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P12242 (UCP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial brown fat uncoupling protein 1

Short name=UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene names
Name:Ucp1
Synonyms:Slc25a7, Ucp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Subunit structure

Acts as a dimer forming a proton channel.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Tissue specificity

Brown adipose tissue.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 307306Mitochondrial brown fat uncoupling protein 1
PRO_0000090659

Regions

Transmembrane11 – 3222Helical; Name=1; Potential
Transmembrane74 – 9623Helical; Name=2; Potential
Transmembrane117 – 13317Helical; Name=3; Potential
Transmembrane179 – 19517Helical; Name=4; Potential
Transmembrane213 – 23220Helical; Name=5; Potential
Transmembrane267 – 28923Helical; Name=6; Potential
Repeat11 – 10292Solcar 1
Repeat111 – 20191Solcar 2
Repeat210 – 29586Solcar 3
Region274 – 29623Purine nucleotide binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P12242 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 33D107EDF04BD1AF

FASTA30733,248
        10         20         30         40         50         60 
MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS STIRYKGVLG 

        70         80         90        100        110        120 
TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ EYFSSGRETP ASLGNKISAG 

       130        140        150        160        170        180 
LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI KPRYTGTYNA YRVIATTESL STLWKGTTPN 

       190        200        210        220        230        240 
LMRNVIINCT ELVTYDLMKG ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF 

       250        260        270        280        290        300 
INSLPGQYPS VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR 


QTVDCTT 

« Hide

References

« Hide 'large scale' references
[1]"The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains."
Kozak L.P., Britton J.H., Kozak U.C., Wells J.M.
J. Biol. Chem. 263:12274-12277(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene."
Kozak U.C., Kopecky J., Teisinger J., Enerbaeck S., Boyer B., Kozak L.P.
Mol. Cell. Biol. 14:59-67(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21247 expand/collapse EMBL AC list , M21222, M21244, M21245, M21246 Genomic DNA. Translation: AAA40521.1.
U63419 mRNA. Translation: AAB05870.1.
U63418 Genomic DNA. Translation: AAB07367.1.
BC012701 mRNA. Translation: AAH12701.1.
PIRA31106.
RefSeqNP_033489.1. NM_009463.3.
UniGeneMm.4177.

3D structure databases

ProteinModelPortalP12242.
SMRP12242. Positions 13-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000034146.

PTM databases

PhosphoSiteP12242.

Proteomic databases

PaxDbP12242.
PRIDEP12242.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034146; ENSMUSP00000034146; ENSMUSG00000031710.
GeneID22227.
KEGGmmu:22227.
UCSCuc009mjx.2. mouse.

Organism-specific databases

CTD7350.
MGIMGI:98894. Ucp1.

Phylogenomic databases

eggNOGNOG277477.
GeneTreeENSGT00750000117384.
HOGENOMHOG000165140.
HOVERGENHBG009528.
InParanoidP12242.
KOK08769.
OMARYTGTYN.
OrthoDBEOG793B7Z.
PhylomeDBP12242.
TreeFamTF323211.

Gene expression databases

BgeeP12242.
GenevestigatorP12242.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00784. MTUNCOUPLING.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio302259.
PROP12242.
SOURCESearch...

Entry information

Entry nameUCP1_MOUSE
AccessionPrimary (citable) accession number: P12242
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot