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Protein

Coagulation factor XIII A chain

Gene

F13A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13A1
Synonyms:F13A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Secreted By similarity

  • Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
PropeptideiPRO_00000336452 – 38Activation peptideAdd BLAST37
ChainiPRO_000035111939 – ›198Coagulation factor XIII A chainAdd BLAST›160

Post-translational modificationi

The activation peptide is released by thrombin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Cleavage; by thrombin; to produce active factor XIII-A2

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiP12260.
PRIDEiP12260.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007268.

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009559.

Structurei

3D structure databases

ProteinModelPortaliP12260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG084695.
InParanoidiP12260.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00868. Transglut_N. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN
60 70 80 90 100
VHLFKERWDS NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPTRDLF
110 120 130 140 150
RVEYVIGLYP QENKGTYIPV PLVSELQSGK WGAKVVMRED RSVRLSVQSS
160 170 180 190
ADCIVGKFRM YVAVWTPYGV IRTSRNPETD TYILFNPWCE EDAVYLEN
Length:198
Mass (Da):22,745
Last modified:September 23, 2008 - v2
Checksum:iA47F7B33469B89A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25N → D AA sequence (PubMed:4831071).Curated1
Non-terminal residuei1981

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025350 mRNA. Translation: ABF57306.1.
PIRiA10933.
UniGeneiBt.19195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025350 mRNA. Translation: ABF57306.1.
PIRiA10933.
UniGeneiBt.19195.

3D structure databases

ProteinModelPortaliP12260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009559.

Proteomic databases

PaxDbiP12260.
PRIDEiP12260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG084695.
InParanoidiP12260.

Gene expression databases

BgeeiENSBTAG00000007268.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00868. Transglut_N. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF13A_BOVIN
AccessioniPrimary (citable) accession number: P12260
Secondary accession number(s): Q1JPK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 23, 2008
Last modified: October 5, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.