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P12260

- F13A_BOVIN

UniProt

P12260 - F13A_BOVIN

Protein

Coagulation factor XIII A chain

Gene

F13A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-A

    GO - Molecular functioni

    1. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. peptide cross-linking Source: Ensembl

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_220023. Common Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coagulation factor XIII A chain (EC:2.3.2.13)
    Short name:
    Coagulation factor XIIIa
    Alternative name(s):
    Protein-glutamine gamma-glutamyltransferase A chain
    Transglutaminase A chain
    Gene namesi
    Name:F13A1
    Synonyms:F13A
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm. Secreted
    Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Propeptidei2 – 3837Activation peptidePRO_0000033645Add
    BLAST
    Chaini39 – ›198›160Coagulation factor XIII A chainPRO_0000351119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Post-translational modificationi

    The activation peptide is released by thrombin.

    Keywords - PTMi

    Acetylation, Zymogen

    Interactioni

    Subunit structurei

    Tetramer of two A chains and two B chains.

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009559.

    Structurei

    3D structure databases

    ProteinModelPortaliP12260.
    SMRiP12260. Positions 7-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG084695.
    InParanoidiP12260.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00868. Transglut_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12260-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN    50
    VHLFKERWDS NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPTRDLF 100
    RVEYVIGLYP QENKGTYIPV PLVSELQSGK WGAKVVMRED RSVRLSVQSS 150
    ADCIVGKFRM YVAVWTPYGV IRTSRNPETD TYILFNPWCE EDAVYLEN 198
    Length:198
    Mass (Da):22,745
    Last modified:September 23, 2008 - v2
    Checksum:iA47F7B33469B89A2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251N → D AA sequence (PubMed:4831071)Curated
    Non-terminal residuei198 – 1981

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025350 mRNA. Translation: ABF57306.1.
    PIRiA10933.
    UniGeneiBt.19195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025350 mRNA. Translation: ABF57306.1 .
    PIRi A10933.
    UniGenei Bt.19195.

    3D structure databases

    ProteinModelPortali P12260.
    SMRi P12260. Positions 7-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG084695.
    InParanoidi P12260.

    Enzyme and pathway databases

    Reactomei REACT_220023. Common Pathway.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Amino acid sequence of the peptide released from bovine factor XIII following activation by thrombin."
      Nakamura S., Iwanaga S., Suzuki T., Mikuni Y., Konishi K.
      Biochem. Biophys. Res. Commun. 58:250-256(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-38.

    Entry informationi

    Entry nameiF13A_BOVIN
    AccessioniPrimary (citable) accession number: P12260
    Secondary accession number(s): Q1JPK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3