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P12260 (F13A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coagulation factor XIII A chain

Short name=Coagulation factor XIIIa
EC=2.3.2.13
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene names
Name:F13A1
Synonyms:F13A
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length198 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Tetramer of two A chains and two B chains.

Subcellular location

Cytoplasm. Secreted. Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

Post-translational modification

The activation peptide is released by thrombin.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Ontologies

Keywords
   Biological processBlood coagulation
Hemostasis
   Cellular componentCytoplasm
Secreted
   LigandCalcium
   Molecular functionAcyltransferase
Transferase
   PTMAcetylation
Zymogen
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Inferred from electronic annotation. Source: UniProtKB-KW

peptide cross-linking

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein-glutamine gamma-glutamyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Propeptide2 – 3837Activation peptide Ref.2
PRO_0000033645
Chain39 – ›198›160Coagulation factor XIII A chain
PRO_0000351119

Sites

Site38 – 392Cleavage; by thrombin; to produce active factor XIII-A

Amino acid modifications

Modified residue21N-acetylserine By similarity

Experimental info

Sequence conflict251N → D AA sequence Ref.2
Non-terminal residue1981

Sequences

Sequence LengthMass (Da)Tools
P12260 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: A47F7B33469B89A2

FASTA19822,745
        10         20         30         40         50         60 
MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN VHLFKERWDS 

        70         80         90        100        110        120 
NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPTRDLF RVEYVIGLYP QENKGTYIPV 

       130        140        150        160        170        180 
PLVSELQSGK WGAKVVMRED RSVRLSVQSS ADCIVGKFRM YVAVWTPYGV IRTSRNPETD 

       190 
TYILFNPWCE EDAVYLEN 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Amino acid sequence of the peptide released from bovine factor XIII following activation by thrombin."
Nakamura S., Iwanaga S., Suzuki T., Mikuni Y., Konishi K.
Biochem. Biophys. Res. Commun. 58:250-256(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-38.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT025350 mRNA. Translation: ABF57306.1.
PIRA10933.
UniGeneBt.19195.

3D structure databases

ProteinModelPortalP12260.
SMRP12260. Positions 7-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG80379.
HOGENOMHOG000231695.
HOVERGENHBG084695.
InParanoidP12260.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00868. Transglut_N. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF13A_BOVIN
AccessionPrimary (citable) accession number: P12260
Secondary accession number(s): Q1JPK3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families