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Protein

Transthyretin

Gene

TTR

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35Thyroid hormoneBy similarity1
Binding sitei74Thyroid hormoneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:TTR
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003576521 – 147TransthyretinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei624-carboxyglutamateBy similarity1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP12303.

Expressioni

Tissue specificityi

Highly expressed in the choroid plexus.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP12303.
SMRiP12303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Thyroid hormone bindingBy similarity5

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000005321.
HOVERGENiHBG000285.
KOiK20731.
OMAiHRHYTIA.
OrthoDBiEOG091G0VSV.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PTHR10395:SF19. PTHR10395:SF19. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiView protein in SMART
SM00095. TR_THY. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFRLLLLC LAGLVFVSEA SPAGAGESKC PLMVKVLDAV RGSPAANVGV
60 70 80 90 100
KVFKKAADET WEPFASGKTS DSGELHGLTT EDKFVEGLYK VELDTKSYWK
110 120 130 140
SLGISPFHEY AEVVFTANDS GLRHYTIAAL LSPYSYSTTA LVSSPKE
Length:147
Mass (Da):15,771
Last modified:October 1, 1989 - v1
Checksum:i867D69DD610E23ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15576 mRNA. Translation: CAA33600.1.
PIRiS05320.
RefSeqiNP_001009800.1. NM_001009800.1.
UniGeneiOar.456.

Genome annotation databases

EnsembliENSOART00000006897; ENSOARP00000006793; ENSOARG00000006342.
GeneIDi443389.
KEGGioas:443389.

Similar proteinsi

Entry informationi

Entry nameiTTHY_SHEEP
AccessioniPrimary (citable) accession number: P12303
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families