Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P12104

- FABPI_HUMAN

UniProt

P12104 - FABPI_HUMAN

Protein

Fatty acid-binding protein, intestinal

Gene

FABP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831Fatty acidBy similarity
    Binding sitei107 – 1071Fatty acidBy similarity

    GO - Molecular functioni

    1. fatty acid binding Source: ProtInc
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. digestion Source: ProtInc

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty acid-binding protein, intestinal
    Alternative name(s):
    Fatty acid-binding protein 2
    Intestinal-type fatty acid-binding protein
    Short name:
    I-FABP
    Gene namesi
    Name:FABP2
    Synonyms:FABPI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3556. FABP2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi39 – 391L → G: Reduced stability. 1 Publication
    Mutagenesisi64 – 641E → G: Localized reduction in stability. 1 Publication
    Mutagenesisi65 – 651L → A: Reduced stability. 1 Publication
    Mutagenesisi65 – 651L → G: Reduced stability. 1 Publication
    Mutagenesisi67 – 671V → G: Localized reduction in stability. 1 Publication
    Mutagenesisi90 – 901L → G: Reduced stability. 1 Publication
    Mutagenesisi123 – 1231V → G: Reduced stability. 1 Publication

    Organism-specific databases

    PharmGKBiPA27957.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 132131Fatty acid-binding protein, intestinalPRO_0000067328Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP12104.
    PRIDEiP12104.

    PTM databases

    PhosphoSiteiP12104.

    Expressioni

    Tissue specificityi

    Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.1 Publication

    Inductioni

    By EGF.1 Publication

    Gene expression databases

    BgeeiP12104.
    CleanExiHS_FABP2.
    GenevestigatoriP12104.

    Organism-specific databases

    HPAiCAB047325.
    CAB047326.
    HPA034607.

    Interactioni

    Protein-protein interaction databases

    BioGridi108467. 2 interactions.
    IntActiP12104. 1 interaction.
    STRINGi9606.ENSP00000274024.

    Structurei

    Secondary structure

    1
    132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 1410
    Helixi15 – 228
    Helixi26 – 327
    Turni33 – 353
    Beta strandi38 – 447
    Beta strandi47 – 537
    Beta strandi58 – 647
    Beta strandi69 – 724
    Beta strandi74 – 763
    Beta strandi78 – 869
    Beta strandi89 – 968
    Turni97 – 993
    Beta strandi102 – 1109
    Beta strandi113 – 1208
    Beta strandi123 – 1319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KZWNMR-A2-132[»]
    1KZXNMR-A2-132[»]
    3AKMX-ray1.90A/B/C/D2-132[»]
    3IFBNMR-A2-132[»]
    ProteinModelPortaliP12104.
    SMRiP12104. Positions 2-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12104.

    Family & Domainsi

    Domaini

    Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG295259.
    HOGENOMiHOG000004829.
    HOVERGENiHBG005633.
    InParanoidiP12104.
    KOiK08751.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiP12104.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV    50
    KESSAFRNIE VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG 100
    NELNTVREII GDELVQTYVY EGVEAKRIFK KD 132
    Length:132
    Mass (Da):15,207
    Last modified:January 23, 2007 - v2
    Checksum:i68330E3D81792CAF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551A → T in 29% of the population; 2-fold greater affinity for long-chain fatty acids; increased fat oxidation and insulin resistance. 3 Publications
    Corresponds to variant rs1799883 [ dbSNP | Ensembl ].
    VAR_002379

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18079 Genomic DNA. Translation: AAA52417.1.
    AC092656 Genomic DNA. No translation available.
    BC069466 mRNA. Translation: AAH69466.1.
    BC069617 mRNA. Translation: AAH69617.1.
    BC069625 mRNA. Translation: AAH69625.1.
    BC069637 mRNA. Translation: AAH69637.1.
    BC111791 mRNA. Translation: AAI11792.1.
    CCDSiCCDS3712.1.
    PIRiA29781. FZHUI.
    RefSeqiNP_000125.2. NM_000134.3.
    UniGeneiHs.282265.

    Genome annotation databases

    EnsembliENST00000274024; ENSP00000274024; ENSG00000145384.
    GeneIDi2169.
    KEGGihsa:2169.
    UCSCiuc003icw.3. human.

    Polymorphism databases

    DMDMi119805.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18079 Genomic DNA. Translation: AAA52417.1 .
    AC092656 Genomic DNA. No translation available.
    BC069466 mRNA. Translation: AAH69466.1 .
    BC069617 mRNA. Translation: AAH69617.1 .
    BC069625 mRNA. Translation: AAH69625.1 .
    BC069637 mRNA. Translation: AAH69637.1 .
    BC111791 mRNA. Translation: AAI11792.1 .
    CCDSi CCDS3712.1.
    PIRi A29781. FZHUI.
    RefSeqi NP_000125.2. NM_000134.3.
    UniGenei Hs.282265.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KZW NMR - A 2-132 [» ]
    1KZX NMR - A 2-132 [» ]
    3AKM X-ray 1.90 A/B/C/D 2-132 [» ]
    3IFB NMR - A 2-132 [» ]
    ProteinModelPortali P12104.
    SMRi P12104. Positions 2-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108467. 2 interactions.
    IntActi P12104. 1 interaction.
    STRINGi 9606.ENSP00000274024.

    Chemistry

    BindingDBi P12104.
    ChEMBLi CHEMBL4879.

    PTM databases

    PhosphoSitei P12104.

    Polymorphism databases

    DMDMi 119805.

    Proteomic databases

    PaxDbi P12104.
    PRIDEi P12104.

    Protocols and materials databases

    DNASUi 2169.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274024 ; ENSP00000274024 ; ENSG00000145384 .
    GeneIDi 2169.
    KEGGi hsa:2169.
    UCSCi uc003icw.3. human.

    Organism-specific databases

    CTDi 2169.
    GeneCardsi GC04M120238.
    H-InvDB HIX0004469.
    HGNCi HGNC:3556. FABP2.
    HPAi CAB047325.
    CAB047326.
    HPA034607.
    MIMi 134640. gene.
    neXtProti NX_P12104.
    PharmGKBi PA27957.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295259.
    HOGENOMi HOG000004829.
    HOVERGENi HBG005633.
    InParanoidi P12104.
    KOi K08751.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi P12104.
    TreeFami TF316894.

    Miscellaneous databases

    ChiTaRSi FABP2. human.
    EvolutionaryTracei P12104.
    GeneWikii FABP2.
    GenomeRNAii 2169.
    NextBioi 8759.
    PROi P12104.
    SOURCEi Search...

    Gene expression databases

    Bgeei P12104.
    CleanExi HS_FABP2.
    Genevestigatori P12104.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships."
      Sweetser D.A., Birkenmeier E.H., Klisak I.J., Zollman S., Sparkes R.S., Mohandas T., Lusis A.J., Gordon J.I.
      J. Biol. Chem. 262:16060-16071(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-55.
    4. "Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility."
      Pelsers M.M.A.L., Namiot Z., Kisielewski W., Namiot A., Januszkiewicz M., Hermens W.T., Glatz J.F.C.
      Clin. Biochem. 36:529-535(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells."
      Darimont C., Gradoux N., de Pover A.
      Am. J. Physiol. 276:G606-G612(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY EGF.
    6. "Consequences of single-site mutations in the intestinal fatty acid binding protein."
      Rajabzadeh M., Kao J., Frieden C.
      Biochemistry 42:12192-12199(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF LEU-39; GLU-64; LEU-65; VAL-67; LEU-90 AND VAL-123.
    7. "Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit."
      Zhang F., Luecke C., Baier L.J., Sacchettini J.C., Hamilton J.A.
      J. Biomol. NMR 9:213-228(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
      Tissue: Intestine.
    8. "Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism."
      Zhang F., Luecke C., Baier L.J., Sacchettini J.C., Hamilton J.A.
      Biochemistry 42:7339-7347(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF VARIANT THR-55.
    9. "An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance."
      Baier L.J., Sacchettini J.C., Knowler W.C., Eads J., Paolisso G., Tataranni P.A., Mochizuki H., Bennett P.H., Bogardus C., Prochazka M.
      J. Clin. Invest. 95:1281-1287(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-55.
    10. "The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots."
      Kunsan X., Taisan Z., Weiping J., Duoqi S., Wei D., Jie L., Junxi L., Rong Z.
      Chin. Med. Sci. J. 14:46-51(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-55.

    Entry informationi

    Entry nameiFABPI_HUMAN
    AccessioniPrimary (citable) accession number: P12104
    Secondary accession number(s): Q2NKJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3