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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

Slc2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei347MonosaccharideBy similarity1
Binding sitei418MonosaccharideBy similarity1

GO - Molecular functioni

  • dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: RGD
  • insulin receptor binding Source: RGD

GO - Biological processi

  • carbohydrate utilization Source: RGD
  • dehydroascorbic acid transport Source: UniProtKB
  • fructose transmembrane transport Source: RGD
  • glucose transmembrane transport Source: UniProtKB
  • response to glucose Source: RGD
  • response to peptide hormone Source: RGD

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3705 Slc2a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 96ExtracellularSequence analysisAdd BLAST65
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 125CytoplasmicSequence analysis8
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini147 – 156ExtracellularSequence analysis10
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 185CytoplasmicSequence analysis8
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 215ExtracellularSequence analysis9
Transmembranei216 – 236Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini237 – 301CytoplasmicSequence analysisAdd BLAST65
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 337ExtracellularSequence analysisAdd BLAST15
Transmembranei338 – 358Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini359 – 365CytoplasmicSequence analysis7
Transmembranei366 – 386Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini387 – 401ExtracellularSequence analysisAdd BLAST15
Transmembranei402 – 422Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini423 – 431CytoplasmicSequence analysis9
Transmembranei432 – 452Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini453 – 459ExtracellularSequence analysis7
Transmembranei460 – 480Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini481 – 522CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503481 – 522Solute carrier family 2, facilitated glucose transporter member 2Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei521PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP12336
PRIDEiP12336

PTM databases

iPTMnetiP12336
PhosphoSitePlusiP12336

Expressioni

Tissue specificityi

Present in liver, intestine, kidney and beta-pancreatic islet cells.

Interactioni

GO - Molecular functioni

  • insulin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015866

Structurei

3D structure databases

ProteinModelPortaliP12336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 318Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP12336
PhylomeDBiP12336

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002440 Glc_transpt_2
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01191 GLUCTRSPORT2
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P12336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL
60 70 80 90 100
DDRRATINYD INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS
110 120 130 140 150
SFAVGGMVAS FFGGWLGDKL GRIKAMLAAN SLSLTGALLM GCSKFGPAHA
160 170 180 190 200
LIIAGRSVSG LYCGLISGLV PMYIGEIAPT TLRGALGTLH QLALVTGILI
210 220 230 240 250
SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES PRYLYLNLEE
260 270 280 290 300
EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ
310 320 330 340 350
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF
360 370 380 390 400
TAVSVLLVEK AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT
410 420 430 440 450
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PTALALAAFS NWVCNFIIAL
460 470 480 490 500
CFQYIADFLG PYVFFLFAGV VLVFTLFTFF KVPETKGKSF DEIAAEFRKK
510 520
SGSAPPRKAT VQMEFLGSSE TV
Length:522
Mass (Da):57,086
Last modified:October 1, 1989 - v1
Checksum:i075AB81E56CF33F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03145 mRNA Translation: AAA41298.1
L28134 Genomic DNA Translation: AAA99958.1
PIRiA31556
UniGeneiRn.89295

Genome annotation databases

UCSCiRGD:3705 rat

Similar proteinsi

Entry informationi

Entry nameiGTR2_RAT
AccessioniPrimary (citable) accession number: P12336
Secondary accession number(s): Q6LE98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health