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Protein

High affinity immunoglobulin gamma Fc receptor I

Gene

FCGR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.5 Publications

GO - Molecular functioni

  • signal transducer activity, downstream of receptor Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150337-MONOMER.
ReactomeiR-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-877300. Interferon gamma signaling.
SignaLinkiP12314.
SIGNORiP12314.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin gamma Fc receptor I
Short name:
IgG Fc receptor I
Alternative name(s):
Fc-gamma RI
Short name:
FcRI
Fc-gamma RIA
Short name:
FcgammaRIa
CD_antigen: CD64
Gene namesi
Name:FCGR1A
Synonyms:FCG1, FCGR1, IGFR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3613. FCGR1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 292ExtracellularSequence analysisAdd BLAST277
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 374CytoplasmicSequence analysisAdd BLAST61

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi306N → D: Decreases cell membrane expression by 50% in absence of FCER1G. 1 Publication1
Mutagenesisi306N → G: Increases cell membrane expression in absence of FCER1G. 1 Publication1

Organism-specific databases

DisGeNETi2209.
OpenTargetsiENSG00000150337.
PharmGKBiPA28060.

Chemistry databases

ChEMBLiCHEMBL5349.
DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00992. Methyl aminolevulinate.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00707. Porfimer.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Polymorphism and mutation databases

BioMutaiFCGR1A.
DMDMi50403717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 151 PublicationAdd BLAST15
ChainiPRO_000001513916 – 374High affinity immunoglobulin gamma Fc receptor IAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 85PROSITE-ProRule annotation1 Publication
Glycosylationi59N-linked (GlcNAc...)1 Publication1
Glycosylationi78N-linked (GlcNAc...)2 Publications1
Disulfide bondi124 ↔ 168PROSITE-ProRule annotation1 Publication
Glycosylationi152N-linked (GlcNAc...)1 Publication1
Glycosylationi159N-linked (GlcNAc...)1 Publication1
Glycosylationi163N-linked (GlcNAc...)1 Publication1
Glycosylationi195N-linked (GlcNAc...)1 Publication1
Disulfide bondi212 ↔ 260PROSITE-ProRule annotation1 Publication
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP12314.
PaxDbiP12314.
PeptideAtlasiP12314.
PRIDEiP12314.

PTM databases

iPTMnetiP12314.
PhosphoSitePlusiP12314.

Expressioni

Tissue specificityi

Monocyte/macrophage specific.

Gene expression databases

BgeeiENSG00000150337.
CleanExiHS_FCGR1A.
ExpressionAtlasiP12314. baseline and differential.
GenevisibleiP12314. HS.

Interactioni

Subunit structurei

Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.7 Publications

Protein-protein interaction databases

BioGridi108503. 20 interactors.
IntActiP12314. 3 interactors.
MINTiMINT-1538623.
STRINGi9606.ENSP00000358165.

Chemistry databases

BindingDBiP12314.

Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Beta strandi31 – 34Combined sources4
Beta strandi39 – 44Combined sources6
Beta strandi54 – 62Combined sources9
Beta strandi67 – 74Combined sources8
Helixi77 – 79Combined sources3
Beta strandi81 – 87Combined sources7
Beta strandi88 – 91Combined sources4
Beta strandi96 – 101Combined sources6
Beta strandi103 – 110Combined sources8
Beta strandi112 – 115Combined sources4
Beta strandi120 – 126Combined sources7
Helixi127 – 129Combined sources3
Beta strandi133 – 139Combined sources7
Beta strandi142 – 149Combined sources8
Beta strandi153 – 157Combined sources5
Helixi160 – 162Combined sources3
Beta strandi164 – 177Combined sources14
Beta strandi181 – 186Combined sources6
Beta strandi193 – 198Combined sources6
Beta strandi200 – 203Combined sources4
Beta strandi208 – 213Combined sources6
Beta strandi225 – 231Combined sources7
Beta strandi234 – 241Combined sources8
Beta strandi244 – 249Combined sources6
Helixi252 – 254Combined sources3
Beta strandi256 – 264Combined sources9
Beta strandi267 – 272Combined sources6
Beta strandi276 – 278Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RJDX-ray2.65A21-282[»]
4W4OX-ray1.80C16-289[»]
4X4MX-ray3.48E/F21-289[»]
4ZNEX-ray2.42A16-282[»]
ProteinModelPortaliP12314.
SMRiP12314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101Ig-like C2-type 1Add BLAST80
Domaini95 – 184Ig-like C2-type 2Add BLAST90
Domaini190 – 277Ig-like C2-type 3Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 332Interaction with EPB41L21 PublicationAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVK2. Eukaryota.
ENOG410YF57. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP12314.
KOiK06498.
OMAiRCHAWKN.
OrthoDBiEOG091G0ETN.
PhylomeDBiP12314.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12314-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG
60 70 80 90 100
SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI
110 120 130 140 150
HRGWLLLQVS SRVFTEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN
160 170 180 190 200
SNLTILKTNI SHNGTYHCSG MGKHRYTSAG ISVTVKELFP APVLNASVTS
210 220 230 240 250
PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN TSSEYQILTA
260 270 280 290 300
RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG
310 320 330 340 350
IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE
360 370
LKCQEQKEEQ LQEGVHRKEP QGAT
Length:374
Mass (Da):42,632
Last modified:July 19, 2004 - v2
Checksum:iD33D59398CEEA699
GO
Isoform 2 (identifier: P12314-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     333-374: HEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT → GQALEAPTQGCA

Show »
Length:344
Mass (Da):38,795
Checksum:iDDBE5DE64A66F6B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25T → S in CAA32537 (PubMed:2974947).Curated1
Sequence conflicti115T → M in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti183V → QY in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti284Q → R in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti324D → N in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti338I → T (PubMed:2974947).Curated1
Sequence conflicti338I → T (PubMed:2911749).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019522105L → P.Corresponds to variant rs619322dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002637333 – 374HEKKV…PQGAT → GQALEAPTQGCA in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14356 mRNA. Translation: CAA32537.1.
X14355 mRNA. Translation: CAA32536.1.
L03418 mRNA. Translation: AAA36049.1.
M91555
, M91550, M91551, M91552, M91553, M91554 Genomic DNA. Translation: AAA58414.1.
AL591493 Genomic DNA. Translation: CAI12557.1.
CCDSiCCDS933.1. [P12314-1]
PIRiA39878.
A41357.
RefSeqiNP_000557.1. NM_000566.3. [P12314-1]
UniGeneiHs.77424.

Genome annotation databases

EnsembliENST00000369168; ENSP00000358165; ENSG00000150337. [P12314-1]
GeneIDi2209.
KEGGihsa:2209.
UCSCiuc001esp.5. human. [P12314-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

FCGR1Abase

FCGR1A mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14356 mRNA. Translation: CAA32537.1.
X14355 mRNA. Translation: CAA32536.1.
L03418 mRNA. Translation: AAA36049.1.
M91555
, M91550, M91551, M91552, M91553, M91554 Genomic DNA. Translation: AAA58414.1.
AL591493 Genomic DNA. Translation: CAI12557.1.
CCDSiCCDS933.1. [P12314-1]
PIRiA39878.
A41357.
RefSeqiNP_000557.1. NM_000566.3. [P12314-1]
UniGeneiHs.77424.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RJDX-ray2.65A21-282[»]
4W4OX-ray1.80C16-289[»]
4X4MX-ray3.48E/F21-289[»]
4ZNEX-ray2.42A16-282[»]
ProteinModelPortaliP12314.
SMRiP12314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108503. 20 interactors.
IntActiP12314. 3 interactors.
MINTiMINT-1538623.
STRINGi9606.ENSP00000358165.

Chemistry databases

BindingDBiP12314.
ChEMBLiCHEMBL5349.
DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00992. Methyl aminolevulinate.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00707. Porfimer.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

PTM databases

iPTMnetiP12314.
PhosphoSitePlusiP12314.

Polymorphism and mutation databases

BioMutaiFCGR1A.
DMDMi50403717.

Proteomic databases

EPDiP12314.
PaxDbiP12314.
PeptideAtlasiP12314.
PRIDEiP12314.

Protocols and materials databases

DNASUi2209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369168; ENSP00000358165; ENSG00000150337. [P12314-1]
GeneIDi2209.
KEGGihsa:2209.
UCSCiuc001esp.5. human. [P12314-1]

Organism-specific databases

CTDi2209.
DisGeNETi2209.
GeneCardsiFCGR1A.
H-InvDBHIX0000999.
HGNCiHGNC:3613. FCGR1A.
MIMi146760. gene.
neXtProtiNX_P12314.
OpenTargetsiENSG00000150337.
PharmGKBiPA28060.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVK2. Eukaryota.
ENOG410YF57. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP12314.
KOiK06498.
OMAiRCHAWKN.
OrthoDBiEOG091G0ETN.
PhylomeDBiP12314.
TreeFamiTF335097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150337-MONOMER.
ReactomeiR-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-877300. Interferon gamma signaling.
SignaLinkiP12314.
SIGNORiP12314.

Miscellaneous databases

GeneWikiiFCGR1A.
GenomeRNAii2209.
PROiP12314.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150337.
CleanExiHS_FCGR1A.
ExpressionAtlasiP12314. baseline and differential.
GenevisibleiP12314. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCGR1_HUMAN
AccessioniPrimary (citable) accession number: P12314
Secondary accession number(s): P12315
, Q5QNW7, Q92495, Q92663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 175 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.