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Protein

Low affinity immunoglobulin gamma Fc region receptor II-a

Gene

FCGR2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143226-MONOMER.
ReactomeiR-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP12318.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-a
Short name:
IgG Fc receptor II-a
Alternative name(s):
CDw32
Fc-gamma RII-a
Short name:
Fc-gamma-RIIa
Short name:
FcRII-a
CD_antigen: CD32
Gene namesi
Name:FCGR2A
Synonyms:CD32, FCG2, FCGR2A1, IGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3616. FCGR2A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 217ExtracellularSequence analysisAdd BLAST184
Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 317CytoplasmicSequence analysisAdd BLAST77

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2212.
MalaCardsiFCGR2A.
OpenTargetsiENSG00000143226.
PharmGKBiPA28063.

Chemistry databases

ChEMBLiCHEMBL5841.
DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Polymorphism and mutation databases

BioMutaiFCGR2A.
DMDMi160332371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001514534 – 317Low affinity immunoglobulin gamma Fc region receptor II-aAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 104Combined sources3 Publications
Glycosylationi97N-linked (GlcNAc...)1 Publication1
Disulfide bondi143 ↔ 187Combined sources3 Publications
Glycosylationi178N-linked (GlcNAc...)1 Publication1
Modified residuei288Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1
Modified residuei304Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1

Post-translational modificationi

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP12318.
PaxDbiP12318.
PeptideAtlasiP12318.
PRIDEiP12318.

PTM databases

iPTMnetiP12318.
PhosphoSitePlusiP12318.

Expressioni

Tissue specificityi

Found on monocytes, neutrophils and eosinophil platelets.

Gene expression databases

BgeeiENSG00000143226.
CleanExiHS_FCGR2A.
ExpressionAtlasiP12318. baseline and differential.
GenevisibleiP12318. HS.

Organism-specific databases

HPAiHPA010718.
HPA014730.

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-1395970,EBI-741480
UBQLN1Q9UMX0-23EBI-1395970,EBI-10173939

Protein-protein interaction databases

BioGridi108506. 28 interactors.
IntActiP12318. 3 interactors.
MINTiMINT-8013486.
STRINGi9606.ENSP00000271450.

Chemistry databases

BindingDBiP12318.

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Beta strandi50 – 53Combined sources4
Beta strandi57 – 64Combined sources8
Beta strandi68 – 71Combined sources4
Beta strandi73 – 77Combined sources5
Beta strandi80 – 82Combined sources3
Beta strandi87 – 93Combined sources7
Helixi96 – 98Combined sources3
Beta strandi100 – 106Combined sources7
Beta strandi107 – 110Combined sources4
Beta strandi115 – 120Combined sources6
Beta strandi123 – 127Combined sources5
Beta strandi131 – 133Combined sources3
Beta strandi139 – 145Combined sources7
Helixi146 – 148Combined sources3
Beta strandi151 – 158Combined sources8
Beta strandi161 – 168Combined sources8
Beta strandi171 – 176Combined sources6
Helixi179 – 181Combined sources3
Beta strandi183 – 191Combined sources9
Beta strandi194 – 197Combined sources4
Beta strandi201 – 205Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FCGX-ray2.00A34-207[»]
1H9VX-ray3.00A37-208[»]
3D5OX-ray2.80F37-207[»]
3RY4X-ray1.50A37-206[»]
3RY5X-ray2.30A37-206[»]
3RY6X-ray3.80C40-206[»]
ProteinModelPortaliP12318.
SMRiP12318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 118Ig-like C2-type 1Add BLAST80
Domaini122 – 204Ig-like C2-type 2Add BLAST83

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP12318.
KOiK06472.
OMAiTALLFLX.
OrthoDBiEOG091G0JSA.
PhylomeDBiP12318.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12318-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI
60 70 80 90 100
NVLQEDSVTL TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG
110 120 130 140 150
EYTCQTGQTS LSDPVHLTVL SEWLVLQTPH LEFQEGETIM LRCHSWKDKP
160 170 180 190 200
LVKVTFFQNG KSQKFSHLDP TFSIPQANHS HSGDYHCTGN IGYTLFSSKP
210 220 230 240 250
VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY CRKKRISANS
260 270 280 290 300
TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD
310
KNIYLTLPPN DHVNSNN
Length:317
Mass (Da):35,001
Last modified:November 13, 2007 - v4
Checksum:i07F73F3BB282DFF6
GO
Isoform 2 (identifier: P12318-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: Missing.

Show »
Length:316
Mass (Da):34,930
Checksum:i3B4B813ECF6DCFCD
GO

Sequence cautioni

The sequence AAA35932 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → A in AAA35827 (PubMed:2529342).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05485763Q → R.Corresponds to variant rs9427398dbSNPEnsembl.1
Natural variantiVAR_054858140M → V.Corresponds to variant rs4986941dbSNPEnsembl.1
Natural variantiVAR_003955167H → R May be associated with susceptibility to lupus nephritis; does not efficiently recognize IgG2. 6 PublicationsCorresponds to variant rs1801274dbSNPEnsembl.1
Natural variantiVAR_054859218I → V.1 PublicationCorresponds to variant rs17851834dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03686535Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00644 mRNA. Translation: CAA68672.1.
M31932 mRNA. Translation: AAA35827.1.
AL590385 Genomic DNA. No translation available.
BC019931 mRNA. Translation: AAH19931.1.
BC020823 mRNA. Translation: AAH20823.1.
J03619 mRNA. Translation: AAA35932.1. Different initiation.
CCDSiCCDS30922.1. [P12318-2]
CCDS44264.1. [P12318-1]
PIRiJL0118.
RefSeqiNP_001129691.1. NM_001136219.1. [P12318-1]
NP_067674.2. NM_021642.3. [P12318-2]
UniGeneiHs.352642.

Genome annotation databases

EnsembliENST00000271450; ENSP00000271450; ENSG00000143226. [P12318-1]
ENST00000367972; ENSP00000356949; ENSG00000143226. [P12318-2]
GeneIDi2212.
KEGGihsa:2212.
UCSCiuc001gam.4. human. [P12318-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00644 mRNA. Translation: CAA68672.1.
M31932 mRNA. Translation: AAA35827.1.
AL590385 Genomic DNA. No translation available.
BC019931 mRNA. Translation: AAH19931.1.
BC020823 mRNA. Translation: AAH20823.1.
J03619 mRNA. Translation: AAA35932.1. Different initiation.
CCDSiCCDS30922.1. [P12318-2]
CCDS44264.1. [P12318-1]
PIRiJL0118.
RefSeqiNP_001129691.1. NM_001136219.1. [P12318-1]
NP_067674.2. NM_021642.3. [P12318-2]
UniGeneiHs.352642.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FCGX-ray2.00A34-207[»]
1H9VX-ray3.00A37-208[»]
3D5OX-ray2.80F37-207[»]
3RY4X-ray1.50A37-206[»]
3RY5X-ray2.30A37-206[»]
3RY6X-ray3.80C40-206[»]
ProteinModelPortaliP12318.
SMRiP12318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108506. 28 interactors.
IntActiP12318. 3 interactors.
MINTiMINT-8013486.
STRINGi9606.ENSP00000271450.

Chemistry databases

BindingDBiP12318.
ChEMBLiCHEMBL5841.
DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

PTM databases

iPTMnetiP12318.
PhosphoSitePlusiP12318.

Polymorphism and mutation databases

BioMutaiFCGR2A.
DMDMi160332371.

Proteomic databases

MaxQBiP12318.
PaxDbiP12318.
PeptideAtlasiP12318.
PRIDEiP12318.

Protocols and materials databases

DNASUi2212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271450; ENSP00000271450; ENSG00000143226. [P12318-1]
ENST00000367972; ENSP00000356949; ENSG00000143226. [P12318-2]
GeneIDi2212.
KEGGihsa:2212.
UCSCiuc001gam.4. human. [P12318-1]

Organism-specific databases

CTDi2212.
DisGeNETi2212.
GeneCardsiFCGR2A.
H-InvDBHIX0018571.
HGNCiHGNC:3616. FCGR2A.
HPAiHPA010718.
HPA014730.
MalaCardsiFCGR2A.
MIMi146790. gene.
neXtProtiNX_P12318.
OpenTargetsiENSG00000143226.
PharmGKBiPA28063.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP12318.
KOiK06472.
OMAiTALLFLX.
OrthoDBiEOG091G0JSA.
PhylomeDBiP12318.
TreeFamiTF335097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143226-MONOMER.
ReactomeiR-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP12318.

Miscellaneous databases

ChiTaRSiFCGR2A. human.
EvolutionaryTraceiP12318.
GeneWikiiFCGR2A.
GenomeRNAii2212.
PROiP12318.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143226.
CleanExiHS_FCGR2A.
ExpressionAtlasiP12318. baseline and differential.
GenevisibleiP12318. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCG2A_HUMAN
AccessioniPrimary (citable) accession number: P12318
Secondary accession number(s): Q8WUN1, Q8WW64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 188 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.