SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P12242

- UCP1_MOUSE

UniProt

P12242 - UCP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitochondrial brown fat uncoupling protein 1
Gene
Ucp1, Slc25a7, Ucp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Molecular functioni

  1. oxidative phosphorylation uncoupler activity Source: MGI
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. brown fat cell differentiation Source: HGNC
  2. mitochondrial transport Source: InterPro
  3. proton transport Source: GOC
  4. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_208819. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name:
UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene namesi
Name:Ucp1
Synonyms:Slc25a7, Ucp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:98894. Ucp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei74 – 9623Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei117 – 13317Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei179 – 19517Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei213 – 23220Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei267 – 28923Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial envelope Source: MGI
  3. mitochondrial inner membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1
PRO_0000090659Add
BLAST

Proteomic databases

MaxQBiP12242.
PaxDbiP12242.
PRIDEiP12242.

PTM databases

PhosphoSiteiP12242.

Expressioni

Tissue specificityi

Brown adipose tissue.

Gene expression databases

BgeeiP12242.
GenevestigatoriP12242.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034146.

Structurei

3D structure databases

ProteinModelPortaliP12242.
SMRiP12242. Positions 13-302.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1
Add
BLAST
Repeati111 – 20191Solcar 2
Add
BLAST
Repeati210 – 29586Solcar 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 29623Purine nucleotide binding By similarity
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277477.
GeneTreeiENSGT00750000117384.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP12242.
KOiK08769.
OMAiKSRQTVD.
OrthoDBiEOG793B7Z.
PhylomeDBiP12242.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12242-1 [UniParc]FASTAAdd to Basket

« Hide

MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS    50
STIRYKGVLG TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ 100
EYFSSGRETP ASLGNKISAG LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI 150
KPRYTGTYNA YRVIATTESL STLWKGTTPN LMRNVIINCT ELVTYDLMKG 200
ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF INSLPGQYPS 250
VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR 300
QTVDCTT 307
Length:307
Mass (Da):33,248
Last modified:January 23, 2007 - v2
Checksum:i33D107EDF04BD1AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21247
, M21222, M21244, M21245, M21246 Genomic DNA. Translation: AAA40521.1.
U63419 mRNA. Translation: AAB05870.1.
U63418 Genomic DNA. Translation: AAB07367.1.
BC012701 mRNA. Translation: AAH12701.1.
CCDSiCCDS22449.1.
PIRiA31106.
RefSeqiNP_033489.1. NM_009463.3.
UniGeneiMm.4177.

Genome annotation databases

EnsembliENSMUST00000034146; ENSMUSP00000034146; ENSMUSG00000031710.
GeneIDi22227.
KEGGimmu:22227.
UCSCiuc009mjx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21247
, M21222 , M21244 , M21245 , M21246 Genomic DNA. Translation: AAA40521.1 .
U63419 mRNA. Translation: AAB05870.1 .
U63418 Genomic DNA. Translation: AAB07367.1 .
BC012701 mRNA. Translation: AAH12701.1 .
CCDSi CCDS22449.1.
PIRi A31106.
RefSeqi NP_033489.1. NM_009463.3.
UniGenei Mm.4177.

3D structure databases

ProteinModelPortali P12242.
SMRi P12242. Positions 13-302.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034146.

PTM databases

PhosphoSitei P12242.

Proteomic databases

MaxQBi P12242.
PaxDbi P12242.
PRIDEi P12242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034146 ; ENSMUSP00000034146 ; ENSMUSG00000031710 .
GeneIDi 22227.
KEGGi mmu:22227.
UCSCi uc009mjx.2. mouse.

Organism-specific databases

CTDi 7350.
MGIi MGI:98894. Ucp1.

Phylogenomic databases

eggNOGi NOG277477.
GeneTreei ENSGT00750000117384.
HOGENOMi HOG000165140.
HOVERGENi HBG009528.
InParanoidi P12242.
KOi K08769.
OMAi KSRQTVD.
OrthoDBi EOG793B7Z.
PhylomeDBi P12242.
TreeFami TF323211.

Enzyme and pathway databases

Reactomei REACT_208819. The proton buffering model.

Miscellaneous databases

NextBioi 302259.
PROi P12242.
SOURCEi Search...

Gene expression databases

Bgeei P12242.
Genevestigatori P12242.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00784. MTUNCOUPLING.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains."
    Kozak L.P., Britton J.H., Kozak U.C., Wells J.M.
    J. Biol. Chem. 263:12274-12277(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene."
    Kozak U.C., Kopecky J., Teisinger J., Enerbaeck S., Boyer B., Kozak L.P.
    Mol. Cell. Biol. 14:59-67(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiUCP1_MOUSE
AccessioniPrimary (citable) accession number: P12242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi