P12275 (ARYL_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Arylamine N-acetyltransferase, liver isozyme Short name=Arylamine acetylase EC=2.3.1.5
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Arylamine N-acetyltransferase, liver isozyme		PRO_0000107900
Sites
	Active site	68	1	Acyl-thioester intermediate By similarity
	Active site	107	1	By similarity
	Active site	122	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12275 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 6E2919AD2979E210	FASTA	287	32,915
	10 20 30 40 50 60 MNIQEYFSRI SFDGSHKDAD LQTLTAIFQH HIQAIPFENL SMHCGETIDL DLQATYNKIV 70 80 90 100 110 120 KKKRGGWCME TNYLLFWALK EMGYDICVLG GNSYEPAKKA YTDEINHILL KVVIKGSSYI 130 140 150 160 170 180 VDAGFGGGPY QTWLPMLLIS GKDQPQIPGI FRFIEDNGIW YLEKVKRKHY VPEGSVPLTD 190 200 210 220 230 240 NPEMGNIRKL YSFTLEPKHI DDFQELNAYL QVAPDTILQK KSICSLQTTD GFYALVGWTF 250 260 270 280 SEMKYKYKED ADLLQTTTLT DEEVEKTLKD KFNIVLENKL IPVNVRG

References

[1]	"Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells." Ohsako S., Ohtomi M., Sakamoto Y., Uyemura K., Deguchi T. J. Biol. Chem. 263:7534-7538(1988) [PubMed: 2897360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences." Deguchi T., Sakamoto Y., Sasaki Y., Uyemura K. J. Biol. Chem. 263:7528-7533(1988) [PubMed: 2897359] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03737 mRNA. Translation: AAA48590.1.
IPI	IPI00572451.
PIR	A28168.
RefSeq	NP_990857.1. NM_205526.1.
UniGene	Gga.879.
3D structure databases
ProteinModelPortal	P12275.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396537.
KEGG	gga:396537.
Organism-specific databases
CTD	396537.
Phylogenomic databases
eggNOG	veNOG16142.
GeneTree	ENSGT00390000012054.
HOGENOM	HBG544563.
HOVERGEN	HBG000165.
InParanoid	P12275.
OrthoDB	EOG4NP75D.
PhylomeDB	P12275.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
KO	K00622.
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...

Entry information

Entry name

ARYL_CHICK

Accession

Primary (citable) accession number: P12275

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program