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P12336 (GTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name=GLUT-2
Gene names
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Facilitative glucose transporter. This isoform likelymediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Present in liver, intestine, kidney and beta-pancreatic islet cells.

Post-translational modification

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate utilization

Inferred from mutant phenotype PubMed 11834736. Source: RGD

dehydroascorbic acid transport

Inferred from direct assay PubMed 18668520. Source: UniProtKB

fructose transport

Inferred from expression pattern PubMed 12095416. Source: RGD

glucose transport

Inferred from direct assay PubMed 18668520. Source: UniProtKB

response to glucose

Inferred from expression pattern PubMed 12095416. Source: RGD

response to peptide hormone

Inferred from expression pattern PubMed 12095416. Source: RGD

   Cellular_componentbasolateral plasma membrane

Inferred from direct assay PubMed 1468587. Source: RGD

brush border

Inferred from direct assay PubMed 12095416. Source: RGD

brush border membrane

Inferred from direct assay PubMed 17272350. Source: RGD

cytoplasm

Inferred from direct assay PubMed 18668520. Source: UniProtKB

cytosol

Inferred from direct assay PubMed 15665515. Source: RGD

endosome

Inferred from direct assay PubMed 15665515. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 15665515. Source: RGD

   Molecular_functionD-glucose transmembrane transporter activity

Inferred from direct assay PubMed 18668520. Source: UniProtKB

dehydroascorbic acid transporter activity

Inferred from direct assay PubMed 18668520. Source: UniProtKB

glucose transmembrane transporter activity

Inferred from direct assay PubMed 11834736. Source: RGD

insulin receptor binding

Inferred from physical interaction PubMed 15665515. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Solute carrier family 2, facilitated glucose transporter member 2
PRO_0000050348

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Name=1; Potential
Topological domain32 – 9665Extracellular Potential
Transmembrane97 – 11721Helical; Name=2; Potential
Topological domain118 – 1258Cytoplasmic Potential
Transmembrane126 – 14621Helical; Name=3; Potential
Topological domain147 – 15610Extracellular Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 1858Cytoplasmic Potential
Transmembrane186 – 20621Helical; Name=5; Potential
Topological domain207 – 2159Extracellular Potential
Transmembrane216 – 23621Helical; Name=6; Potential
Topological domain237 – 30165Cytoplasmic Potential
Transmembrane302 – 32221Helical; Name=7; Potential
Topological domain323 – 33715Extracellular Potential
Transmembrane338 – 35821Helical; Name=8; Potential
Topological domain359 – 3657Cytoplasmic Potential
Transmembrane366 – 38621Helical; Name=9; Potential
Topological domain387 – 40115Extracellular Potential
Transmembrane402 – 42221Helical; Name=10; Potential
Topological domain423 – 4319Cytoplasmic Potential
Transmembrane432 – 45221Helical; Name=11; Potential
Topological domain453 – 4597Extracellular Potential
Transmembrane460 – 48021Helical; Name=12; Potential
Topological domain481 – 52242Cytoplasmic Potential

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P12336 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 075AB81E56CF33F7

FASTA52257,086
        10         20         30         40         50         60 
MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL DDRRATINYD 

        70         80         90        100        110        120 
INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS SFAVGGMVAS FFGGWLGDKL 

       130        140        150        160        170        180 
GRIKAMLAAN SLSLTGALLM GCSKFGPAHA LIIAGRSVSG LYCGLISGLV PMYIGEIAPT 

       190        200        210        220        230        240 
TLRGALGTLH QLALVTGILI SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES 

       250        260        270        280        290        300 
PRYLYLNLEE EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ 

       310        320        330        340        350        360 
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF TAVSVLLVEK 

       370        380        390        400        410        420 
AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT AIFLFVSFFE IGPGPIPWFM 

       430        440        450        460        470        480 
VAEFFSQGPR PTALALAAFS NWVCNFIIAL CFQYIADFLG PYVFFLFAGV VLVFTLFTFF 

       490        500        510        520 
KVPETKGKSF DEIAAEFRKK SGSAPPRKAT VQMEFLGSSE TV 

« Hide

References

[1]"Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells."
Thorens B., Sarkar H.K., Kaback H.R., Lodish H.F.
Cell 55:281-290(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization."
Ahn Y.H., Kim J.W., Han G.S., Lee B.G., Kim Y.S.
Arch. Biochem. Biophys. 323:387-396(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 389-456.
Strain: Holtzman.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03145 mRNA. Translation: AAA41298.1.
L28134 Genomic DNA. Translation: AAA99958.1.
PIRA31556.
UniGeneRn.89295.

3D structure databases

ProteinModelPortalP12336.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP12336.

Proteomic databases

PaxDbP12336.
PRIDEP12336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3705. rat.

Organism-specific databases

RGD3705. Slc2a2.

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202871.
HOVERGENHBG014816.
InParanoidP12336.
PhylomeDBP12336.

Gene expression databases

GenevestigatorP12336.

Family and domain databases

InterProIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP12336.

Entry information

Entry nameGTR2_RAT
AccessionPrimary (citable) accession number: P12336
Secondary accession number(s): Q6LE98
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families