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P12246

- SAMP_MOUSE

UniProt

P12246 - SAMP_MOUSE

Protein

Serum amyloid P-component

Gene

Apcs

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Calcium 1By similarity
    Metal bindingi79 – 791Calcium 1By similarity
    Metal bindingi156 – 1561Calcium 1By similarity
    Metal bindingi156 – 1561Calcium 2By similarity
    Metal bindingi157 – 1571Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi158 – 1581Calcium 1By similarity
    Metal bindingi158 – 1581Calcium 2By similarity
    Metal bindingi168 – 1681Calcium 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein complex assembly Source: Ensembl

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum amyloid P-component
    Short name:
    SAP
    Gene namesi
    Name:Apcs
    Synonyms:Ptx2, Sap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98229. Apcs.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: Ensembl
    3. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Amyloid, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 224204Serum amyloid P-componentPRO_0000023542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)1 Publication
    Disulfide bondi56 ↔ 115By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP12246.
    PRIDEiP12246.

    PTM databases

    PhosphoSiteiP12246.

    Expressioni

    Gene expression databases

    ArrayExpressiP12246.
    BgeeiP12246.
    CleanExiMM_APCS.
    GenevestigatoriP12246.

    Interactioni

    Subunit structurei

    Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027824.

    Structurei

    3D structure databases

    ProteinModelPortaliP12246.
    SMRiP12246. Positions 21-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 224204PentaxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pentaxin family.Curated
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44770.
    HOGENOMiHOG000247043.
    HOVERGENiHBG005405.
    InParanoidiP12246.
    OMAiDSETSIM.
    OrthoDBiEOG71RXMB.
    PhylomeDBiP12246.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12246-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKLLLWMFV FTSLLSEAFC QTDLKRKVFV FPRESETDHV KLIPHLEKPL    50
    QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV 100
    TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS 150
    IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP 200
    NILNWQALNY EINGYVVIRP RVWD 224
    Length:224
    Mass (Da):26,247
    Last modified:January 1, 1990 - v2
    Checksum:i1CDBC15F45E50DCA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511I → V in AAA40092. (PubMed:3183383)Curated
    Sequence conflicti151 – 1511I → V in CAA32243. (PubMed:3183383)Curated
    Sequence conflicti154 – 1541G → R in CAA68488. (PubMed:3658681)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23552 mRNA. Translation: AAA40092.1.
    M29535 Genomic DNA. Translation: AAA40093.1.
    X16899 Genomic DNA. Translation: CAA34774.1.
    X14079 mRNA. Translation: CAA32243.1.
    Y00426 mRNA. Translation: CAA68488.1.
    BC061125 mRNA. Translation: AAH61125.1.
    M23248 mRNA. Translation: AAA40091.1.
    CCDSiCCDS15520.1.
    PIRiA30528.
    RefSeqiNP_035448.2. NM_011318.2.
    UniGeneiMm.330510.

    Genome annotation databases

    EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542.
    GeneIDi20219.
    KEGGimmu:20219.
    UCSCiuc007dqy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23552 mRNA. Translation: AAA40092.1 .
    M29535 Genomic DNA. Translation: AAA40093.1 .
    X16899 Genomic DNA. Translation: CAA34774.1 .
    X14079 mRNA. Translation: CAA32243.1 .
    Y00426 mRNA. Translation: CAA68488.1 .
    BC061125 mRNA. Translation: AAH61125.1 .
    M23248 mRNA. Translation: AAA40091.1 .
    CCDSi CCDS15520.1.
    PIRi A30528.
    RefSeqi NP_035448.2. NM_011318.2.
    UniGenei Mm.330510.

    3D structure databases

    ProteinModelPortali P12246.
    SMRi P12246. Positions 21-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027824.

    PTM databases

    PhosphoSitei P12246.

    Proteomic databases

    PaxDbi P12246.
    PRIDEi P12246.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027824 ; ENSMUSP00000027824 ; ENSMUSG00000026542 .
    GeneIDi 20219.
    KEGGi mmu:20219.
    UCSCi uc007dqy.2. mouse.

    Organism-specific databases

    CTDi 325.
    MGIi MGI:98229. Apcs.

    Phylogenomic databases

    eggNOGi NOG44770.
    HOGENOMi HOG000247043.
    HOVERGENi HBG005405.
    InParanoidi P12246.
    OMAi DSETSIM.
    OrthoDBi EOG71RXMB.
    PhylomeDBi P12246.
    TreeFami TF330208.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    NextBioi 297831.
    PROi P12246.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12246.
    Bgeei P12246.
    CleanExi MM_APCS.
    Genevestigatori P12246.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "Characterization of the gene encoding mouse serum amyloid P component. Comparison with genes encoding other pentraxins."
      Whitehead A.S., Rits M.
      Biochem. J. 263:25-31(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CBA/J.
    3. "Isolation and analysis of murine serum amyloid P component cDNA clones."
      Mole J.E., Beaulieu B.L., Geheran C.A., Carnazza J.A., Anderson J.K.
      J. Immunol. 141:3642-3646(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2J.
      Tissue: Liver.
    4. "The complete nucleotide and deduced amino acid sequence of mouse serum amyloid P component."
      Ishikawa N., Shigemoto K., Maruyama N.
      Nucleic Acids Res. 15:7186-7186(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NZB.
      Tissue: Liver.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    6. "Molecular genetics of mouse serum amyloid P component (SAP): cloning and gene mapping."
      Whitehead A.S., Rits M., Michaelson J.
      Immunogenetics 28:388-390(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224.
      Strain: CBA/J.
      Tissue: Liver.
    7. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiSAMP_MOUSE
    AccessioniPrimary (citable) accession number: P12246
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3