P12252 (PDE4B_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase
EC=3.1.4.17

Alternative name(s):
Learning/memory process protein
Protein dunce

Gene names

Name:	dnc
ORF Names:	CG32498

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1070 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity. Vital for female fertility. Required for learning/memory. Ref.1
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. Ref.1
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Subunit structure	Monomer. Ref.1
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Ontologies

Keywords
Coding sequence diversity	Alternative initiation Alternative splicing
Ligand	Metal-binding cAMP
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension Inferred from mutant phenotype PubMed 14960616. Source: FlyBase behavioral response to ethanol Non-traceable author statement PubMed 11715043. Source: FlyBase cAMP catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cAMP-mediated signaling Non-traceable author statement PubMed 11092827PubMed 11462211PubMed 11741030PubMed 14515157. Source: FlyBase conditioned taste aversion Inferred from mutant phenotype PubMed 19158309. Source: FlyBase courtship behavior Traceable author statement PubMed 11092827PubMed 11715043PubMed 12486700. Source: FlyBase lateral inhibition Inferred from mutant phenotype PubMed 19363474. Source: FlyBase locomotor rhythm Non-traceable author statement PubMed 11715043. Source: FlyBase nonassociative learning Traceable author statement PubMed 14504657. Source: FlyBase olfactory learning Traceable author statement PubMed 11462211PubMed 11715043. Source: FlyBase oogenesis Traceable author statement PubMed 3089870. Source: FlyBase short-term memory Inferred from mutant phenotype PubMed 19158309. Source: FlyBase synaptic transmission Inferred from mutant phenotype PubMed 12040051PubMed 14507965. Source: FlyBase
Molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Isoform II (identifier: P12252-1)

Also known as: I; J;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform IV (identifier: P12252-3)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.
     370-385: LSPRISFPGSDSDLFG → MVCSFCCCCYNFRNSP

Isoform V (identifier: P12252-4)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     444-456: Missing.

Isoform VI (identifier: P12252-5)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: Missing.

Isoform VII (identifier: P12252-6)

Also known as: L;

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Isoform I (identifier: Q9W4T4-1)

Also known as: B; O;

The sequence of this isoform can be found in the external entry Q9W4T4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform F (identifier: Q8IRU4-1)

The sequence of this isoform can be found in the external entry Q8IRU4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform G (identifier: Q9W4S9-2)

The sequence of this isoform can be found in the external entry Q9W4S9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform M (identifier: Q9W4T0-1)

The sequence of this isoform can be found in the external entry Q9W4T0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform N (identifier: Q9W4S9-1)

The sequence of this isoform can be found in the external entry Q9W4S9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform III (identifier: P12252-7)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     1-428: Missing.

Note: Produced by alternative initiation at Met-429 of isoform II.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1070	1070	cAMP-specific 3',5'-cyclic phosphodiesterase		PRO_0000023342
Regions
	Nucleotide binding	732 – 736	5	cAMP By similarity
	Compositional bias	57 – 210	154	Ser-rich
	Compositional bias	1020 – 1069	50	Gly-rich
Sites
	Active site	732	1	Proton donor By similarity
	Metal binding	736	1	Divalent metal cation 1 By similarity
	Metal binding	772	1	Divalent metal cation 1 By similarity
	Metal binding	773	1	Divalent metal cation 1 By similarity
	Metal binding	773	1	Divalent metal cation 2 By similarity
	Metal binding	890	1	Divalent metal cation 1 By similarity
	Binding site	773	1	cAMP By similarity
	Binding site	890	1	cAMP By similarity
	Binding site	941	1	cAMP By similarity
	Site	893	1	Binds AMP, but not cAMP By similarity
Natural variations
	Alternative sequence	1 – 549	549	Missing in isoform VII.		VSP_004587
	Alternative sequence	1 – 428	428	Missing in isoform III.		VSP_018826
	Alternative sequence	1 – 369	369	Missing in isoform IV.		VSP_004585
	Alternative sequence	370 – 385	16	LSPRI…SDLFG → MVCSFCCCCYNFRNSP in isoform IV.		VSP_004586
	Alternative sequence	444 – 456	13	Missing in isoform V.		VSP_004588
	Alternative sequence	493 – 494	2	Missing in isoform VI.		VSP_004589
Experimental info
	Sequence conflict	958	1	D → S Ref.1
	Sequence conflict	958	1	D → S Ref.2
	Sequence conflict	1027	1	S → T Ref.1
	Sequence conflict	1027	1	S → T Ref.2
	Sequence conflict	1042 – 1043	2	SG → R Ref.1
	Sequence conflict	1042 – 1043	2	SG → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform II (I) (J) [UniParc]. Last modified August 16, 2005. Version 4. Checksum: 50A63BF7BCC8EDD9	FASTA	1,070	115,079
	10 20 30 40 50 60 MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE KQVQVQSQKF 70 80 90 100 110 120 SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ LQQLQQLQQQ QQQQQSQRII 130 140 150 160 170 180 SSSTRSQSLQ SSTIVGEATT ITSGAAQILS ASAAASLAQQ LKAQSSTSII TSSEQRTSTS 190 200 210 220 230 240 TSSSSSTRYI ASGSSNLAGG NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR 250 260 270 280 290 300 STSAHSEAAA GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 310 320 330 340 350 360 GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP IHAPPGLHDM 370 380 390 400 410 420 LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG GSPSAGLVLQ NLPQRRESFL 430 440 450 460 470 480 YRSDSDFEMS PKSMSRNSSI ASERFKEQEA SILVDRSHGE DLIVTPFAQI LASLRSVRNN 490 500 510 520 530 540 LLSLTNVPAS NKSRRPNQSS SASRSGNPPG APLSQGEEAY TRLATDTIEE LDWCLDQLET 550 560 570 580 590 600 IQTHRSVSDM ASLKFKRMLN KELSHFSESS RSGNQISEYI CSTFLDKQQE FDLPSLRVED 610 620 630 640 650 660 NPELVAANAA AGQQSAGQYA RSRSPRGPPM SQISGVKRPL SHTNSFTGER LPTFGVETPR 670 680 690 700 710 720 ENELGTLLGE LDTWGIQIFS IGEFSVNRPL TCVAYTIFQS RELLTSLMIP PKTFLNFMST 730 740 750 760 770 780 LEDHYVKDNP FHNSLHAADV TQSTNVLLNT PALEGVFTPL EVGGALFAAC IHDVDHPGLT 790 800 810 820 830 840 NQFLVNSSSE LALMYNDESV LENHHLAVAF KLLQNQGCDI FCNMQKKQRQ TLRKMVIDIV 850 860 870 880 890 900 LSTDMSKHMS LLADLKTMVE TKKVAGSGVL LLDNYTDRIQ VLENLVHCAD LSNPTKPLPL 910 920 930 940 950 960 YKRWVALLME EFFLQGDKER ESGMDISPMC DRHNATIEKS QVGFIDYIVH PLWETWADLV 970 980 990 1000 1010 1020 HPDAQDILDT LEENRDYYQS MIPPSPPPSG VDENPQEDRI RFQVTLEESD QENLAELEEG 1030 1040 1050 1060 1070 DESGGESTTT GTTGTTAASA LSGAGGGGGG GGGMAPRTGG CQNQPQHGGM
	Isoform IV (A) [UniParc]. Checksum: 52B25B32753A0EFE	FASTA	701	77,193
	10 20 30 40 50 60 MVCSFCCCCY NFRNSPFDVE NGQGARSPLE GGSPSAGLVL QNLPQRRESF LYRSDSDFEM 70 80 90 100 110 120 SPKSMSRNSS IASERFKEQE ASILVDRSHG EDLIVTPFAQ ILASLRSVRN NLLSLTNVPA 130 140 150 160 170 180 SNKSRRPNQS SSASRSGNPP GAPLSQGEEA YTRLATDTIE ELDWCLDQLE TIQTHRSVSD 190 200 210 220 230 240 MASLKFKRML NKELSHFSES SRSGNQISEY ICSTFLDKQQ EFDLPSLRVE DNPELVAANA 250 260 270 280 290 300 AAGQQSAGQY ARSRSPRGPP MSQISGVKRP LSHTNSFTGE RLPTFGVETP RENELGTLLG 310 320 330 340 350 360 ELDTWGIQIF SIGEFSVNRP LTCVAYTIFQ SRELLTSLMI PPKTFLNFMS TLEDHYVKDN 370 380 390 400 410 420 PFHNSLHAAD VTQSTNVLLN TPALEGVFTP LEVGGALFAA CIHDVDHPGL TNQFLVNSSS 430 440 450 460 470 480 ELALMYNDES VLENHHLAVA FKLLQNQGCD IFCNMQKKQR QTLRKMVIDI VLSTDMSKHM 490 500 510 520 530 540 SLLADLKTMV ETKKVAGSGV LLLDNYTDRI QVLENLVHCA DLSNPTKPLP LYKRWVALLM 550 560 570 580 590 600 EEFFLQGDKE RESGMDISPM CDRHNATIEK SQVGFIDYIV HPLWETWADL VHPDAQDILD 610 620 630 640 650 660 TLEENRDYYQ SMIPPSPPPS GVDENPQEDR IRFQVTLEES DQENLAELEE GDESGGESTT 670 680 690 700 TGTTGTTAAS ALSGAGGGGG GGGGMAPRTG GCQNQPQHGG M
	Isoform V (C) [UniParc]. Checksum: F6A7B73FAB4F196B	FASTA	1,057	113,506
	10 20 30 40 50 60 MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE KQVQVQSQKF 70 80 90 100 110 120 SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ LQQLQQLQQQ QQQQQSQRII 130 140 150 160 170 180 SSSTRSQSLQ SSTIVGEATT ITSGAAQILS ASAAASLAQQ LKAQSSTSII TSSEQRTSTS 190 200 210 220 230 240 TSSSSSTRYI ASGSSNLAGG NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR 250 260 270 280 290 300 STSAHSEAAA GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 310 320 330 340 350 360 GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP IHAPPGLHDM 370 380 390 400 410 420 LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG GSPSAGLVLQ NLPQRRESFL 430 440 450 460 470 480 YRSDSDFEMS PKSMSRNSSI ASESHGEDLI VTPFAQILAS LRSVRNNLLS LTNVPASNKS 490 500 510 520 530 540 RRPNQSSSAS RSGNPPGAPL SQGEEAYTRL ATDTIEELDW CLDQLETIQT HRSVSDMASL 550 560 570 580 590 600 KFKRMLNKEL SHFSESSRSG NQISEYICST FLDKQQEFDL PSLRVEDNPE LVAANAAAGQ 610 620 630 640 650 660 QSAGQYARSR SPRGPPMSQI SGVKRPLSHT NSFTGERLPT FGVETPRENE LGTLLGELDT 670 680 690 700 710 720 WGIQIFSIGE FSVNRPLTCV AYTIFQSREL LTSLMIPPKT FLNFMSTLED HYVKDNPFHN 730 740 750 760 770 780 SLHAADVTQS TNVLLNTPAL EGVFTPLEVG GALFAACIHD VDHPGLTNQF LVNSSSELAL 790 800 810 820 830 840 MYNDESVLEN HHLAVAFKLL QNQGCDIFCN MQKKQRQTLR KMVIDIVLST DMSKHMSLLA 850 860 870 880 890 900 DLKTMVETKK VAGSGVLLLD NYTDRIQVLE NLVHCADLSN PTKPLPLYKR WVALLMEEFF 910 920 930 940 950 960 LQGDKERESG MDISPMCDRH NATIEKSQVG FIDYIVHPLW ETWADLVHPD AQDILDTLEE 970 980 990 1000 1010 1020 NRDYYQSMIP PSPPPSGVDE NPQEDRIRFQ VTLEESDQEN LAELEEGDES GGESTTTGTT 1030 1040 1050 GTTAASALSG AGGGGGGGGG MAPRTGGCQN QPQHGGM
	Isoform VI (D) [UniParc]. Checksum: BA4F5909F5F710C3	FASTA	1,068	114,836
	10 20 30 40 50 60 MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE KQVQVQSQKF 70 80 90 100 110 120 SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ LQQLQQLQQQ QQQQQSQRII 130 140 150 160 170 180 SSSTRSQSLQ SSTIVGEATT ITSGAAQILS ASAAASLAQQ LKAQSSTSII TSSEQRTSTS 190 200 210 220 230 240 TSSSSSTRYI ASGSSNLAGG NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR 250 260 270 280 290 300 STSAHSEAAA GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 310 320 330 340 350 360 GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP IHAPPGLHDM 370 380 390 400 410 420 LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG GSPSAGLVLQ NLPQRRESFL 430 440 450 460 470 480 YRSDSDFEMS PKSMSRNSSI ASERFKEQEA SILVDRSHGE DLIVTPFAQI LASLRSVRNN 490 500 510 520 530 540 LLSLTNVPAS NKRPNQSSSA SRSGNPPGAP LSQGEEAYTR LATDTIEELD WCLDQLETIQ 550 560 570 580 590 600 THRSVSDMAS LKFKRMLNKE LSHFSESSRS GNQISEYICS TFLDKQQEFD LPSLRVEDNP 610 620 630 640 650 660 ELVAANAAAG QQSAGQYARS RSPRGPPMSQ ISGVKRPLSH TNSFTGERLP TFGVETPREN 670 680 690 700 710 720 ELGTLLGELD TWGIQIFSIG EFSVNRPLTC VAYTIFQSRE LLTSLMIPPK TFLNFMSTLE 730 740 750 760 770 780 DHYVKDNPFH NSLHAADVTQ STNVLLNTPA LEGVFTPLEV GGALFAACIH DVDHPGLTNQ 790 800 810 820 830 840 FLVNSSSELA LMYNDESVLE NHHLAVAFKL LQNQGCDIFC NMQKKQRQTL RKMVIDIVLS 850 860 870 880 890 900 TDMSKHMSLL ADLKTMVETK KVAGSGVLLL DNYTDRIQVL ENLVHCADLS NPTKPLPLYK 910 920 930 940 950 960 RWVALLMEEF FLQGDKERES GMDISPMCDR HNATIEKSQV GFIDYIVHPL WETWADLVHP 970 980 990 1000 1010 1020 DAQDILDTLE ENRDYYQSMI PPSPPPSGVD ENPQEDRIRF QVTLEESDQE NLAELEEGDE 1030 1040 1050 1060 SGGESTTTGT TGTTAASALS GAGGGGGGGG GMAPRTGGCQ NQPQHGGM
	Isoform VII (L) [UniParc]. Checksum: 0F40B7345882579D	FASTA	521	57,358
	10 20 30 40 50 60 MASLKFKRML NKELSHFSES SRSGNQISEY ICSTFLDKQQ EFDLPSLRVE DNPELVAANA 70 80 90 100 110 120 AAGQQSAGQY ARSRSPRGPP MSQISGVKRP LSHTNSFTGE RLPTFGVETP RENELGTLLG 130 140 150 160 170 180 ELDTWGIQIF SIGEFSVNRP LTCVAYTIFQ SRELLTSLMI PPKTFLNFMS TLEDHYVKDN 190 200 210 220 230 240 PFHNSLHAAD VTQSTNVLLN TPALEGVFTP LEVGGALFAA CIHDVDHPGL TNQFLVNSSS 250 260 270 280 290 300 ELALMYNDES VLENHHLAVA FKLLQNQGCD IFCNMQKKQR QTLRKMVIDI VLSTDMSKHM 310 320 330 340 350 360 SLLADLKTMV ETKKVAGSGV LLLDNYTDRI QVLENLVHCA DLSNPTKPLP LYKRWVALLM 370 380 390 400 410 420 EEFFLQGDKE RESGMDISPM CDRHNATIEK SQVGFIDYIV HPLWETWADL VHPDAQDILD 430 440 450 460 470 480 TLEENRDYYQ SMIPPSPPPS GVDENPQEDR IRFQVTLEES DQENLAELEE GDESGGESTT 490 500 510 520 TGTTGTTAAS ALSGAGGGGG GGGGMAPRTG GCQNQPQHGG M
	Isoform I (B) (O) [UniParc]. See Q9W4T4.		–	–
	Isoform F [UniParc]. See Q8IRU4.		–	–
	Isoform G [UniParc]. See Q9W4S9.		–	–
	Isoform M [UniParc]. See Q9W4T0.		–	–
	Isoform N [UniParc]. See Q9W4S9.		–	–
	Isoform III (E) [UniParc]. Checksum: 5F2BA8CE14598DCD	FASTA	642	70,625
	10 20 30 40 50 60 MSPKSMSRNS SIASERFKEQ EASILVDRSH GEDLIVTPFA QILASLRSVR NNLLSLTNVP 70 80 90 100 110 120 ASNKSRRPNQ SSSASRSGNP PGAPLSQGEE AYTRLATDTI EELDWCLDQL ETIQTHRSVS 130 140 150 160 170 180 DMASLKFKRM LNKELSHFSE SSRSGNQISE YICSTFLDKQ QEFDLPSLRV EDNPELVAAN 190 200 210 220 230 240 AAAGQQSAGQ YARSRSPRGP PMSQISGVKR PLSHTNSFTG ERLPTFGVET PRENELGTLL 250 260 270 280 290 300 GELDTWGIQI FSIGEFSVNR PLTCVAYTIF QSRELLTSLM IPPKTFLNFM STLEDHYVKD 310 320 330 340 350 360 NPFHNSLHAA DVTQSTNVLL NTPALEGVFT PLEVGGALFA ACIHDVDHPG LTNQFLVNSS 370 380 390 400 410 420 SELALMYNDE SVLENHHLAV AFKLLQNQGC DIFCNMQKKQ RQTLRKMVID IVLSTDMSKH 430 440 450 460 470 480 MSLLADLKTM VETKKVAGSG VLLLDNYTDR IQVLENLVHC ADLSNPTKPL PLYKRWVALL 490 500 510 520 530 540 MEEFFLQGDK ERESGMDISP MCDRHNATIE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL 550 560 570 580 590 600 DTLEENRDYY QSMIPPSPPP SGVDENPQED RIRFQVTLEE SDQENLAELE EGDESGGEST 610 620 630 640 TTGTTGTTAA SALSGAGGGG GGGGGMAPRT GGCQNQPQHG GM

References

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[1]	"Characterization of the memory gene dunce of Drosophila melanogaster." Qiu Y.H., Chen C.-N., Malone T., Richter L., Beckendorf S.K., Davis R.L. J. Mol. Biol. 222:553-565(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS III AND IV), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 293-1070 (ISOFORMS II; V AND VI), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 356-1070 (ISOFORM I), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 708-1070 (ISOFORM III), SEQUENCE REVISION, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT. Strain: Canton-S.
[2]	"Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase." Chen C.-N., Denome S., Davis R.L. Proc. Natl. Acad. Sci. U.S.A. 83:9313-9317(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM VII).
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[5]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Oregon-R.
[6]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VII). Strain: Berkeley. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55167 , X55168, X55169, X55170, X55171, X55172, X55173, X55174, X55175 Genomic DNA. Translation: CAA38960.1. Sequence problems. M14982 , M14978, M14979, M14980, M14981 Genomic RNA. Translation: AAC34201.1. AE014298 Genomic DNA. Translation: AAF45861.2. AE014298 Genomic DNA. Translation: AAF45865.2. AE014298 Genomic DNA. Translation: AAN09600.1. AE014298 Genomic DNA. Translation: AAN09602.2. AE014298 Genomic DNA. Translation: AAN09604.1. AE014298 Genomic DNA. Translation: AAN09607.2. AL024484 Genomic DNA. Translation: CAA19668.1. Sequence problems. AL121800 Genomic DNA. Translation: CAB57995.1. Sequence problems. AL121800 Genomic DNA. Translation: CAD24781.1. Sequence problems. AY119511 mRNA. Translation: AAM50165.1.
PIR	S65543.
RefSeq	NP_001259201.1. NM_001272272.1. NP_726849.1. NM_166961.2. NP_726850.1. NM_166962.2. NP_726852.2. NM_166964.2. NP_726853.2. NM_166965.2. NP_726855.1. NM_166967.2. NP_726857.1. NM_166969.2. NP_726859.2. NM_166971.2.
UniGene	Dm.4817.
3D structure databases
ProteinModelPortal	P12252.
SMR	P12252. Positions 552-586, 661-982.
ModBase	Search...
Protein-protein interaction databases
IntAct	P12252. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0070511; FBpp0070487; FBgn0000479. FBtr0070513; FBpp0070489; FBgn0000479.
GeneID	31309.
KEGG	dme:Dmel_CG32498.
UCSC	CG32498-RA. d. melanogaster.
Organism-specific databases
CTD	31309.
FlyBase	FBgn0000479. dnc.
Phylogenomic databases
GeneTree	ENSGT00690000101692.
InParanoid	P12252.
KO	K01120.
Enzyme and pathway databases
UniPathway	UPA00762; UER00747.
Gene expression databases
Bgee	P12252.
GermOnline	CG32498. Drosophila melanogaster.
Family and domain databases
Gene3D	1.10.1300.10. 1 hit.
InterPro	IPR003607. HD/PDEase_dom. IPR023088. PDEase. IPR002073. PDEase_catalytic_dom. IPR023174. PDEase_CS. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	dnc. drosophila.
GenomeRNAi	31309.
NextBio	772953.

Entry information

Entry name

PDE4B_DROME

Accession

Primary (citable) accession number: P12252
Secondary accession number(s): O76918 , Q8IRU3, Q8IRU6, Q8IRU8, Q8IRV0, Q8MRN3, Q8T8M0, Q9NF62, Q9W4S8, Q9W4T1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	August 16, 2005
Last modified:	April 3, 2013
This is version 121 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project