P12274 (HMGN1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-histone chromosomal protein HMG-14B

Gene names

Name:

HMG14

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular location	Nucleus.
Miscellaneous	There are two HMG-14 proteins in chicken: HMG-14A the major component, and HMG-14B the minor component.
Sequence similarities	Belongs to the HMGN family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromatin Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleosomal DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 103	102	Non-histone chromosomal protein HMG-14B		PRO_0000206693

Sequences

	Sequence		Length	Mass (Da)
	P12274 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 86E532DF9774D969	FASTA	103	11,180
	10 20 30 40 50 60 MPKRKVAASR GGREEVPKRR SARLSAKPVP DKAEPKAKAL AAKDKSENKK AQSKGKKGPK 70 80 90 100 GKQTEETNQE QIKDNLPAEN GETKSEETPA SDAAVEKEEV KSE

References

[1]	"Cloning of the chicken chromosomal protein HMG-14 cDNA reveals a unique protein with a conserved DNA binding domain." Srikantha T., Landsman D., Bustin M. J. Biol. Chem. 263:13500-13503(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A single copy gene for chicken chromosomal protein HMG-14b has evolutionarily conserved features, has lost one of its introns and codes for a rapidly evolving protein." Srikantha T., Landsman D., Bustin M. J. Mol. Biol. 211:49-61(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M20817 mRNA. Translation: AAB59965.1. X52707, X52708 Genomic DNA. Translation: CAA36932.1.
IPI	IPI00592692.
PIR	S08180.
RefSeq	NP_990437.1. NM_205106.1.
UniGene	Gga.1189.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000025837.
Proteomic databases
PaxDb	P12274.
PRIDE	P12274.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395999.
KEGG	gga:395999.
Organism-specific databases
CTD	3150.
Phylogenomic databases
eggNOG	NOG29368.
HOGENOM	HOG000116394.
HOVERGEN	HBG073479.
InParanoid	P12274.
KO	K11299.
OrthoDB	EOG4CZBHP.
Family and domain databases
InterPro	IPR000079. HMGN_fam. [Graphical view]
PANTHER	PTHR23087. PTHR23087. 1 hit.
Pfam	PF01101. HMG14_17. 1 hit. [Graphical view]
PRINTS	PR00925. NONHISHMG17.
SMART	SM00527. HMG17. 1 hit. [Graphical view]
PROSITE	PS00355. HMG14_17. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816062.

Entry information

Entry name

HMGN1_CHICK

Accession

Primary (citable) accession number: P12274

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program