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Protein

Regulatory protein BlaR1

Gene

blaR1

Organism
Bacillus licheniformis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

BlaR1 is a potential penicillin-binding protein required for induction of beta-lactamase in Bacillus licheniformis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei402Acyl-ester intermediateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM56.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein BlaR1
Gene namesi
Name:blaR1
Synonyms:penR1
OrganismiBacillus licheniformis
Taxonomic identifieri1402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 24HelicalSequence analysisAdd BLAST20
Topological domaini25 – 40ExtracellularSequence analysisAdd BLAST16
Transmembranei41 – 60HelicalSequence analysisAdd BLAST20
Topological domaini61 – 115CytoplasmicSequence analysisAdd BLAST55
Transmembranei116 – 134HelicalSequence analysisAdd BLAST19
Topological domaini135 – 225ExtracellularSequence analysisAdd BLAST91
Transmembranei226 – 245HelicalSequence analysisAdd BLAST20
Topological domaini246 – 324CytoplasmicSequence analysisAdd BLAST79
Transmembranei325 – 344HelicalSequence analysisAdd BLAST20
Topological domaini345 – 601ExtracellularSequence analysisAdd BLAST257

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1744487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001954691 – 601Regulatory protein BlaR1Add BLAST601

Structurei

Secondary structure

1601
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi357 – 360Combined sources4
Helixi364 – 368Combined sources5
Turni369 – 371Combined sources3
Beta strandi372 – 380Combined sources9
Turni381 – 384Combined sources4
Beta strandi385 – 389Combined sources5
Helixi391 – 395Combined sources5
Helixi401 – 404Combined sources4
Helixi405 – 414Combined sources10
Turni435 – 437Combined sources3
Helixi443 – 449Combined sources7
Helixi452 – 462Combined sources11
Helixi464 – 473Combined sources10
Turni484 – 489Combined sources6
Beta strandi490 – 493Combined sources4
Helixi497 – 508Combined sources12
Turni509 – 512Combined sources4
Helixi516 – 526Combined sources11
Beta strandi527 – 531Combined sources5
Beta strandi534 – 544Combined sources11
Beta strandi546 – 548Combined sources3
Beta strandi550 – 559Combined sources10
Beta strandi564 – 574Combined sources11
Helixi578 – 592Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRFX-ray2.50A346-601[»]
ProteinModelPortaliP12287.
SMRiP12287.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12287.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni354 – 601Penicillin-bindingBy similarityAdd BLAST248

Sequence similaritiesi

Belongs to the peptidase M56 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P12287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSFFIPFL VSQILLSLFF SIIILIKKLL RTQITVGTHY YISVISLLAL
60 70 80 90 100
IAPFIPFHFL KSHHFDWILN LGGAQSALSQ THSTDKTTEA IGQHVNWVQD
110 120 130 140 150
FSLSIEQSSS KMIDSAFFAV WILGVAVMLL ATLYSNLKIG KIKKNLQIVN
160 170 180 190 200
NKELLSLFHT CKEEIRFHQK VILSRSPLIK SPITFGVIRP YIILPKDISM
210 220 230 240 250
FSADEMKCVL LHELYHCKRK DMLINYFLCL LKIVYWFNPL VWYLSKEAKT
260 270 280 290 300
EMEISCDFAV LKTLDKKLHL KYGEVILKFT SIKQRTSSLL AASEFSSSYK
310 320 330 340 350
HIKRRIVTVV NFQTASPLLK AKSALVFTLV LGAILAGTPS VSILAMQKET
360 370 380 390 400
RFLPGTNVEY EDYSTFFDKF SASGGFVLFN SNRKKYTIYN RKESTSRFAP
410 420 430 440 450
ASTYKVFSAL LALESGIITK NDSHMTWDGT QYPYKEWNQD QDLFSAMSSS
460 470 480 490 500
TTWYFQKLDR QIGEDHLRHY LKSIHYGNED FSVPADYWLD GSLQISPLEQ
510 520 530 540 550
VNILKKFYDN EFDFKQSNIE TVKDSIRLEE SNGRVLSGKT GTSVINGELH
560 570 580 590 600
AGWFIGYVET ADNTFFFAVH IQGEKRAAGS SAAEIALSIL DKKGIYPSVS

R
Length:601
Mass (Da):68,417
Last modified:October 1, 1989 - v1
Checksum:i84677A8DA448518E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17368 Genomic DNA. Translation: AAA22273.1.
M21337 Genomic DNA. Translation: AAA22651.1.
PIRiI39790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17368 Genomic DNA. Translation: AAA22273.1.
M21337 Genomic DNA. Translation: AAA22651.1.
PIRiI39790.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRFX-ray2.50A346-601[»]
ProteinModelPortaliP12287.
SMRiP12287.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1744487.

Protein family/group databases

MEROPSiM56.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP12287.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBLAR_BACLI
AccessioniPrimary (citable) accession number: P12287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.