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Protein

Serum amyloid P-component

Gene

Apcs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Calcium 1By similarity1
Metal bindingi79Calcium 1By similarity1
Metal bindingi156Calcium 1By similarity1
Metal bindingi156Calcium 2By similarity1
Metal bindingi157Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi158Calcium 1By similarity1
Metal bindingi158Calcium 2By similarity1
Metal bindingi168Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:Apcs
Synonyms:Ptx2, Sap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98229. Apcs.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000002354221 – 224Serum amyloid P-componentAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)1 Publication1
Disulfide bondi56 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12246.
PeptideAtlasiP12246.
PRIDEiP12246.

PTM databases

iPTMnetiP12246.
PhosphoSitePlusiP12246.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026542.
CleanExiMM_APCS.
ExpressionAtlasiP12246. baseline and differential.
GenevisibleiP12246. MM.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027824.

Structurei

3D structure databases

ProteinModelPortaliP12246.
SMRiP12246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 224PentaxinAdd BLAST204

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1FD. Eukaryota.
ENOG410YN8S. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP12246.
OMAiDNTNKEM.
OrthoDBiEOG091G0H6X.
PhylomeDBiP12246.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLLLWMFV FTSLLSEAFC QTDLKRKVFV FPRESETDHV KLIPHLEKPL
60 70 80 90 100
QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV
110 120 130 140 150
TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS
160 170 180 190 200
IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP
210 220
NILNWQALNY EINGYVVIRP RVWD
Length:224
Mass (Da):26,247
Last modified:January 1, 1990 - v2
Checksum:i1CDBC15F45E50DCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151I → V in AAA40092 (PubMed:3183383).Curated1
Sequence conflicti151I → V in CAA32243 (PubMed:3183383).Curated1
Sequence conflicti154G → R in CAA68488 (PubMed:3658681).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23552 mRNA. Translation: AAA40092.1.
M29535 Genomic DNA. Translation: AAA40093.1.
X16899 Genomic DNA. Translation: CAA34774.1.
X14079 mRNA. Translation: CAA32243.1.
Y00426 mRNA. Translation: CAA68488.1.
BC061125 mRNA. Translation: AAH61125.1.
M23248 mRNA. Translation: AAA40091.1.
CCDSiCCDS15520.1.
PIRiA30528.
RefSeqiNP_035448.2. NM_011318.2.
UniGeneiMm.330510.

Genome annotation databases

EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542.
GeneIDi20219.
KEGGimmu:20219.
UCSCiuc007dqy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23552 mRNA. Translation: AAA40092.1.
M29535 Genomic DNA. Translation: AAA40093.1.
X16899 Genomic DNA. Translation: CAA34774.1.
X14079 mRNA. Translation: CAA32243.1.
Y00426 mRNA. Translation: CAA68488.1.
BC061125 mRNA. Translation: AAH61125.1.
M23248 mRNA. Translation: AAA40091.1.
CCDSiCCDS15520.1.
PIRiA30528.
RefSeqiNP_035448.2. NM_011318.2.
UniGeneiMm.330510.

3D structure databases

ProteinModelPortaliP12246.
SMRiP12246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027824.

PTM databases

iPTMnetiP12246.
PhosphoSitePlusiP12246.

Proteomic databases

PaxDbiP12246.
PeptideAtlasiP12246.
PRIDEiP12246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542.
GeneIDi20219.
KEGGimmu:20219.
UCSCiuc007dqy.2. mouse.

Organism-specific databases

CTDi325.
MGIiMGI:98229. Apcs.

Phylogenomic databases

eggNOGiENOG410J1FD. Eukaryota.
ENOG410YN8S. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP12246.
OMAiDNTNKEM.
OrthoDBiEOG091G0H6X.
PhylomeDBiP12246.
TreeFamiTF330208.

Miscellaneous databases

PROiP12246.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026542.
CleanExiMM_APCS.
ExpressionAtlasiP12246. baseline and differential.
GenevisibleiP12246. MM.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAMP_MOUSE
AccessioniPrimary (citable) accession number: P12246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.