SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P12322

- KLK1_CAVPO

UniProt

P12322 - KLK1_CAVPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Kallikrein-1
Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.160.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-1 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein, submandibular
    Tissue kallikrein
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›31›31Kallikrein-1
    PRO_0000088700Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000014440.

    Structurei

    3D structure databases

    ProteinModelPortaliP12322.
    SMRiP12322. Positions 1-31.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – ›31›31Peptidase S1
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    InParanoidiP12322.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P12322-1 [UniParc]FASTAAdd to Basket

    « Hide

    VIGGQECARD SHPWQAAVYH FSDIECGGVL V                       31
    Length:31
    Mass (Da):3,345
    Last modified:October 1, 1989 - v1
    Checksum:i8FFFB84D46B8DC93
    GO

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei31 – 311

    Sequence databases

    PIRiA18671.

    Cross-referencesi

    Sequence databases

    PIRi A18671.

    3D structure databases

    ProteinModelPortali P12322.
    SMRi P12322. Positions 1-31.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000014440.

    Protein family/group databases

    MEROPSi S01.160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    InParanoidi P12322.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purification and properties of guinea-pig submandibular-gland kallikrein."
      Fiedler F., Lemon M.J.C., Hirschauer C., Leysath G., Lottspeich F., Henschen A., Gau W., Bhoola K.D.
      Biochem. J. 209:125-134(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiKLK1_CAVPO
    AccessioniPrimary (citable) accession number: P12322
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: May 14, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi