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P12236 (ADT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 165. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP/ATP translocase 3
Alternative name(s):
ADP,ATP carrier protein 3
ADP,ATP carrier protein, isoform T2
Short name=ANT 2
Adenine nucleotide translocator 3
Short name=ANT 3
Solute carrier family 25 member 6

Cleaved into the following chain:

  1. ADP/ATP translocase 3, N-terminally processed
Gene names
Name:SLC25A6
Synonyms:ANT3
ORF Names:CDABP0051
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Ref.6

Subunit structure

Found in a complex with ARL2, ARL2BP and SLC25A6 By similarity. Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr. Ref.7 Ref.8

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein. Note: The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria By similarity.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Ontologies

Keywords
   Biological processApoptosis
Host-virus interaction
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processADP transport

Non-traceable author statement Ref.1. Source: GOC

ATP transport

Non-traceable author statement Ref.1. Source: GOC

active induction of host immune response by virus

Traceable author statement. Source: Reactome

apoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular protein metabolic process

Traceable author statement. Source: Reactome

energy reserve metabolic process

Traceable author statement. Source: Reactome

modulation by virus of host morphology or physiology

Traceable author statement. Source: Reactome

protein targeting to mitochondrion

Traceable author statement. Source: Reactome

regulation of insulin secretion

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Traceable author statement. Source: Reactome

mitochondrial inner membrane presequence translocase complex

Traceable author statement Ref.1. Source: UniProtKB

mitochondrion

Inferred from direct assay PubMed 20833797. Source: UniProt

   Molecular_functionATP:ADP antiporter activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298ADP/ATP translocase 3
PRO_0000425781
Initiator methionine11Removed; alternate Ref.4
Chain2 – 298297ADP/ATP translocase 3, N-terminally processed
PRO_0000090584

Regions

Transmembrane5 – 3935Helical; Name=1; By similarity
Transmembrane75 – 10026Helical; Name=2; By similarity
Transmembrane109 – 14335Helical; Name=3; By similarity
Transmembrane176 – 20227Helical; Name=4; By similarity
Transmembrane207 – 24135Helical; Name=5; By similarity
Transmembrane273 – 29826Helical; Name=6; By similarity
Repeat6 – 9893Solcar 1
Repeat111 – 20191Solcar 2
Repeat212 – 29786Solcar 3
Motif235 – 2406Substrate recognition By similarity

Sites

Binding site801Nucleotide By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.13
Modified residue21N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processed Ref.4 Ref.10 Ref.13
Modified residue1051N6-acetyllysine Ref.11
Modified residue2681N6-acetyllysine Ref.11

Natural variations

Natural variant2421S → F. Ref.2
Corresponds to variant rs17851235 [ dbSNP | Ensembl ].
VAR_054819

Experimental info

Sequence conflict105 – 1084KHTQ → RHA in AAA36750. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P12236 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 18534E9F0E49672F

FASTA29832,866
        10         20         30         40         50         60 
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR 

        70         80         90        100        110        120 
IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG 

       130        140        150        160        170        180 
GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS 

       190        200        210        220        230        240 
VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM 

       250        260        270        280        290 
QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase."
Cozens A.L., Runswick M.J., Walker J.E.
J. Mol. Biol. 206:261-280(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Pediatric leukemia cDNA sequencing project."
Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-242.
Tissue: Leukemia.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Cervix, Eye and Lung.
[4]Bienvenut W.V.
Submitted (JUL-2004) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-10, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[5]"Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver."
Houldsworth J., Attardi G.
Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-298.
Tissue: Liver.
[6]"Study of PTPC composition during apoptosis for identification of viral protein target."
Verrier F., Mignotte B., Jan G., Brenner C.
Ann. N. Y. Acad. Sci. 1010:126-142(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN APOPTOSIS.
[7]"Mitochondrial membrane permeabilization by HIV-1 Vpr."
Deniaud A., Brenner C., Kroemer G.
Mitochondrion 4:223-233(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HIV-1 VPR.
[8]"Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.
PLoS Pathog. 1:40-54(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
[9]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105 AND LYS-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY007135 mRNA. Translation: AAG01998.1.
BC007295 mRNA. Translation: AAH07295.1.
BC007850 mRNA. Translation: AAH07850.1.
BC008737 mRNA. Translation: AAH08737.1.
BC008935 mRNA. Translation: AAH08935.1.
BC014775 mRNA. Translation: AAH14775.1.
BC031912 mRNA. Translation: AAH31912.1.
J03592 mRNA. Translation: AAA36750.1.
PIRS03894.
RefSeqNP_001627.2. NM_001636.3.
UniGeneHs.350927.

3D structure databases

ProteinModelPortalP12236.
SMRP12236. Positions 2-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106790. 66 interactions.
IntActP12236. 42 interactions.
MINTMINT-1154461.
STRING9606.ENSP00000370808.

Chemistry

DrugBankDB00720. Clodronate.

Protein family/group databases

TCDB2.A.29.1.10. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteP12236.

Polymorphism databases

DMDM113463.

Proteomic databases

PaxDbP12236.
PeptideAtlasP12236.
PRIDEP12236.

Protocols and materials databases

DNASU293.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381401; ENSP00000370808; ENSG00000169100.
GeneID293.
KEGGhsa:293.
UCSCuc004cpt.3. human.

Organism-specific databases

CTD293.
GeneCardsGC0XM001505.
H-InvDBHIX0034763.
HGNCHGNC:10992. SLC25A6.
MIM300151. gene.
403000. gene.
neXtProtNX_P12236.
PharmGKBPA35868.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238123.
HOVERGENHBG108348.
InParanoidP12236.
KOK05863.
OMACWRKIFK.
OrthoDBEOG7T1RBR.
PhylomeDBP12236.
TreeFamTF300743.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
REACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressP12236.
BgeeP12236.
CleanExHS_SLC25A6.
GenevestigatorP12236.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC25A6.
GenomeRNAi293.
NextBio1195.
PROP12236.
SOURCESearch...

Entry information

Entry nameADT3_HUMAN
AccessionPrimary (citable) accession number: P12236
Secondary accession number(s): Q96C49
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 165 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM