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Protein

Filamentous hemagglutinin

Gene

fhaB

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Evidence for a role in host-cell binding and infection.

Keywords - Molecular functioni

Hemagglutinin

Enzyme and pathway databases

BioCyciBPER257313:BP1879-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Filamentous hemagglutinin
Gene namesi
Name:fhaB
Ordered Locus Names:BP1879
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

  • Cell surface

  • Note: Secreted to the cell surface by FhaC, its two partner secretion pathway (TPS) partner.Curated

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35903590Filamentous hemagglutininPRO_0000087234Add
BLAST

Proteomic databases

PRIDEiP12255.

Interactioni

Protein-protein interaction databases

IntActiP12255. 1 interaction.
MINTiMINT-7996260.
STRINGi257313.BP1879.

Structurei

Secondary structure

1
3590
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi81 – 833Combined sources
Beta strandi91 – 933Combined sources
Beta strandi101 – 1099Combined sources
Beta strandi116 – 1216Combined sources
Beta strandi126 – 1283Combined sources
Turni129 – 1313Combined sources
Beta strandi132 – 1343Combined sources
Beta strandi145 – 1517Combined sources
Beta strandi157 – 16812Combined sources
Beta strandi170 – 1756Combined sources
Beta strandi180 – 19617Combined sources
Beta strandi198 – 2036Combined sources
Beta strandi206 – 2116Combined sources
Beta strandi215 – 2184Combined sources
Beta strandi229 – 24012Combined sources
Beta strandi254 – 26512Combined sources
Turni266 – 2694Combined sources
Beta strandi270 – 2734Combined sources
Beta strandi285 – 2906Combined sources
Beta strandi299 – 3057Combined sources
Beta strandi311 – 3144Combined sources
Beta strandi318 – 33013Combined sources
Beta strandi332 – 35019Combined sources
Beta strandi352 – 3598Combined sources
Beta strandi363 – 3675Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RWRX-ray1.72A72-372[»]
ProteinModelPortaliP12255.
SMRiP12255. Positions 72-368.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12255.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108QZZ. Bacteria.
COG3210. LUCA.
HOGENOMiHOG000112584.
KOiK15125.
OMAiHSESHNF.
OrthoDBiEOG6FBWSX.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR024973. ESPR.
IPR008619. Filamentous_hemagglutn_rpt.
IPR008638. Filamn_hemagglutn_N.
IPR025157. Haemagluttinin_rpt.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF13018. ESPR. 1 hit.
PF05594. Fil_haemagg. 9 hits.
PF13332. Fil_haemagg_2. 1 hit.
PF05860. Haemagg_act. 1 hit.
[Graphical view]
SMARTiSM00912. Haemagg_act. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.
TIGRFAMsiTIGR01901. adhes_NPXG. 1 hit.

Sequencei

Sequence statusi: Complete.

P12255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTNLYRLVF SHVRGMLVPV SEHCTVGNTF CGRTRGQARS GARATSLSVA
60 70 80 90 100
PNALAWALML ACTGLPLVTH AQGLVPQGQT QVLQGGNKVP VVNIADPNSG
110 120 130 140 150
GVSHNKFQQF NVANPGVVFN NGLTDGVSRI GGALTKNPNL TRQASAILAE
160 170 180 190 200
VTDTSPSRLA GTLEVYGKGA DLIIANPNGI SVNGLSTLNA SNLTLTTGRP
210 220 230 240 250
SVNGGRIGLD VQQGTVTIER GGVNATGLGY FDVVARLVKL QGAVSSKQGK
260 270 280 290 300
PLADIAVVAG ANRYDHATRR ATPIAAGARG AAAGAYAIDG TAAGAMYGKH
310 320 330 340 350
ITLVSSDSGL GVRQLGSLSS PSAITVSSQG EIALGDATVQ RGPLSLKGAG
360 370 380 390 400
VVSAGKLASG GGAVNVAGGG AVKIASASSV GNLAVQGGGK VQATLLNAGG
410 420 430 440 450
TLLVSGRQAV QLGAASSRQA LSVNAGGALK ADKLSATRRV DVDGKQAVAL
460 470 480 490 500
GSASSNALSV RAGGALKAGK LSATGRLDVD GKQAVTLGSV ASDGALSVSA
510 520 530 540 550
GGNLRAKQLV SSAQLEVRGQ REVALDDASS ARGMTVVAAG ALAARNLQSK
560 570 580 590 600
GAIGVQGGEA VSVANANSDA ELRVRGRGQV DLHDLSAARG ADISGEGRVN
610 620 630 640 650
IGRARSDSDV KVSAHGALSI DSMTALGAIG VQAGGSVSAK DMRSRGAVTV
660 670 680 690 700
SGGGAVNLGD VQSDGQVRAT SAGAMTVRDV AAAADLALQA GDALQAGFLK
710 720 730 740 750
SAGAMTVNGR DAVRLDGAHA GGQLRVSSDG QAALGSLAAK GELTVSAARA
760 770 780 790 800
ATVAELKSLD NISVTGGERV SVQSVNSASR VAISAHGALD VGKVSAKSGI
810 820 830 840 850
GLEGWGAVGA DSLGSDGAIS VSGRDAVRVD QARSLADISL GAEGGATLGA
860 870 880 890 900
VEAAGSIDVR GGSTVAANSL HANRDVRVSG KDAVRVTAAT SGGGLHVSSG
910 920 930 940 950
RQLDLGAVQA RGALALDGGA GVALQSAKAS GTLHVQGGEH LDLGTLAAVG
960 970 980 990 1000
AVDVNGTGDV RVAKLVSDAG ADLQAGRSMT LGIVDTTGDL QARAQQKLEL
1010 1020 1030 1040 1050
GSVKSDGGLQ AAAGGALSLA AAEVAGALEL SGQGVTVDRA SASRARIDST
1060 1070 1080 1090 1100
GSVGIGALKA GAVEAASPRR ARRALRQDFF TPGSVVVRAQ GNVTVGRGDP
1110 1120 1130 1140 1150
HQGVLAQGDI IMDAKGGTLL LRNDALTENG TVTISADSAV LEHSTIESKI
1160 1170 1180 1190 1200
SQSVLAAKGD KGKPAVSVKV AKKLFLNGTL RAVNDNNETM SGRQIDVVDG
1210 1220 1230 1240 1250
RPQITDAVTG EARKDESVVS DAALVADGGP IVVEAGELVS HAGGIGNGRN
1260 1270 1280 1290 1300
KENGASVTVR TTGNLVNKGY ISAGKQGVLE VGGALTNEFL VGSDGTQRIE
1310 1320 1330 1340 1350
AQRIENRGTF QSQAPAGTAG ALVVKAAEAI VHDGVMATKG EMQIAGKGGG
1360 1370 1380 1390 1400
SPTVTAGAKA TTSANKLSVD VASWDNAGSL DIKKGGAQVT VAGRYAEHGE
1410 1420 1430 1440 1450
VSIQGDYTVS ADAIALAAQV TQRGGAANLT SRHDTRFSNK IRLMGPLQVN
1460 1470 1480 1490 1500
AGGAVSNTGN LKVREGVTVT AASFDNETGA EVMAKSATLT TSGAARNAGK
1510 1520 1530 1540 1550
MQVKEAATIV AASVSNPGTF TAGKDITVTS RGGFDNEGKM ESNKDIVIKT
1560 1570 1580 1590 1600
EQFSNGRVLD AKHDLTVTAS GQADNRGSLK AGHDFTVQAQ RIDNSGTMAA
1610 1620 1630 1640 1650
GHDATLKAPH LRNTGQVVAG HDIHIINSAK LENTGRVDAR NDIALDVADF
1660 1670 1680 1690 1700
TNTGSLYAEH DATLTLAQGT QRDLVVDQDH ILPVAEGTLR VKAKSLTTEI
1710 1720 1730 1740 1750
ETGNPGSLIA EVQENIDNKQ AIVVGKDLTL SSAHGNVANE ANALLWAAGE
1760 1770 1780 1790 1800
LTVKAQNITN KRAALIEAGG NARLTAAVAL LNKLGRIRAG EDMHLDAPRI
1810 1820 1830 1840 1850
ENTAKLSGEV QRKGVQDVGG GEHGRWSGIG YVNYWLRAGN GKKAGTIAAP
1860 1870 1880 1890 1900
WYGGDLTAEQ SLIEVGKDLY LNAGARKDEH RHLLNEGVIQ AGGHGHIGGD
1910 1920 1930 1940 1950
VDNRSVVRTV SAMEYFKTPL PVSLTALDNR AGLSPATWNF QSTYELLDYL
1960 1970 1980 1990 2000
LDQNRYEYIW GLYPTYTEWS VNTLKNLDLG YQAKPAPTAP PMPKAPELDL
2010 2020 2030 2040 2050
RGHTLESAEG RKIFGEYKKL QGEYEKAKMA VQAVEAYGEA TRRVHDQLGQ
2060 2070 2080 2090 2100
RYGKALGGMD AETKEVDGII QEFAADLRTV YAKQADQATI DAETDKVAQR
2110 2120 2130 2140 2150
YKSQIDAVRL QAIQPGRVTL AKALSAALGA DWRALGHSQL MQRWKDFKAG
2160 2170 2180 2190 2200
KRGAEIAFYP KEQTVLAAGA GLTLSNGAIH NGENAAQNRG RPEGLKIGAH
2210 2220 2230 2240 2250
SATSVSGSFD ALRDVGLEKR LDIDDALAAV LVNPHIFTRI GAAQTSLADG
2260 2270 2280 2290 2300
AAGPALARQA RQAPETDGMV DARGLGSADA LASLASLDAA QGLEVSGRRN
2310 2320 2330 2340 2350
AQVADAGLAG PSAVAAPAVG AADVGVEPVT GDQVDQPVVA VGLEQPVATV
2360 2370 2380 2390 2400
RVAPPAVALP RPLFETRIKF IDQSKFYGSR YFFEQIGYKP DRAARVAGDN
2410 2420 2430 2440 2450
YFDTTLVREQ VRRALGGYES RLPVRGVALV AKLMDSAGTV GKALGLKVGV
2460 2470 2480 2490 2500
APTAQQLKQA DRDFVWYVDT VIDGQKVLAP RLYLTEATRQ GITDQYAGGG
2510 2520 2530 2540 2550
ALIASGGDVT VNTDGHDVSS VNGLIQGRSV KVDAGKGKVV VADSKGAGGG
2560 2570 2580 2590 2600
IEADDEVDVS GRDIGIEGGK LRGKDVRLKA DTVKVATSMR YDDKGRLAAR
2610 2620 2630 2640 2650
GDGALDAQGG QLHIEAKRLE TAGATLKGGK VKLDVDDVKL GGVYEAGSSY
2660 2670 2680 2690 2700
ENKSSTPLGS LFAILSSTTE TNQSAHANHY GTRIEAGTLE GKMQNLEIEG
2710 2720 2730 2740 2750
GSVDAAHTDL SVARDARFKA AADFAHAEHE KDVRQLSLGA KVGAGGYEAG
2760 2770 2780 2790 2800
FSLGSESGLE AHAGRGMTAG AEVKVGYRAS HEQSSETEKS YRNANLNFGG
2810 2820 2830 2840 2850
GSVEAGNVLD IGGADINRNR YGGAAKGNAG TEEALRMRAK KVESTKYVSE
2860 2870 2880 2890 2900
QTSQSSGWSV EVASTASARS SLLTAATRLG DSVAQNVEDG REIRGELMAA
2910 2920 2930 2940 2950
QVAAEATQLV TADTAAVALS AGISADFDSS HSRSTSQNTQ YLGGNLSIEA
2960 2970 2980 2990 3000
TEGDATLVGA KFGGGDQVSL KAAKSVNLMA AESTFESYSE SHNFHASADA
3010 3020 3030 3040 3050
NLGANAVQGA VGLGLTAGMG TSHQITNETG KTYAGTSVDA ANVSIDAGKD
3060 3070 3080 3090 3100
LNLSGSRVRG KHVVLDVEGD INATSKQDER NYNSSGGGWD ASAGVAIQNR
3110 3120 3130 3140 3150
TLVAPVGSAG FNFNTEHDNS RLTNDGAAGV VASDGLTGHV KGDANLTGAT
3160 3170 3180 3190 3200
IADLSGKGNL KVDGAVNAQN LKDYRDKDGG SGGLNVGISS TTLAPTVGVA
3210 3220 3230 3240 3250
FGRVAGEDYQ AEQRATIDVG QTKDPARLQV GGGVKGTLNQ DAAQATVVQR
3260 3270 3280 3290 3300
NKHWAGGGSE FSVAGKSLKK KNQVRPVETP TPDVVDGPPS RPTTPPASPQ
3310 3320 3330 3340 3350
PIRATVEVSS PPPVSVATVE VVPRPKVETA QPLPPRPVAA QVVPVTPPKV
3360 3370 3380 3390 3400
EVAKVEVVPR PKVETAQPLP PRPVVAEKVT TPAVQPQLAK VETVQPVKPE
3410 3420 3430 3440 3450
TTKPLPKPLP VAKVTKAPPP VVETAQPLPP VKPQKATPGP VAEVGKATVT
3460 3470 3480 3490 3500
TVQVQSAPPK PAPVAKQPAP APKPKPKPKP KAERPKPGKT TPLSGRHVVQ
3510 3520 3530 3540 3550
QQVQVLQRQA SDINNTKSLP GGKLPKPVTV KLTDENGKPQ TYTINRREDL
3560 3570 3580 3590
MKLNGKVLST KTTLGLEQTF RLRVEDIGGK NYRVFYETNK
Length:3,590
Mass (Da):367,522
Last modified:September 19, 2003 - v4
Checksum:iC00BD8E22C9DB41D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801G → R in CAA37481 (PubMed:1696934).Curated
Sequence conflicti284 – 2841G → A in CAA37481 (PubMed:1696934).Curated
Sequence conflicti507 – 5082KQ → NE in AAA22974 (PubMed:2388559).Curated
Sequence conflicti507 – 5082KQ → NE (PubMed:2539596).Curated
Sequence conflicti507 – 5082KQ → NE in CAA37481 (PubMed:1696934).Curated
Sequence conflicti516 – 5161E → V in CAA37481 (PubMed:1696934).Curated
Sequence conflicti614 – 6141A → G in CAA37481 (PubMed:1696934).Curated
Sequence conflicti1454 – 14541A → P in AAA22974 (PubMed:2388559).Curated
Sequence conflicti1454 – 14541A → P (PubMed:2539596).Curated
Sequence conflicti3574 – 359017VEDIG…YETNK → SRISAARTTGSSMKPTNR in AAA22974 (PubMed:2388559).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60351 Genomic DNA. Translation: AAA22974.1.
BX640416 Genomic DNA. Translation: CAE42162.1.
X53405 Genomic DNA. Translation: CAA37481.1.
PIRiS21010.
RefSeqiNP_880571.1. NC_002929.2.
WP_010930610.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE42162; CAE42162; BP1879.
GeneIDi2667059.
KEGGibpe:BP1879.
PATRICi21157046. VBIBorPer7866_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60351 Genomic DNA. Translation: AAA22974.1.
BX640416 Genomic DNA. Translation: CAE42162.1.
X53405 Genomic DNA. Translation: CAA37481.1.
PIRiS21010.
RefSeqiNP_880571.1. NC_002929.2.
WP_010930610.1. NC_002929.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RWRX-ray1.72A72-372[»]
ProteinModelPortaliP12255.
SMRiP12255. Positions 72-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12255. 1 interaction.
MINTiMINT-7996260.
STRINGi257313.BP1879.

Proteomic databases

PRIDEiP12255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE42162; CAE42162; BP1879.
GeneIDi2667059.
KEGGibpe:BP1879.
PATRICi21157046. VBIBorPer7866_2018.

Phylogenomic databases

eggNOGiENOG4108QZZ. Bacteria.
COG3210. LUCA.
HOGENOMiHOG000112584.
KOiK15125.
OMAiHSESHNF.
OrthoDBiEOG6FBWSX.

Enzyme and pathway databases

BioCyciBPER257313:BP1879-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP12255.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR024973. ESPR.
IPR008619. Filamentous_hemagglutn_rpt.
IPR008638. Filamn_hemagglutn_N.
IPR025157. Haemagluttinin_rpt.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF13018. ESPR. 1 hit.
PF05594. Fil_haemagg. 9 hits.
PF13332. Fil_haemagg_2. 1 hit.
PF05860. Haemagg_act. 1 hit.
[Graphical view]
SMARTiSM00912. Haemagg_act. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.
TIGRFAMsiTIGR01901. adhes_NPXG. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor."
    Relman D.A., Domenighini M., Tuomanen E., Rappuoli R., Falkow S.
    Mol. Microbiol. 4:787-800(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
  3. "Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence."
    Relman D.A., Domenighini M., Tuomanen E., Rappuoli R., Falkow S.
    Proc. Natl. Acad. Sci. U.S.A. 86:2637-2641(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3261.
    Strain: BP338.
  4. "Cloning, partial sequence, expression and antigenic analysis of the filamentous hemagglutinin gene of Bordetella pertussis."
    Delisse-Gathoye A.M., Locht C., Jacob F., Raaschou-Nielsen M., Heron I., Ruelle J.L., De Wilde M., Cabezon T.
    Infect. Immun. 58:2895-2905(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1087.
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
  5. "The bvg-dependent promoters show similar behaviour in different Bordetella species and share sequence homologies."
    Scarlato V., Prugnola A., Arico B., Rappuoli R.
    Mol. Microbiol. 5:2493-2498(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.

Entry informationi

Entry nameiFHAB_BORPE
AccessioniPrimary (citable) accession number: P12255
Secondary accession number(s): Q45364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 19, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.