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Protein

Xylose isomerase

Gene

xylA

Organism
Arthrobacter sp. (strain NRRL B3728)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+Note: Binds 2 magnesium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei541 Publication1
Active sitei571 Publication1
Metal bindingi181Magnesium 11
Metal bindingi217Magnesium 11
Metal bindingi217Magnesium 21
Metal bindingi220Magnesium 21
Metal bindingi245Magnesium 11
Metal bindingi255Magnesium 21
Metal bindingi257Magnesium 21
Metal bindingi293Magnesium 11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKP12070.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiArthrobacter sp. (strain NRRL B3728)
Taxonomic identifieri1669 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB01638. D-Sorbitol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001957602 – 395Xylose isomeraseAdd BLAST394

Proteomic databases

PRIDEiP12070.

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1395
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi11 – 14Combined sources4
Helixi15 – 18Combined sources4
Helixi36 – 46Combined sources11
Beta strandi50 – 54Combined sources5
Helixi55 – 58Combined sources4
Helixi65 – 82Combined sources18
Beta strandi88 – 90Combined sources3
Beta strandi94 – 96Combined sources3
Helixi97 – 99Combined sources3
Helixi109 – 128Combined sources20
Beta strandi132 – 136Combined sources5
Beta strandi142 – 145Combined sources4
Helixi146 – 148Combined sources3
Helixi151 – 172Combined sources22
Beta strandi177 – 180Combined sources4
Beta strandi184 – 193Combined sources10
Helixi196 – 203Combined sources8
Helixi209 – 211Combined sources3
Beta strandi212 – 214Combined sources3
Helixi218 – 222Combined sources5
Turni223 – 225Combined sources3
Helixi228 – 237Combined sources10
Beta strandi251 – 254Combined sources4
Helixi265 – 277Combined sources13
Beta strandi290 – 292Combined sources3
Helixi302 – 328Combined sources27
Helixi330 – 338Combined sources9
Turni339 – 342Combined sources4
Helixi343 – 345Combined sources3
Helixi355 – 360Combined sources6
Turni362 – 367Combined sources6
Helixi370 – 373Combined sources4
Helixi380 – 391Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DIDX-ray2.50A/B2-395[»]
1DIEX-ray2.50A/B2-395[»]
1XLAX-ray2.30A/B2-395[»]
1XLBX-ray2.50A/B2-395[»]
1XLCX-ray2.50A/B2-395[»]
1XLDX-ray2.50A/B2-395[»]
1XLEX-ray2.50A/B2-395[»]
1XLFX-ray2.50A/B2-395[»]
1XLGX-ray2.50A/B2-395[»]
1XLHX-ray2.50A/B2-395[»]
1XLIX-ray2.50A/B2-395[»]
1XLJX-ray2.50A/B2-395[»]
1XLKX-ray2.50A/B2-395[»]
1XLLX-ray2.50A/B2-395[»]
1XLMX-ray2.40A/B2-395[»]
4XIAX-ray2.30A/B3-395[»]
5XIAX-ray2.50A/B3-395[»]
ProteinModelPortaliP12070.
SMRiP12070.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12070.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQPTPADH FTFGLWTVGW TGADPFGVAT RKNLDPVEAV HKLAELGAYG
60 70 80 90 100
ITFHDNDLIP FDATEAEREK ILGDFNQALK DTGLKVPMVT TNLFSHPVFK
110 120 130 140 150
DGGFTSNDRS IRRFALAKVL HNIDLAAEMG AETFVMWGGR EGSEYDGSKD
160 170 180 190 200
LAAALDRMRE GVDTAAGYIK DKGYNLRIAL EPKPNEPRGD IFLPTVGHGL
210 220 230 240 250
AFIEQLEHGD IVGLNPETGH EQMAGLNFTH GIAQALWAEK LFHIDLNGQR
260 270 280 290 300
GIKYDQDLVF GHGDLTSAFF TVDLLENGFP NGGPKYTGPR HFDYKPSRTD
310 320 330 340 350
GYDGVWDSAK ANMSMYLLLK ERALAFRADP EVQEAMKTSG VFELGETTLN
360 370 380 390
AGESAADLMN DSASFAGFDA EAAAERNFAF IRLNQLAIEH LLGSR
Length:395
Mass (Da):43,292
Last modified:January 23, 2007 - v3
Checksum:iEA7A21FC47726369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59466 Genomic DNA. Translation: CAA42073.1.
PIRiS16214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59466 Genomic DNA. Translation: CAA42073.1.
PIRiS16214.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DIDX-ray2.50A/B2-395[»]
1DIEX-ray2.50A/B2-395[»]
1XLAX-ray2.30A/B2-395[»]
1XLBX-ray2.50A/B2-395[»]
1XLCX-ray2.50A/B2-395[»]
1XLDX-ray2.50A/B2-395[»]
1XLEX-ray2.50A/B2-395[»]
1XLFX-ray2.50A/B2-395[»]
1XLGX-ray2.50A/B2-395[»]
1XLHX-ray2.50A/B2-395[»]
1XLIX-ray2.50A/B2-395[»]
1XLJX-ray2.50A/B2-395[»]
1XLKX-ray2.50A/B2-395[»]
1XLLX-ray2.50A/B2-395[»]
1XLMX-ray2.40A/B2-395[»]
4XIAX-ray2.30A/B3-395[»]
5XIAX-ray2.50A/B3-395[»]
ProteinModelPortaliP12070.
SMRiP12070.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB01638. D-Sorbitol.

Proteomic databases

PRIDEiP12070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP12070.

Miscellaneous databases

EvolutionaryTraceiP12070.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_ARTS7
AccessioniPrimary (citable) accession number: P12070
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.