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Protein

Coagulation factor XIII A chain

Gene

F13A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N5-alkylglutamine + NH3.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processBlood coagulation, Hemostasis
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13By similarity)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13A1
Synonyms:F13A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
PropeptideiPRO_00000336452 – 38Activation peptideAdd BLAST37
ChainiPRO_000035111939 – ›198Coagulation factor XIII A chainAdd BLAST›160

Post-translational modificationi

The activation peptide is released by thrombin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Cleavage; by thrombin; to produce active factor XIII-A2

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiP12260.
PRIDEiP12260.

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009559.

Structurei

3D structure databases

ProteinModelPortaliP12260.
SMRiP12260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG084695.
InParanoidiP12260.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR034810. Factor_XIII_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001102. Transglutaminase_N.
PANTHERiPTHR11590:SF62. PTHR11590:SF62. 1 hit.
PfamiView protein in Pfam
PF00868. Transglut_N. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN
60 70 80 90 100
VHLFKERWDS NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPTRDLF
110 120 130 140 150
RVEYVIGLYP QENKGTYIPV PLVSELQSGK WGAKVVMRED RSVRLSVQSS
160 170 180 190
ADCIVGKFRM YVAVWTPYGV IRTSRNPETD TYILFNPWCE EDAVYLEN
Length:198
Mass (Da):22,745
Last modified:September 23, 2008 - v2
Checksum:iA47F7B33469B89A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25N → D AA sequence (PubMed:4831071).Curated1
Non-terminal residuei1981

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025350 mRNA. Translation: ABF57306.1.
PIRiA10933.
UniGeneiBt.19195.

Similar proteinsi

Entry informationi

Entry nameiF13A_BOVIN
AccessioniPrimary (citable) accession number: P12260
Secondary accession number(s): Q1JPK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families