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P12252

- PDE4B_DROME

UniProt

P12252 - PDE4B_DROME

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Protein
cAMP-specific 3',5'-cyclic phosphodiesterase
Gene
dnc, CG32498
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity. Vital for female fertility. Required for learning/memory.1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.1 Publication

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei732 – 7321Proton donor By similarity
Metal bindingi736 – 7361Divalent metal cation 1 By similarity
Metal bindingi772 – 7721Divalent metal cation 1 By similarity
Metal bindingi773 – 7731Divalent metal cation 1 By similarity
Metal bindingi773 – 7731Divalent metal cation 2 By similarity
Binding sitei773 – 7731cAMP By similarity
Metal bindingi890 – 8901Divalent metal cation 1 By similarity
Binding sitei890 – 8901cAMP By similarity
Sitei893 – 8931Binds AMP, but not cAMP By similarity
Binding sitei941 – 9411cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi732 – 7365cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. associative learning Source: FlyBase
  2. axon extension Source: FlyBase
  3. behavioral response to ethanol Source: FlyBase
  4. cAMP catabolic process Source: UniProtKB-UniPathway
  5. cAMP-mediated signaling Source: FlyBase
  6. circadian rhythm Source: FlyBase
  7. conditioned taste aversion Source: FlyBase
  8. courtship behavior Source: FlyBase
  9. lateral inhibition Source: FlyBase
  10. learning Source: FlyBase
  11. learning or memory Source: FlyBase
  12. locomotor rhythm Source: FlyBase
  13. mating behavior Source: FlyBase
  14. memory Source: FlyBase
  15. nonassociative learning Source: FlyBase
  16. olfactory learning Source: FlyBase
  17. oogenesis Source: FlyBase
  18. regulation of protein kinase A signaling Source: FlyBase
  19. reproduction Source: FlyBase
  20. short-term memory Source: FlyBase
  21. synaptic transmission Source: FlyBase
  22. thermosensory behavior Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_209420. G alpha (s) signalling events.
REACT_213958. DARPP-32 events.
UniPathwayiUPA00762; UER00747.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.53)
Alternative name(s):
Learning/memory process protein
Protein dunce
Gene namesi
Name:dnc
ORF Names:CG32498
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000479. dnc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10701070cAMP-specific 3',5'-cyclic phosphodiesterase
PRO_0000023342Add
BLAST

Proteomic databases

PRIDEiP12252.

Expressioni

Gene expression databases

BgeeiP12252.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi57834. 7 interactions.
IntActiP12252. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP12252.
SMRiP12252. Positions 552-586, 661-983.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 235Poly-Pro
Compositional biasi57 – 210154Ser-rich
Add
BLAST
Compositional biasi85 – 13046Gln-rich
Add
BLAST
Compositional biasi1020 – 106950Gly-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00660000095451.
InParanoidiP12252.
KOiK01120.
OMAiTWGIEIF.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform II (identifier: P12252-1) [UniParc]FASTAAdd to Basket

Also known as: I, J

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE     50
KQVQVQSQKF SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ 100
LQQLQQLQQQ QQQQQSQRII SSSTRSQSLQ SSTIVGEATT ITSGAAQILS 150
ASAAASLAQQ LKAQSSTSII TSSEQRTSTS TSSSSSTRYI ASGSSNLAGG 200
NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR STSAHSEAAA 250
GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 300
GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP 350
IHAPPGLHDM LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG 400
GSPSAGLVLQ NLPQRRESFL YRSDSDFEMS PKSMSRNSSI ASERFKEQEA 450
SILVDRSHGE DLIVTPFAQI LASLRSVRNN LLSLTNVPAS NKSRRPNQSS 500
SASRSGNPPG APLSQGEEAY TRLATDTIEE LDWCLDQLET IQTHRSVSDM 550
ASLKFKRMLN KELSHFSESS RSGNQISEYI CSTFLDKQQE FDLPSLRVED 600
NPELVAANAA AGQQSAGQYA RSRSPRGPPM SQISGVKRPL SHTNSFTGER 650
LPTFGVETPR ENELGTLLGE LDTWGIQIFS IGEFSVNRPL TCVAYTIFQS 700
RELLTSLMIP PKTFLNFMST LEDHYVKDNP FHNSLHAADV TQSTNVLLNT 750
PALEGVFTPL EVGGALFAAC IHDVDHPGLT NQFLVNSSSE LALMYNDESV 800
LENHHLAVAF KLLQNQGCDI FCNMQKKQRQ TLRKMVIDIV LSTDMSKHMS 850
LLADLKTMVE TKKVAGSGVL LLDNYTDRIQ VLENLVHCAD LSNPTKPLPL 900
YKRWVALLME EFFLQGDKER ESGMDISPMC DRHNATIEKS QVGFIDYIVH 950
PLWETWADLV HPDAQDILDT LEENRDYYQS MIPPSPPPSG VDENPQEDRI 1000
RFQVTLEESD QENLAELEEG DESGGESTTT GTTGTTAASA LSGAGGGGGG 1050
GGGMAPRTGG CQNQPQHGGM 1070
Length:1,070
Mass (Da):115,079
Last modified:August 16, 2005 - v4
Checksum:i50A63BF7BCC8EDD9
GO
Isoform IV (identifier: P12252-3) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.
     370-385: LSPRISFPGSDSDLFG → MVCSFCCCCYNFRNSP

Show »
Length:701
Mass (Da):77,193
Checksum:i52B25B32753A0EFE
GO
Isoform V (identifier: P12252-4) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     444-456: Missing.

Show »
Length:1,057
Mass (Da):113,506
Checksum:iF6A7B73FAB4F196B
GO
Isoform VI (identifier: P12252-5) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: Missing.

Show »
Length:1,068
Mass (Da):114,836
Checksum:iBA4F5909F5F710C3
GO
Isoform VII (identifier: P12252-6) [UniParc]FASTAAdd to Basket

Also known as: L

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Show »
Length:521
Mass (Da):57,358
Checksum:i0F40B7345882579D
GO
Isoform III (identifier: P12252-7) [UniParc]FASTAAdd to Basket

Also known as: E, P

The sequence of this isoform differs from the canonical sequence as follows:
     1-428: Missing.

Note: Produced by alternative initiation at Met-429 of isoform II.

Show »
Length:642
Mass (Da):70,625
Checksum:i5F2BA8CE14598DCD
GO
Isoform R (identifier: P12252-8) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: Q

The sequence of this isoform differs from the canonical sequence as follows:
     1-367: Missing.
     368-385: SPLSPRISFPGSDSDLFG → MVCSFCCCCYNFRNSPSS

Note: No experimental confirmation available.

Show »
Length:703
Mass (Da):77,368
Checksum:iCA37B22CA8E46A0B
GO
Isoform U (identifier: P12252-9) [UniParc]FASTAAdd to Basket

Also known as: T

The sequence of this isoform differs from the canonical sequence as follows:
     1-355: Missing.
     356-385: GLHDMLKRAQGRSPLSPRISFPGSDSDLFG → MQAEQGSIGDLQKYHSRYLKNRRHTLANVR

Note: No experimental confirmation available.

Show »
Length:715
Mass (Da):78,887
Checksum:i595158832F5806D4
GO
Isoform I (identifier: Q9W4T4-1) [UniParc]FASTAAdd to Basket

Also known as: B, S

The sequence of this isoform can be found in the external entry Q9W4T4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,209
Mass (Da):129,413
GO
Isoform F (identifier: Q8IRU4-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q8IRU4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:662
Mass (Da):72,954
GO
Isoform G (identifier: Q9W4S9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9W4S9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:814
Mass (Da):89,085
GO
Isoform N (identifier: Q9W4S9-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9W4S9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:983
Mass (Da):107,341
GO

Sequence cautioni

The sequence AAC34201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA38960.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAD24781.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 549549Missing in isoform VII.
VSP_004587Add
BLAST
Alternative sequencei1 – 428428Missing in isoform III.
VSP_018826Add
BLAST
Alternative sequencei1 – 369369Missing in isoform IV.
VSP_004585Add
BLAST
Alternative sequencei1 – 367367Missing in isoform R.
VSP_054955Add
BLAST
Alternative sequencei1 – 355355Missing in isoform U.
VSP_054956Add
BLAST
Alternative sequencei356 – 38530GLHDM…SDLFG → MQAEQGSIGDLQKYHSRYLK NRRHTLANVR in isoform U.
VSP_054957Add
BLAST
Alternative sequencei368 – 38518SPLSP…SDLFG → MVCSFCCCCYNFRNSPSS in isoform R.
VSP_054958Add
BLAST
Alternative sequencei370 – 38516LSPRI…SDLFG → MVCSFCCCCYNFRNSP in isoform IV.
VSP_004586Add
BLAST
Alternative sequencei444 – 45613Missing in isoform V.
VSP_004588Add
BLAST
Alternative sequencei493 – 4942Missing in isoform VI.
VSP_004589

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti958 – 9581D → S in CAA38960. 1 Publication
Sequence conflicti958 – 9581D → S in AAC34201. 1 Publication
Sequence conflicti1027 – 10271S → T in CAA38960. 1 Publication
Sequence conflicti1027 – 10271S → T in AAC34201. 1 Publication
Sequence conflicti1042 – 10432SG → R in CAA38960. 1 Publication
Sequence conflicti1042 – 10432SG → R in AAC34201. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55167
, X55168, X55169, X55170, X55171, X55172, X55173, X55174, X55175 Genomic DNA. Translation: CAA38960.1. Sequence problems.
M14982
, M14978, M14979, M14980, M14981 Unassigned DNA. Translation: AAC34201.1. Different initiation.
AE014298 Genomic DNA. Translation: AAF45861.2.
AE014298 Genomic DNA. Translation: AAF45862.3.
AE014298 Genomic DNA. Translation: AAF45865.2.
AE014298 Genomic DNA. Translation: AAN09600.1.
AE014298 Genomic DNA. Translation: AAN09601.3.
AE014298 Genomic DNA. Translation: AAN09602.2.
AE014298 Genomic DNA. Translation: AAN09604.1.
AE014298 Genomic DNA. Translation: AAN09607.2.
AE014298 Genomic DNA. Translation: AGB95048.1.
AE014298 Genomic DNA. Translation: AGB95049.1.
AL121800 Genomic DNA. Translation: CAD24781.1. Sequence problems.
AY119511 mRNA. Translation: AAM50165.1.
PIRiS65543.
RefSeqiNP_001259201.1. NM_001272272.1. [P12252-7]
NP_001259202.1. NM_001272273.1. [P12252-8]
NP_001259203.1. NM_001272274.1. [P12252-9]
NP_726849.1. NM_166961.2. [P12252-1]
NP_726850.1. NM_166962.2. [P12252-4]
NP_726851.3. NM_166963.2. [P12252-9]
NP_726852.2. NM_166964.2. [P12252-5]
NP_726853.2. NM_166965.2. [P12252-1]
NP_726854.2. NM_166966.3. [P12252-8]
NP_726855.1. NM_166967.2. [P12252-3]
NP_726857.1. NM_166969.2. [P12252-7]
NP_726859.2. NM_166971.2. [P12252-6]
UniGeneiDm.4817.

Genome annotation databases

EnsemblMetazoaiFBtr0070511; FBpp0070487; FBgn0000479. [P12252-1]
FBtr0070513; FBpp0070489; FBgn0000479. [P12252-1]
FBtr0333313; FBpp0305505; FBgn0000479. [P12252-8]
FBtr0333314; FBpp0305506; FBgn0000479. [P12252-8]
FBtr0333316; FBpp0305508; FBgn0000479. [P12252-9]
FBtr0333317; FBpp0305509; FBgn0000479. [P12252-9]
GeneIDi31309.
KEGGidme:Dmel_CG32498.
UCSCiCG32498-RA. d. melanogaster. [P12252-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55167
, X55168 , X55169 , X55170 , X55171 , X55172 , X55173 , X55174 , X55175 Genomic DNA. Translation: CAA38960.1 . Sequence problems.
M14982
, M14978 , M14979 , M14980 , M14981 Unassigned DNA. Translation: AAC34201.1 . Different initiation.
AE014298 Genomic DNA. Translation: AAF45861.2 .
AE014298 Genomic DNA. Translation: AAF45862.3 .
AE014298 Genomic DNA. Translation: AAF45865.2 .
AE014298 Genomic DNA. Translation: AAN09600.1 .
AE014298 Genomic DNA. Translation: AAN09601.3 .
AE014298 Genomic DNA. Translation: AAN09602.2 .
AE014298 Genomic DNA. Translation: AAN09604.1 .
AE014298 Genomic DNA. Translation: AAN09607.2 .
AE014298 Genomic DNA. Translation: AGB95048.1 .
AE014298 Genomic DNA. Translation: AGB95049.1 .
AL121800 Genomic DNA. Translation: CAD24781.1 . Sequence problems.
AY119511 mRNA. Translation: AAM50165.1 .
PIRi S65543.
RefSeqi NP_001259201.1. NM_001272272.1. [P12252-7 ]
NP_001259202.1. NM_001272273.1. [P12252-8 ]
NP_001259203.1. NM_001272274.1. [P12252-9 ]
NP_726849.1. NM_166961.2. [P12252-1 ]
NP_726850.1. NM_166962.2. [P12252-4 ]
NP_726851.3. NM_166963.2. [P12252-9 ]
NP_726852.2. NM_166964.2. [P12252-5 ]
NP_726853.2. NM_166965.2. [P12252-1 ]
NP_726854.2. NM_166966.3. [P12252-8 ]
NP_726855.1. NM_166967.2. [P12252-3 ]
NP_726857.1. NM_166969.2. [P12252-7 ]
NP_726859.2. NM_166971.2. [P12252-6 ]
UniGenei Dm.4817.

3D structure databases

ProteinModelPortali P12252.
SMRi P12252. Positions 552-586, 661-983.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 57834. 7 interactions.
IntActi P12252. 1 interaction.

Proteomic databases

PRIDEi P12252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0070511 ; FBpp0070487 ; FBgn0000479 . [P12252-1 ]
FBtr0070513 ; FBpp0070489 ; FBgn0000479 . [P12252-1 ]
FBtr0333313 ; FBpp0305505 ; FBgn0000479 . [P12252-8 ]
FBtr0333314 ; FBpp0305506 ; FBgn0000479 . [P12252-8 ]
FBtr0333316 ; FBpp0305508 ; FBgn0000479 . [P12252-9 ]
FBtr0333317 ; FBpp0305509 ; FBgn0000479 . [P12252-9 ]
GeneIDi 31309.
KEGGi dme:Dmel_CG32498.
UCSCi CG32498-RA. d. melanogaster. [P12252-1 ]

Organism-specific databases

CTDi 31309.
FlyBasei FBgn0000479. dnc.

Phylogenomic databases

GeneTreei ENSGT00660000095451.
InParanoidi P12252.
KOi K01120.
OMAi TWGIEIF.

Enzyme and pathway databases

UniPathwayi UPA00762 ; UER00747 .
Reactomei REACT_209420. G alpha (s) signalling events.
REACT_213958. DARPP-32 events.

Miscellaneous databases

ChiTaRSi dnc. drosophila.
GenomeRNAii 31309.
NextBioi 772953.

Gene expression databases

Bgeei P12252.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the memory gene dunce of Drosophila melanogaster."
    Qiu Y.H., Chen C.-N., Malone T., Richter L., Beckendorf S.K., Davis R.L.
    J. Mol. Biol. 222:553-565(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS III; IV AND R), NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 293-1070 (ISOFORMS II; V AND VI), NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 356-1070 (ISOFORM I), SEQUENCE REVISION, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
    Strain: Canton-S.
  2. "Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase."
    Chen C.-N., Denome S., Davis R.L.
    Proc. Natl. Acad. Sci. U.S.A. 83:9313-9317(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 699-1070.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS I; G AND VII).
    Strain: Oregon-R.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VII).
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiPDE4B_DROME
AccessioniPrimary (citable) accession number: P12252
Secondary accession number(s): M9PGD1
, M9PGX1, O76918, Q8IRU3, Q8IRU6, Q8IRU8, Q8IRV0, Q8MRN3, Q8T8M0, Q9NF62, Q9W4S8, Q9W4T0, Q9W4T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 16, 2005
Last modified: September 3, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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