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Protein

Phosphate carrier protein, mitochondrial

Gene

SLC25A3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP).

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.29.4.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate carrier protein, mitochondrial
Alternative name(s):
Phosphate transport protein
Short name:
PTP
Solute carrier family 25 member 3
Gene namesi
Name:SLC25A3
Synonyms:PHC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 63Mitochondrial intermembraneSequence analysisAdd BLAST14
Transmembranei64 – 86Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini87 – 121Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei122 – 141Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini142 – 161Mitochondrial intermembraneSequence analysisAdd BLAST20
Transmembranei162 – 183Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini184 – 218Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei219 – 238Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini239 – 261Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei262 – 284Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini285 – 314Mitochondrial matrixSequence analysisAdd BLAST30
Transmembranei315 – 333Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini334 – 362Mitochondrial intermembraneSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49Mitochondrion1 PublicationAdd BLAST49
ChainiPRO_000001925550 – 362Phosphate carrier protein, mitochondrialAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99N6-acetyllysineBy similarity1
Modified residuei112N6-methyllysineBy similarity1
Modified residuei196PhosphotyrosineBy similarity1
Modified residuei209N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP12234.
PeptideAtlasiP12234.
PRIDEiP12234.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012890.

Interactioni

Subunit structurei

Interacts with PPIF; the interaction is impaired by CsA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017131.

Structurei

3D structure databases

ProteinModelPortaliP12234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 147Solcar 1Add BLAST85
Repeati160 – 244Solcar 2Add BLAST85
Repeati261 – 339Solcar 3Add BLAST79

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0767. Eukaryota.
ENOG410XPST. LUCA.
GeneTreeiENSGT00390000008708.
HOGENOMiHOG000164438.
HOVERGENiHBG024440.
InParanoidiP12234.
KOiK15102.
OMAiLKFYALC.
OrthoDBiEOG091G0FJF.
TreeFamiTF314119.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P12234-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSSVVHLAR ANPFNAPHLQ LVHDGLAGPR SDPAGPPGPP RRSRNLAAAA
60 70 80 90 100
VEEQYSCDYG SGRFFILCGL GGIISCGTTH TALVPLDLVK CRMQVDPQKY
110 120 130 140 150
KSIFNGFSVT LKEDGFRGLA KGWAPTFIGY SLQGLCKFGF YEVFKVLYSN
160 170 180 190 200
MLGEENAYLW RTSLYLAASA SAEFFADIAL APMEAAKVRI QTQPGYANTL
210 220 230 240 250
RDAAPKMYKE EGLKAFYKGV APLWMRQIPY TMMKFACFER TVEALYKFVV
260 270 280 290 300
PKPRSECSKP EQLVVTFVAG YIAGVFCAIV SHPADSVVSV LNKEKGSSAS
310 320 330 340 350
EVLKRLGFRG VWKGLFARII MIGTLTALQW FIYDSVKVYF RLPRPPPPEM
360
PESLKKKLGY TQ
Length:362
Mass (Da):40,140
Last modified:October 1, 1989 - v1
Checksum:i500DD66867B95A10
GO
Isoform B (identifier: P12234-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-83: QYSCDYGSGRFFILCGLGGIISCGTTHTAL → YSCEYGSAKFYALCGFGGVLSCGLTHTAV

Show »
Length:361
Mass (Da):40,004
Checksum:iDEB0B7BA37377D30
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00326854 – 83QYSCD…THTAL → YSCEYGSAKFYALCGFGGVL SCGLTHTAV in isoform B. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77338 Genomic DNA. No translation available.
X05340 mRNA. Translation: CAA28951.1.
BC149996 mRNA. Translation: AAI49997.1.
PIRiC53737.
D53737.
RefSeqiNP_777082.1. NM_174657.2. [P12234-1]
XP_005206570.1. XM_005206513.3. [P12234-2]
UniGeneiBt.4880.

Genome annotation databases

EnsembliENSBTAT00000017131; ENSBTAP00000017131; ENSBTAG00000012890. [P12234-1]
ENSBTAT00000053663; ENSBTAP00000048807; ENSBTAG00000012890. [P12234-2]
GeneIDi282477.
KEGGibta:282477.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77338 Genomic DNA. No translation available.
X05340 mRNA. Translation: CAA28951.1.
BC149996 mRNA. Translation: AAI49997.1.
PIRiC53737.
D53737.
RefSeqiNP_777082.1. NM_174657.2. [P12234-1]
XP_005206570.1. XM_005206513.3. [P12234-2]
UniGeneiBt.4880.

3D structure databases

ProteinModelPortaliP12234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017131.

Protein family/group databases

TCDBi2.A.29.4.1. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbiP12234.
PeptideAtlasiP12234.
PRIDEiP12234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017131; ENSBTAP00000017131; ENSBTAG00000012890. [P12234-1]
ENSBTAT00000053663; ENSBTAP00000048807; ENSBTAG00000012890. [P12234-2]
GeneIDi282477.
KEGGibta:282477.

Organism-specific databases

CTDi5250.

Phylogenomic databases

eggNOGiKOG0767. Eukaryota.
ENOG410XPST. LUCA.
GeneTreeiENSGT00390000008708.
HOGENOMiHOG000164438.
HOVERGENiHBG024440.
InParanoidiP12234.
KOiK15102.
OMAiLKFYALC.
OrthoDBiEOG091G0FJF.
TreeFamiTF314119.

Gene expression databases

BgeeiENSBTAG00000012890.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPCP_BOVIN
AccessioniPrimary (citable) accession number: P12234
Secondary accession number(s): A6QQU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.