Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serum amyloid P-component

Gene

Apcs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Calcium 1By similarity
Metal bindingi79 – 791Calcium 1By similarity
Metal bindingi156 – 1561Calcium 1By similarity
Metal bindingi156 – 1561Calcium 2By similarity
Metal bindingi157 – 1571Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi158 – 1581Calcium 1By similarity
Metal bindingi158 – 1581Calcium 2By similarity
Metal bindingi168 – 1681Calcium 2By similarity

GO - Molecular functioni

  1. calcium ion binding Source: MGI
  2. carbohydrate binding Source: UniProtKB-KW
  3. complement component C1q binding Source: MGI
  4. virion binding Source: MGI

GO - Biological processi

  1. innate immune response Source: MGI
  2. negative regulation by host of viral exo-alpha-sialidase activity Source: MGI
  3. negative regulation by host of viral glycoprotein metabolic process Source: MGI
  4. negative regulation of exo-alpha-sialidase activity Source: MGI
  5. negative regulation of glycoprotein metabolic process Source: MGI
  6. negative regulation of monocyte differentiation Source: MGI
  7. negative regulation of viral entry into host cell Source: MGI
  8. negative regulation of viral process Source: MGI
  9. protein complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_342573. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:Apcs
Synonyms:Ptx2, Sap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98229. Apcs.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: MGI
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: MGI
  4. extracellular vesicular exosome Source: MGI
  5. nucleus Source: MGI
  6. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 224204Serum amyloid P-componentPRO_0000023542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)1 Publication
Disulfide bondi56 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP12246.
PaxDbiP12246.
PRIDEiP12246.

PTM databases

PhosphoSiteiP12246.

Expressioni

Gene expression databases

BgeeiP12246.
CleanExiMM_APCS.
ExpressionAtlasiP12246. baseline and differential.
GenevestigatoriP12246.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027824.

Structurei

3D structure databases

ProteinModelPortaliP12246.
SMRiP12246. Positions 21-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 224204PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44770.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP12246.
OMAiDKLLLWM.
OrthoDBiEOG71RXMB.
PhylomeDBiP12246.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLLLWMFV FTSLLSEAFC QTDLKRKVFV FPRESETDHV KLIPHLEKPL
60 70 80 90 100
QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV
110 120 130 140 150
TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS
160 170 180 190 200
IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP
210 220
NILNWQALNY EINGYVVIRP RVWD
Length:224
Mass (Da):26,247
Last modified:January 1, 1990 - v2
Checksum:i1CDBC15F45E50DCA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511I → V in AAA40092 (PubMed:3183383).Curated
Sequence conflicti151 – 1511I → V in CAA32243 (PubMed:3183383).Curated
Sequence conflicti154 – 1541G → R in CAA68488 (PubMed:3658681).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23552 mRNA. Translation: AAA40092.1.
M29535 Genomic DNA. Translation: AAA40093.1.
X16899 Genomic DNA. Translation: CAA34774.1.
X14079 mRNA. Translation: CAA32243.1.
Y00426 mRNA. Translation: CAA68488.1.
BC061125 mRNA. Translation: AAH61125.1.
M23248 mRNA. Translation: AAA40091.1.
CCDSiCCDS15520.1.
PIRiA30528.
RefSeqiNP_035448.2. NM_011318.2.
UniGeneiMm.330510.

Genome annotation databases

EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542.
GeneIDi20219.
KEGGimmu:20219.
UCSCiuc007dqy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23552 mRNA. Translation: AAA40092.1.
M29535 Genomic DNA. Translation: AAA40093.1.
X16899 Genomic DNA. Translation: CAA34774.1.
X14079 mRNA. Translation: CAA32243.1.
Y00426 mRNA. Translation: CAA68488.1.
BC061125 mRNA. Translation: AAH61125.1.
M23248 mRNA. Translation: AAA40091.1.
CCDSiCCDS15520.1.
PIRiA30528.
RefSeqiNP_035448.2. NM_011318.2.
UniGeneiMm.330510.

3D structure databases

ProteinModelPortaliP12246.
SMRiP12246. Positions 21-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027824.

PTM databases

PhosphoSiteiP12246.

Proteomic databases

MaxQBiP12246.
PaxDbiP12246.
PRIDEiP12246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542.
GeneIDi20219.
KEGGimmu:20219.
UCSCiuc007dqy.2. mouse.

Organism-specific databases

CTDi325.
MGIiMGI:98229. Apcs.

Phylogenomic databases

eggNOGiNOG44770.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP12246.
OMAiDKLLLWM.
OrthoDBiEOG71RXMB.
PhylomeDBiP12246.
TreeFamiTF330208.

Enzyme and pathway databases

ReactomeiREACT_342573. Amyloids.

Miscellaneous databases

NextBioi297831.
PROiP12246.
SOURCEiSearch...

Gene expression databases

BgeeiP12246.
CleanExiMM_APCS.
ExpressionAtlasiP12246. baseline and differential.
GenevestigatoriP12246.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Characterization of the gene encoding mouse serum amyloid P component. Comparison with genes encoding other pentraxins."
    Whitehead A.S., Rits M.
    Biochem. J. 263:25-31(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CBA/J.
  3. "Isolation and analysis of murine serum amyloid P component cDNA clones."
    Mole J.E., Beaulieu B.L., Geheran C.A., Carnazza J.A., Anderson J.K.
    J. Immunol. 141:3642-3646(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2J.
    Tissue: Liver.
  4. "The complete nucleotide and deduced amino acid sequence of mouse serum amyloid P component."
    Ishikawa N., Shigemoto K., Maruyama N.
    Nucleic Acids Res. 15:7186-7186(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NZB.
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  6. "Molecular genetics of mouse serum amyloid P component (SAP): cloning and gene mapping."
    Whitehead A.S., Rits M., Michaelson J.
    Immunogenetics 28:388-390(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 159-224.
    Strain: CBA/J.
    Tissue: Liver.
  7. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiSAMP_MOUSE
AccessioniPrimary (citable) accession number: P12246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: April 1, 2015
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.