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P12074

- CX6A1_HUMAN

UniProt

P12074 - CX6A1_HUMAN

Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

COX6A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. generation of precursor metabolites and energy Source: ProtInc
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6A1, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIa-liver
    Cytochrome c oxidase subunit VIA-liver
    Short name:
    COX VIa-L
    Gene namesi
    Name:COX6A1
    Synonyms:COX6AL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2277. COX6A1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Reactome
    2. mitochondrial respiratory chain complex IV Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26794.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
    BLAST
    Chaini25 – 10985Cytochrome c oxidase subunit 6A1, mitochondrialPRO_0000006119Add
    BLAST

    Proteomic databases

    MaxQBiP12074.
    PaxDbiP12074.
    PRIDEiP12074.

    2D gel databases

    SWISS-2DPAGEP12074.

    PTM databases

    PhosphoSiteiP12074.

    Expressioni

    Gene expression databases

    BgeeiP12074.
    CleanExiHS_COX6A1.
    GenevestigatoriP12074.

    Interactioni

    Protein-protein interaction databases

    BioGridi107730. 3 interactions.
    IntActiP12074. 2 interactions.
    STRINGi9606.ENSP00000229379.

    Structurei

    3D structure databases

    ProteinModelPortaliP12074.
    SMRiP12074. Positions 25-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG279259.
    HOGENOMiHOG000193965.
    HOVERGENiHBG060482.
    InParanoidiP12074.
    KOiK02266.
    OMAiREKRFPW.
    OrthoDBiEOG757D0Z.
    PhylomeDBiP12074.
    TreeFamiTF105064.

    Family and domain databases

    Gene3Di4.10.95.10. 1 hit.
    InterProiIPR001349. Cyt_c_oxidase_su6a.
    IPR018507. Cyt_c_oxidase_su6a_CS.
    [Graphical view]
    PANTHERiPTHR11504. PTHR11504. 1 hit.
    PfamiPF02046. COX6A. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000277. COX6A1. 1 hit.
    ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF81411. SSF81411. 1 hit.
    PROSITEiPS01329. COX6A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVVGVSSVS RLLGRSRPQL GRPMSSGAHG EEGSARMWKT LTFFVALPGV    50
    AVSMLNVYLK SHHGEHERPE FIAYPHLRIR TKPFPWGDGN HTLFHNPHVN 100
    PLPTGYEDE 109
    Length:109
    Mass (Da):12,155
    Last modified:July 15, 1999 - v4
    Checksum:i0040F47CECE767B1
    GO

    Sequence cautioni

    The sequence CAA33392.1 differs from that shown. Reason: Frameshift at position 17.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312009 mRNA. Translation: BAG34947.1.
    AL021546 Genomic DNA. Translation: CAA16494.1.
    BC007723 mRNA. Translation: AAH07723.1.
    BC070186 mRNA. Translation: AAH70186.1.
    BC107861 mRNA. Translation: AAI07862.1.
    X15341 mRNA. Translation: CAA33392.1. Frameshift.
    CCDSiCCDS9197.1.
    RefSeqiNP_004364.2. NM_004373.3.
    UniGeneiHs.369624.

    Genome annotation databases

    EnsembliENST00000229379; ENSP00000229379; ENSG00000111775.
    GeneIDi1337.
    KEGGihsa:1337.
    UCSCiuc001tyf.2. human.

    Polymorphism databases

    DMDMi6166030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312009 mRNA. Translation: BAG34947.1 .
    AL021546 Genomic DNA. Translation: CAA16494.1 .
    BC007723 mRNA. Translation: AAH07723.1 .
    BC070186 mRNA. Translation: AAH70186.1 .
    BC107861 mRNA. Translation: AAI07862.1 .
    X15341 mRNA. Translation: CAA33392.1 . Frameshift.
    CCDSi CCDS9197.1.
    RefSeqi NP_004364.2. NM_004373.3.
    UniGenei Hs.369624.

    3D structure databases

    ProteinModelPortali P12074.
    SMRi P12074. Positions 25-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107730. 3 interactions.
    IntActi P12074. 2 interactions.
    STRINGi 9606.ENSP00000229379.

    PTM databases

    PhosphoSitei P12074.

    Polymorphism databases

    DMDMi 6166030.

    2D gel databases

    SWISS-2DPAGE P12074.

    Proteomic databases

    MaxQBi P12074.
    PaxDbi P12074.
    PRIDEi P12074.

    Protocols and materials databases

    DNASUi 1337.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229379 ; ENSP00000229379 ; ENSG00000111775 .
    GeneIDi 1337.
    KEGGi hsa:1337.
    UCSCi uc001tyf.2. human.

    Organism-specific databases

    CTDi 1337.
    GeneCardsi GC12P120875.
    HGNCi HGNC:2277. COX6A1.
    MIMi 602072. gene.
    neXtProti NX_P12074.
    PharmGKBi PA26794.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279259.
    HOGENOMi HOG000193965.
    HOVERGENi HBG060482.
    InParanoidi P12074.
    KOi K02266.
    OMAi REKRFPW.
    OrthoDBi EOG757D0Z.
    PhylomeDBi P12074.
    TreeFami TF105064.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi COX6A1. human.
    GeneWikii COX6A1.
    GenomeRNAii 1337.
    NextBioi 5431.
    PROi P12074.
    SOURCEi Search...

    Gene expression databases

    Bgeei P12074.
    CleanExi HS_COX6A1.
    Genevestigatori P12074.

    Family and domain databases

    Gene3Di 4.10.95.10. 1 hit.
    InterProi IPR001349. Cyt_c_oxidase_su6a.
    IPR018507. Cyt_c_oxidase_su6a_CS.
    [Graphical view ]
    PANTHERi PTHR11504. PTHR11504. 1 hit.
    Pfami PF02046. COX6A. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000277. COX6A1. 1 hit.
    ProDomi PD006036. Cyt_c_oxidase_su6a. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF81411. SSF81411. 1 hit.
    PROSITEi PS01329. COX6A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Testis and Uterus.
    4. "Sequence of a cDNA specifying subunit VIa of human cytochrome c oxidase."
      Fabrizi G.M., Rizzuto R., Nakase H., Mita S., Kadenbach B., Schon E.A.
      Nucleic Acids Res. 17:6409-6409(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-109.
      Tissue: Liver.
    5. "Human liver protein map: a reference database established by microsequencing and gel comparison."
      Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
      Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-36.
      Tissue: Liver.

    Entry informationi

    Entry nameiCX6A1_HUMAN
    AccessioniPrimary (citable) accession number: P12074
    Secondary accession number(s): B2R500, O43714, Q32Q37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 143 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3