Reviewed,
UniProtKB/Swiss-Prot P12252 (PDE4B_DROME)
Last modified
September 22, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: cAMP-specific 3',5'-cyclic phosphodiesterase EC=3.1.4.17 Alternative name(s): Learning/memory process protein Protein dunce | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 1070 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Vital for female fertility. Required for learning/memory. Ref.1 |
| Catalytic activity | Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. Ref.1 |
| Pathway | Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. |
| Subunit structure | Monomer. Ref.1 |
| Sequence similarities | Belongs to the cyclic nucleotide phosphodiesterase family. |
Ontologies
Alternative products
| This entry describes 11 isoforms produced by alternative splicing and alternative initiation. [Align] [Select] | ||||||
| Isoform II (identifier: P12252-1) Also known as: I; J; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform IV (identifier: P12252-3) Also known as: A; The sequence of this isoform differs from the canonical sequence as follows: 1-369: Missing. 370-385: LSPRISFPGSDSDLFG → MVCSFCCCCYNFRNSP | ||||||
| Isoform V (identifier: P12252-4) Also known as: C; The sequence of this isoform differs from the canonical sequence as follows: 444-456: Missing. | ||||||
| Isoform VI (identifier: P12252-5) Also known as: D; The sequence of this isoform differs from the canonical sequence as follows: 493-494: Missing. | ||||||
| Isoform VII (identifier: P12252-6) Also known as: L; The sequence of this isoform differs from the canonical sequence as follows: 1-549: Missing. | ||||||
| Isoform I (identifier: Q9W4T4-1) Also known as: B; O; The sequence of this isoform can be found in the external entry Q9W4T4-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Isoform F (identifier: Q8IRU4-1) The sequence of this isoform can be found in the external entry Q8IRU4-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform G (identifier: Q9W4S9-2) The sequence of this isoform can be found in the external entry Q9W4S9-2. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform M (identifier: Q9W4T0-1) The sequence of this isoform can be found in the external entry Q9W4T0-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform N (identifier: Q9W4S9-1) The sequence of this isoform can be found in the external entry Q9W4S9-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform III (identifier: P12252-7) Also known as: E; The sequence of this isoform differs from the canonical sequence as follows: 1-428: Missing. | ||||||
| Note: Produced by alternative initiation at Met-429 of isoform II. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1070 | 1070 | cAMP-specific 3',5'-cyclic phosphodiesterase | PRO_0000023342 | |||||
Regions | |||||||||
| Compositional bias | 57 – 210 | 154 | Ser-rich | ||||||
| Compositional bias | 1020 – 1069 | 50 | Gly-rich | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 549 | 549 | Missing in isoform VII. | VSP_004587 | |||||
| Alternative sequence | 1 – 428 | 428 | Missing in isoform III. | VSP_018826 | |||||
| Alternative sequence | 1 – 369 | 369 | Missing in isoform IV. | VSP_004585 | |||||
| Alternative sequence | 370 – 385 | 16 | LSPRI…SDLFG → MVCSFCCCCYNFRNSP in isoform IV. | VSP_004586 | |||||
| Alternative sequence | 444 – 456 | 13 | Missing in isoform V. | VSP_004588 | |||||
| Alternative sequence | 493 – 494 | 2 | Missing in isoform VI. | VSP_004589 | |||||
Experimental info | |||||||||
| Sequence conflict | 958 | 1 | D → S Ref.1 | ||||||
| Sequence conflict | 958 | 1 | D → S Ref.2 | ||||||
| Sequence conflict | 1027 | 1 | S → T Ref.1 | ||||||
| Sequence conflict | 1027 | 1 | S → T Ref.2 | ||||||
| Sequence conflict | 1042 – 1043 | 2 | SG → R Ref.1 | ||||||
| Sequence conflict | 1042 – 1043 | 2 | SG → R Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the memory gene dunce of Drosophila melanogaster." Qiu Y.H., Chen C.-N., Malone T., Richter L., Beckendorf S.K., Davis R.L. J. Mol. Biol. 222:553-565(1991) [PubMed: 1660926] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS III AND IV), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 293-1070 (ISOFORMS II; V AND VI), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 356-1070 (ISOFORM I), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 708-1070 (ISOFORM III), SEQUENCE REVISION, FUNCTION, CATALYTIC ACTIVITY, SUBUNIT. Strain: Canton-S. |
| [2] | "Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase." Chen C.-N., Denome S., Davis R.L. Proc. Natl. Acad. Sci. U.S.A. 83:9313-9317(1986) [PubMed: 3025834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM VII). |
| [3] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [4] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. |
| [5] | "From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. Glover D.M.Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Oregon-R. |
| [6] | "A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VII). Strain: Berkeley. Tissue: Head. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
X55167 X55175 Genomic DNA. Translation: CAA38960.1. Sequence problems.M14982 M14981 Genomic RNA. Translation: AAC34201.1. AE014298 Genomic DNA. Translation: AAF45861.2. AE014298 Genomic DNA. Translation: AAF45865.2. AE014298 Genomic DNA. Translation: AAN09600.1. AE014298 Genomic DNA. Translation: AAN09602.2. AE014298 Genomic DNA. Translation: AAN09604.1. AE014298 Genomic DNA. Translation: AAN09607.2. AL024484 Genomic DNA. Translation: CAA19668.1. Sequence problems. AL121800 Genomic DNA. Translation: CAB57995.1. Sequence problems. AL121800 Genomic DNA. Translation: CAD24781.1. Sequence problems. AY119511 mRNA. Translation: AAM50165.1. | |
| PIR | S65543. |
| RefSeq | NP_726849.1. NP_726850.1. NP_726851.2. NP_726852.2. NP_726853.2. NP_726855.1. NP_726857.1. NP_726859.2. |
| UniGene | Dm.4817 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1F0J based on UniProtKB Q07343. |
| SMR | P12252. Positions 651-983. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P12252. 1 interaction. |
| STRING | P12252. |
Genome annotation databases | |
| Ensembl | FBtr0070509; FBpp0070485; FBgn0000479; Drosophila melanogaster. [Genome view] |
| GeneID | 31309. |
| UCSC | CG32498-RA. d. melanogaster. |
Organism-specific databases | |
| CTD | 31309. |
| FlyBase | FBgn0000479. dnc. |
Enzyme and pathway databases | |
| BRENDA | 3.1.4.17. 48. |
Gene expression databases | |
| ArrayExpress | P12252. |
| GermOnline | CG32498. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR003607. Met-dep_phosphohydro_HD. IPR002073. PDEase. [Graphical view] |
| Pfam | PF00233. PDEase_I. 1 hit. [Graphical view] |
| PRINTS | PR00387. PDIESTERASE1. |
| SMART | SM00471. HDc. 1 hit. [Graphical view] |
| PROSITE | PS00126. PDEASE_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 772953. |
Entry information
| Entry name | PDE4B_DROME | ||||||||
| Accession | Primary (citable) accession number: P12252 Secondary accession number(s): O76918 Q9W4T1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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