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P12323 (KLK2_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glandular kallikrein, prostatic

EC=3.4.21.35
Alternative name(s):
Prostate esterase
Tissue kallikrein
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Glandular kallikrein, prostatic
PRO_0000088701

Regions

Domain1 – 236236Peptidase S1

Sites

Active site411Charge relay system
Active site961Charge relay system
Active site1911Charge relay system

Amino acid modifications

Glycosylation781N-linked (GlcNAc...)
Glycosylation1691N-linked (GlcNAc...)
Disulfide bond7 ↔ 151 By similarity
Disulfide bond26 ↔ 42 By similarity
Disulfide bond128 ↔ 197 By similarity
Disulfide bond162 ↔ 176 By similarity
Disulfide bond187 ↔ 212 By similarity

Natural variations

Natural variant501K → W.

Sequences

Sequence LengthMass (Da)Tools
P12323 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 56DC81BC10D49A64

FASTA23925,989
        10         20         30         40         50         60 
VIGGQECARD SHPWQAAVYY YSDIKCGGVL VDPQWVLTAA HCINDSNQVK LGRHNLFEDE 

        70         80         90        100        110        120 
DTAQHFLVSQ SVPHPDFNMS LLEPHNVLPN EDYSHDLMLL RLNQPAQITD SVQVMPLPTQ 

       130        140        150        160        170        180 
EVQVGTTCRA LGWGSIDPDP AHPVFPDELQ CVGLEILPSK NCDDAHIANV TGTMLCAGDL 

       190        200        210        220        230 
AGGKDTCVGD SGGPLICDGV LQGLTSWGDS PCGVAHSPSL YTKVIEYREW IERTMADNP 

« Hide

References

[1]"Amino acid sequence of guinea pig prostate kallikrein."
Dunbar J.C., Bradshaw R.A.
Biochemistry 26:3471-3478(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRA27207.

3D structure databases

ProteinModelPortalP12323.
SMRP12323. Positions 1-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000020997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKLK2_CAVPO
AccessionPrimary (citable) accession number: P12323
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries