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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

Cox5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91ZincPROSITE-ProRule annotation1
Metal bindingi93ZincPROSITE-ProRule annotation1
Metal bindingi113ZincPROSITE-ProRule annotation1
Metal bindingi116ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Cytochrome c oxidase subunit VIA*
Gene namesi
Name:Cox5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620608. Cox5b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31Mitochondrion1 PublicationAdd BLAST31
ChainiPRO_000000611132 – 129Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP12075.
PRIDEiP12075.

2D gel databases

UCD-2DPAGEiP12075.

PTM databases

iPTMnetiP12075.
PhosphoSitePlusiP12075.
SwissPalmiP12075.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016660.
GenevisibleiP12075. RN.

Interactioni

Protein-protein interaction databases

BioGridi250174. 1 interactor.
CORUMiP12075.
STRINGi10116.ENSRNOP00000022487.

Structurei

3D structure databases

ProteinModelPortaliP12075.
SMRiP12075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP12075.
KOiK02265.
OMAiDSHDTIY.
OrthoDBiEOG091G0S9L.
PhylomeDBiP12075.
TreeFamiTF105063.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiView protein in InterPro
IPR002124. Cyt_c_oxidase_su5b.
IPR036972. Cyt_c_oxidase_su5b_sf.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiView protein in Pfam
PF01215. COX5B. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007270. Cyt_c_oxidase_su5b. 1 hit.
PROSITEiView protein in PROSITE
PS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALAAQALRAH GPRGVAATRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
IMIAAQRGLD PYNMLPPKAA SGTKEDPNLV PSVSNKRIVG CICEEDNCTV
110 120
IWFWLHQGES QRCPNCGTHY KLVPYQMVH
Length:129
Mass (Da):13,915
Last modified:February 1, 1996 - v2
Checksum:i5C5DD1F9C20D59A5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti109E → Q. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10952 mRNA. Translation: BAA01744.1.
D10951 Genomic DNA. Translation: BAA01743.1.
BC083179 mRNA. Translation: AAH83179.1.
X14208 mRNA. Translation: CAA32425.1.
PIRiJC2254.
RefSeqiNP_446038.1. NM_053586.1.
UniGeneiRn.6686.

Genome annotation databases

EnsembliENSRNOT00000022487; ENSRNOP00000022487; ENSRNOG00000016660.
GeneIDi94194.
KEGGirno:94194.
UCSCiRGD:620608. rat.

Similar proteinsi

Entry informationi

Entry nameiCOX5B_RAT
AccessioniPrimary (citable) accession number: P12075
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: November 22, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families