Reviewed, UniProtKB/Swiss-Prot P12322 (KLK1_CAVPO)

Names and origin

Protein names	Recommended name:     Kallikrein-1     EC=3.4.21.35 Alternative name(s):     Glandular kallikrein, submandibular     Tissue kallikrein
Organism	Cavia porcellus (Guinea pig)
Taxonomic identifier	10141 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	31 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Catalytic activity	Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.
Sequence similarities	Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Molecular function	Hydrolase Protease Serine protease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›31	›31	Kallikrein-1		PRO_0000088700
Regions
	Domain	1 – ›31	›31	Peptidase S1
Experimental info
	Non-terminal residue	31	1

Sequences

	Sequence		Length	Mass (Da)
	P12322-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 8FFFB84D46B8DC93	FASTA	31	3,345
	10 20 30 VIGGQECARD SHPWQAAVYH FSDIECGGVL V

References

[1]	"Purification and properties of guinea-pig submandibular-gland kallikrein." Fiedler F., Lemon M.J.C., Hirschauer C., Leysath G., Lottspeich F., Henschen A., Gau W., Bhoola K.D. Biochem. J. 209:125-134(1983) [PubMed: 6552183] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	A18671.
3D structure databases
HSSP	HSSP built from PDB template 1HIA based on UniProtKB P00752.
ModBase	Search...
Protein family/group databases
MEROPS	S01.160.
Genome annotation databases
Ensembl	ENSCPOG00000005638. Cavia porcellus. [Contig view] ENSCPOG00000026955. Cavia porcellus. [Contig view]
Phylogenomic databases
HOVERGEN	P12322.
Enzyme and pathway databases
BRENDA	3.4.21.35. 44.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KLK1_CAVPO

Accession

Primary (citable) accession number: P12322

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	May 5, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)