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P12074

- CX6A1_HUMAN

UniProt

P12074 - CX6A1_HUMAN

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Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

COX6A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. generation of precursor metabolites and energy Source: ProtInc
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-liver
Cytochrome c oxidase subunit VIA-liver
Short name:
COX VIa-L
Gene namesi
Name:COX6A1
Synonyms:COX6AL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2277. COX6A1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial respiratory chain complex IV Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
BLAST
Chaini25 – 10985Cytochrome c oxidase subunit 6A1, mitochondrialPRO_0000006119Add
BLAST

Proteomic databases

MaxQBiP12074.
PaxDbiP12074.
PRIDEiP12074.

2D gel databases

SWISS-2DPAGEP12074.

PTM databases

PhosphoSiteiP12074.

Expressioni

Gene expression databases

BgeeiP12074.
CleanExiHS_COX6A1.
ExpressionAtlasiP12074. baseline.
GenevestigatoriP12074.

Interactioni

Protein-protein interaction databases

BioGridi107730. 3 interactions.
IntActiP12074. 2 interactions.
STRINGi9606.ENSP00000229379.

Structurei

3D structure databases

ProteinModelPortaliP12074.
SMRiP12074. Positions 25-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG279259.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP12074.
KOiK02266.
OMAiREKRFPW.
OrthoDBiEOG757D0Z.
PhylomeDBiP12074.
TreeFamiTF105064.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12074 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVVGVSSVS RLLGRSRPQL GRPMSSGAHG EEGSARMWKT LTFFVALPGV
60 70 80 90 100
AVSMLNVYLK SHHGEHERPE FIAYPHLRIR TKPFPWGDGN HTLFHNPHVN

PLPTGYEDE
Length:109
Mass (Da):12,155
Last modified:July 15, 1999 - v4
Checksum:i0040F47CECE767B1
GO

Sequence cautioni

The sequence CAA33392.1 differs from that shown. Reason: Frameshift at position 17.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312009 mRNA. Translation: BAG34947.1.
AL021546 Genomic DNA. Translation: CAA16494.1.
BC007723 mRNA. Translation: AAH07723.1.
BC070186 mRNA. Translation: AAH70186.1.
BC107861 mRNA. Translation: AAI07862.1.
X15341 mRNA. Translation: CAA33392.1. Frameshift.
CCDSiCCDS9197.1.
RefSeqiNP_004364.2. NM_004373.3.
UniGeneiHs.369624.

Genome annotation databases

EnsembliENST00000229379; ENSP00000229379; ENSG00000111775.
GeneIDi1337.
KEGGihsa:1337.
UCSCiuc001tyf.2. human.

Polymorphism databases

DMDMi6166030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312009 mRNA. Translation: BAG34947.1 .
AL021546 Genomic DNA. Translation: CAA16494.1 .
BC007723 mRNA. Translation: AAH07723.1 .
BC070186 mRNA. Translation: AAH70186.1 .
BC107861 mRNA. Translation: AAI07862.1 .
X15341 mRNA. Translation: CAA33392.1 . Frameshift.
CCDSi CCDS9197.1.
RefSeqi NP_004364.2. NM_004373.3.
UniGenei Hs.369624.

3D structure databases

ProteinModelPortali P12074.
SMRi P12074. Positions 25-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107730. 3 interactions.
IntActi P12074. 2 interactions.
STRINGi 9606.ENSP00000229379.

PTM databases

PhosphoSitei P12074.

Polymorphism databases

DMDMi 6166030.

2D gel databases

SWISS-2DPAGE P12074.

Proteomic databases

MaxQBi P12074.
PaxDbi P12074.
PRIDEi P12074.

Protocols and materials databases

DNASUi 1337.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229379 ; ENSP00000229379 ; ENSG00000111775 .
GeneIDi 1337.
KEGGi hsa:1337.
UCSCi uc001tyf.2. human.

Organism-specific databases

CTDi 1337.
GeneCardsi GC12P120875.
HGNCi HGNC:2277. COX6A1.
MIMi 602072. gene.
neXtProti NX_P12074.
PharmGKBi PA26794.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279259.
GeneTreei ENSGT00390000002756.
HOGENOMi HOG000193965.
HOVERGENi HBG060482.
InParanoidi P12074.
KOi K02266.
OMAi REKRFPW.
OrthoDBi EOG757D0Z.
PhylomeDBi P12074.
TreeFami TF105064.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi COX6A1. human.
GeneWikii COX6A1.
GenomeRNAii 1337.
NextBioi 5431.
PROi P12074.
SOURCEi Search...

Gene expression databases

Bgeei P12074.
CleanExi HS_COX6A1.
ExpressionAtlasi P12074. baseline.
Genevestigatori P12074.

Family and domain databases

Gene3Di 4.10.95.10. 1 hit.
InterProi IPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view ]
PANTHERi PTHR11504. PTHR11504. 1 hit.
Pfami PF02046. COX6A. 1 hit.
[Graphical view ]
PIRSFi PIRSF000277. COX6A1. 1 hit.
ProDomi PD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF81411. SSF81411. 1 hit.
PROSITEi PS01329. COX6A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Testis and Uterus.
  4. "Sequence of a cDNA specifying subunit VIa of human cytochrome c oxidase."
    Fabrizi G.M., Rizzuto R., Nakase H., Mita S., Kadenbach B., Schon E.A.
    Nucleic Acids Res. 17:6409-6409(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-109.
    Tissue: Liver.
  5. "Human liver protein map: a reference database established by microsequencing and gel comparison."
    Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
    Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-36.
    Tissue: Liver.

Entry informationi

Entry nameiCX6A1_HUMAN
AccessioniPrimary (citable) accession number: P12074
Secondary accession number(s): B2R500, O43714, Q32Q37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1999
Last modified: October 29, 2014
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3