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Protein

Histidine--tRNA ligase, cytoplasmic

Gene

HARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance.Curated1 Publication

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • histidine-tRNA ligase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10130-MONOMER.
BRENDAi6.1.1.21. 2681.
ReactomeiR-HSA-379716. Cytosolic tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase, cytoplasmic (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:HARS
Synonyms:HRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:4816. HARS.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • cytosol Source: Reactome
  • mitochondrion Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Usher syndrome 3B (USH3B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by progressive vision and hearing loss during early childhood. Some patients have the so-called 'Charles Bonnet syndrome,' involving decreased visual acuity and vivid visual hallucinations. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual, progressive hearing loss, variable vestibular dysfunction, and onset of retinitis pigmentosa symptoms, including nyctalopia, constriction of the visual fields, and loss of central visual acuity, usually by the second decade of life.
See also OMIM:614504
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067918454Y → S in USH3B. 1 PublicationCorresponds to variant rs387906639dbSNPEnsembl.1
Charcot-Marie-Tooth disease 2W (CMT2W)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant, axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2W patients manifest a peripheral neuropathy mainly affecting the lower limbs and resulting in gait difficulties and distal sensory impairment. Most patients also have upper limb involvement.
See also OMIM:616625
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075064132T → I in CMT2W; loss-of-function mutation. 1 Publication1
Natural variantiVAR_075065134P → H in CMT2W; loss-of-function mutation. 1 Publication1
Natural variantiVAR_069022137R → Q in CMT2W; has a neurotoxic effect in an animal model; results in loss of function. 1 PublicationCorresponds to variant rs191391414dbSNPEnsembl.1
Natural variantiVAR_075066175D → E in CMT2W; hypomorphic mutation. 1 Publication1
Natural variantiVAR_069024238V → A in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant rs536175170dbSNPEnsembl.1
Natural variantiVAR_075067364D → Y in CMT2W; loss-of-function mutation. 1 Publication1
Natural variantiVAR_069026505P → S in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant rs747156884dbSNPEnsembl.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Deafness, Disease mutation, Neurodegeneration, Neuropathy, Retinitis pigmentosa, Usher syndrome

Organism-specific databases

DisGeNETi3035.
MalaCardsiHARS.
MIMi614504. phenotype.
616625. phenotype.
OpenTargetsiENSG00000170445.
Orphaneti231183. Usher syndrome type 3.
PharmGKBiPA29191.

Chemistry databases

ChEMBLiCHEMBL4002.
DrugBankiDB00117. L-Histidine.

Polymorphism and mutation databases

BioMutaiHARS.
DMDMi135123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001363322 – 509Histidine--tRNA ligase, cytoplasmicAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei356PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP12081.
MaxQBiP12081.
PaxDbiP12081.
PeptideAtlasiP12081.
PRIDEiP12081.

PTM databases

iPTMnetiP12081.
PhosphoSitePlusiP12081.
SwissPalmiP12081.

Expressioni

Tissue specificityi

Brain, heart, liver and kidney.

Gene expression databases

BgeeiENSG00000170445.
CleanExiHS_HARS.
ExpressionAtlasiP12081. baseline and differential.
GenevisibleiP12081. HS.

Organism-specific databases

HPAiHPA036539.

Interactioni

Protein-protein interaction databases

BioGridi109285. 48 interactors.
DIPiDIP-37596N.
IntActiP12081. 3 interactors.
MINTiMINT-3007818.
STRINGi9606.ENSP00000425634.

Chemistry databases

BindingDBiP12081.

Structurei

Secondary structure

1509
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 23Combined sources22
Helixi28 – 45Combined sources18
Helixi67 – 86Combined sources20
Beta strandi96 – 99Combined sources4
Helixi100 – 103Combined sources4
Turni104 – 106Combined sources3
Helixi109 – 113Combined sources5
Beta strandi120 – 122Combined sources3
Beta strandi125 – 127Combined sources3
Helixi132 – 141Combined sources10
Beta strandi147 – 156Combined sources10
Beta strandi163 – 165Combined sources3
Beta strandi169 – 180Combined sources12
Helixi186 – 202Combined sources17
Beta strandi207 – 213Combined sources7
Helixi214 – 224Combined sources11
Helixi228 – 238Combined sources11
Helixi239 – 242Combined sources4
Helixi246 – 255Combined sources10
Helixi261 – 271Combined sources11
Beta strandi274 – 276Combined sources3
Helixi277 – 283Combined sources7
Helixi287 – 290Combined sources4
Helixi293 – 311Combined sources19
Helixi315 – 317Combined sources3
Beta strandi318 – 321Combined sources4
Turni328 – 330Combined sources3
Beta strandi332 – 342Combined sources11
Beta strandi352 – 362Combined sources11
Helixi367 – 369Combined sources3
Beta strandi371 – 373Combined sources3
Beta strandi379 – 384Combined sources6
Helixi386 – 398Combined sources13
Turni399 – 401Combined sources3
Beta strandi411 – 414Combined sources4
Beta strandi416 – 419Combined sources4
Helixi421 – 433Combined sources13
Beta strandi438 – 440Combined sources3
Beta strandi442 – 445Combined sources4
Helixi448 – 458Combined sources11
Beta strandi462 – 465Combined sources4
Helixi468 – 473Combined sources6
Beta strandi475 – 480Combined sources6
Turni481 – 483Combined sources3
Beta strandi486 – 490Combined sources5
Helixi491 – 493Combined sources3
Helixi494 – 502Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X59NMR-A1-60[»]
2LW7NMR-A2-509[»]
4G84X-ray2.40A/B54-506[»]
4G85X-ray3.11A/B1-506[»]
4PHCX-ray2.84A/B/C/D1-509[»]
4X5OX-ray2.80A/B1-509[»]
ProteinModelPortaliP12081.
SMRiP12081.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 59WHEP-TRSAdd BLAST57

Sequence similaritiesi

Contains 1 WHEP-TRS domain.Curated

Phylogenomic databases

eggNOGiKOG1936. Eukaryota.
COG0124. LUCA.
GeneTreeiENSGT00390000005922.
HOGENOMiHOG000018075.
HOVERGENiHBG002731.
InParanoidiP12081.
KOiK01892.
OMAiTRDYGPQ.
OrthoDBiEOG091G05P3.
PhylomeDBiP12081.
TreeFamiTF300652.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di1.10.287.10. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
IPR009068. S15_NS1_RNA-bd.
IPR000738. WHEP-TRS_dom.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00458. WHEP-TRS. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SMARTiSM00991. WHEP-TRS. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
SSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00762. WHEP_TRS_1. 1 hit.
PS51185. WHEP_TRS_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES
60 70 80 90 100
KQKFVLKTPK GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK
110 120 130 140 150
ETLMGKYGED SKLIYDLKDQ GGELLSLRYD LTVPFARYLA MNKLTNIKRY
160 170 180 190 200
HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG NFDPMIPDAE CLKIMCEILS
210 220 230 240 250
SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK LDKVSWEEVK
260 270 280 290 300
NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
310 320 330 340 350
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE
360 370 380 390 400
PLGVGSVAAG GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL
410 420 430 440 450
EEKIRTTETQ VLVASAQKKL LEERLKLVSE LWDAGIKAEL LYKKNPKLLN
460 470 480 490 500
QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS VTSREEVDVR REDLVEEIKR

RTGQPLCIC
Length:509
Mass (Da):57,411
Last modified:May 1, 1992 - v2
Checksum:i65D8BB71CE79B1FF
GO
Isoform 2 (identifier: P12081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-99: Missing.

Show »
Length:469
Mass (Da):52,720
Checksum:iB02783AB9FED1E1D
GO
Isoform 3 (identifier: P12081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-99: Missing.
     155-174: Missing.

Show »
Length:449
Mass (Da):50,156
Checksum:i9B97F9CC4FE63BB9
GO
Isoform 4 (identifier: P12081-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-174: Missing.

Show »
Length:489
Mass (Da):54,847
Checksum:iE0C0825FF411F391
GO

Sequence cautioni

The sequence CAA28956 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → P in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti126S → P in BAG58213 (PubMed:14702039).Curated1
Sequence conflicti165R → G in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti181N → Q in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti186I → N in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti191C → S in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti206D → N in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti223I → V in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti227S → P in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti284L → V in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti347A → E in CAA28956 (PubMed:3554142).Curated1
Sequence conflicti373 – 374KG → QR in CAA28956 (PubMed:3554142).Curated2
Sequence conflicti375R → L in BAG58213 (PubMed:14702039).Curated1
Sequence conflicti493D → E in CAA28956 (PubMed:3554142).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0690215A → E.1 PublicationCorresponds to variant rs78741041dbSNPEnsembl.1
Natural variantiVAR_075064132T → I in CMT2W; loss-of-function mutation. 1 Publication1
Natural variantiVAR_075065134P → H in CMT2W; loss-of-function mutation. 1 Publication1
Natural variantiVAR_069022137R → Q in CMT2W; has a neurotoxic effect in an animal model; results in loss of function. 1 PublicationCorresponds to variant rs191391414dbSNPEnsembl.1
Natural variantiVAR_075066175D → E in CMT2W; hypomorphic mutation. 1 Publication1
Natural variantiVAR_069023205G → D.1 PublicationCorresponds to variant rs147288996dbSNPEnsembl.1
Natural variantiVAR_069024238V → A in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant rs536175170dbSNPEnsembl.1
Natural variantiVAR_075067364D → Y in CMT2W; loss-of-function mutation. 1 Publication1
Natural variantiVAR_069025376K → R.1 PublicationCorresponds to variant rs139447495dbSNPEnsembl.1
Natural variantiVAR_061908399A → V.Corresponds to variant rs34732372dbSNPEnsembl.1
Natural variantiVAR_067918454Y → S in USH3B. 1 PublicationCorresponds to variant rs387906639dbSNPEnsembl.1
Natural variantiVAR_069026505P → S in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant rs747156884dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04511860 – 99Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_046662155 – 174Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11518 mRNA. Translation: CAA77607.1.
X05345 mRNA. Translation: CAA28956.1. Frameshift.
AK295219 mRNA. Translation: BAG58213.1.
AK302295 mRNA. Translation: BAG63635.1.
AK225776 mRNA. No translation available.
AC116353 Genomic DNA. No translation available.
BC011807 mRNA. Translation: AAH11807.1.
BC080514 mRNA. Translation: AAH80514.1.
M96646 Genomic DNA. Translation: AAA58668.1.
U18936 Genomic DNA. Translation: AAA73973.1.
CCDSiCCDS4237.1. [P12081-1]
CCDS58976.1. [P12081-2]
CCDS58977.1. [P12081-3]
CCDS58978.1. [P12081-4]
PIRiI37559. SYHUHT.
RefSeqiNP_001244969.1. NM_001258040.2. [P12081-2]
NP_001244970.1. NM_001258041.2. [P12081-4]
NP_001244971.1. NM_001258042.2. [P12081-3]
NP_002100.2. NM_002109.5. [P12081-1]
UniGeneiHs.528050.

Genome annotation databases

EnsembliENST00000307633; ENSP00000304668; ENSG00000170445. [P12081-3]
ENST00000438307; ENSP00000411511; ENSG00000170445. [P12081-2]
ENST00000457527; ENSP00000387893; ENSG00000170445. [P12081-4]
ENST00000504156; ENSP00000425634; ENSG00000170445. [P12081-1]
GeneIDi3035.
KEGGihsa:3035.
UCSCiuc003lgv.6. human. [P12081-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11518 mRNA. Translation: CAA77607.1.
X05345 mRNA. Translation: CAA28956.1. Frameshift.
AK295219 mRNA. Translation: BAG58213.1.
AK302295 mRNA. Translation: BAG63635.1.
AK225776 mRNA. No translation available.
AC116353 Genomic DNA. No translation available.
BC011807 mRNA. Translation: AAH11807.1.
BC080514 mRNA. Translation: AAH80514.1.
M96646 Genomic DNA. Translation: AAA58668.1.
U18936 Genomic DNA. Translation: AAA73973.1.
CCDSiCCDS4237.1. [P12081-1]
CCDS58976.1. [P12081-2]
CCDS58977.1. [P12081-3]
CCDS58978.1. [P12081-4]
PIRiI37559. SYHUHT.
RefSeqiNP_001244969.1. NM_001258040.2. [P12081-2]
NP_001244970.1. NM_001258041.2. [P12081-4]
NP_001244971.1. NM_001258042.2. [P12081-3]
NP_002100.2. NM_002109.5. [P12081-1]
UniGeneiHs.528050.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X59NMR-A1-60[»]
2LW7NMR-A2-509[»]
4G84X-ray2.40A/B54-506[»]
4G85X-ray3.11A/B1-506[»]
4PHCX-ray2.84A/B/C/D1-509[»]
4X5OX-ray2.80A/B1-509[»]
ProteinModelPortaliP12081.
SMRiP12081.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109285. 48 interactors.
DIPiDIP-37596N.
IntActiP12081. 3 interactors.
MINTiMINT-3007818.
STRINGi9606.ENSP00000425634.

Chemistry databases

BindingDBiP12081.
ChEMBLiCHEMBL4002.
DrugBankiDB00117. L-Histidine.

PTM databases

iPTMnetiP12081.
PhosphoSitePlusiP12081.
SwissPalmiP12081.

Polymorphism and mutation databases

BioMutaiHARS.
DMDMi135123.

Proteomic databases

EPDiP12081.
MaxQBiP12081.
PaxDbiP12081.
PeptideAtlasiP12081.
PRIDEiP12081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307633; ENSP00000304668; ENSG00000170445. [P12081-3]
ENST00000438307; ENSP00000411511; ENSG00000170445. [P12081-2]
ENST00000457527; ENSP00000387893; ENSG00000170445. [P12081-4]
ENST00000504156; ENSP00000425634; ENSG00000170445. [P12081-1]
GeneIDi3035.
KEGGihsa:3035.
UCSCiuc003lgv.6. human. [P12081-1]

Organism-specific databases

CTDi3035.
DisGeNETi3035.
GeneCardsiHARS.
HGNCiHGNC:4816. HARS.
HPAiHPA036539.
MalaCardsiHARS.
MIMi142810. gene.
614504. phenotype.
616625. phenotype.
neXtProtiNX_P12081.
OpenTargetsiENSG00000170445.
Orphaneti231183. Usher syndrome type 3.
PharmGKBiPA29191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1936. Eukaryota.
COG0124. LUCA.
GeneTreeiENSGT00390000005922.
HOGENOMiHOG000018075.
HOVERGENiHBG002731.
InParanoidiP12081.
KOiK01892.
OMAiTRDYGPQ.
OrthoDBiEOG091G05P3.
PhylomeDBiP12081.
TreeFamiTF300652.

Enzyme and pathway databases

BioCyciZFISH:HS10130-MONOMER.
BRENDAi6.1.1.21. 2681.
ReactomeiR-HSA-379716. Cytosolic tRNA aminoacylation.

Miscellaneous databases

ChiTaRSiHARS. human.
EvolutionaryTraceiP12081.
GeneWikiiHARS.
GenomeRNAii3035.
PROiP12081.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170445.
CleanExiHS_HARS.
ExpressionAtlasiP12081. baseline and differential.
GenevisibleiP12081. HS.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di1.10.287.10. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
IPR009068. S15_NS1_RNA-bd.
IPR000738. WHEP-TRS_dom.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00458. WHEP-TRS. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SMARTiSM00991. WHEP-TRS. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
SSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00762. WHEP_TRS_1. 1 hit.
PS51185. WHEP_TRS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYHC_HUMAN
AccessioniPrimary (citable) accession number: P12081
Secondary accession number(s): B4DHQ1
, B4DY73, D6REN6, J3KNE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.