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P12246 (SAMP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serum amyloid P-component

Short name=SAP
Gene names
Name:Apcs
Synonyms:Ptx2, Sap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular location

Secreted.

Involvement in disease

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Sequence similarities

Belongs to the pentaxin family.

Contains 1 pentaxin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 224204Serum amyloid P-component
PRO_0000023542

Regions

Domain21 – 224204Pentaxin

Sites

Metal binding781Calcium 1 By similarity
Metal binding791Calcium 1 By similarity
Metal binding1561Calcium 1 By similarity
Metal binding1561Calcium 2 By similarity
Metal binding1571Calcium 1; via carbonyl oxygen By similarity
Metal binding1581Calcium 1 By similarity
Metal binding1581Calcium 2 By similarity
Metal binding1681Calcium 2 By similarity

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Ref.7
Disulfide bond56 ↔ 115 By similarity

Experimental info

Sequence conflict1511I → V in AAA40092. Ref.3
Sequence conflict1511I → V in CAA32243. Ref.3
Sequence conflict1541G → R in CAA68488. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P12246 [UniParc].

Last modified January 1, 1990. Version 2.
Checksum: 1CDBC15F45E50DCA

FASTA22426,247
        10         20         30         40         50         60 
MDKLLLWMFV FTSLLSEAFC QTDLKRKVFV FPRESETDHV KLIPHLEKPL QNFTLCFRTY 

        70         80         90        100        110        120 
SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV TVRGMEEYLS PVHLCTTWES 

       130        140        150        160        170        180 
SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW 

       190        200        210        220 
DYVLTPQDIL FVYRDSPVNP NILNWQALNY EINGYVVIRP RVWD 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the mouse serum amyloid P component gene."
Nishiguchi S., Maeda S., Araki S., Shimada K.
Biochem. Biophys. Res. Commun. 155:1366-1373(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Characterization of the gene encoding mouse serum amyloid P component. Comparison with genes encoding other pentraxins."
Whitehead A.S., Rits M.
Biochem. J. 263:25-31(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CBA/J.
[3]"Isolation and analysis of murine serum amyloid P component cDNA clones."
Mole J.E., Beaulieu B.L., Geheran C.A., Carnazza J.A., Anderson J.K.
J. Immunol. 141:3642-3646(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA/2J.
Tissue: Liver.
[4]"The complete nucleotide and deduced amino acid sequence of mouse serum amyloid P component."
Ishikawa N., Shigemoto K., Maruyama N.
Nucleic Acids Res. 15:7186-7186(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NZB.
Tissue: Liver.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[6]"Molecular genetics of mouse serum amyloid P component (SAP): cloning and gene mapping."
Whitehead A.S., Rits M., Michaelson J.
Immunogenetics 28:388-390(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224.
Strain: CBA/J.
Tissue: Liver.
[7]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M23552 mRNA. Translation: AAA40092.1.
M29535 Genomic DNA. Translation: AAA40093.1.
X16899 Genomic DNA. Translation: CAA34774.1.
X14079 mRNA. Translation: CAA32243.1.
Y00426 mRNA. Translation: CAA68488.1.
BC061125 mRNA. Translation: AAH61125.1.
M23248 mRNA. Translation: AAA40091.1.
PIRA30528.
RefSeqNP_035448.2. NM_011318.2.
UniGeneMm.330510.

3D structure databases

ProteinModelPortalP12246.
SMRP12246. Positions 21-223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000027824.

PTM databases

PhosphoSiteP12246.

Proteomic databases

PaxDbP12246.
PRIDEP12246.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542.
GeneID20219.
KEGGmmu:20219.
UCSCuc007dqy.2. mouse.

Organism-specific databases

CTD325.
MGIMGI:98229. Apcs.

Phylogenomic databases

eggNOGNOG44770.
HOGENOMHOG000247043.
HOVERGENHBG005405.
InParanoidP12246.
OMADLKRDHA.
OrthoDBEOG71RXMB.
PhylomeDBP12246.
TreeFamTF330208.

Gene expression databases

ArrayExpressP12246.
BgeeP12246.
CleanExMM_APCS.
GenevestigatorP12246.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297831.
PROP12246.
SOURCESearch...

Entry information

Entry nameSAMP_MOUSE
AccessionPrimary (citable) accession number: P12246
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot