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Protein

ADP/ATP translocase 3

Gene

SLC25A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801NucleotideBy similarity

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: UniProtKB

GO - Biological processi

  1. active induction of host immune response by virus Source: Reactome
  2. ADP transport Source: GOC
  3. apoptotic process Source: UniProtKB-KW
  4. ATP transport Source: GOC
  5. cellular protein metabolic process Source: Reactome
  6. energy reserve metabolic process Source: Reactome
  7. modulation by virus of host morphology or physiology Source: Reactome
  8. protein targeting to mitochondrion Source: Reactome
  9. regulation of insulin secretion Source: Reactome
  10. small molecule metabolic process Source: Reactome
  11. viral life cycle Source: Reactome
  12. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Transport

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.
REACT_18325. Regulation of insulin secretion.
REACT_6213. Influenza Virus Induced Apoptosis.
REACT_8016. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.

Protein family/group databases

TCDBi2.A.29.1.10. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 3
Alternative name(s):
ADP,ATP carrier protein 3
ADP,ATP carrier protein, isoform T2
Short name:
ANT 2
Adenine nucleotide translocator 3
Short name:
ANT 3
Solute carrier family 25 member 6
Cleaved into the following chain:
Gene namesi
Name:SLC25A6
Synonyms:ANT3
ORF Names:CDABP0051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10992. SLC25A6.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein
Note: The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 3935Helical; Name=1By similarityAdd
BLAST
Transmembranei75 – 10026Helical; Name=2By similarityAdd
BLAST
Transmembranei109 – 14335Helical; Name=3By similarityAdd
BLAST
Transmembranei176 – 20227Helical; Name=4By similarityAdd
BLAST
Transmembranei207 – 24135Helical; Name=5By similarityAdd
BLAST
Transmembranei273 – 29826Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial inner membrane presequence translocase complex Source: UniProtKB
  4. mitochondrion Source: UniProtKB
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ADP/ATP translocase 3PRO_0000425781Add
BLAST
Initiator methioninei1 – 11Removed; alternate3 Publications
Chaini2 – 298297ADP/ATP translocase 3, N-terminally processedPRO_0000090584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei2 – 21N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processed3 Publications
Modified residuei105 – 1051N6-acetyllysine1 Publication
Modified residuei268 – 2681N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP12236.
PaxDbiP12236.
PeptideAtlasiP12236.
PRIDEiP12236.

PTM databases

PhosphoSiteiP12236.

Expressioni

Gene expression databases

BgeeiP12236.
CleanExiHS_SLC25A6.
ExpressionAtlasiP12236. baseline and differential.
GenevestigatoriP12236.

Organism-specific databases

HPAiHPA060665.

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-356254,EBI-5323863

Protein-protein interaction databases

BioGridi106790. 73 interactions.
IntActiP12236. 43 interactions.
MINTiMINT-1154461.
STRINGi9606.ENSP00000370808.

Structurei

3D structure databases

ProteinModelPortaliP12236.
SMRiP12236. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9893Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati212 – 29786Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi235 – 2406Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
HOVERGENiHBG108348.
InParanoidiP12236.
KOiK05863.
OMAiCWRKIFK.
OrthoDBiEOG7T1RBR.
PhylomeDBiP12236.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ
60 70 80 90 100
YKGIVDCIVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKHTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKSGT
160 170 180 190 200
EREFRGLGDC LVKITKSDGI RGLYQGFSVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
Length:298
Mass (Da):32,866
Last modified:January 22, 2007 - v4
Checksum:i18534E9F0E49672F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1084KHTQ → RHA in AAA36750 (PubMed:2829183).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421S → F.1 Publication
Corresponds to variant rs17851235 [ dbSNP | Ensembl ].
VAR_054819

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007135 mRNA. Translation: AAG01998.1.
BC007295 mRNA. Translation: AAH07295.1.
BC007850 mRNA. Translation: AAH07850.1.
BC008737 mRNA. Translation: AAH08737.1.
BC008935 mRNA. Translation: AAH08935.1.
BC014775 mRNA. Translation: AAH14775.1.
BC031912 mRNA. Translation: AAH31912.1.
J03592 mRNA. Translation: AAA36750.1.
CCDSiCCDS14114.1.
PIRiS03894.
RefSeqiNP_001627.2. NM_001636.3.
UniGeneiHs.350927.

Genome annotation databases

EnsembliENST00000381401; ENSP00000370808; ENSG00000169100.
GeneIDi293.
KEGGihsa:293.
UCSCiuc004cpt.3. human.

Polymorphism databases

DMDMi113463.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007135 mRNA. Translation: AAG01998.1.
BC007295 mRNA. Translation: AAH07295.1.
BC007850 mRNA. Translation: AAH07850.1.
BC008737 mRNA. Translation: AAH08737.1.
BC008935 mRNA. Translation: AAH08935.1.
BC014775 mRNA. Translation: AAH14775.1.
BC031912 mRNA. Translation: AAH31912.1.
J03592 mRNA. Translation: AAA36750.1.
CCDSiCCDS14114.1.
PIRiS03894.
RefSeqiNP_001627.2. NM_001636.3.
UniGeneiHs.350927.

3D structure databases

ProteinModelPortaliP12236.
SMRiP12236. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106790. 73 interactions.
IntActiP12236. 43 interactions.
MINTiMINT-1154461.
STRINGi9606.ENSP00000370808.

Chemistry

DrugBankiDB00720. Clodronate.

Protein family/group databases

TCDBi2.A.29.1.10. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiP12236.

Polymorphism databases

DMDMi113463.

Proteomic databases

MaxQBiP12236.
PaxDbiP12236.
PeptideAtlasiP12236.
PRIDEiP12236.

Protocols and materials databases

DNASUi293.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381401; ENSP00000370808; ENSG00000169100.
GeneIDi293.
KEGGihsa:293.
UCSCiuc004cpt.3. human.

Organism-specific databases

CTDi293.
GeneCardsiGC0XM001505.
H-InvDBHIX0034763.
HGNCiHGNC:10992. SLC25A6.
HPAiHPA060665.
MIMi300151. gene.
403000. gene.
neXtProtiNX_P12236.
PharmGKBiPA35868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238123.
HOVERGENiHBG108348.
InParanoidiP12236.
KOiK05863.
OMAiCWRKIFK.
OrthoDBiEOG7T1RBR.
PhylomeDBiP12236.
TreeFamiTF300743.

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.
REACT_18325. Regulation of insulin secretion.
REACT_6213. Influenza Virus Induced Apoptosis.
REACT_8016. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.

Miscellaneous databases

GeneWikiiSLC25A6.
GenomeRNAii293.
NextBioi1195.
PROiP12236.
SOURCEiSearch...

Gene expression databases

BgeeiP12236.
CleanExiHS_SLC25A6.
ExpressionAtlasiP12236. baseline and differential.
GenevestigatoriP12236.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase."
    Cozens A.L., Runswick M.J., Walker J.E.
    J. Mol. Biol. 206:261-280(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-242.
    Tissue: Leukemia.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Cervix, Eye and Lung.
  4. Bienvenut W.V.
    Submitted (JUN-2004) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  5. "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver."
    Houldsworth J., Attardi G.
    Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-298.
    Tissue: Liver.
  6. "Study of PTPC composition during apoptosis for identification of viral protein target."
    Verrier F., Mignotte B., Jan G., Brenner C.
    Ann. N. Y. Acad. Sci. 1010:126-142(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN APOPTOSIS.
  7. "Mitochondrial membrane permeabilization by HIV-1 Vpr."
    Deniaud A., Brenner C., Kroemer G.
    Mitochondrion 4:223-233(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 VPR.
  8. "Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
    Zamarin D., Garcia-Sastre A., Xiao X., Wang R., Palese P.
    PLoS Pathog. 1:40-54(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105 AND LYS-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADT3_HUMAN
AccessioniPrimary (citable) accession number: P12236
Secondary accession number(s): Q96C49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1989
Last sequence update: January 22, 2007
Last modified: March 3, 2015
This is version 174 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.