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P12242

- UCP1_MOUSE

UniProt

P12242 - UCP1_MOUSE

Protein

Mitochondrial brown fat uncoupling protein 1

Gene

Ucp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

    GO - Molecular functioni

    1. oxidative phosphorylation uncoupler activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. brown fat cell differentiation Source: HGNC
    2. mitochondrial transport Source: InterPro
    3. proton transport Source: GOC
    4. regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_208819. The proton buffering model.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial brown fat uncoupling protein 1
    Short name:
    UCP 1
    Alternative name(s):
    Solute carrier family 25 member 7
    Thermogenin
    Gene namesi
    Name:Ucp1
    Synonyms:Slc25a7, Ucp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:98894. Ucp1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial envelope Source: MGI
    3. mitochondrial inner membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1PRO_0000090659Add
    BLAST

    Proteomic databases

    MaxQBiP12242.
    PaxDbiP12242.
    PRIDEiP12242.

    PTM databases

    PhosphoSiteiP12242.

    Expressioni

    Tissue specificityi

    Brown adipose tissue.

    Gene expression databases

    BgeeiP12242.
    GenevestigatoriP12242.

    Interactioni

    Subunit structurei

    Acts as a dimer forming a proton channel.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034146.

    Structurei

    3D structure databases

    ProteinModelPortaliP12242.
    SMRiP12242. Positions 13-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9623Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13317Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19517Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23220Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28923Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 10292Solcar 1Add
    BLAST
    Repeati111 – 20191Solcar 2Add
    BLAST
    Repeati210 – 29586Solcar 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni274 – 29623Purine nucleotide bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277477.
    GeneTreeiENSGT00750000117384.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    InParanoidiP12242.
    KOiK08769.
    OMAiKSRQTVD.
    OrthoDBiEOG793B7Z.
    PhylomeDBiP12242.
    TreeFamiTF323211.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS    50
    STIRYKGVLG TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ 100
    EYFSSGRETP ASLGNKISAG LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI 150
    KPRYTGTYNA YRVIATTESL STLWKGTTPN LMRNVIINCT ELVTYDLMKG 200
    ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF INSLPGQYPS 250
    VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR 300
    QTVDCTT 307
    Length:307
    Mass (Da):33,248
    Last modified:January 23, 2007 - v2
    Checksum:i33D107EDF04BD1AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21247
    , M21222, M21244, M21245, M21246 Genomic DNA. Translation: AAA40521.1.
    U63419 mRNA. Translation: AAB05870.1.
    U63418 Genomic DNA. Translation: AAB07367.1.
    BC012701 mRNA. Translation: AAH12701.1.
    CCDSiCCDS22449.1.
    PIRiA31106.
    RefSeqiNP_033489.1. NM_009463.3.
    UniGeneiMm.4177.

    Genome annotation databases

    EnsembliENSMUST00000034146; ENSMUSP00000034146; ENSMUSG00000031710.
    GeneIDi22227.
    KEGGimmu:22227.
    UCSCiuc009mjx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21247
    , M21222 , M21244 , M21245 , M21246 Genomic DNA. Translation: AAA40521.1 .
    U63419 mRNA. Translation: AAB05870.1 .
    U63418 Genomic DNA. Translation: AAB07367.1 .
    BC012701 mRNA. Translation: AAH12701.1 .
    CCDSi CCDS22449.1.
    PIRi A31106.
    RefSeqi NP_033489.1. NM_009463.3.
    UniGenei Mm.4177.

    3D structure databases

    ProteinModelPortali P12242.
    SMRi P12242. Positions 13-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034146.

    PTM databases

    PhosphoSitei P12242.

    Proteomic databases

    MaxQBi P12242.
    PaxDbi P12242.
    PRIDEi P12242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034146 ; ENSMUSP00000034146 ; ENSMUSG00000031710 .
    GeneIDi 22227.
    KEGGi mmu:22227.
    UCSCi uc009mjx.2. mouse.

    Organism-specific databases

    CTDi 7350.
    MGIi MGI:98894. Ucp1.

    Phylogenomic databases

    eggNOGi NOG277477.
    GeneTreei ENSGT00750000117384.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    InParanoidi P12242.
    KOi K08769.
    OMAi KSRQTVD.
    OrthoDBi EOG793B7Z.
    PhylomeDBi P12242.
    TreeFami TF323211.

    Enzyme and pathway databases

    Reactomei REACT_208819. The proton buffering model.

    Miscellaneous databases

    NextBioi 302259.
    PROi P12242.
    SOURCEi Search...

    Gene expression databases

    Bgeei P12242.
    Genevestigatori P12242.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains."
      Kozak L.P., Britton J.H., Kozak U.C., Wells J.M.
      J. Biol. Chem. 263:12274-12277(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene."
      Kozak U.C., Kopecky J., Teisinger J., Enerbaeck S., Boyer B., Kozak L.P.
      Mol. Cell. Biol. 14:59-67(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiUCP1_MOUSE
    AccessioniPrimary (citable) accession number: P12242
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3