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Protein

Prolactin-inducible protein

Gene

PIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • aspartic-type endopeptidase activity Source: UniProtKB
  • glycoprotein binding Source: UniProtKB
  • IgG binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • negative regulation of T cell apoptotic process Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • proteolysis Source: UniProtKB
  • regulation of immune system process Source: Ensembl
  • retina homeostasis Source: UniProtKB
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-inducible protein
Alternative name(s):
Gross cystic disease fluid protein 15
Short name:
GCDFP-15
Prolactin-induced protein
Secretory actin-binding protein
Short name:
SABP
gp17
Gene namesi
Name:PIP
Synonyms:GCDFP15, GPIP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8993. PIP.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33326.

Polymorphism and mutation databases

BioMutaiPIP.
DMDMi134170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28282 PublicationsAdd
BLAST
Chaini29 – 146118Prolactin-inducible protein1 PublicationPRO_0000024288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291Pyrrolidone carboxylic acid2 Publications
Disulfide bondi65 ↔ 911 Publication
Disulfide bondi89 ↔ 1231 Publication
Glycosylationi105 – 1051N-linked (GlcNAc...)4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP12273.
MaxQBiP12273.
PaxDbiP12273.
PeptideAtlasiP12273.
PRIDEiP12273.

PTM databases

iPTMnetiP12273.
PhosphoSiteiP12273.
SwissPalmiP12273.

Expressioni

Tissue specificityi

Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.

Inductioni

By prolactin and androgen; inhibited by estrogen.

Gene expression databases

BgeeiENSG00000159763.
CleanExiHS_PIP.
GenevisibleiP12273. HS.

Organism-specific databases

HPAiCAB002661.
HPA009177.

Interactioni

Subunit structurei

Monomer. Interacts with AZGP1.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • glycoprotein binding Source: UniProtKB
  • IgG binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi111321. 15 interactions.
IntActiP12273. 15 interactions.
STRINGi9606.ENSP00000291009.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi44 – 463Combined sources
Beta strandi52 – 609Combined sources
Beta strandi66 – 7611Combined sources
Helixi81 – 833Combined sources
Beta strandi85 – 906Combined sources
Beta strandi92 – 943Combined sources
Beta strandi96 – 1027Combined sources
Beta strandi108 – 1169Combined sources
Beta strandi120 – 1234Combined sources
Helixi124 – 1263Combined sources
Beta strandi136 – 14510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ES6X-ray3.23B29-146[»]
ProteinModelPortaliP12273.
SMRiP12273. Positions 29-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12273.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZUS. Eukaryota.
ENOG41116UQ. LUCA.
GeneTreeiENSGT00390000002099.
HOGENOMiHOG000253013.
HOVERGENiHBG065978.
InParanoidiP12273.
OMAiLKECMVV.
OrthoDBiEOG091G0YJ1.
PhylomeDBiP12273.
TreeFamiTF336919.

Family and domain databases

InterProiIPR014756. Ig_E-set.
IPR007990. PIP.
[Graphical view]
PfamiPF05326. SVA. 1 hit.
[Graphical view]
PIRSFiPIRSF002572. PIP-GCDFP-15. 1 hit.
ProDomiPD021604. SV_autoAg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIKNF DIPKSVRPND
60 70 80 90 100
EVTAVLAVQT ELKECMVVKT YLISSIPLQG AFNYKYTACL CDDNPKTFYW
110 120 130 140
DFYTNRTVQI AAVVDVIREL GICPDDAAVI PIKNNRFYTI EILKVE
Length:146
Mass (Da):16,572
Last modified:October 1, 1989 - v1
Checksum:i93F3DA201133F03C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03460 mRNA. Translation: AAA60091.1.
X51501, X51502, X51504 Genomic DNA. Translation: CAA35870.1.
Y10179 mRNA. Translation: CAA71252.1.
AK312227 mRNA. Translation: BAG35160.1.
CH236959 Genomic DNA. Translation: EAL23781.1.
CH471198 Genomic DNA. Translation: EAW51887.1.
BC010950 mRNA. Translation: AAH10950.1.
BC010951 mRNA. Translation: AAH10951.1.
AB267097 Genomic DNA. Translation: BAF35627.1.
AB267098 Genomic DNA. Translation: BAF35628.1.
AB267099 Genomic DNA. Translation: BAF35629.1.
AB267100 Genomic DNA. Translation: BAF35630.1.
AB267101 Genomic DNA. Translation: BAF35631.1.
AB267102 Genomic DNA. Translation: BAF35632.1.
AB267103 Genomic DNA. Translation: BAF35633.1.
AB267104 Genomic DNA. Translation: BAF35634.1.
AB267105 Genomic DNA. Translation: BAF35635.1.
AB267106 Genomic DNA. Translation: BAF35636.1.
AB267107 Genomic DNA. Translation: BAF35637.1.
AB267108 Genomic DNA. Translation: BAF35638.1.
AB267109 Genomic DNA. Translation: BAF35639.1.
AB267110 Genomic DNA. Translation: BAF35640.1.
AB267111 Genomic DNA. Translation: BAF35641.1.
AB267112 Genomic DNA. Translation: BAF35642.1.
AB267113 Genomic DNA. Translation: BAF35643.1.
AB267114 Genomic DNA. Translation: BAF35644.1.
AB267115 Genomic DNA. Translation: BAF35645.1.
AB267116 Genomic DNA. Translation: BAF35646.1.
AB267117 Genomic DNA. Translation: BAF35647.1.
AB267118 Genomic DNA. Translation: BAF35648.1.
AB267119 Genomic DNA. Translation: BAF35649.1.
AB267120 Genomic DNA. Translation: BAF35650.1.
AB267121 Genomic DNA. Translation: BAF35651.1.
AB267122 Genomic DNA. Translation: BAF35652.1.
AB267123 Genomic DNA. Translation: BAF35653.1.
AB267124 Genomic DNA. Translation: BAF35654.1.
AB267125 Genomic DNA. Translation: BAF35655.1.
AB267126 Genomic DNA. Translation: BAF35656.1.
AB267127 Genomic DNA. Translation: BAF35657.1.
AB267128 Genomic DNA. Translation: BAF35658.1.
AB267129 Genomic DNA. Translation: BAF35659.1.
AB267130 Genomic DNA. Translation: BAF35660.1.
AB267131 Genomic DNA. Translation: BAF35661.1.
AB267132 Genomic DNA. Translation: BAF35662.1.
AB267133 Genomic DNA. Translation: BAF35663.1.
AB267134 Genomic DNA. Translation: BAF35664.1.
AB267135 Genomic DNA. Translation: BAF35665.1.
AB267136 Genomic DNA. Translation: BAF35666.1.
AB267137 Genomic DNA. Translation: BAF35667.1.
AB267138 Genomic DNA. Translation: BAF35668.1.
AB267139 Genomic DNA. Translation: BAF35669.1.
AB267140 Genomic DNA. Translation: BAF35670.1.
AB267141 Genomic DNA. Translation: BAF35671.1.
AB267142 Genomic DNA. Translation: BAF35672.1.
AB267143 Genomic DNA. Translation: BAF35673.1.
AB267144 Genomic DNA. Translation: BAF35674.1.
AB267145 Genomic DNA. Translation: BAF35675.1.
AB267146 Genomic DNA. Translation: BAF35676.1.
AB267147 Genomic DNA. Translation: BAF35677.1.
AB267148 Genomic DNA. Translation: BAF35678.1.
AB267149 Genomic DNA. Translation: BAF35679.1.
AB267150 Genomic DNA. Translation: BAF35680.1.
AB267151 Genomic DNA. Translation: BAF35681.1.
AB267152 Genomic DNA. Translation: BAF35682.1.
AB267153 Genomic DNA. Translation: BAF35683.1.
AB267154 Genomic DNA. Translation: BAF35684.1.
AB267155 Genomic DNA. Translation: BAF35685.1.
AB267156 Genomic DNA. Translation: BAF35686.1.
AB267157 Genomic DNA. Translation: BAF35687.1.
AB267158 Genomic DNA. Translation: BAF35688.1.
AB267159 Genomic DNA. Translation: BAF35689.1.
AB267160 Genomic DNA. Translation: BAF35690.1.
AB267161 Genomic DNA. Translation: BAF35691.1.
AB267162 Genomic DNA. Translation: BAF35692.1.
AB267163 Genomic DNA. Translation: BAF35693.1.
AB267164 Genomic DNA. Translation: BAF35694.1.
AB267165 Genomic DNA. Translation: BAF35695.1.
AB267166 Genomic DNA. Translation: BAF35696.1.
AB267167 Genomic DNA. Translation: BAF35697.1.
AB267168 Genomic DNA. Translation: BAF35698.1.
AB267169 Genomic DNA. Translation: BAF35699.1.
AB267170 Genomic DNA. Translation: BAF35700.1.
AB267171 Genomic DNA. Translation: BAF35701.1.
AB267172 Genomic DNA. Translation: BAF35702.1.
AB267173 Genomic DNA. Translation: BAF35703.1.
AB267174 Genomic DNA. Translation: BAF35704.1.
AB267175 Genomic DNA. Translation: BAF35705.1.
AB267176 Genomic DNA. Translation: BAF35706.1.
AB267177 Genomic DNA. Translation: BAF35707.1.
AB267178 Genomic DNA. Translation: BAF35708.1.
AB267179 Genomic DNA. Translation: BAF35709.1.
AB267180 Genomic DNA. Translation: BAF35710.1.
AB267181 Genomic DNA. Translation: BAF35711.1.
AB267182 Genomic DNA. Translation: BAF35712.1.
AB267183 Genomic DNA. Translation: BAF35713.1.
AB267184 Genomic DNA. Translation: BAF35714.1.
AB267185 Genomic DNA. Translation: BAF35715.1.
AB267186 Genomic DNA. Translation: BAF35716.1.
AB267187 Genomic DNA. Translation: BAF35717.1.
AB267188 Genomic DNA. Translation: BAF35718.1.
AB267189 Genomic DNA. Translation: BAF35719.1.
AB267190 Genomic DNA. Translation: BAF35720.1.
AB267191 Genomic DNA. Translation: BAF35721.1.
AB267192 Genomic DNA. Translation: BAF35722.1.
AB267193 Genomic DNA. Translation: BAF35723.1.
AB267194 Genomic DNA. Translation: BAF35724.1.
AB267195 Genomic DNA. Translation: BAF35725.1.
AB267196 Genomic DNA. Translation: BAF35726.1.
AB267197 Genomic DNA. Translation: BAF35727.1.
AB267198 Genomic DNA. Translation: BAF35728.1.
AB267199 Genomic DNA. Translation: BAF35729.1.
AB267200 Genomic DNA. Translation: BAF35730.1.
AB267201 Genomic DNA. Translation: BAF35731.1.
AB267202 Genomic DNA. Translation: BAF35732.1.
AB267203 Genomic DNA. Translation: BAF35733.1.
AB267204 Genomic DNA. Translation: BAF35734.1.
AB267205 Genomic DNA. Translation: BAF35735.1.
AB267206 Genomic DNA. Translation: BAF35736.1.
AB267207 Genomic DNA. Translation: BAF35737.1.
AB267208 Genomic DNA. Translation: BAF35738.1.
AB267209 Genomic DNA. Translation: BAF35739.1.
AB267210 Genomic DNA. Translation: BAF35740.1.
AB267211 Genomic DNA. Translation: BAF35741.1.
AB267212 Genomic DNA. Translation: BAF35742.1.
AB267213 Genomic DNA. Translation: BAF35743.1.
AB267214 Genomic DNA. Translation: BAF35744.1.
AB267215 Genomic DNA. Translation: BAF35745.1.
AB267216 Genomic DNA. Translation: BAF35746.1.
CCDSiCCDS34768.1.
PIRiI37432. SQHUAC.
RefSeqiNP_002643.1. NM_002652.2.
UniGeneiHs.99949.

Genome annotation databases

EnsembliENST00000291009; ENSP00000291009; ENSG00000159763.
GeneIDi5304.
KEGGihsa:5304.
UCSCiuc003wcf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03460 mRNA. Translation: AAA60091.1.
X51501, X51502, X51504 Genomic DNA. Translation: CAA35870.1.
Y10179 mRNA. Translation: CAA71252.1.
AK312227 mRNA. Translation: BAG35160.1.
CH236959 Genomic DNA. Translation: EAL23781.1.
CH471198 Genomic DNA. Translation: EAW51887.1.
BC010950 mRNA. Translation: AAH10950.1.
BC010951 mRNA. Translation: AAH10951.1.
AB267097 Genomic DNA. Translation: BAF35627.1.
AB267098 Genomic DNA. Translation: BAF35628.1.
AB267099 Genomic DNA. Translation: BAF35629.1.
AB267100 Genomic DNA. Translation: BAF35630.1.
AB267101 Genomic DNA. Translation: BAF35631.1.
AB267102 Genomic DNA. Translation: BAF35632.1.
AB267103 Genomic DNA. Translation: BAF35633.1.
AB267104 Genomic DNA. Translation: BAF35634.1.
AB267105 Genomic DNA. Translation: BAF35635.1.
AB267106 Genomic DNA. Translation: BAF35636.1.
AB267107 Genomic DNA. Translation: BAF35637.1.
AB267108 Genomic DNA. Translation: BAF35638.1.
AB267109 Genomic DNA. Translation: BAF35639.1.
AB267110 Genomic DNA. Translation: BAF35640.1.
AB267111 Genomic DNA. Translation: BAF35641.1.
AB267112 Genomic DNA. Translation: BAF35642.1.
AB267113 Genomic DNA. Translation: BAF35643.1.
AB267114 Genomic DNA. Translation: BAF35644.1.
AB267115 Genomic DNA. Translation: BAF35645.1.
AB267116 Genomic DNA. Translation: BAF35646.1.
AB267117 Genomic DNA. Translation: BAF35647.1.
AB267118 Genomic DNA. Translation: BAF35648.1.
AB267119 Genomic DNA. Translation: BAF35649.1.
AB267120 Genomic DNA. Translation: BAF35650.1.
AB267121 Genomic DNA. Translation: BAF35651.1.
AB267122 Genomic DNA. Translation: BAF35652.1.
AB267123 Genomic DNA. Translation: BAF35653.1.
AB267124 Genomic DNA. Translation: BAF35654.1.
AB267125 Genomic DNA. Translation: BAF35655.1.
AB267126 Genomic DNA. Translation: BAF35656.1.
AB267127 Genomic DNA. Translation: BAF35657.1.
AB267128 Genomic DNA. Translation: BAF35658.1.
AB267129 Genomic DNA. Translation: BAF35659.1.
AB267130 Genomic DNA. Translation: BAF35660.1.
AB267131 Genomic DNA. Translation: BAF35661.1.
AB267132 Genomic DNA. Translation: BAF35662.1.
AB267133 Genomic DNA. Translation: BAF35663.1.
AB267134 Genomic DNA. Translation: BAF35664.1.
AB267135 Genomic DNA. Translation: BAF35665.1.
AB267136 Genomic DNA. Translation: BAF35666.1.
AB267137 Genomic DNA. Translation: BAF35667.1.
AB267138 Genomic DNA. Translation: BAF35668.1.
AB267139 Genomic DNA. Translation: BAF35669.1.
AB267140 Genomic DNA. Translation: BAF35670.1.
AB267141 Genomic DNA. Translation: BAF35671.1.
AB267142 Genomic DNA. Translation: BAF35672.1.
AB267143 Genomic DNA. Translation: BAF35673.1.
AB267144 Genomic DNA. Translation: BAF35674.1.
AB267145 Genomic DNA. Translation: BAF35675.1.
AB267146 Genomic DNA. Translation: BAF35676.1.
AB267147 Genomic DNA. Translation: BAF35677.1.
AB267148 Genomic DNA. Translation: BAF35678.1.
AB267149 Genomic DNA. Translation: BAF35679.1.
AB267150 Genomic DNA. Translation: BAF35680.1.
AB267151 Genomic DNA. Translation: BAF35681.1.
AB267152 Genomic DNA. Translation: BAF35682.1.
AB267153 Genomic DNA. Translation: BAF35683.1.
AB267154 Genomic DNA. Translation: BAF35684.1.
AB267155 Genomic DNA. Translation: BAF35685.1.
AB267156 Genomic DNA. Translation: BAF35686.1.
AB267157 Genomic DNA. Translation: BAF35687.1.
AB267158 Genomic DNA. Translation: BAF35688.1.
AB267159 Genomic DNA. Translation: BAF35689.1.
AB267160 Genomic DNA. Translation: BAF35690.1.
AB267161 Genomic DNA. Translation: BAF35691.1.
AB267162 Genomic DNA. Translation: BAF35692.1.
AB267163 Genomic DNA. Translation: BAF35693.1.
AB267164 Genomic DNA. Translation: BAF35694.1.
AB267165 Genomic DNA. Translation: BAF35695.1.
AB267166 Genomic DNA. Translation: BAF35696.1.
AB267167 Genomic DNA. Translation: BAF35697.1.
AB267168 Genomic DNA. Translation: BAF35698.1.
AB267169 Genomic DNA. Translation: BAF35699.1.
AB267170 Genomic DNA. Translation: BAF35700.1.
AB267171 Genomic DNA. Translation: BAF35701.1.
AB267172 Genomic DNA. Translation: BAF35702.1.
AB267173 Genomic DNA. Translation: BAF35703.1.
AB267174 Genomic DNA. Translation: BAF35704.1.
AB267175 Genomic DNA. Translation: BAF35705.1.
AB267176 Genomic DNA. Translation: BAF35706.1.
AB267177 Genomic DNA. Translation: BAF35707.1.
AB267178 Genomic DNA. Translation: BAF35708.1.
AB267179 Genomic DNA. Translation: BAF35709.1.
AB267180 Genomic DNA. Translation: BAF35710.1.
AB267181 Genomic DNA. Translation: BAF35711.1.
AB267182 Genomic DNA. Translation: BAF35712.1.
AB267183 Genomic DNA. Translation: BAF35713.1.
AB267184 Genomic DNA. Translation: BAF35714.1.
AB267185 Genomic DNA. Translation: BAF35715.1.
AB267186 Genomic DNA. Translation: BAF35716.1.
AB267187 Genomic DNA. Translation: BAF35717.1.
AB267188 Genomic DNA. Translation: BAF35718.1.
AB267189 Genomic DNA. Translation: BAF35719.1.
AB267190 Genomic DNA. Translation: BAF35720.1.
AB267191 Genomic DNA. Translation: BAF35721.1.
AB267192 Genomic DNA. Translation: BAF35722.1.
AB267193 Genomic DNA. Translation: BAF35723.1.
AB267194 Genomic DNA. Translation: BAF35724.1.
AB267195 Genomic DNA. Translation: BAF35725.1.
AB267196 Genomic DNA. Translation: BAF35726.1.
AB267197 Genomic DNA. Translation: BAF35727.1.
AB267198 Genomic DNA. Translation: BAF35728.1.
AB267199 Genomic DNA. Translation: BAF35729.1.
AB267200 Genomic DNA. Translation: BAF35730.1.
AB267201 Genomic DNA. Translation: BAF35731.1.
AB267202 Genomic DNA. Translation: BAF35732.1.
AB267203 Genomic DNA. Translation: BAF35733.1.
AB267204 Genomic DNA. Translation: BAF35734.1.
AB267205 Genomic DNA. Translation: BAF35735.1.
AB267206 Genomic DNA. Translation: BAF35736.1.
AB267207 Genomic DNA. Translation: BAF35737.1.
AB267208 Genomic DNA. Translation: BAF35738.1.
AB267209 Genomic DNA. Translation: BAF35739.1.
AB267210 Genomic DNA. Translation: BAF35740.1.
AB267211 Genomic DNA. Translation: BAF35741.1.
AB267212 Genomic DNA. Translation: BAF35742.1.
AB267213 Genomic DNA. Translation: BAF35743.1.
AB267214 Genomic DNA. Translation: BAF35744.1.
AB267215 Genomic DNA. Translation: BAF35745.1.
AB267216 Genomic DNA. Translation: BAF35746.1.
CCDSiCCDS34768.1.
PIRiI37432. SQHUAC.
RefSeqiNP_002643.1. NM_002652.2.
UniGeneiHs.99949.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ES6X-ray3.23B29-146[»]
ProteinModelPortaliP12273.
SMRiP12273. Positions 29-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111321. 15 interactions.
IntActiP12273. 15 interactions.
STRINGi9606.ENSP00000291009.

PTM databases

iPTMnetiP12273.
PhosphoSiteiP12273.
SwissPalmiP12273.

Polymorphism and mutation databases

BioMutaiPIP.
DMDMi134170.

Proteomic databases

EPDiP12273.
MaxQBiP12273.
PaxDbiP12273.
PeptideAtlasiP12273.
PRIDEiP12273.

Protocols and materials databases

DNASUi5304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291009; ENSP00000291009; ENSG00000159763.
GeneIDi5304.
KEGGihsa:5304.
UCSCiuc003wcf.2. human.

Organism-specific databases

CTDi5304.
GeneCardsiPIP.
HGNCiHGNC:8993. PIP.
HPAiCAB002661.
HPA009177.
MIMi176720. gene.
neXtProtiNX_P12273.
PharmGKBiPA33326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZUS. Eukaryota.
ENOG41116UQ. LUCA.
GeneTreeiENSGT00390000002099.
HOGENOMiHOG000253013.
HOVERGENiHBG065978.
InParanoidiP12273.
OMAiLKECMVV.
OrthoDBiEOG091G0YJ1.
PhylomeDBiP12273.
TreeFamiTF336919.

Enzyme and pathway databases

ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

EvolutionaryTraceiP12273.
GeneWikiiProlactin-induced_protein.
GenomeRNAii5304.
PROiP12273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159763.
CleanExiHS_PIP.
GenevisibleiP12273. HS.

Family and domain databases

InterProiIPR014756. Ig_E-set.
IPR007990. PIP.
[Graphical view]
PfamiPF05326. SVA. 1 hit.
[Graphical view]
PIRSFiPIRSF002572. PIP-GCDFP-15. 1 hit.
ProDomiPD021604. SV_autoAg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIP_HUMAN
AccessioniPrimary (citable) accession number: P12273
Secondary accession number(s): A0A963
, A0A9C3, A0A9F3, A4D2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.