Reviewed,
UniProtKB/Swiss-Prot P12318 (FCG2A_HUMAN)
Last modified
November 3, 2009.
Version 119.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Low affinity immunoglobulin gamma Fc region receptor II-a Short name=IgG Fc receptor II-a Alternative name(s): Fc-gamma RII-a Fc-gamma-RIIa Short name=FcRII-a CDw32 CD_antigen=CD32 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 317 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. |
| Subunit structure | Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Ref.9 |
| Subcellular location | |
| Tissue specificity | Found on monocytes, neutrophils and eosinophil platelets. |
| Sequence similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Immunoglobulin domain Repeat Signal Transmembrane |
| Ligand | IgG-binding protein |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneNon-traceable author statement. Source: ProtInc |
| Molecular function | IgG binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P12318-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P12318-2) The sequence of this isoform differs from the canonical sequence as follows: 35-35: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 33 | 33 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Chain | 34 – 317 | 284 | Low affinity immunoglobulin gamma Fc region receptor II-a | PRO_0000015145 | ||||||||||||||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Topological domain | 34 – 217 | 184 | Extracellular Potential | |||||||||||||||||||||||||||||||||||||||||||||||
| Transmembrane | 218 – 240 | 23 | Potential | |||||||||||||||||||||||||||||||||||||||||||||||
| Topological domain | 241 – 317 | 77 | Cytoplasmic Potential | |||||||||||||||||||||||||||||||||||||||||||||||
| Domain | 39 – 118 | 80 | Ig-like C2-type 1 | |||||||||||||||||||||||||||||||||||||||||||||||
| Domain | 122 – 204 | 83 | Ig-like C2-type 2 | |||||||||||||||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 288 | 1 | Phosphotyrosine Ref.10 | |||||||||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 97 | 1 | N-linked (GlcNAc...) Ref.8 | |||||||||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 178 | 1 | N-linked (GlcNAc...) Ref.8 | |||||||||||||||||||||||||||||||||||||||||||||||
| Disulfide bond | 62 ↔ 104 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Disulfide bond | 143 ↔ 187 | |||||||||||||||||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 35 | 1 | Missing in isoform 2. | VSP_036865 | ||||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 63 | 1 | Q → R: dbSNP rs9427398. | VAR_054857 | ||||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 140 | 1 | M → V: dbSNP rs4986941. | VAR_054858 | ||||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 167 | 1 | H → R May be associated with susceptibility to lupus nephritis; does not efficiently recognize IgG2. dbSNP rs1801274. Ref.1 Ref.2 Ref.4 Ref.5 Ref.6 Ref.12 | VAR_003955 | ||||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 218 | 1 | I → V: dbSNP rs17851834. Ref.4 | VAR_054859 | ||||||||||||||||||||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 2 | 1 | T → A in AAA35827. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 42 – 47 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 50 – 53 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 57 – 64 | 8 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 68 – 71 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 73 – 77 | 5 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 80 – 82 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 87 – 93 | 7 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 96 – 98 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 100 – 106 | 7 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 115 – 120 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 122 – 127 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 131 – 133 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 139 – 145 | 7 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 146 – 148 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 151 – 158 | 8 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 161 – 168 | 8 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 171 – 176 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 179 – 181 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 183 – 191 | 9 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 194 – 197 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 201 – 205 | 5 | ||||||||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)." Stuart S.G., Trounstine M.L., Vaux D.J.T., Koch T., Martens C.L., Moore K.W. J. Exp. Med. 166:1668-1684(1987) [PubMed: 2824655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-167. |
| [2] | "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes." Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V. J. Exp. Med. 170:1369-1385(1989) [PubMed: 2529342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-167. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-167 AND VAL-218. Tissue: Lung and Testis. |
| [5] | "Molecular cloning of a human immunoglobulin G Fc receptor." Hibbs M.L., Bonadonna L., Scott B.M., McKenzie I.F.C., Hogarth P.M. Proc. Natl. Acad. Sci. U.S.A. 85:2240-2244(1988) [PubMed: 2965389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-317 (ISOFORM 1), VARIANT ARG-167. |
| [6] | "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning." Stengelin S., Stamenkovic I., Seed B. EMBO J. 7:1053-1059(1988) [PubMed: 3402431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-317 (ISOFORM 1), VARIANT ARG-167. |
| [7] | "Identification of multiple isoforms of the low-affinity human IgG Fc receptor." Seki T. Immunogenetics 30:5-12(1989) [PubMed: 2526077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-317 (ISOFORM 1). |
| [8] | "Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG." Powell M.S., Barton P.A., Emmanouilidis D., Wines B.D., Neumann G.M., Peitersz G.A., Maxwell K.F., Garrett T.P., Hogarth P.M. Immunol. Lett. 68:17-23(1999) [PubMed: 10397151] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE OF N-TERMINUS, GLYCOSYLATION AT ASN-97 AND ASN-178, CRYSTALLIZATION. |
| [9] | "SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling." Pengal R.A., Ganesan L.P., Fang H., Marsh C.B., Anderson C.L., Tridandapani S. J. Biol. Chem. 278:22657-22663(2003) [PubMed: 12690104] [Abstract] Cited for: INTERACTION WITH INPPL1. |
| [10] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-288, MASS SPECTROMETRY. |
| [11] | "Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa." Maxwell K.F., Powell M.S., Hulett M.D., Barton P.A., McKenzie I.F., Garrett T.P., Hogarth P.M. Nat. Struct. Biol. 6:437-442(1999) [PubMed: 10331870] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 37-207. |
| [12] | "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans." Salmon J.E., Millard S., Schachter L.A., Arnett F.C., Ginzler E.M., Gourley M.F., Ramsey-Goldman R., Peterson M.G.E., Kimberly R.P. J. Clin. Invest. 97:1348-1354(1996) [PubMed: 8636449] [Abstract] Cited for: VARIANT ARG-167. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Y00644 mRNA. Translation: CAA68672.1. M31932 mRNA. Translation: AAA35827.1. AL590385 Genomic DNA. No translation available. BC019931 mRNA. Translation: AAH19931.1. BC020823 mRNA. Translation: AAH20823.1. J03619 mRNA. Translation: AAA35932.1. Different initiation. | |||||||||||||||||||||||||
| IPI | IPI00023505. IPI00646445. | ||||||||||||||||||||||||
| PIR | JL0118. | ||||||||||||||||||||||||
| RefSeq | NP_001129691.1. NP_067674.2. | ||||||||||||||||||||||||
| UniGene | Hs.352642 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | P12318. 1 interaction. | ||||||||||||||||||||||||
| STRING | P12318. | ||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||
| PhosphoSite | P12318. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000271450; ENSP00000271450; ENSG00000143226; Homo sapiens. [Genome view] ENST00000367972; ENSP00000356949; ENSG00000143226; Homo sapiens. [Genome view] ENST00000429333; ENSP00000393544; ENSG00000143226; Homo sapiens. [Genome view] | ||||||||||||||||||||||||
| GeneID | 2212. | ||||||||||||||||||||||||
| KEGG | hsa:2212. | ||||||||||||||||||||||||
| NMPDR | fig|9606.3.peg.2491. | ||||||||||||||||||||||||
| UCSC | uc001gam.1. human. uc001gan.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 2212. | ||||||||||||||||||||||||
| GeneCards | GC01P159741. | ||||||||||||||||||||||||
| H-InvDB | HIX0018571. | ||||||||||||||||||||||||
| HGNC | HGNC:3616. FCGR2A. | ||||||||||||||||||||||||
| HPA | HPA010718. | ||||||||||||||||||||||||
| MIM | 146790. gene. | ||||||||||||||||||||||||
| PharmGKB | PA28063. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | P12318. | ||||||||||||||||||||||||
| HOVERGEN | P12318. | ||||||||||||||||||||||||
| OMA | MTMETQM. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Pathway_Interaction_DB | ptp1bpathway. Signaling events mediated by PTP1B. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P12318. | ||||||||||||||||||||||||
| Bgee | P12318. | ||||||||||||||||||||||||
| CleanEx | HS_FCGR2A. | ||||||||||||||||||||||||
| Genevestigator | P12318. | ||||||||||||||||||||||||
| GermOnline | ENSG00000143226. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 2 hits. | ||||||||||||||||||||||||
| Pfam | PF00047. ig. 2 hits. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00409. IG. 2 hits. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS50835. IG_LIKE. 2 hits. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| DrugBank | DB00054. Abciximab. DB00051. Adalimumab. DB00092. Alefacept. DB00087. Alemtuzumab. DB00074. Basiliximab. DB00112. Bevacizumab. DB00002. Cetuximab. DB00111. Daclizumab. DB00095. Efalizumab. DB00005. Etanercept. DB00056. Gemtuzumab ozogamicin. DB00078. Ibritumomab. DB00028. Immune globulin. DB00075. Muromonab. DB00108. Natalizumab. DB00110. Palivizumab. DB00073. Rituximab. DB00081. Tositumomab. DB00072. Trastuzumab. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | FCG2A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P12318 Secondary accession number(s): Q8WUN1, Q8WW64 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


