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Protein

ADP/ATP translocase 3

Gene

SLC25A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80NucleotideBy similarity1

GO - Molecular functioni

  • adenine transmembrane transporter activity Source: Reactome
  • ATP:ADP antiporter activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169100-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-168277. Influenza Virus Induced Apoptosis.
R-HSA-180897. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.
R-HSA-422356. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.10. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 3
Alternative name(s):
ADP,ATP carrier protein 3
ADP,ATP carrier protein, isoform T2
Short name:
ANT 2
Adenine nucleotide translocator 3
Short name:
ANT 3
Solute carrier family 25 member 6
Cleaved into the following chain:
Gene namesi
Name:SLC25A6
Synonyms:ANT3
ORF Names:CDABP0051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10992. SLC25A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 39Helical; Name=1By similarityAdd BLAST35
Transmembranei75 – 100Helical; Name=2By similarityAdd BLAST26
Transmembranei109 – 143Helical; Name=3By similarityAdd BLAST35
Transmembranei176 – 202Helical; Name=4By similarityAdd BLAST27
Transmembranei207 – 241Helical; Name=5By similarityAdd BLAST35
Transmembranei273 – 298Helical; Name=6By similarityAdd BLAST26

GO - Cellular componenti

  • extracellular matrix Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial inner membrane presequence translocase complex Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi293.
OpenTargetsiENSG00000169100.
PharmGKBiPA35868.

Chemistry databases

DrugBankiDB00720. Clodronate.

Polymorphism and mutation databases

BioMutaiSLC25A6.
DMDMi113463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004257811 – 298ADP/ATP translocase 3Add BLAST298
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00000905842 – 298ADP/ATP translocase 3, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processedCombined sources1 Publication1
Modified residuei52N6,N6,N6-trimethyllysineCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei268N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP12236.
PaxDbiP12236.
PeptideAtlasiP12236.
PRIDEiP12236.
TopDownProteomicsiP12236.

PTM databases

iPTMnetiP12236.
PhosphoSitePlusiP12236.
SwissPalmiP12236.

Expressioni

Gene expression databases

BgeeiENSG00000169100.
CleanExiHS_SLC25A6.
ExpressionAtlasiP12236. baseline and differential.
GenevisibleiP12236. HS.

Organism-specific databases

HPAiHPA060665.

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AP2B1P630103EBI-356254,EBI-432924
KRT31Q153233EBI-356254,EBI-948001
LRRK2Q5S0072EBI-356254,EBI-5323863
LZTS2Q9BRK43EBI-356254,EBI-741037
MID2Q9UJV3-23EBI-356254,EBI-10172526
MTUS2Q5JR594EBI-356254,EBI-742948
NOTCH2NLQ7Z3S93EBI-356254,EBI-945833
TEKT4Q8WW243EBI-356254,EBI-750487
TRAF1Q130773EBI-356254,EBI-359224
TRIM23P364063EBI-356254,EBI-740098
TRIP6Q156543EBI-356254,EBI-742327

Protein-protein interaction databases

BioGridi106790. 112 interactors.
IntActiP12236. 64 interactors.
MINTiMINT-1154461.
STRINGi9606.ENSP00000370808.

Structurei

3D structure databases

ProteinModelPortaliP12236.
SMRiP12236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Substrate recognitionBy similarity6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP12236.
KOiK05863.
OMAiTRSHVIN.
OrthoDBiEOG091G0ULB.
PhylomeDBiP12236.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ
60 70 80 90 100
YKGIVDCIVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKHTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKSGT
160 170 180 190 200
EREFRGLGDC LVKITKSDGI RGLYQGFSVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
Length:298
Mass (Da):32,866
Last modified:January 23, 2007 - v4
Checksum:i18534E9F0E49672F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105 – 108KHTQ → RHA in AAA36750 (PubMed:2829183).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054819242S → F.1 PublicationCorresponds to variant rs17851235dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007135 mRNA. Translation: AAG01998.1.
BC007295 mRNA. Translation: AAH07295.1.
BC007850 mRNA. Translation: AAH07850.1.
BC008737 mRNA. Translation: AAH08737.1.
BC008935 mRNA. Translation: AAH08935.1.
BC014775 mRNA. Translation: AAH14775.1.
BC031912 mRNA. Translation: AAH31912.1.
J03592 mRNA. Translation: AAA36750.1.
CCDSiCCDS14114.1.
PIRiS03894.
RefSeqiNP_001627.2. NM_001636.3.
UniGeneiHs.350927.
Hs.680626.

Genome annotation databases

EnsembliENST00000381401; ENSP00000370808; ENSG00000169100.
GeneIDi293.
KEGGihsa:293.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007135 mRNA. Translation: AAG01998.1.
BC007295 mRNA. Translation: AAH07295.1.
BC007850 mRNA. Translation: AAH07850.1.
BC008737 mRNA. Translation: AAH08737.1.
BC008935 mRNA. Translation: AAH08935.1.
BC014775 mRNA. Translation: AAH14775.1.
BC031912 mRNA. Translation: AAH31912.1.
J03592 mRNA. Translation: AAA36750.1.
CCDSiCCDS14114.1.
PIRiS03894.
RefSeqiNP_001627.2. NM_001636.3.
UniGeneiHs.350927.
Hs.680626.

3D structure databases

ProteinModelPortaliP12236.
SMRiP12236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106790. 112 interactors.
IntActiP12236. 64 interactors.
MINTiMINT-1154461.
STRINGi9606.ENSP00000370808.

Chemistry databases

DrugBankiDB00720. Clodronate.

Protein family/group databases

TCDBi2.A.29.1.10. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP12236.
PhosphoSitePlusiP12236.
SwissPalmiP12236.

Polymorphism and mutation databases

BioMutaiSLC25A6.
DMDMi113463.

Proteomic databases

EPDiP12236.
PaxDbiP12236.
PeptideAtlasiP12236.
PRIDEiP12236.
TopDownProteomicsiP12236.

Protocols and materials databases

DNASUi293.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381401; ENSP00000370808; ENSG00000169100.
GeneIDi293.
KEGGihsa:293.

Organism-specific databases

CTDi293.
DisGeNETi293.
GeneCardsiSLC25A6.
H-InvDBHIX0034763.
HGNCiHGNC:10992. SLC25A6.
HPAiHPA060665.
MIMi300151. gene.
403000. gene.
neXtProtiNX_P12236.
OpenTargetsiENSG00000169100.
PharmGKBiPA35868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP12236.
KOiK05863.
OMAiTRSHVIN.
OrthoDBiEOG091G0ULB.
PhylomeDBiP12236.
TreeFamiTF300743.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169100-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-168277. Influenza Virus Induced Apoptosis.
R-HSA-180897. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.
R-HSA-422356. Regulation of insulin secretion.

Miscellaneous databases

GeneWikiiSLC25A6.
GenomeRNAii293.
PROiP12236.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169100.
CleanExiHS_SLC25A6.
ExpressionAtlasiP12236. baseline and differential.
GenevisibleiP12236. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT3_HUMAN
AccessioniPrimary (citable) accession number: P12236
Secondary accession number(s): Q96C49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 193 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.