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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

Cox5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91ZincPROSITE-ProRule annotation1
Metal bindingi93ZincPROSITE-ProRule annotation1
Metal bindingi113ZincPROSITE-ProRule annotation1
Metal bindingi116ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Cytochrome c oxidase subunit VIA*
Gene namesi
Name:Cox5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620608. Cox5b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31Mitochondrion1 PublicationAdd BLAST31
ChainiPRO_000000611132 – 129Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP12075.
PRIDEiP12075.

2D gel databases

UCD-2DPAGEP12075.

PTM databases

iPTMnetiP12075.
PhosphoSitePlusiP12075.
SwissPalmiP12075.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016660.
GenevisibleiP12075. RN.

Interactioni

Protein-protein interaction databases

BioGridi250174. 1 interactor.
STRINGi10116.ENSRNOP00000022487.

Structurei

3D structure databases

ProteinModelPortaliP12075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP12075.
KOiK02265.
OMAiPYNMLPP.
OrthoDBiEOG091G0S9L.
PhylomeDBiP12075.
TreeFamiTF105063.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALAAQALRAH GPRGVAATRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
IMIAAQRGLD PYNMLPPKAA SGTKEDPNLV PSVSNKRIVG CICEEDNCTV
110 120
IWFWLHQGES QRCPNCGTHY KLVPYQMVH
Length:129
Mass (Da):13,915
Last modified:February 1, 1996 - v2
Checksum:i5C5DD1F9C20D59A5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti109E → Q.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10952 mRNA. Translation: BAA01744.1.
D10951 Genomic DNA. Translation: BAA01743.1.
BC083179 mRNA. Translation: AAH83179.1.
X14208 mRNA. Translation: CAA32425.1.
PIRiJC2254.
RefSeqiNP_446038.1. NM_053586.1.
UniGeneiRn.6686.

Genome annotation databases

EnsembliENSRNOT00000022487; ENSRNOP00000022487; ENSRNOG00000016660.
GeneIDi94194.
KEGGirno:94194.
UCSCiRGD:620608. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10952 mRNA. Translation: BAA01744.1.
D10951 Genomic DNA. Translation: BAA01743.1.
BC083179 mRNA. Translation: AAH83179.1.
X14208 mRNA. Translation: CAA32425.1.
PIRiJC2254.
RefSeqiNP_446038.1. NM_053586.1.
UniGeneiRn.6686.

3D structure databases

ProteinModelPortaliP12075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250174. 1 interactor.
STRINGi10116.ENSRNOP00000022487.

PTM databases

iPTMnetiP12075.
PhosphoSitePlusiP12075.
SwissPalmiP12075.

2D gel databases

UCD-2DPAGEP12075.

Proteomic databases

PaxDbiP12075.
PRIDEiP12075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022487; ENSRNOP00000022487; ENSRNOG00000016660.
GeneIDi94194.
KEGGirno:94194.
UCSCiRGD:620608. rat.

Organism-specific databases

CTDi1329.
RGDi620608. Cox5b.

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP12075.
KOiK02265.
OMAiPYNMLPP.
OrthoDBiEOG091G0S9L.
PhylomeDBiP12075.
TreeFamiTF105063.

Miscellaneous databases

PROiP12075.

Gene expression databases

BgeeiENSRNOG00000016660.
GenevisibleiP12075. RN.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX5B_RAT
AccessioniPrimary (citable) accession number: P12075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.