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Protein

Integrin alpha-PS2

Gene

if

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.4 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • extracellular matrix binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase
  • receptor activity Source: FlyBase

GO - Biological processi

  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • axonal defasciculation Source: FlyBase
  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell adhesion mediated by integrin Source: FlyBase
  • cell-matrix adhesion Source: FlyBase
  • cell migration Source: FlyBase
  • central nervous system morphogenesis Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • hemocyte migration Source: FlyBase
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • maintenance of epithelial integrity, open tracheal system Source: FlyBase
  • maintenance of protein location Source: FlyBase
  • midgut development Source: FlyBase
  • muscle attachment Source: FlyBase
  • myofibril assembly Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of stress fiber assembly Source: FlyBase
  • salivary gland development Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • sarcomere organization Source: FlyBase
  • sensory perception of smell Source: FlyBase
  • single organismal cell-cell adhesion Source: FlyBase
  • substrate adhesion-dependent cell spreading Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-DME-1566948. Elastic fibre formation.
R-DME-2129379. Molecules associated with elastic fibres.
R-DME-216083. Integrin cell surface interactions.
R-DME-3000170. Syndecan interactions.
R-DME-3000178. ECM proteoglycans.
R-DME-354192. Integrin alphaIIb beta3 signaling.
R-DME-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-DME-372708. p130Cas linkage to MAPK signaling for integrins.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-PS2
Alternative name(s):
Position-specific antigen subunit alpha-2
Protein inflated
Cleaved into the following 2 chains:
Gene namesi
Name:if
ORF Names:CG9623
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001250. if.

Subcellular locationi

  • Apical cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Lateral cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Basal cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

  • Note: During mid-oogenesis, localizes to the apical, to the lateral and to the basal membranes of follicle cells. Apical membrane localization peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte while decreases in the most posterior follicle cells. During embryogenesis, at the end of germband extension concentrates at the basal membrane of mesodermal cells, where they adhere to the ectoderm. Then, in visceral mesoderm localizes basally, whereas in somatic mesoderm is homogenously distributed.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 13411310ExtracellularSequence analysisAdd
BLAST
Transmembranei1342 – 136625HelicalSequence analysisAdd
BLAST
Topological domaini1367 – 139630CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • basal plasma membrane Source: FlyBase
  • focal adhesion Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • integrin complex Source: FlyBase
  • lateral plasma membrane Source: UniProtKB-SubCell
  • plasma membrane Source: FlyBase
  • sarcolemma Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 13961365Integrin alpha-PS2PRO_0000016323Add
BLAST
Chaini32 – ?12431212Integrin alpha-PS2 heavy chainPRO_0000016324Add
BLAST
Chaini?1244 – 1396153Integrin alpha-PS2 light chainPRO_0000016325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence analysis
Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence analysis
Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence analysis
Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence analysis
Glycosylationi783 – 7831N-linked (GlcNAc...)Sequence analysis
Glycosylationi833 – 8331N-linked (GlcNAc...)Sequence analysis
Glycosylationi959 – 9591N-linked (GlcNAc...)Sequence analysis
Glycosylationi1005 – 10051N-linked (GlcNAc...)Sequence analysis
Glycosylationi1299 – 12991N-linked (GlcNAc...)Sequence analysis
Glycosylationi1307 – 13071N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The heavy-light chain cleavage site is either in 1230-1231, or 1233-1234, or 1243-1244.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12080.

Expressioni

Tissue specificityi

In ovaries, highly expressed in follicle cells. At syncytial blastoderm stage, expressed in the embryonic mesodermal precursors but not in the ectoderm. At embryonic stages 7 and 10, expression is restricted to the mesoderm. At stage 12, expressed in the gonadal sheath and the interstitial cells of the gonad. In stage 16 embryos, expressed in the somatic and visceral muscles where localizes to sites of attachment between adjacent muscles. In third larval instar wing imaginal disk, expressed in the ventral compartment and in a subset of adepithelial and peripodial cells (at protein level).4 Publications

Developmental stagei

Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar (at protein level). The relative ratio of isoform 1/PS2C and isoform 2/PS2M8 varies widely during development.3 Publications

Gene expression databases

BgeeiFBgn0001250.
GenevisibleiP12080. DM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi58994. 15 interactions.
DIPiDIP-23111N.
IntActiP12080. 2 interactions.
MINTiMINT-836239.
STRINGi7227.FBpp0074131.

Structurei

3D structure databases

ProteinModelPortaliP12080.
SMRiP12080. Positions 32-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 10671FG-GAP 1PROSITE-ProRule annotationAdd
BLAST
Repeati117 – 17458FG-GAP 2PROSITE-ProRule annotationAdd
BLAST
Repeati186 – 23954FG-GAP 3PROSITE-ProRule annotationAdd
BLAST
Repeati266 – 31752FG-GAP 4PROSITE-ProRule annotationAdd
BLAST
Repeati318 – 38366FG-GAP 5PROSITE-ProRule annotationAdd
BLAST
Repeati386 – 44560FG-GAP 6PROSITE-ProRule annotationAdd
BLAST
Repeati452 – 51463FG-GAP 7PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi932 – 9387Ser-rich
Compositional biasi1015 – 10239Ser-rich
Compositional biasi1049 – 10546Ser-rich
Compositional biasi1217 – 122610Ser-rich

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
InParanoidiP12080.
OMAiQVVHIYE.
OrthoDBiEOG091G02JI.
PhylomeDBiP12080.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 4 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PS2C (identifier: P12080-1) [UniParc]FASTAAdd to basket
Also known as: D, F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGDSIHRRR MALHCPITSL ILLLIAMSAH GYNIDLPSYV RFRQSSNSMF
60 70 80 90 100
GFSIAMHKGR SGFYGNQNNV SLIVGAPKFD TSRYQQGVTE AGGVFKCSLN
110 120 130 140 150
DDDCKLVPFD SKGNNRNVDK EVVDRKSYQW LGATVATGRD SDLVVACAPR
160 170 180 190 200
YVFHTMTPSR AFRIDPVGTC FTSHNFEEFY EVSPCRTNNW GYHRQGSCQA
210 220 230 240 250
GFSAAINGNG SRLFIGAPGS WYWQGQTYSI PPDAKFPFKP PLYQPFGTGG
260 270 280 290 300
MASSHDVTRP ENQVFSTSES ASVNDDSYLG YSMVTGDFDG DRSEDVAIGM
310 320 330 340 350
PRGGNLVGRI VVNRWNMANI FNITGRQIGE YFGYSLATSD VDGDGLDDLL
360 370 380 390 400
IGAPMYTDPD NVEGKYDVGR VYILLQGGPT EEKRWTTEHI RDGYHSKGRF
410 420 430 440 450
GLALTTLGDV NGDGYGDFAV GAPYDGPEGR GVVYIFHGSP MGPLAKPSQI
460 470 480 490 500
IKSEQLVEGA PYPRTFGFAL SGGLDMDGNT YPDLAVGAYS SDQVFIFKSR
510 520 530 540 550
PVAAVNAETS FASNSKLISL DDRSCQLVRD HKKVPCMLLT TCWSYTGRYL
560 570 580 590 600
PEQLDFDVSW LLDAKKLLNP RMFFLRDEGK NIRNQTIRLN YGQKYCLNET
610 620 630 640 650
VYLLDKVQDK LTPLEVEARY NLRSSRPLDP MVRHRRSILE PVIDQNREIV
660 670 680 690 700
LRDAINIQKN CGPDNICEPD LKLKVSTVDK YLFGSPEPLV IEVFISNTNE
710 720 730 740 750
DAFEAAFYMV TPPDLQFRKL QQLGEKKDTP ITCSPPTPEN NHTLKCDIGN
760 770 780 790 800
PLESGKIAHF KISLVPEEKY GSSSSYDFYW EANSTNLEKP GSEYDNKIRQ
810 820 830 840 850
SVGIWVDTDL DIKGTSLPDY QLYKADDYKE LENATKEDDI GPQVVHIYEI
860 870 880 890 900
RNNRPSIIEE AEVFIHLPYE TIVGDPLMYL LNQPETGGKI QCDDVAFNEY
910 920 930 940 950
NLLLDEKLVK KSYLQAQGAI WNSAQVSGQS SSSSSSGGAS VHIEKARGEG
960 970 980 990 1000
FVRGVLVSNS TDAGDKLSPK QVEQRRQEDT LEALGDASFV HRDRASQAVQ
1010 1020 1030 1040 1050
EPQVNQTSFT TYSTSSSSSG SGAPSAQLRG HSTQGHIQMA GPVQHTSSSS
1060 1070 1080 1090 1100
SSNYRSWPAQ QQQQHQQLLL AGSGGSGLGS PVTFNDKSQF GGRNNNFHTG
1110 1120 1130 1140 1150
TLDLGTLNRG NVDNELYRSQ GQYQNPSQSL GQSQGQFQAN ANQGHYQGQN
1160 1170 1180 1190 1200
QAQFQARNPG FQGQTSYQGQ TQYSGQPGGY QTHHVTYSSG SKPYYGRENE
1210 1220 1230 1240 1250
DFYDEDNLQQ ATPGHWSSSS SSSSSSGTRR LRRSNDKDGA TEKPLQIDLN
1260 1270 1280 1290 1300
SPCQSARCKS IRCVVTNLGT EDGDAAFVAI RARMVAKTME KLASNVPLNV
1310 1320 1330 1340 1350
STLAVANVTL LPFIGAPKDA IVKTHEIFYK AEPEPLQVPD VVPLWVVVLA
1360 1370 1380 1390
ACAGALIFLL LVWLLYKCGF FNRNRPTDHS QERQPLRNGY HGDEHL
Length:1,396
Mass (Da):154,322
Last modified:December 1, 2000 - v2
Checksum:i2384B07DDBA28372
GO
Isoform PS2M8 (identifier: P12080-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     225-249: Missing.

Note: No experimental confirmation available.
Show »
Length:1,371
Mass (Da):151,586
Checksum:iCC0A5E79515FEF92
GO

Sequence cautioni

The sequence AAM50700 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM50700 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291A → G in AAC12788 (PubMed:2961459).Curated
Sequence conflicti968 – 9769SPKQVEQRR → RSQASGATA in AAC12788 (PubMed:2961459).Curated
Sequence conflicti1063 – 10642Missing (PubMed:2961459).Curated
Sequence conflicti1235 – 12351N → D in AAC12788 (PubMed:2961459).Curated
Sequence conflicti1242 – 12421E → K in AAC12788 (PubMed:2961459).Curated
Sequence conflicti1245 – 12451L → Q in AAC12788 (PubMed:2961459).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 24925Missing in isoform PS2M8. 1 PublicationVSP_002739Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19059 mRNA. Translation: AAC12788.1.
AE014298 Genomic DNA. Translation: AAF48661.1.
AE014298 Genomic DNA. Translation: AAN09423.2.
AE014298 Genomic DNA. Translation: ACZ95312.1.
AE014298 Genomic DNA. Translation: ACZ95313.1.
AY118840 mRNA. Translation: AAM50700.1. Sequence problems.
PIRiA29637.
RefSeqiNP_001162777.1. NM_001169306.2. [P12080-1]
NP_001162778.1. NM_001169307.1. [P12080-1]
NP_523378.2. NM_078654.2. [P12080-1]
NP_728021.2. NM_167544.2. [P12080-2]
UniGeneiDm.7766.

Genome annotation databases

EnsemblMetazoaiFBtr0074357; FBpp0074131; FBgn0001250. [P12080-1]
FBtr0301353; FBpp0290567; FBgn0001250. [P12080-1]
FBtr0301354; FBpp0290568; FBgn0001250. [P12080-1]
GeneIDi32661.
KEGGidme:Dmel_CG9623.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19059 mRNA. Translation: AAC12788.1.
AE014298 Genomic DNA. Translation: AAF48661.1.
AE014298 Genomic DNA. Translation: AAN09423.2.
AE014298 Genomic DNA. Translation: ACZ95312.1.
AE014298 Genomic DNA. Translation: ACZ95313.1.
AY118840 mRNA. Translation: AAM50700.1. Sequence problems.
PIRiA29637.
RefSeqiNP_001162777.1. NM_001169306.2. [P12080-1]
NP_001162778.1. NM_001169307.1. [P12080-1]
NP_523378.2. NM_078654.2. [P12080-1]
NP_728021.2. NM_167544.2. [P12080-2]
UniGeneiDm.7766.

3D structure databases

ProteinModelPortaliP12080.
SMRiP12080. Positions 32-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58994. 15 interactions.
DIPiDIP-23111N.
IntActiP12080. 2 interactions.
MINTiMINT-836239.
STRINGi7227.FBpp0074131.

Proteomic databases

PaxDbiP12080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074357; FBpp0074131; FBgn0001250. [P12080-1]
FBtr0301353; FBpp0290567; FBgn0001250. [P12080-1]
FBtr0301354; FBpp0290568; FBgn0001250. [P12080-1]
GeneIDi32661.
KEGGidme:Dmel_CG9623.

Organism-specific databases

CTDi32661.
FlyBaseiFBgn0001250. if.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
InParanoidiP12080.
OMAiQVVHIYE.
OrthoDBiEOG091G02JI.
PhylomeDBiP12080.

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-DME-1566948. Elastic fibre formation.
R-DME-2129379. Molecules associated with elastic fibres.
R-DME-216083. Integrin cell surface interactions.
R-DME-3000170. Syndecan interactions.
R-DME-3000178. ECM proteoglycans.
R-DME-354192. Integrin alphaIIb beta3 signaling.
R-DME-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-DME-372708. p130Cas linkage to MAPK signaling for integrins.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.

Miscellaneous databases

GenomeRNAii32661.
PROiP12080.

Gene expression databases

BgeeiFBgn0001250.
GenevisibleiP12080. DM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 4 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA2_DROME
AccessioniPrimary (citable) accession number: P12080
Secondary accession number(s): E1JJN2
, Q8IR07, Q8MSG3, Q9VXB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.