Reviewed, UniProtKB/Swiss-Prot P12275 (ARYL_CHICK)

Names and origin

Protein names	Recommended name:     Arylamine N-acetyltransferase, liver isozyme       Short name=Arylamine acetylase     EC=2.3.1.5
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Arylamine N-acetyltransferase, liver isozyme		PRO_0000107900
Sites
	Active site	68	1	Acyl-thioester intermediate By similarity
	Active site	107	1	By similarity
	Active site	122	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12275-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 6E2919AD2979E210	FASTA	287	32,915
	10 20 30 40 50 60 MNIQEYFSRI SFDGSHKDAD LQTLTAIFQH HIQAIPFENL SMHCGETIDL DLQATYNKIV 70 80 90 100 110 120 KKKRGGWCME TNYLLFWALK EMGYDICVLG GNSYEPAKKA YTDEINHILL KVVIKGSSYI 130 140 150 160 170 180 VDAGFGGGPY QTWLPMLLIS GKDQPQIPGI FRFIEDNGIW YLEKVKRKHY VPEGSVPLTD 190 200 210 220 230 240 NPEMGNIRKL YSFTLEPKHI DDFQELNAYL QVAPDTILQK KSICSLQTTD GFYALVGWTF 250 260 270 280 SEMKYKYKED ADLLQTTTLT DEEVEKTLKD KFNIVLENKL IPVNVRG

References

[1]	"Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells." Ohsako S., Ohtomi M., Sakamoto Y., Uyemura K., Deguchi T. J. Biol. Chem. 263:7534-7538(1988) [PubMed: 2897360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences." Deguchi T., Sakamoto Y., Sasaki Y., Uyemura K. J. Biol. Chem. 263:7528-7533(1988) [PubMed: 2897359] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03737 mRNA. Translation: AAA48590.1.
IPI	IPI00572451.
PIR	A28168.
RefSeq	NP_990857.1.
UniGene	Gga.879
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P12275.
Genome annotation databases
Ensembl	ENSGALT00000008792; ENSGALP00000008778; ENSGALG00000005472; Gallus gallus. [Genome view]
GeneID	396537.
KEGG	gga:396537.
Organism-specific databases
CTD	396537.
Phylogenomic databases
eggNOG	veNOG16142.
HOGENOM	HBG544563.
HOVERGEN	P12275.
InParanoid	P12275.
PhylomeDB	P12275.
Enzyme and pathway databases
BRENDA	2.3.1.5. 4.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...

Entry information

Entry name

ARYL_CHICK

Accession

Primary (citable) accession number: P12275

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)