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Protein

Transthyretin

Gene

TTR

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351Thyroid hormoneBy similarity
Binding sitei74 – 741Thyroid hormoneBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Thyroid hormone

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:TTR
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 147127TransthyretinPRO_0000035765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 6214-carboxyglutamateBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Highly expressed in the choroid plexus.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP12303.
SMRiP12303. Positions 22-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1395Thyroid hormone bindingBy similarity

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000005321.
HOVERGENiHBG000285.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFRLLLLC LAGLVFVSEA SPAGAGESKC PLMVKVLDAV RGSPAANVGV
60 70 80 90 100
KVFKKAADET WEPFASGKTS DSGELHGLTT EDKFVEGLYK VELDTKSYWK
110 120 130 140
SLGISPFHEY AEVVFTANDS GLRHYTIAAL LSPYSYSTTA LVSSPKE
Length:147
Mass (Da):15,771
Last modified:October 1, 1989 - v1
Checksum:i867D69DD610E23ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15576 mRNA. Translation: CAA33600.1.
PIRiS05320.
RefSeqiNP_001009800.1. NM_001009800.1.
UniGeneiOar.456.

Genome annotation databases

EnsembliENSOART00000006897; ENSOARP00000006793; ENSOARG00000006342.
GeneIDi443389.
KEGGioas:443389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15576 mRNA. Translation: CAA33600.1.
PIRiS05320.
RefSeqiNP_001009800.1. NM_001009800.1.
UniGeneiOar.456.

3D structure databases

ProteinModelPortaliP12303.
SMRiP12303. Positions 22-147.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000006897; ENSOARP00000006793; ENSOARG00000006342.
GeneIDi443389.
KEGGioas:443389.

Organism-specific databases

CTDi7276.

Phylogenomic databases

GeneTreeiENSGT00390000005321.
HOVERGENiHBG000285.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTHY_SHEEP
AccessioniPrimary (citable) accession number: P12303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.