Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-PS2

Gene

if

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.4 Publications

Caution

GO - Molecular functioni

  • extracellular matrix binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • axonal defasciculation Source: FlyBase
  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell adhesion mediated by integrin Source: FlyBase
  • cell-cell adhesion Source: FlyBase
  • cell-matrix adhesion Source: FlyBase
  • cell migration Source: FlyBase
  • central nervous system morphogenesis Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • hemocyte migration Source: FlyBase
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • maintenance of epithelial integrity, open tracheal system Source: FlyBase
  • maintenance of protein location Source: FlyBase
  • midgut development Source: FlyBase
  • muscle attachment Source: FlyBase
  • myofibril assembly Source: FlyBase
  • regulation of stress fiber assembly Source: FlyBase
  • salivary gland development Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • sarcomere organization Source: FlyBase
  • sensory perception of smell Source: FlyBase
  • substrate adhesion-dependent cell spreading Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-DME-1566977 Fibronectin matrix formation
R-DME-202733 Cell surface interactions at the vascular wall
R-DME-2129379 Molecules associated with elastic fibres
R-DME-216083 Integrin cell surface interactions
R-DME-3000178 ECM proteoglycans
R-DME-354192 Integrin alphaIIb beta3 signaling
R-DME-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DME-372708 p130Cas linkage to MAPK signaling for integrins
R-DME-445144 Signal transduction by L1
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-PS2
Alternative name(s):
Position-specific antigen subunit alpha-2
Protein inflated
Cleaved into the following 2 chains:
Gene namesi
Name:if
ORF Names:CG9623
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001250 if

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 1341ExtracellularSequence analysisAdd BLAST1310
Transmembranei1342 – 1366HelicalSequence analysisAdd BLAST25
Topological domaini1367 – 1396CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001632332 – 1396Integrin alpha-PS2Add BLAST1365
ChainiPRO_000001632432 – ?1243Integrin alpha-PS2 heavy chainAdd BLAST1212
ChainiPRO_0000016325?1244 – 1396Integrin alpha-PS2 light chainAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi783N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi833N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi959N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1005N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1307N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The heavy-light chain cleavage site is either in 1230-1231, or 1233-1234, or 1243-1244.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12080
PRIDEiP12080

Expressioni

Tissue specificityi

In ovaries, highly expressed in follicle cells. At syncytial blastoderm stage, expressed in the embryonic mesodermal precursors but not in the ectoderm. At embryonic stages 7 and 10, expression is restricted to the mesoderm. At stage 12, expressed in the gonadal sheath and the interstitial cells of the gonad. In stage 16 embryos, expressed in the somatic and visceral muscles where localizes to sites of attachment between adjacent muscles. In third larval instar wing imaginal disk, expressed in the ventral compartment and in a subset of adepithelial and peripodial cells (at protein level).4 Publications

Developmental stagei

Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar (at protein level). The relative ratio of isoform 1/PS2C and isoform 2/PS2M8 varies widely during development.3 Publications

Gene expression databases

BgeeiFBgn0001250
ExpressionAtlasiP12080 differential
GenevisibleiP12080 DM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi5899429 interactors.
DIPiDIP-23111N
IntActiP12080 6 interactors.
STRINGi7227.FBpp0074131

Structurei

3D structure databases

ProteinModelPortaliP12080
SMRiP12080
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 106FG-GAP 1PROSITE-ProRule annotationAdd BLAST71
Repeati117 – 174FG-GAP 2PROSITE-ProRule annotationAdd BLAST58
Repeati186 – 239FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati266 – 317FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati318 – 383FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati386 – 445FG-GAP 6PROSITE-ProRule annotationAdd BLAST60
Repeati452 – 514FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi932 – 938Ser-rich7
Compositional biasi1015 – 1023Ser-rich9
Compositional biasi1049 – 1054Ser-rich6
Compositional biasi1217 – 1226Ser-rich10

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00760000118782
InParanoidiP12080
OMAiESNPREV
OrthoDBiEOG091G02JI
PhylomeDBiP12080

Family and domain databases

Gene3Di2.130.10.1301 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 4 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PS2C (identifier: P12080-1) [UniParc]FASTAAdd to basket
Also known as: D, F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGDSIHRRR MALHCPITSL ILLLIAMSAH GYNIDLPSYV RFRQSSNSMF
60 70 80 90 100
GFSIAMHKGR SGFYGNQNNV SLIVGAPKFD TSRYQQGVTE AGGVFKCSLN
110 120 130 140 150
DDDCKLVPFD SKGNNRNVDK EVVDRKSYQW LGATVATGRD SDLVVACAPR
160 170 180 190 200
YVFHTMTPSR AFRIDPVGTC FTSHNFEEFY EVSPCRTNNW GYHRQGSCQA
210 220 230 240 250
GFSAAINGNG SRLFIGAPGS WYWQGQTYSI PPDAKFPFKP PLYQPFGTGG
260 270 280 290 300
MASSHDVTRP ENQVFSTSES ASVNDDSYLG YSMVTGDFDG DRSEDVAIGM
310 320 330 340 350
PRGGNLVGRI VVNRWNMANI FNITGRQIGE YFGYSLATSD VDGDGLDDLL
360 370 380 390 400
IGAPMYTDPD NVEGKYDVGR VYILLQGGPT EEKRWTTEHI RDGYHSKGRF
410 420 430 440 450
GLALTTLGDV NGDGYGDFAV GAPYDGPEGR GVVYIFHGSP MGPLAKPSQI
460 470 480 490 500
IKSEQLVEGA PYPRTFGFAL SGGLDMDGNT YPDLAVGAYS SDQVFIFKSR
510 520 530 540 550
PVAAVNAETS FASNSKLISL DDRSCQLVRD HKKVPCMLLT TCWSYTGRYL
560 570 580 590 600
PEQLDFDVSW LLDAKKLLNP RMFFLRDEGK NIRNQTIRLN YGQKYCLNET
610 620 630 640 650
VYLLDKVQDK LTPLEVEARY NLRSSRPLDP MVRHRRSILE PVIDQNREIV
660 670 680 690 700
LRDAINIQKN CGPDNICEPD LKLKVSTVDK YLFGSPEPLV IEVFISNTNE
710 720 730 740 750
DAFEAAFYMV TPPDLQFRKL QQLGEKKDTP ITCSPPTPEN NHTLKCDIGN
760 770 780 790 800
PLESGKIAHF KISLVPEEKY GSSSSYDFYW EANSTNLEKP GSEYDNKIRQ
810 820 830 840 850
SVGIWVDTDL DIKGTSLPDY QLYKADDYKE LENATKEDDI GPQVVHIYEI
860 870 880 890 900
RNNRPSIIEE AEVFIHLPYE TIVGDPLMYL LNQPETGGKI QCDDVAFNEY
910 920 930 940 950
NLLLDEKLVK KSYLQAQGAI WNSAQVSGQS SSSSSSGGAS VHIEKARGEG
960 970 980 990 1000
FVRGVLVSNS TDAGDKLSPK QVEQRRQEDT LEALGDASFV HRDRASQAVQ
1010 1020 1030 1040 1050
EPQVNQTSFT TYSTSSSSSG SGAPSAQLRG HSTQGHIQMA GPVQHTSSSS
1060 1070 1080 1090 1100
SSNYRSWPAQ QQQQHQQLLL AGSGGSGLGS PVTFNDKSQF GGRNNNFHTG
1110 1120 1130 1140 1150
TLDLGTLNRG NVDNELYRSQ GQYQNPSQSL GQSQGQFQAN ANQGHYQGQN
1160 1170 1180 1190 1200
QAQFQARNPG FQGQTSYQGQ TQYSGQPGGY QTHHVTYSSG SKPYYGRENE
1210 1220 1230 1240 1250
DFYDEDNLQQ ATPGHWSSSS SSSSSSGTRR LRRSNDKDGA TEKPLQIDLN
1260 1270 1280 1290 1300
SPCQSARCKS IRCVVTNLGT EDGDAAFVAI RARMVAKTME KLASNVPLNV
1310 1320 1330 1340 1350
STLAVANVTL LPFIGAPKDA IVKTHEIFYK AEPEPLQVPD VVPLWVVVLA
1360 1370 1380 1390
ACAGALIFLL LVWLLYKCGF FNRNRPTDHS QERQPLRNGY HGDEHL
Length:1,396
Mass (Da):154,322
Last modified:December 1, 2000 - v2
Checksum:i2384B07DDBA28372
GO
Isoform PS2M8 (identifier: P12080-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     225-249: Missing.

Note: No experimental confirmation available.
Show »
Length:1,371
Mass (Da):151,586
Checksum:iCC0A5E79515FEF92
GO

Sequence cautioni

The sequence AAM50700 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM50700 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → G in AAC12788 (PubMed:2961459).Curated1
Sequence conflicti968 – 976SPKQVEQRR → RSQASGATA in AAC12788 (PubMed:2961459).Curated9
Sequence conflicti1063 – 1064Missing (PubMed:2961459).Curated2
Sequence conflicti1235N → D in AAC12788 (PubMed:2961459).Curated1
Sequence conflicti1242E → K in AAC12788 (PubMed:2961459).Curated1
Sequence conflicti1245L → Q in AAC12788 (PubMed:2961459).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002739225 – 249Missing in isoform PS2M8. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19059 mRNA Translation: AAC12788.1
AE014298 Genomic DNA Translation: AAF48661.1
AE014298 Genomic DNA Translation: AAN09423.2
AE014298 Genomic DNA Translation: ACZ95312.1
AE014298 Genomic DNA Translation: ACZ95313.1
AY118840 mRNA Translation: AAM50700.1 Sequence problems.
PIRiA29637
RefSeqiNP_001162777.1, NM_001169306.2 [P12080-1]
NP_001162778.1, NM_001169307.1 [P12080-1]
NP_523378.2, NM_078654.2 [P12080-1]
NP_728021.2, NM_167544.2 [P12080-2]
UniGeneiDm.7766

Genome annotation databases

EnsemblMetazoaiFBtr0074357; FBpp0074131; FBgn0001250 [P12080-1]
FBtr0301352; FBpp0290566; FBgn0001250 [P12080-2]
FBtr0301353; FBpp0290567; FBgn0001250 [P12080-1]
FBtr0301354; FBpp0290568; FBgn0001250 [P12080-1]
GeneIDi32661
KEGGidme:Dmel_CG9623
UCSCiCG9623-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiITA2_DROME
AccessioniPrimary (citable) accession number: P12080
Secondary accession number(s): E1JJN2
, Q8IR07, Q8MSG3, Q9VXB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome