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Protein

High affinity immunoglobulin epsilon receptor subunit alpha

Gene

FCER1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit alpha
Alternative name(s):
Fc-epsilon RI-alpha
Short name:
FcERI
IgE Fc receptor subunit alpha
Gene namesi
Name:FCER1A
Synonyms:FCE1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179639.10.
HGNCiHGNC:3609. FCER1A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 205ExtracellularSequence analysisAdd BLAST180
Transmembranei206 – 224HelicalSequence analysisAdd BLAST19
Topological domaini225 – 257CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2205.
OpenTargetsiENSG00000179639.
PharmGKBiPA28056.

Chemistry databases

ChEMBLiCHEMBL2248.
DrugBankiDB00895. Benzylpenicilloyl Polylysine.
DB00043. Omalizumab.
DB05797. TNX-901.
GuidetoPHARMACOLOGYi2933.

Polymorphism and mutation databases

BioMutaiFCER1A.
DMDMi119865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001516126 – 257High affinity immunoglobulin epsilon receptor subunit alphaAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi51 ↔ 93Combined sources2 Publications
Glycosylationi67N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi132 ↔ 176Combined sources2 Publications
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi191N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12319.
PeptideAtlasiP12319.
PRIDEiP12319.

PTM databases

iPTMnetiP12319.
PhosphoSitePlusiP12319.

Expressioni

Gene expression databases

BgeeiENSG00000179639.
CleanExiHS_FCER1A.
ExpressionAtlasiP12319. baseline and differential.
GenevisibleiP12319. HS.

Organism-specific databases

HPAiCAB022102.
CAB055526.
HPA036051.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108499. 28 interactors.
DIPiDIP-6166N.
IntActiP12319. 1 interactor.
STRINGi9606.ENSP00000357097.

Chemistry databases

BindingDBiP12319.

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 37Combined sources5
Beta strandi39 – 42Combined sources4
Beta strandi47 – 50Combined sources4
Beta strandi53 – 55Combined sources3
Beta strandi63 – 66Combined sources4
Beta strandi69 – 72Combined sources4
Beta strandi75 – 80Combined sources6
Helixi85 – 87Combined sources3
Beta strandi89 – 94Combined sources6
Beta strandi96 – 99Combined sources4
Beta strandi104 – 109Combined sources6
Beta strandi111 – 118Combined sources8
Beta strandi120 – 123Combined sources4
Beta strandi128 – 134Combined sources7
Helixi135 – 137Combined sources3
Beta strandi140 – 147Combined sources8
Beta strandi150 – 157Combined sources8
Beta strandi158 – 165Combined sources8
Helixi168 – 170Combined sources3
Beta strandi172 – 180Combined sources9
Beta strandi183 – 186Combined sources4
Beta strandi190 – 195Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALSmodel-A26-197[»]
1ALTmodel-A26-197[»]
1F2QX-ray2.40A26-201[»]
1F6AX-ray3.50A26-201[»]
1J86X-ray3.20A/B26-201[»]
1J87X-ray3.20A26-197[»]
1J88X-ray3.20A/B/C/D/E26-197[»]
1J89X-ray4.10A/B/C/D/E26-197[»]
1RPQX-ray3.00A/B/C/D26-201[»]
2Y7QX-ray3.40A26-201[»]
ProteinModelPortaliP12319.
SMRiP12319.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12319.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 110Ig-like 1Add BLAST81
Domaini111 – 193Ig-like 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJME. Eukaryota.
ENOG410ZPGM. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP12319.
KOiK08089.
OMAiYENHNIS.
OrthoDBiEOG091G0ETN.
PhylomeDBiP12319.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF13895. Ig_2. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT
60 70 80 90 100
CNGNNFFEVS STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE
110 120 130 140 150
SEPVYLEVFS DWLLLQASAE VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE
160 170 180 190 200
ALKYWYENHN ISITNATVED SGTYYCTGKV WQLDYESEPL NITVIKAPRE
210 220 230 240 250
KYWLQFFIPL LVVILFAVDT GLFISTQQQV TFLLKIKRTR KGFRLLNPHP

KPNPKNN
Length:257
Mass (Da):29,596
Last modified:October 1, 1989 - v1
Checksum:iF183BB2357DDAD58
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02009184K → R. Corresponds to variant dbSNP:rs2298804Ensembl.1
Natural variantiVAR_020092101S → N. Corresponds to variant dbSNP:rs2298805Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06948 mRNA. Translation: CAA30025.1.
J03605 mRNA. Translation: AAA36204.1.
BC005912 mRNA. Translation: AAH05912.1.
CCDSiCCDS1184.1.
PIRiS00682.
RefSeqiNP_001992.1. NM_002001.3.
UniGeneiHs.897.

Genome annotation databases

EnsembliENST00000368115; ENSP00000357097; ENSG00000179639.
GeneIDi2205.
KEGGihsa:2205.
UCSCiuc001ftq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFCERA_HUMAN
AccessioniPrimary (citable) accession number: P12319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 27, 2017
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references