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P12322 (KLK1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein-1

EC=3.4.21.35
Alternative name(s):
Glandular kallikrein, submandibular
Tissue kallikrein
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length31 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›31›31Kallikrein-1
PRO_0000088700

Regions

Domain1 – ›31›31Peptidase S1

Experimental info

Non-terminal residue311

Sequences

Sequence LengthMass (Da)Tools
P12322 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 8FFFB84D46B8DC93

FASTA313,345
        10         20         30 
VIGGQECARD SHPWQAAVYH FSDIECGGVL V 

« Hide

References

[1]"Purification and properties of guinea-pig submandibular-gland kallikrein."
Fiedler F., Lemon M.J.C., Hirschauer C., Leysath G., Lottspeich F., Henschen A., Gau W., Bhoola K.D.
Biochem. J. 209:125-134(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRA18671.

3D structure databases

ProteinModelPortalP12322.
SMRP12322. Positions 1-31.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000014440.

Protein family/group databases

MEROPSS01.160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
InParanoidP12322.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKLK1_CAVPO
AccessionPrimary (citable) accession number: P12322
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries