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Protein

Xylose isomerase

Gene

xylA

Organism
Arthrobacter sp. (strain NRRL B3728)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+Note: Binds 2 magnesium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei541 Publication1
Active sitei571 Publication1
Metal bindingi181Magnesium 11
Metal bindingi217Magnesium 11
Metal bindingi217Magnesium 21
Metal bindingi220Magnesium 21
Metal bindingi245Magnesium 11
Metal bindingi255Magnesium 21
Metal bindingi257Magnesium 21
Metal bindingi293Magnesium 11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKP12070

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiArthrobacter sp. (strain NRRL B3728)
Taxonomic identifieri1669 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB01904 D-Xylitol
DB03206 Duvoglustat
DB01638 Sorbitol

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001957602 – 395Xylose isomeraseAdd BLAST394

Proteomic databases

PRIDEiP12070

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1395
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi11 – 14Combined sources4
Helixi15 – 18Combined sources4
Helixi36 – 46Combined sources11
Beta strandi50 – 54Combined sources5
Helixi55 – 58Combined sources4
Helixi65 – 82Combined sources18
Beta strandi88 – 90Combined sources3
Beta strandi94 – 96Combined sources3
Helixi97 – 99Combined sources3
Helixi109 – 128Combined sources20
Beta strandi132 – 136Combined sources5
Beta strandi142 – 145Combined sources4
Helixi146 – 148Combined sources3
Helixi151 – 172Combined sources22
Beta strandi177 – 180Combined sources4
Beta strandi184 – 193Combined sources10
Helixi196 – 203Combined sources8
Helixi209 – 211Combined sources3
Beta strandi212 – 214Combined sources3
Helixi218 – 222Combined sources5
Turni223 – 225Combined sources3
Helixi228 – 237Combined sources10
Beta strandi251 – 254Combined sources4
Helixi265 – 277Combined sources13
Beta strandi290 – 292Combined sources3
Helixi302 – 328Combined sources27
Helixi330 – 338Combined sources9
Turni339 – 342Combined sources4
Helixi343 – 345Combined sources3
Helixi355 – 360Combined sources6
Turni362 – 367Combined sources6
Helixi370 – 373Combined sources4
Helixi380 – 391Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DIDX-ray2.50A/B2-395[»]
1DIEX-ray2.50A/B2-395[»]
1XLAX-ray2.30A/B2-395[»]
1XLBX-ray2.50A/B2-395[»]
1XLCX-ray2.50A/B2-395[»]
1XLDX-ray2.50A/B2-395[»]
1XLEX-ray2.50A/B2-395[»]
1XLFX-ray2.50A/B2-395[»]
1XLGX-ray2.50A/B2-395[»]
1XLHX-ray2.50A/B2-395[»]
1XLIX-ray2.50A/B2-395[»]
1XLJX-ray2.50A/B2-395[»]
1XLKX-ray2.50A/B2-395[»]
1XLLX-ray2.50A/B2-395[»]
1XLMX-ray2.40A/B2-395[»]
4XIAX-ray2.30A/B3-395[»]
5XIAX-ray2.50A/B3-395[»]
ProteinModelPortaliP12070
SMRiP12070
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12070

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013453 XylA_actinobac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02631 xylA_Arthro, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQPTPADH FTFGLWTVGW TGADPFGVAT RKNLDPVEAV HKLAELGAYG
60 70 80 90 100
ITFHDNDLIP FDATEAEREK ILGDFNQALK DTGLKVPMVT TNLFSHPVFK
110 120 130 140 150
DGGFTSNDRS IRRFALAKVL HNIDLAAEMG AETFVMWGGR EGSEYDGSKD
160 170 180 190 200
LAAALDRMRE GVDTAAGYIK DKGYNLRIAL EPKPNEPRGD IFLPTVGHGL
210 220 230 240 250
AFIEQLEHGD IVGLNPETGH EQMAGLNFTH GIAQALWAEK LFHIDLNGQR
260 270 280 290 300
GIKYDQDLVF GHGDLTSAFF TVDLLENGFP NGGPKYTGPR HFDYKPSRTD
310 320 330 340 350
GYDGVWDSAK ANMSMYLLLK ERALAFRADP EVQEAMKTSG VFELGETTLN
360 370 380 390
AGESAADLMN DSASFAGFDA EAAAERNFAF IRLNQLAIEH LLGSR
Length:395
Mass (Da):43,292
Last modified:January 23, 2007 - v3
Checksum:iEA7A21FC47726369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59466 Genomic DNA Translation: CAA42073.1
PIRiS16214

Similar proteinsi

Entry informationi

Entry nameiXYLA_ARTS7
AccessioniPrimary (citable) accession number: P12070
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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