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P12105

- CO3A1_CHICK

UniProt

P12105 - CO3A1_CHICK

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Protein
Collagen alpha-1(III) chain
Gene
COL3A1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Collagen type III occurs in most soft connective tissues along with type I collagen.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1076 – 10761Calcium By similarity
Metal bindingi1078 – 10781Calcium By similarity
Metal bindingi1079 – 10791Calcium; via carbonyl oxygen By similarity
Metal bindingi1081 – 10811Calcium; via carbonyl oxygen By similarity
Metal bindingi1084 – 10841Calcium By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_197897. Syndecan interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(III) chain
Gene namesi
Name:COL3A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: Reactome
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Propeptidei24 – 150127N-terminal propeptide By similarity
PRO_0000005737Add
BLAST
Chaini151 – 1017867Collagen alpha-1(III) chain
PRO_0000005738Add
BLAST
Propeptidei1018 – 1262245C-terminal propeptide By similarity
PRO_0000005739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 26215-hydroxylysine By similarity
Modified residuei283 – 28315-hydroxylysine By similarity
Modified residuei859 – 85915-hydroxylysine By similarity
Disulfide bondi994 – 994Interchain By similarity
Disulfide bondi995 – 995Interchain By similarity
Disulfide bondi1058 ↔ 1090 By similarity
Disulfide bondi1064 – 1064Interchain (with C-1285) By similarity
Disulfide bondi1081 – 1081Interchain (with C-1268) By similarity
Disulfide bondi1098 ↔ 1260 By similarity
Glycosylationi1163 – 11631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1168 ↔ 1213 By similarity

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP12105.

Interactioni

Subunit structurei

Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

Structurei

3D structure databases

ProteinModelPortaliP12105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 8860VWFC
Add
BLAST
Domaini1028 – 1262235Fibrillar collagen NC1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 16420Nonhelical region (N-terminal)
Add
BLAST
Regioni165 – 994830Triple-helical region
Add
BLAST
Regioni995 – 10039Nonhelical region (C-terminal)

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Sequence similaritiesi

Contains 1 VWFC domain.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG004933.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF00093. VWC. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12105-1 [UniParc]FASTAAdd to Basket

« Hide

MMSFVQKVSL FILAVFQPSV ILAQQDALGG CTHLGQEYAD RDVWKPEPCQ     50
ICVCDSGSVL CDDIICDDQE LDCPNPEIPL GECCPVCPQT TPQPTELPYT 100
QGPKGDPGSP GSPGRTGAPG PPGQPGSPGA PGPPGICQSC PSISGGSFSP 150
QYDSYDVKAG SVGMGYPPQP ISGFPGPPGP SGPPGPPGHA GPPGSNGYQG 200
PPGEPGQPGP SGPPGPAGMI GPAGPPGKDG EPGRPGRNGD RGIPGLPGHK 250
GHPGMPGMPG MKGARGFDGK DGAKGDSGAP GPKGEAGQPG ANGSPGQPGP 300
GGPTGERGRP GNPGGPGAHG KDGAPGTAGP LGPPGPPGTA GFPGSPGFKG 350
EAGPPGPAGA SGNPGERGEP GPQGQAGPPG PQGPPGRAGS PGGKGEMGPS 400
GIPGGPGPPG GRGLPGPPGT SGNPGAKGTP GEPGKNGAKG DPGPKGERGE 450
NGTPGARGPP GEEGKRGANG EPGQNGVPGT PGERGSPGFR GLPGSNGLPG 500
EKGPAGERGS PGPPGPSGPA GDRGQDGGPG LPGMRGLPGI PGSPGSDGKP 550
GPPGNQGEPG RSGPPGPAGP RGQPGVMGFP GPKGNEGAPG KNGERGPGGP 600
PGTPGPAGKN GDVGLPGPPG PAGPAGDRGE PGPSGSPGLQ GLPGGPGPAG 650
ENGKPGEPGP KGDIGGPGFP GPKGENGIPG ERGPQGPPGP TGARGGPGPA 700
GSEGAKGPPG PPGAPGGTGL PGLQGMPGER GASGSPGPKG DKGEPGGKGA 750
DGLPGARGER GNVGPIGPPG PAGPPGDKGE TGPAGAPGPA GSRGGPGERG 800
EQGLPGPAGF PGAPGQNGEP GGKGERGPPG LRGEAGPPGA AGPQGGPGAP 850
GPPGPQGVKG ERGSPGGPGA AGFPGARGPP GPPGNNGDRG ESGPPGVPGP 900
PGHPGPAGNN GAPGKAGERG FQGPLGPQGA IGSPGASGAR GPPGPAGPPG 950
KDGRGGYPGP IGPPGPRGNR GESGPAGPPG QPGLPGPSGP PGPCCGGGVA 1000
SLGAGEKGPV GYGYEYRDEP KENEINLGEI MSSMKSINNQ IENILSPDGS 1050
RKNPARNCRD LKFCHPELKS GEYWIDPNQG CKMDAIKVYC NMETGETCLS 1100
ANPATVPRKN WWTTESSGKK HVWFGESMKG GFQFSYGDPD LPEDVSEVQL 1150
AFLRILSSRA SQNITYHCKN SIAYMNQASG NVKKALKLMS SVETDIKAEG 1200
NSKYMYAVLE DGCTKHTGEW GKTVFEYRTR KTMRLPVVDI APIDIGGPDQ 1250
EFGVDVGPVC FL 1262
Length:1,262
Mass (Da):121,249
Last modified:August 29, 2001 - v2
Checksum:i96ABE7B2E9DEB43D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961E → K1 Publication
Sequence conflicti881 – 8811G → R in CAA23689. 1 Publication
Sequence conflicti884 – 8841G → V in CAA23689. 1 Publication
Sequence conflicti984 – 9841L → V in CAA23690. 1 Publication
Sequence conflicti1132 – 11321F → S in AAA18519. 1 Publication

Non-adjacent residues

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi886 – 8872
Non-adjacent residuesi922 – 9232

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07973 mRNA. Translation: AAA83407.1.
X00822, X00823 Genomic DNA. Translation: CAB52686.1.
X00826, X00825 Genomic DNA. Translation: CAA25397.1. Sequence problems.
X00827 Genomic DNA. Translation: CAA25398.1.
X00828 Genomic DNA. Translation: CAA25399.1.
X00830 Genomic DNA. Translation: CAA25401.1.
X00831 Genomic DNA. Translation: CAA25402.1.
K02302 Genomic DNA. Translation: AAD15299.1.
K02301 Genomic DNA. Translation: AAD15298.1.
V00391 Genomic DNA. Translation: CAA23689.1.
V00392 Genomic DNA. Translation: CAA23690.1.
M36662 Unassigned DNA. Translation: AAA18519.1. Sequence problems.
PIRiA05269.
I50694.
UniGeneiGga.42140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07973 mRNA. Translation: AAA83407.1 .
X00822 , X00823 Genomic DNA. Translation: CAB52686.1 .
X00826 , X00825 Genomic DNA. Translation: CAA25397.1 . Sequence problems.
X00827 Genomic DNA. Translation: CAA25398.1 .
X00828 Genomic DNA. Translation: CAA25399.1 .
X00830 Genomic DNA. Translation: CAA25401.1 .
X00831 Genomic DNA. Translation: CAA25402.1 .
K02302 Genomic DNA. Translation: AAD15299.1 .
K02301 Genomic DNA. Translation: AAD15298.1 .
V00391 Genomic DNA. Translation: CAA23689.1 .
V00392 Genomic DNA. Translation: CAA23690.1 .
M36662 Unassigned DNA. Translation: AAA18519.1 . Sequence problems.
PIRi A05269.
I50694.
UniGenei Gga.42140.

3D structure databases

ProteinModelPortali P12105.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P12105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG004933.

Enzyme and pathway databases

Reactomei REACT_197897. Syndecan interactions.

Miscellaneous databases

PROi P12105.

Family and domain databases

InterProi IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An alternative transcript of the chick type III collagen gene that does not encode type III collagen."
    Nah H.-D., Niu Z., Adams S.L.
    J. Biol. Chem. 269:16443-16448(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-886.
    Tissue: Kidney.
  2. "Conservation of the sizes for one but not another class of exons in two chick collagen genes."
    Yamada Y., Liau G., Mudryj M., Obici S., de Crombrugghe B.
    Nature 310:333-337(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-96; 332-397; 431-484; 503-535 AND 869-976.
  3. "Isolation and characterization of a genomic clone encoding chick alpha-1 type III collagen."
    Yamada Y., Mudryj M., Sullivan M., de Crombrugghe B.
    J. Biol. Chem. 258:2758-2761(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 869-886 AND 977-994.
  4. "A conserved nucleotide sequence, coding for a segment of the C-propeptide, is found at the same location in different collagen genes."
    Yamada Y., Kuhn K., de Crombrugghe B.
    Nucleic Acids Res. 11:2733-2744(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 977-1262.

Entry informationi

Entry nameiCO3A1_CHICK
AccessioniPrimary (citable) accession number: P12105
Secondary accession number(s): P79758
, P79759, Q90790, Q90791, Q90794, Q92029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 29, 2001
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi