1
Binding sitei418MonosaccharideBy similarity1

GO - Molecular functioni

  • dehydroascorbic acid transporter activity Source: UniProtKB
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: RGD
  • insulin receptor binding Source: RGD

GO - Biological processi

  • carbohydrate utilization Source: RGD
  • dehydroascorbic acid transport Source: UniProtKB
  • fructose transport Source: RGD
  • glucose transport Source: UniProtKB
  • response to glucose Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3705. Slc2a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 96ExtracellularSequence analysisAdd BLAST65
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 125CytoplasmicSequence analysis8
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini147 – 156ExtracellularSequence analysis10
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 185CytoplasmicSequence analysis8
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 215ExtracellularSequence analysis9
Transmembranei216 – 236Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini237 – 301CytoplasmicSequence analysisAdd BLAST65
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 337ExtracellularSequence analysisAdd BLAST15
Transmembranei338 – 358Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini359 – 365CytoplasmicSequence analysis7
Transmembranei366 – 386Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini387 – 401ExtracellularSequence analysisAdd BLAST15
Transmembranei402 – 422Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini423 – 431CytoplasmicSequence analysis9
Transmembranei432 – 452Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini453 – 459ExtracellularSequence analysis7
Transmembranei460 – 480Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini481 – 522CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • brush border Source: RGD
  • brush border membrane Source: RGD
  • cytoplasm Source: UniProtKB
  • cytosol Source: RGD
  • endosome Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503481 – 522Solute carrier family 2, facilitated glucose transporter member 2Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Modified residuei521PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP12336.
PRIDEiP12336.

PTM databases

iPTMnetiP12336.
PhosphoSitePlusiP12336.

Expressioni

Tissue specificityi

Present in liver, intestine, kidney and beta-pancreatic islet cells.

Interactioni

GO - Molecular functioni

  • insulin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015866.

Structurei

3D structure databases

ProteinModelPortaliP12336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 318Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP12336.
PhylomeDBiP12336.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL
60 70 80 90 100
DDRRATINYD INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS
110 120 130 140 150
SFAVGGMVAS FFGGWLGDKL GRIKAMLAAN SLSLTGALLM GCSKFGPAHA
160 170 180 190 200
LIIAGRSVSG LYCGLISGLV PMYIGEIAPT TLRGALGTLH QLALVTGILI
210 220 230 240 250
SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES PRYLYLNLEE
260 270 280 290 300
EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ
310 320 330 340 350
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF
360 370 380 390 400
TAVSVLLVEK AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT
410 420 430 440 450
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PTALALAAFS NWVCNFIIAL
460 470 480 490 500
CFQYIADFLG PYVFFLFAGV VLVFTLFTFF KVPETKGKSF DEIAAEFRKK
510 520
SGSAPPRKAT VQMEFLGSSE TV
Length:522
Mass (Da):57,086
Last modified:October 1, 1989 - v1
Checksum:i075AB81E56CF33F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03145 mRNA. Translation: AAA41298.1.
L28134 Genomic DNA. Translation: AAA99958.1.
PIRiA31556.
UniGeneiRn.89295.

Genome annotation databases

UCSCiRGD:3705. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03145 mRNA. Translation: AAA41298.1.
L28134 Genomic DNA. Translation: AAA99958.1.
PIRiA31556.
UniGeneiRn.89295.

3D structure databases

ProteinModelPortaliP12336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015866.

PTM databases

iPTMnetiP12336.
PhosphoSitePlusiP12336.

Proteomic databases

PaxDbiP12336.
PRIDEiP12336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3705. rat.

Organism-specific databases

RGDi3705. Slc2a2.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP12336.
PhylomeDBiP12336.

Miscellaneous databases

PROiP12336.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR2_RAT
AccessioniPrimary (citable) accession number: P12336
Secondary accession number(s): Q6LE98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.