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Protein

Phosphate carrier protein, mitochondrial

Gene

SLC25A3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.29.4.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate carrier protein, mitochondrial
Alternative name(s):
Phosphate transport protein
Short name:
PTP
Solute carrier family 25 member 3
Gene namesi
Name:SLC25A3
Synonyms:PHC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:49965 SLC25A3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 63Mitochondrial intermembraneSequence analysisAdd BLAST14
Transmembranei64 – 86Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini87 – 121Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei122 – 141Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini142 – 161Mitochondrial intermembraneSequence analysisAdd BLAST20
Transmembranei162 – 183Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini184 – 218Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei219 – 238Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini239 – 261Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei262 – 284Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini285 – 314Mitochondrial matrixSequence analysisAdd BLAST30
Transmembranei315 – 333Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini334 – 362Mitochondrial intermembraneSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49Mitochondrion1 PublicationAdd BLAST49
ChainiPRO_000001925550 – 362Phosphate carrier protein, mitochondrialAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99N6-acetyllysineBy similarity1
Modified residuei112N6-methyllysineBy similarity1
Modified residuei196PhosphotyrosineBy similarity1
Modified residuei209N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP12234
PeptideAtlasiP12234
PRIDEiP12234

Expressioni

Gene expression databases

BgeeiENSBTAG00000012890

Interactioni

Subunit structurei

Interacts with PPIF; the interaction is impaired by CsA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017131

Structurei

3D structure databases

ProteinModelPortaliP12234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 147Solcar 1Add BLAST85
Repeati160 – 244Solcar 2Add BLAST85
Repeati261 – 339Solcar 3Add BLAST79

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0767 Eukaryota
ENOG410XPST LUCA
GeneTreeiENSGT00390000008708
HOGENOMiHOG000164438
HOVERGENiHBG024440
InParanoidiP12234
KOiK15102
OMAiGFQWWIY
OrthoDBiEOG091G0FJF
TreeFamiTF314119

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P12234-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSSVVHLAR ANPFNAPHLQ LVHDGLAGPR SDPAGPPGPP RRSRNLAAAA
60 70 80 90 100
VEEQYSCDYG SGRFFILCGL GGIISCGTTH TALVPLDLVK CRMQVDPQKY
110 120 130 140 150
KSIFNGFSVT LKEDGFRGLA KGWAPTFIGY SLQGLCKFGF YEVFKVLYSN
160 170 180 190 200
MLGEENAYLW RTSLYLAASA SAEFFADIAL APMEAAKVRI QTQPGYANTL
210 220 230 240 250
RDAAPKMYKE EGLKAFYKGV APLWMRQIPY TMMKFACFER TVEALYKFVV
260 270 280 290 300
PKPRSECSKP EQLVVTFVAG YIAGVFCAIV SHPADSVVSV LNKEKGSSAS
310 320 330 340 350
EVLKRLGFRG VWKGLFARII MIGTLTALQW FIYDSVKVYF RLPRPPPPEM
360
PESLKKKLGY TQ
Length:362
Mass (Da):40,140
Last modified:October 1, 1989 - v1
Checksum:i500DD66867B95A10
GO
Isoform B (identifier: P12234-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-83: QYSCDYGSGRFFILCGLGGIISCGTTHTAL → YSCEYGSAKFYALCGFGGVLSCGLTHTAV

Show »
Length:361
Mass (Da):40,004
Checksum:iDEB0B7BA37377D30
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00326854 – 83QYSCD…THTAL → YSCEYGSAKFYALCGFGGVL SCGLTHTAV in isoform B. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77338 Genomic DNA No translation available.
X05340 mRNA Translation: CAA28951.1
BC149996 mRNA Translation: AAI49997.1
PIRiC53737
D53737
RefSeqiNP_777082.1, NM_174657.2 [P12234-1]
XP_005206570.1, XM_005206513.3 [P12234-2]
UniGeneiBt.4880

Genome annotation databases

EnsembliENSBTAT00000017131; ENSBTAP00000017131; ENSBTAG00000012890 [P12234-1]
ENSBTAT00000053663; ENSBTAP00000048807; ENSBTAG00000012890 [P12234-2]
GeneIDi282477
KEGGibta:282477

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMPCP_BOVIN
AccessioniPrimary (citable) accession number: P12234
Secondary accession number(s): A6QQU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health