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P12242

- UCP1_MOUSE

UniProt

P12242 - UCP1_MOUSE

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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

Ucp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Molecular functioni

  1. oxidative phosphorylation uncoupler activity Source: MGI

GO - Biological processi

  1. brown fat cell differentiation Source: HGNC
  2. mitochondrial transport Source: InterPro
  3. proton transport Source: GOC
  4. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_208819. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name:
UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene namesi
Name:Ucp1
Synonyms:Slc25a7, Ucp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:98894. Ucp1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial envelope Source: MGI
  3. mitochondrial inner membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1PRO_0000090659Add
BLAST

Proteomic databases

MaxQBiP12242.
PaxDbiP12242.
PRIDEiP12242.

PTM databases

PhosphoSiteiP12242.

Expressioni

Tissue specificityi

Brown adipose tissue.

Gene expression databases

BgeeiP12242.
GenevestigatoriP12242.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034146.

Structurei

3D structure databases

ProteinModelPortaliP12242.
SMRiP12242. Positions 13-302.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei74 – 9623Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei117 – 13317Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei179 – 19517Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei213 – 23220Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei267 – 28923Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati210 – 29586Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 29623Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277477.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP12242.
KOiK08769.
OMAiKSRQTVD.
OrthoDBiEOG793B7Z.
PhylomeDBiP12242.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12242-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS
60 70 80 90 100
STIRYKGVLG TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ
110 120 130 140 150
EYFSSGRETP ASLGNKISAG LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI
160 170 180 190 200
KPRYTGTYNA YRVIATTESL STLWKGTTPN LMRNVIINCT ELVTYDLMKG
210 220 230 240 250
ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF INSLPGQYPS
260 270 280 290 300
VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR

QTVDCTT
Length:307
Mass (Da):33,248
Last modified:January 23, 2007 - v2
Checksum:i33D107EDF04BD1AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21247
, M21222, M21244, M21245, M21246 Genomic DNA. Translation: AAA40521.1.
U63419 mRNA. Translation: AAB05870.1.
U63418 Genomic DNA. Translation: AAB07367.1.
BC012701 mRNA. Translation: AAH12701.1.
CCDSiCCDS22449.1.
PIRiA31106.
RefSeqiNP_033489.1. NM_009463.3.
UniGeneiMm.4177.

Genome annotation databases

EnsembliENSMUST00000034146; ENSMUSP00000034146; ENSMUSG00000031710.
GeneIDi22227.
KEGGimmu:22227.
UCSCiuc009mjx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21247
, M21222 , M21244 , M21245 , M21246 Genomic DNA. Translation: AAA40521.1 .
U63419 mRNA. Translation: AAB05870.1 .
U63418 Genomic DNA. Translation: AAB07367.1 .
BC012701 mRNA. Translation: AAH12701.1 .
CCDSi CCDS22449.1.
PIRi A31106.
RefSeqi NP_033489.1. NM_009463.3.
UniGenei Mm.4177.

3D structure databases

ProteinModelPortali P12242.
SMRi P12242. Positions 13-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034146.

PTM databases

PhosphoSitei P12242.

Proteomic databases

MaxQBi P12242.
PaxDbi P12242.
PRIDEi P12242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034146 ; ENSMUSP00000034146 ; ENSMUSG00000031710 .
GeneIDi 22227.
KEGGi mmu:22227.
UCSCi uc009mjx.2. mouse.

Organism-specific databases

CTDi 7350.
MGIi MGI:98894. Ucp1.

Phylogenomic databases

eggNOGi NOG277477.
GeneTreei ENSGT00760000119170.
HOGENOMi HOG000165140.
HOVERGENi HBG009528.
InParanoidi P12242.
KOi K08769.
OMAi KSRQTVD.
OrthoDBi EOG793B7Z.
PhylomeDBi P12242.
TreeFami TF323211.

Enzyme and pathway databases

Reactomei REACT_208819. The proton buffering model.

Miscellaneous databases

NextBioi 302259.
PROi P12242.
SOURCEi Search...

Gene expression databases

Bgeei P12242.
Genevestigatori P12242.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00784. MTUNCOUPLING.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains."
    Kozak L.P., Britton J.H., Kozak U.C., Wells J.M.
    J. Biol. Chem. 263:12274-12277(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene."
    Kozak U.C., Kopecky J., Teisinger J., Enerbaeck S., Boyer B., Kozak L.P.
    Mol. Cell. Biol. 14:59-67(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiUCP1_MOUSE
AccessioniPrimary (citable) accession number: P12242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3