P12115 (KAD1_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase isoenzyme 1
Short name=AK 1
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 1
Myokinase

Gene names

Name:

ak1

Organism

Cyprinus carpio (Common carp)

Taxonomic identifier

7962 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprinus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	ATP metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 194	193	Adenylate kinase isoenzyme 1		PRO_0000158908
Regions
	Nucleotide binding	15 – 23	9	ATP By similarity
	Nucleotide binding	94 – 101	8	AMP By similarity
Sites
	Binding site	39	1	AMP By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P12115 [UniParc]. Last modified July 1, 2008. Version 2. Checksum: 75DF3A42C6BA2A65	FASTA	194	21,489
	10 20 30 40 50 60 MADKIKDAKI VFVVGGPGSG KGTQCEKIVE KYGYTHLSSG DLLRAEVASG SERGKQLQAI 70 80 90 100 110 120 MQKGELVPLD TVLDMIKDAM IAKADVSKGY LIDGYPREVK QGEEFEKKIG APALLLYIDA 130 140 150 160 170 180 KAETMVQRLM KRGQTSGRSD DNEETIKKRL DLYYKATEPV IAYYETRGIV RKINSELPVD 190 EVFAIVVKAI DELK

References

[1]	"Amino acid sequence and three-dimensional structure of cytosolic adenylate kinase from carp muscle." Reuner C., Hable M., Wilmanns M., Kiefer E., Schiltz E., Schulz G.E. Protein Seq. Data Anal. 1:335-343(1988) [PubMed: 2851785] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-194, ACETYLATION AT ALA-2, X-RAY CRYSTALLOGRAPHY (5.8 ANGSTROMS). Tissue: Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	KICAC. S00394.
3D structure databases
ProteinModelPortal	P12115.
SMR	P12115. Positions 1-194.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG108060.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR006267. Adenylate_kin1. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01360. Aden_kin_iso1. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_CYPCA

Accession

Primary (citable) accession number: P12115

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	July 1, 2008
Last modified:	May 31, 2011
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program