P12322 (KLK1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Kallikrein-1 EC=3.4.21.35 Alternative name(s): Glandular kallikrein, submandibular Tissue kallikrein
Organism	Cavia porcellus (Guinea pig)
Taxonomic identifier	10141 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	31 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Catalytic activity	Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.
Sequence similarities	Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Molecular function	Hydrolase Protease Serine protease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›31	›31	Kallikrein-1		PRO_0000088700
Regions
	Domain	1 – ›31	›31	Peptidase S1
Experimental info
	Non-terminal residue	31	1

Sequences

	Sequence		Length	Mass (Da)
	P12322 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 8FFFB84D46B8DC93	FASTA	31	3,345
	10 20 30 VIGGQECARD SHPWQAAVYH FSDIECGGVL V

References

[1]	"Purification and properties of guinea-pig submandibular-gland kallikrein." Fiedler F., Lemon M.J.C., Hirschauer C., Leysath G., Lottspeich F., Henschen A., Gau W., Bhoola K.D. Biochem. J. 209:125-134(1983) [PubMed: 6552183] [Abstract] Cited for: PROTEIN SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	A18671.
3D structure databases
ProteinModelPortal	P12322.
SMR	P12322. Positions 1-31.
ModBase	Search...
Protein family/group databases
MEROPS	S01.160.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000005699; ENSCPOP00000005082; ENSCPOG00000005638. ENSCPOT00000020328; ENSCPOP00000014440; ENSCPOG00000026955. ENSCPOT00000021124; ENSCPOP00000016851; ENSCPOG00000005638. ENSCPOT00000021901; ENSCPOP00000017140; ENSCPOG00000026955. ENSCPOT00000024300; ENSCPOP00000020997; ENSCPOG00000005638.
Phylogenomic databases
GeneTree	ENSGT00590000082811.
InParanoid	P12322.
OrthoDB	EOG4DZ1VW.
Family and domain databases
InterPro	IPR009003. Pept_cys/ser_Trypsin-like. IPR001254. Peptidase_S1_S6. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KLK1_CAVPO

Accession

Primary (citable) accession number: P12322

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program