P12279 (APOC3_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein C-III
Short name=Apo-CIII
Short name=ApoC-III

Alternative name(s):
Apolipoprotein C3

Gene names

Name:

APOC3

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular location	Secreted.
Tissue specificity	Mainly VLDL and also in HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Sequence similarities	Belongs to the apolipoprotein C3 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism Lipid transport Transport
Cellular component	Chylomicron Secreted VLDL
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid transport Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	chylomicron Inferred from electronic annotation. Source: UniProtKB-KW very-low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 100	80	Apolipoprotein C-III		PRO_0000002029
Regions
	Region	68 – 99	32	Lipid-binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12279 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 3D24443AB3B42D7D	FASTA	100	10,906
	10 20 30 40 50 60 MQPRVLLVAA LLALLASARA LEEEDPSLLG LMQGYMQHAT KTAQDTLTSV QESQVAQRAR 70 80 90 100 GWMTDSFSSL KDYCSTFKGK FTGFWDSASE AKPTPASDAF

References

[1]

"Structure and expression of dog apolipoprotein C-II and C-III mRNAs. Implications for the evolution and functional constraints of apolipoprotein structure." Datta S., Li W.-H., Ghosh I., Luo C.-C., Chan L. J. Biol. Chem. 262:10588-10593(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17178 mRNA. Translation: AAA30830.1.
PIR	B28487.
RefSeq	NP_001003369.1. NM_001003369.1.
UniGene	Cfa.3891.
3D structure databases
ProteinModelPortal	P12279.
SMR	P12279. Positions 22-99.
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000019635.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	442970.
KEGG	cfa:442970.
Organism-specific databases
CTD	345.
Phylogenomic databases
eggNOG	NOG39866.
HOGENOM	HOG000247042.
HOVERGEN	HBG050549.
InParanoid	P12279.
KO	K08759.
OrthoDB	EOG4WDDDG.
Family and domain databases
InterPro	IPR008403. Apo-CIII. [Graphical view]
PANTHER	PTHR14225. PTHR14225. 1 hit.
Pfam	PF05778. Apo-CIII. 1 hit. [Graphical view]
ProDom	PD010414. Apo-CIII. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	20831641.

Entry information

Entry name

APOC3_CANFA

Accession

Primary (citable) accession number: P12279

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program