Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P12236

- ADT3_HUMAN

UniProt

P12236 - ADT3_HUMAN

Protein

ADP/ATP translocase 3

Gene

SLC25A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 170 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801NucleotideBy similarity

    GO - Molecular functioni

    1. ATP:ADP antiporter activity Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. active induction of host immune response by virus Source: Reactome
    2. ADP transport Source: GOC
    3. apoptotic process Source: UniProtKB-KW
    4. ATP transport Source: GOC
    5. cellular protein metabolic process Source: Reactome
    6. energy reserve metabolic process Source: Reactome
    7. modulation by virus of host morphology or physiology Source: Reactome
    8. protein targeting to mitochondrion Source: Reactome
    9. regulation of insulin secretion Source: Reactome
    10. small molecule metabolic process Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome

    Keywords - Biological processi

    Apoptosis, Host-virus interaction, Transport

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.
    REACT_18325. Regulation of insulin secretion.
    REACT_6213. Influenza Virus Induced Apoptosis.
    REACT_8016. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.

    Protein family/group databases

    TCDBi2.A.29.1.10. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP/ATP translocase 3
    Alternative name(s):
    ADP,ATP carrier protein 3
    ADP,ATP carrier protein, isoform T2
    Short name:
    ANT 2
    Adenine nucleotide translocator 3
    Short name:
    ANT 3
    Solute carrier family 25 member 6
    Cleaved into the following chain:
    Gene namesi
    Name:SLC25A6
    Synonyms:ANT3
    ORF Names:CDABP0051
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:10992. SLC25A6.

    Subcellular locationi

    Mitochondrion inner membrane; Multi-pass membrane protein
    Note: The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrial inner membrane presequence translocase complex Source: UniProtKB
    4. mitochondrion Source: UniProt
    5. nucleus Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35868.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298ADP/ATP translocase 3PRO_0000425781Add
    BLAST
    Initiator methioninei1 – 11Removed; alternate2 Publications
    Chaini2 – 298297ADP/ATP translocase 3, N-terminally processedPRO_0000090584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei2 – 21N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processed3 Publications
    Modified residuei105 – 1051N6-acetyllysine1 Publication
    Modified residuei268 – 2681N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP12236.
    PaxDbiP12236.
    PeptideAtlasiP12236.
    PRIDEiP12236.

    PTM databases

    PhosphoSiteiP12236.

    Expressioni

    Gene expression databases

    ArrayExpressiP12236.
    BgeeiP12236.
    CleanExiHS_SLC25A6.
    GenevestigatoriP12236.

    Interactioni

    Subunit structurei

    Found in a complex with ARL2, ARL2BP and SLC25A6 By similarity. Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRK2Q5S0072EBI-356254,EBI-5323863

    Protein-protein interaction databases

    BioGridi106790. 57 interactions.
    IntActiP12236. 42 interactions.
    MINTiMINT-1154461.
    STRINGi9606.ENSP00000370808.

    Structurei

    3D structure databases

    ProteinModelPortaliP12236.
    SMRiP12236. Positions 2-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 3935Helical; Name=1By similarityAdd
    BLAST
    Transmembranei75 – 10026Helical; Name=2By similarityAdd
    BLAST
    Transmembranei109 – 14335Helical; Name=3By similarityAdd
    BLAST
    Transmembranei176 – 20227Helical; Name=4By similarityAdd
    BLAST
    Transmembranei207 – 24135Helical; Name=5By similarityAdd
    BLAST
    Transmembranei273 – 29826Helical; Name=6By similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati6 – 9893Solcar 1Add
    BLAST
    Repeati111 – 20191Solcar 2Add
    BLAST
    Repeati212 – 29786Solcar 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi235 – 2406Substrate recognitionBy similarity

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238123.
    HOVERGENiHBG108348.
    InParanoidiP12236.
    KOiK05863.
    OMAiCWRKIFK.
    OrthoDBiEOG7T1RBR.
    PhylomeDBiP12236.
    TreeFamiTF300743.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12236-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ    50
    YKGIVDCIVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 100
    GGVDKHTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKSGT 150
    EREFRGLGDC LVKITKSDGI RGLYQGFSVS VQGIIIYRAA YFGVYDTAKG 200
    MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM QSGRKGADIM 250
    YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI 298
    Length:298
    Mass (Da):32,866
    Last modified:January 23, 2007 - v4
    Checksum:i18534E9F0E49672F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1084KHTQ → RHA in AAA36750. (PubMed:2829183)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti242 – 2421S → F.1 Publication
    Corresponds to variant rs17851235 [ dbSNP | Ensembl ].
    VAR_054819

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY007135 mRNA. Translation: AAG01998.1.
    BC007295 mRNA. Translation: AAH07295.1.
    BC007850 mRNA. Translation: AAH07850.1.
    BC008737 mRNA. Translation: AAH08737.1.
    BC008935 mRNA. Translation: AAH08935.1.
    BC014775 mRNA. Translation: AAH14775.1.
    BC031912 mRNA. Translation: AAH31912.1.
    J03592 mRNA. Translation: AAA36750.1.
    CCDSiCCDS14114.1.
    PIRiS03894.
    RefSeqiNP_001627.2. NM_001636.3.
    UniGeneiHs.350927.

    Genome annotation databases

    EnsembliENST00000381401; ENSP00000370808; ENSG00000169100.
    GeneIDi293.
    KEGGihsa:293.
    UCSCiuc004cpt.3. human.

    Polymorphism databases

    DMDMi113463.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY007135 mRNA. Translation: AAG01998.1 .
    BC007295 mRNA. Translation: AAH07295.1 .
    BC007850 mRNA. Translation: AAH07850.1 .
    BC008737 mRNA. Translation: AAH08737.1 .
    BC008935 mRNA. Translation: AAH08935.1 .
    BC014775 mRNA. Translation: AAH14775.1 .
    BC031912 mRNA. Translation: AAH31912.1 .
    J03592 mRNA. Translation: AAA36750.1 .
    CCDSi CCDS14114.1.
    PIRi S03894.
    RefSeqi NP_001627.2. NM_001636.3.
    UniGenei Hs.350927.

    3D structure databases

    ProteinModelPortali P12236.
    SMRi P12236. Positions 2-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106790. 57 interactions.
    IntActi P12236. 42 interactions.
    MINTi MINT-1154461.
    STRINGi 9606.ENSP00000370808.

    Chemistry

    DrugBanki DB00720. Clodronate.

    Protein family/group databases

    TCDBi 2.A.29.1.10. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei P12236.

    Polymorphism databases

    DMDMi 113463.

    Proteomic databases

    MaxQBi P12236.
    PaxDbi P12236.
    PeptideAtlasi P12236.
    PRIDEi P12236.

    Protocols and materials databases

    DNASUi 293.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381401 ; ENSP00000370808 ; ENSG00000169100 .
    GeneIDi 293.
    KEGGi hsa:293.
    UCSCi uc004cpt.3. human.

    Organism-specific databases

    CTDi 293.
    GeneCardsi GC0XM001505.
    H-InvDB HIX0034763.
    HGNCi HGNC:10992. SLC25A6.
    MIMi 300151. gene.
    403000. gene.
    neXtProti NX_P12236.
    PharmGKBi PA35868.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238123.
    HOVERGENi HBG108348.
    InParanoidi P12236.
    KOi K05863.
    OMAi CWRKIFK.
    OrthoDBi EOG7T1RBR.
    PhylomeDBi P12236.
    TreeFami TF300743.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.
    REACT_18325. Regulation of insulin secretion.
    REACT_6213. Influenza Virus Induced Apoptosis.
    REACT_8016. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.

    Miscellaneous databases

    GeneWikii SLC25A6.
    GenomeRNAii 293.
    NextBioi 1195.
    PROi P12236.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12236.
    Bgeei P12236.
    CleanExi HS_SLC25A6.
    Genevestigatori P12236.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase."
      Cozens A.L., Runswick M.J., Walker J.E.
      J. Mol. Biol. 206:261-280(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-242.
      Tissue: Leukemia.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Cervix, Eye and Lung.
    4. Bienvenut W.V.
      Submitted (JUL-2004) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-10, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    5. "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver."
      Houldsworth J., Attardi G.
      Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-298.
      Tissue: Liver.
    6. "Study of PTPC composition during apoptosis for identification of viral protein target."
      Verrier F., Mignotte B., Jan G., Brenner C.
      Ann. N. Y. Acad. Sci. 1010:126-142(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN APOPTOSIS.
    7. "Mitochondrial membrane permeabilization by HIV-1 Vpr."
      Deniaud A., Brenner C., Kroemer G.
      Mitochondrion 4:223-233(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIV-1 VPR.
    8. "Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
      Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.
      PLoS Pathog. 1:40-54(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105 AND LYS-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADT3_HUMAN
    AccessioniPrimary (citable) accession number: P12236
    Secondary accession number(s): Q96C49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 170 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.By similarity
    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3