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P12255 (FHAB_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Filamentous hemagglutinin
Gene names
Name:fhaB
Ordered Locus Names:BP1879
OrganismBordetella pertussis
Taxonomic identifier520 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length3590 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Evidence for a role in host-cell binding and infection.

Subcellular location

Cell surface.

Ontologies

Keywords
   Molecular functionHemagglutinin
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular componentcell surface

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 35903590Filamentous hemagglutinin
PRO_0000087234

Experimental info

Sequence conflict2801G → R in CAA37481. Ref.4
Sequence conflict2841G → A in CAA37481. Ref.4
Sequence conflict507 – 5082KQ → NE Ref.1
Sequence conflict507 – 5082KQ → NE Ref.3
Sequence conflict507 – 5082KQ → NE Ref.4
Sequence conflict5161E → V in CAA37481. Ref.4
Sequence conflict6141A → G in CAA37481. Ref.4
Sequence conflict14541A → P Ref.1
Sequence conflict14541A → P Ref.3
Sequence conflict3574 – 359017VEDIG…YETNK → SRISAARTTGSSMKPTNR in AAA22974. Ref.1

Secondary structure

1 ............................................... 3590
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P12255 [UniParc].

Last modified September 19, 2003. Version 4.
Checksum: C00BD8E22C9DB41D

FASTA3,590367,522
        10         20         30         40         50         60 
MNTNLYRLVF SHVRGMLVPV SEHCTVGNTF CGRTRGQARS GARATSLSVA PNALAWALML 

        70         80         90        100        110        120 
ACTGLPLVTH AQGLVPQGQT QVLQGGNKVP VVNIADPNSG GVSHNKFQQF NVANPGVVFN 

       130        140        150        160        170        180 
NGLTDGVSRI GGALTKNPNL TRQASAILAE VTDTSPSRLA GTLEVYGKGA DLIIANPNGI 

       190        200        210        220        230        240 
SVNGLSTLNA SNLTLTTGRP SVNGGRIGLD VQQGTVTIER GGVNATGLGY FDVVARLVKL 

       250        260        270        280        290        300 
QGAVSSKQGK PLADIAVVAG ANRYDHATRR ATPIAAGARG AAAGAYAIDG TAAGAMYGKH 

       310        320        330        340        350        360 
ITLVSSDSGL GVRQLGSLSS PSAITVSSQG EIALGDATVQ RGPLSLKGAG VVSAGKLASG 

       370        380        390        400        410        420 
GGAVNVAGGG AVKIASASSV GNLAVQGGGK VQATLLNAGG TLLVSGRQAV QLGAASSRQA 

       430        440        450        460        470        480 
LSVNAGGALK ADKLSATRRV DVDGKQAVAL GSASSNALSV RAGGALKAGK LSATGRLDVD 

       490        500        510        520        530        540 
GKQAVTLGSV ASDGALSVSA GGNLRAKQLV SSAQLEVRGQ REVALDDASS ARGMTVVAAG 

       550        560        570        580        590        600 
ALAARNLQSK GAIGVQGGEA VSVANANSDA ELRVRGRGQV DLHDLSAARG ADISGEGRVN 

       610        620        630        640        650        660 
IGRARSDSDV KVSAHGALSI DSMTALGAIG VQAGGSVSAK DMRSRGAVTV SGGGAVNLGD 

       670        680        690        700        710        720 
VQSDGQVRAT SAGAMTVRDV AAAADLALQA GDALQAGFLK SAGAMTVNGR DAVRLDGAHA 

       730        740        750        760        770        780 
GGQLRVSSDG QAALGSLAAK GELTVSAARA ATVAELKSLD NISVTGGERV SVQSVNSASR 

       790        800        810        820        830        840 
VAISAHGALD VGKVSAKSGI GLEGWGAVGA DSLGSDGAIS VSGRDAVRVD QARSLADISL 

       850        860        870        880        890        900 
GAEGGATLGA VEAAGSIDVR GGSTVAANSL HANRDVRVSG KDAVRVTAAT SGGGLHVSSG 

       910        920        930        940        950        960 
RQLDLGAVQA RGALALDGGA GVALQSAKAS GTLHVQGGEH LDLGTLAAVG AVDVNGTGDV 

       970        980        990       1000       1010       1020 
RVAKLVSDAG ADLQAGRSMT LGIVDTTGDL QARAQQKLEL GSVKSDGGLQ AAAGGALSLA 

      1030       1040       1050       1060       1070       1080 
AAEVAGALEL SGQGVTVDRA SASRARIDST GSVGIGALKA GAVEAASPRR ARRALRQDFF 

      1090       1100       1110       1120       1130       1140 
TPGSVVVRAQ GNVTVGRGDP HQGVLAQGDI IMDAKGGTLL LRNDALTENG TVTISADSAV 

      1150       1160       1170       1180       1190       1200 
LEHSTIESKI SQSVLAAKGD KGKPAVSVKV AKKLFLNGTL RAVNDNNETM SGRQIDVVDG 

      1210       1220       1230       1240       1250       1260 
RPQITDAVTG EARKDESVVS DAALVADGGP IVVEAGELVS HAGGIGNGRN KENGASVTVR 

      1270       1280       1290       1300       1310       1320 
TTGNLVNKGY ISAGKQGVLE VGGALTNEFL VGSDGTQRIE AQRIENRGTF QSQAPAGTAG 

      1330       1340       1350       1360       1370       1380 
ALVVKAAEAI VHDGVMATKG EMQIAGKGGG SPTVTAGAKA TTSANKLSVD VASWDNAGSL 

      1390       1400       1410       1420       1430       1440 
DIKKGGAQVT VAGRYAEHGE VSIQGDYTVS ADAIALAAQV TQRGGAANLT SRHDTRFSNK 

      1450       1460       1470       1480       1490       1500 
IRLMGPLQVN AGGAVSNTGN LKVREGVTVT AASFDNETGA EVMAKSATLT TSGAARNAGK 

      1510       1520       1530       1540       1550       1560 
MQVKEAATIV AASVSNPGTF TAGKDITVTS RGGFDNEGKM ESNKDIVIKT EQFSNGRVLD 

      1570       1580       1590       1600       1610       1620 
AKHDLTVTAS GQADNRGSLK AGHDFTVQAQ RIDNSGTMAA GHDATLKAPH LRNTGQVVAG 

      1630       1640       1650       1660       1670       1680 
HDIHIINSAK LENTGRVDAR NDIALDVADF TNTGSLYAEH DATLTLAQGT QRDLVVDQDH 

      1690       1700       1710       1720       1730       1740 
ILPVAEGTLR VKAKSLTTEI ETGNPGSLIA EVQENIDNKQ AIVVGKDLTL SSAHGNVANE 

      1750       1760       1770       1780       1790       1800 
ANALLWAAGE LTVKAQNITN KRAALIEAGG NARLTAAVAL LNKLGRIRAG EDMHLDAPRI 

      1810       1820       1830       1840       1850       1860 
ENTAKLSGEV QRKGVQDVGG GEHGRWSGIG YVNYWLRAGN GKKAGTIAAP WYGGDLTAEQ 

      1870       1880       1890       1900       1910       1920 
SLIEVGKDLY LNAGARKDEH RHLLNEGVIQ AGGHGHIGGD VDNRSVVRTV SAMEYFKTPL 

      1930       1940       1950       1960       1970       1980 
PVSLTALDNR AGLSPATWNF QSTYELLDYL LDQNRYEYIW GLYPTYTEWS VNTLKNLDLG 

      1990       2000       2010       2020       2030       2040 
YQAKPAPTAP PMPKAPELDL RGHTLESAEG RKIFGEYKKL QGEYEKAKMA VQAVEAYGEA 

      2050       2060       2070       2080       2090       2100 
TRRVHDQLGQ RYGKALGGMD AETKEVDGII QEFAADLRTV YAKQADQATI DAETDKVAQR 

      2110       2120       2130       2140       2150       2160 
YKSQIDAVRL QAIQPGRVTL AKALSAALGA DWRALGHSQL MQRWKDFKAG KRGAEIAFYP 

      2170       2180       2190       2200       2210       2220 
KEQTVLAAGA GLTLSNGAIH NGENAAQNRG RPEGLKIGAH SATSVSGSFD ALRDVGLEKR 

      2230       2240       2250       2260       2270       2280 
LDIDDALAAV LVNPHIFTRI GAAQTSLADG AAGPALARQA RQAPETDGMV DARGLGSADA 

      2290       2300       2310       2320       2330       2340 
LASLASLDAA QGLEVSGRRN AQVADAGLAG PSAVAAPAVG AADVGVEPVT GDQVDQPVVA 

      2350       2360       2370       2380       2390       2400 
VGLEQPVATV RVAPPAVALP RPLFETRIKF IDQSKFYGSR YFFEQIGYKP DRAARVAGDN 

      2410       2420       2430       2440       2450       2460 
YFDTTLVREQ VRRALGGYES RLPVRGVALV AKLMDSAGTV GKALGLKVGV APTAQQLKQA 

      2470       2480       2490       2500       2510       2520 
DRDFVWYVDT VIDGQKVLAP RLYLTEATRQ GITDQYAGGG ALIASGGDVT VNTDGHDVSS 

      2530       2540       2550       2560       2570       2580 
VNGLIQGRSV KVDAGKGKVV VADSKGAGGG IEADDEVDVS GRDIGIEGGK LRGKDVRLKA 

      2590       2600       2610       2620       2630       2640 
DTVKVATSMR YDDKGRLAAR GDGALDAQGG QLHIEAKRLE TAGATLKGGK VKLDVDDVKL 

      2650       2660       2670       2680       2690       2700 
GGVYEAGSSY ENKSSTPLGS LFAILSSTTE TNQSAHANHY GTRIEAGTLE GKMQNLEIEG 

      2710       2720       2730       2740       2750       2760 
GSVDAAHTDL SVARDARFKA AADFAHAEHE KDVRQLSLGA KVGAGGYEAG FSLGSESGLE 

      2770       2780       2790       2800       2810       2820 
AHAGRGMTAG AEVKVGYRAS HEQSSETEKS YRNANLNFGG GSVEAGNVLD IGGADINRNR 

      2830       2840       2850       2860       2870       2880 
YGGAAKGNAG TEEALRMRAK KVESTKYVSE QTSQSSGWSV EVASTASARS SLLTAATRLG 

      2890       2900       2910       2920       2930       2940 
DSVAQNVEDG REIRGELMAA QVAAEATQLV TADTAAVALS AGISADFDSS HSRSTSQNTQ 

      2950       2960       2970       2980       2990       3000 
YLGGNLSIEA TEGDATLVGA KFGGGDQVSL KAAKSVNLMA AESTFESYSE SHNFHASADA 

      3010       3020       3030       3040       3050       3060 
NLGANAVQGA VGLGLTAGMG TSHQITNETG KTYAGTSVDA ANVSIDAGKD LNLSGSRVRG 

      3070       3080       3090       3100       3110       3120 
KHVVLDVEGD INATSKQDER NYNSSGGGWD ASAGVAIQNR TLVAPVGSAG FNFNTEHDNS 

      3130       3140       3150       3160       3170       3180 
RLTNDGAAGV VASDGLTGHV KGDANLTGAT IADLSGKGNL KVDGAVNAQN LKDYRDKDGG 

      3190       3200       3210       3220       3230       3240 
SGGLNVGISS TTLAPTVGVA FGRVAGEDYQ AEQRATIDVG QTKDPARLQV GGGVKGTLNQ 

      3250       3260       3270       3280       3290       3300 
DAAQATVVQR NKHWAGGGSE FSVAGKSLKK KNQVRPVETP TPDVVDGPPS RPTTPPASPQ 

      3310       3320       3330       3340       3350       3360 
PIRATVEVSS PPPVSVATVE VVPRPKVETA QPLPPRPVAA QVVPVTPPKV EVAKVEVVPR 

      3370       3380       3390       3400       3410       3420 
PKVETAQPLP PRPVVAEKVT TPAVQPQLAK VETVQPVKPE TTKPLPKPLP VAKVTKAPPP 

      3430       3440       3450       3460       3470       3480 
VVETAQPLPP VKPQKATPGP VAEVGKATVT TVQVQSAPPK PAPVAKQPAP APKPKPKPKP 

      3490       3500       3510       3520       3530       3540 
KAERPKPGKT TPLSGRHVVQ QQVQVLQRQA SDINNTKSLP GGKLPKPVTV KLTDENGKPQ 

      3550       3560       3570       3580       3590 
TYTINRREDL MKLNGKVLST KTTLGLEQTF RLRVEDIGGK NYRVFYETNK

« Hide

References

« Hide 'large scale' references
[1]"Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor."
Relman D.A., Domenighini M., Tuomanen E., Rappuoli R., Falkow S.
Mol. Microbiol. 4:787-800(1990) [PubMed: 2388559] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. expand/collapse author list , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[3]"Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence."
Relman D.A., Domenighini M., Tuomanen E., Rappuoli R., Falkow S.
Proc. Natl. Acad. Sci. U.S.A. 86:2637-2641(1989) [PubMed: 2539596] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3261.
[4]"Cloning, partial sequence, expression and antigenic analysis of the filamentous hemagglutinin gene of Bordetella pertussis."
Delisse-Gathoye A.M., Locht C., Jacob F., Raaschou-Nielsen M., Heron I., Ruelle J.L., De Wilde M., Cabezon T.
Infect. Immun. 58:2895-2905(1990) [PubMed: 1696934] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1087.
Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[5]"The bvg-dependent promoters show similar behaviour in different Bordetella species and share sequence homologies."
Scarlato V., Prugnola A., Arico B., Rappuoli R.
Mol. Microbiol. 5:2493-2498(1991) [PubMed: 1791761] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M60351 Genomic DNA. Translation: AAA22974.1.
BX640416 Genomic DNA. Translation: CAE42162.1.
X53405 Genomic DNA. Translation: CAA37481.1.
PIRS21010.
RefSeqNP_880571.1. NC_002929.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RWRX-ray1.72A72-372[»]
ProteinModelPortalP12255.
SMRP12255. Positions 72-368.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2667059.
GenomeReviewsGene locus BP1879 in contig BX470248_GR.
KEGGbpe:BP1879.
NMPDRfig|257313.1.peg.1647.
PATRIC21157046. VBIBorPer7866_2018.

Phylogenomic databases

HOGENOMHBG037648.
OMAEVVPRPK.
ProtClustDBCLSK396915.

Enzyme and pathway databases

BioCycBPER257313:BP1879-MONOMER.

Family and domain databases

InterProIPR008619. Filamentous_hemagglutn_rpt.
IPR008638. Filamn_hemagglutn_N_bac.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
Gene3DG3DSA:2.160.20.10. Pectin_lyas_fold. 1 hit.
KOK15125.
PfamPF05594. Fil_haemagg. 7 hits.
PF05860. Haemagg_act. 1 hit.
[Graphical view]
SMARTSM00912. Haemagg_act. 1 hit.
[Graphical view]
SUPFAMSSF51126. Pectin_lyas_like. 1 hit.
TIGRFAMsTIGR01901. Adhes_NPXG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFHAB_BORPE
AccessionPrimary (citable) accession number: P12255
Secondary accession number(s): Q45364
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 19, 2003
Last modified: January 25, 2012
This is version 82 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents