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P12275 (ARYL_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arylamine N-acetyltransferase, liver isozyme
Short name=Arylamine acetylase
EC=2.3.1.5
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sequence similarities

Belongs to the arylamine N-acetyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Arylamine N-acetyltransferase, liver isozyme
PRO_0000107900

Sites

Active site681Acyl-thioester intermediate By similarity
Active site1071 By similarity
Active site1221 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12275 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 6E2919AD2979E210

FASTA28732,915
        10         20         30         40         50         60 
MNIQEYFSRI SFDGSHKDAD LQTLTAIFQH HIQAIPFENL SMHCGETIDL DLQATYNKIV 

        70         80         90        100        110        120 
KKKRGGWCME TNYLLFWALK EMGYDICVLG GNSYEPAKKA YTDEINHILL KVVIKGSSYI 

       130        140        150        160        170        180 
VDAGFGGGPY QTWLPMLLIS GKDQPQIPGI FRFIEDNGIW YLEKVKRKHY VPEGSVPLTD 

       190        200        210        220        230        240 
NPEMGNIRKL YSFTLEPKHI DDFQELNAYL QVAPDTILQK KSICSLQTTD GFYALVGWTF 

       250        260        270        280 
SEMKYKYKED ADLLQTTTLT DEEVEKTLKD KFNIVLENKL IPVNVRG

« Hide

References

[1]"Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells."
Ohsako S., Ohtomi M., Sakamoto Y., Uyemura K., Deguchi T.
J. Biol. Chem. 263:7534-7538(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences."
Deguchi T., Sakamoto Y., Sasaki Y., Uyemura K.
J. Biol. Chem. 263:7528-7533(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J03737 mRNA. Translation: AAA48590.1.
IPIIPI00572451.
PIRA28168.
RefSeqNP_990857.1. NM_205526.1.
UniGeneGga.879.

3D structure databases

ProteinModelPortalP12275.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000008778.

Proteomic databases

PaxDbP12275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396537.
KEGGgga:396537.

Organism-specific databases

CTD396537.

Phylogenomic databases

eggNOGCOG2162.
HOGENOMHOG000205435.
HOVERGENHBG000165.
InParanoidP12275.
KOK00622.
OrthoDBEOG4NP75D.

Family and domain databases

InterProIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERPTHR11786. PTHR11786. 1 hit.
PfamPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSPR01543. ANATRNSFRASE.
ProtoNetSearch...

Other

NextBio20816573.

Entry information

Entry nameARYL_CHICK
AccessionPrimary (citable) accession number: P12275
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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