P12242 (UCP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name=UCP 1

Alternative name(s):
Solute carrier family 25 member 7
Thermogenin

Gene names

Name:	Ucp1
Synonyms:	Slc25a7, Ucp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Subunit structure	Acts as a dimer forming a proton channel.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue specificity	Brown adipose tissue.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brown fat cell differentiation Inferred from expression pattern PubMed 15567149. Source: HGNC mitochondrial transport Inferred from electronic annotation. Source: InterPro regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17670746. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial envelope Inferred from direct assay PubMed 12910269. Source: MGI mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidative phosphorylation uncoupler activity Inferred from direct assay PubMed 12910269. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 307	306	Mitochondrial brown fat uncoupling protein 1		PRO_0000090659
Regions
	Transmembrane	11 – 32	22	Helical; Name=1; Potential
	Transmembrane	74 – 96	23	Helical; Name=2; Potential
	Transmembrane	117 – 133	17	Helical; Name=3; Potential
	Transmembrane	179 – 195	17	Helical; Name=4; Potential
	Transmembrane	213 – 232	20	Helical; Name=5; Potential
	Transmembrane	267 – 289	23	Helical; Name=6; Potential
	Repeat	11 – 102	92	Solcar 1
	Repeat	111 – 201	91	Solcar 2
	Repeat	210 – 295	86	Solcar 3
	Region	274 – 296	23	Purine nucleotide binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12242 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 33D107EDF04BD1AF	FASTA	307	33,248
	10 20 30 40 50 60 MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS STIRYKGVLG 70 80 90 100 110 120 TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ EYFSSGRETP ASLGNKISAG 130 140 150 160 170 180 LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI KPRYTGTYNA YRVIATTESL STLWKGTTPN 190 200 210 220 230 240 LMRNVIINCT ELVTYDLMKG ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF 250 260 270 280 290 300 INSLPGQYPS VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR QTVDCTT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains." Kozak L.P., Britton J.H., Kozak U.C., Wells J.M. J. Biol. Chem. 263:12274-12277(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene." Kozak U.C., Kopecky J., Teisinger J., Enerbaeck S., Boyer B., Kozak L.P. Mol. Cell. Biol. 14:59-67(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/SvJ.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M21247 , M21222, M21244, M21245, M21246 Genomic DNA. Translation: AAA40521.1. U63419 mRNA. Translation: AAB05870.1. U63418 Genomic DNA. Translation: AAB07367.1. BC012701 mRNA. Translation: AAH12701.1.
IPI	IPI00223236.
PIR	A31106.
RefSeq	NP_033489.1. NM_009463.3.
UniGene	Mm.4177.
3D structure databases
ProteinModelPortal	P12242.
SMR	P12242. Positions 13-302.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000034146.
PTM databases
PhosphoSite	P12242.
Proteomic databases
PaxDb	P12242.
PRIDE	P12242.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034146; ENSMUSP00000034146; ENSMUSG00000031710.
GeneID	22227.
KEGG	mmu:22227.
UCSC	uc009mjx.2. mouse.
Organism-specific databases
CTD	7350.
MGI	MGI:98894. Ucp1.
Phylogenomic databases
eggNOG	NOG277477.
GeneTree	ENSGT00550000074223.
HOGENOM	HOG000165140.
HOVERGEN	HBG009528.
InParanoid	P12242.
KO	K08769.
OMA	LVAGFCT.
OrthoDB	EOG4V6ZH7.
Gene expression databases
Bgee	P12242.
Genevestigator	P12242.
GermOnline	ENSMUSG00000031710. Mus musculus.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002030. Mit_uncoupling. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00784. MTUNCOUPLING.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	302259.
SOURCE	Search...

Entry information

Entry name

UCP1_MOUSE

Accession

Primary (citable) accession number: P12242

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program