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Protein

High affinity immunoglobulin epsilon receptor subunit alpha

Gene

FCER1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
SIGNORiP12319

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit alpha
Alternative name(s):
Fc-epsilon RI-alpha
Short name:
FcERI
IgE Fc receptor subunit alpha
Gene namesi
Name:FCER1A
Synonyms:FCE1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179639.10
HGNCiHGNC:3609 FCER1A
MIMi147140 gene
neXtProtiNX_P12319

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 205ExtracellularSequence analysisAdd BLAST180
Transmembranei206 – 224HelicalSequence analysisAdd BLAST19
Topological domaini225 – 257CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2205
OpenTargetsiENSG00000179639
PharmGKBiPA28056

Chemistry databases

ChEMBLiCHEMBL2248
DrugBankiDB00895 Benzylpenicilloyl Polylysine
DB00043 Omalizumab
DB05797 TNX-901
GuidetoPHARMACOLOGYi2933

Polymorphism and mutation databases

BioMutaiFCER1A
DMDMi119865

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001516126 – 257High affinity immunoglobulin epsilon receptor subunit alphaAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi51 ↔ 93Combined sources2 Publications
Glycosylationi67N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi132 ↔ 176Combined sources2 Publications
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12319
PeptideAtlasiP12319
PRIDEiP12319

PTM databases

iPTMnetiP12319
PhosphoSitePlusiP12319

Expressioni

Gene expression databases

BgeeiENSG00000179639
CleanExiHS_FCER1A
ExpressionAtlasiP12319 baseline and differential
GenevisibleiP12319 HS

Organism-specific databases

HPAiCAB022102
CAB055526
HPA036051

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

Protein-protein interaction databases

BioGridi10849929 interactors.
DIPiDIP-6166N
IntActiP12319 1 interactor.
STRINGi9606.ENSP00000357097

Chemistry databases

BindingDBiP12319

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 37Combined sources5
Beta strandi39 – 42Combined sources4
Beta strandi47 – 50Combined sources4
Beta strandi53 – 55Combined sources3
Beta strandi63 – 66Combined sources4
Beta strandi69 – 72Combined sources4
Beta strandi75 – 80Combined sources6
Helixi85 – 87Combined sources3
Beta strandi89 – 94Combined sources6
Beta strandi96 – 99Combined sources4
Beta strandi104 – 109Combined sources6
Beta strandi111 – 118Combined sources8
Beta strandi120 – 123Combined sources4
Beta strandi128 – 134Combined sources7
Helixi135 – 137Combined sources3
Beta strandi140 – 147Combined sources8
Beta strandi150 – 157Combined sources8
Beta strandi158 – 165Combined sources8
Helixi168 – 170Combined sources3
Beta strandi172 – 180Combined sources9
Beta strandi183 – 186Combined sources4
Beta strandi190 – 195Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALSmodel-A26-197[»]
1ALTmodel-A26-197[»]
1F2QX-ray2.40A26-201[»]
1F6AX-ray3.50A26-201[»]
1J86X-ray3.20A/B26-201[»]
1J87X-ray3.20A26-197[»]
1J88X-ray3.20A/B/C/D/E26-197[»]
1J89X-ray4.10A/B/C/D/E26-197[»]
1RPQX-ray3.00A/B/C/D26-201[»]
2Y7QX-ray3.40A26-201[»]
ProteinModelPortaliP12319
SMRiP12319
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12319

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 110Ig-like 1Add BLAST81
Domaini111 – 193Ig-like 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJME Eukaryota
ENOG410ZPGM LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP12319
KOiK08089
OMAiYENHNIS
OrthoDBiEOG091G0ETN
PhylomeDBiP12319
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.102 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT
60 70 80 90 100
CNGNNFFEVS STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE
110 120 130 140 150
SEPVYLEVFS DWLLLQASAE VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE
160 170 180 190 200
ALKYWYENHN ISITNATVED SGTYYCTGKV WQLDYESEPL NITVIKAPRE
210 220 230 240 250
KYWLQFFIPL LVVILFAVDT GLFISTQQQV TFLLKIKRTR KGFRLLNPHP

KPNPKNN
Length:257
Mass (Da):29,596
Last modified:October 1, 1989 - v1
Checksum:iF183BB2357DDAD58
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02009184K → R. Corresponds to variant dbSNP:rs2298804Ensembl.1
Natural variantiVAR_020092101S → N. Corresponds to variant dbSNP:rs2298805Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06948 mRNA Translation: CAA30025.1
J03605 mRNA Translation: AAA36204.1
BC005912 mRNA Translation: AAH05912.1
CCDSiCCDS1184.1
PIRiS00682
RefSeqiNP_001992.1, NM_002001.3
UniGeneiHs.897

Genome annotation databases

EnsembliENST00000368115; ENSP00000357097; ENSG00000179639
GeneIDi2205
KEGGihsa:2205
UCSCiuc001ftq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFCERA_HUMAN
AccessioniPrimary (citable) accession number: P12319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 25, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome