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Protein

Endothelin-2

Gene

EDN2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000808425 – 46Add BLAST22
PeptideiPRO_000000808549 – 69Endothelin-2Add BLAST21
PropeptideiPRO_000000808670 – 178Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 63By similarity
Disulfide bondi51 ↔ 59By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69 – 70Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP12064.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038061.

Structurei

3D structure databases

ProteinModelPortaliP12064.
SMRiP12064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 111Endothelin-likeAdd BLAST16

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XQ. Eukaryota.
ENOG410YUMW. LUCA.
GeneTreeiENSGT00530000063310.
HOVERGENiHBG051441.
InParanoidiP12064.
KOiK16367.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF9. PTHR13874:SF9. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPGVHHPN TASPFLKTVA AGKGQVAAAP EHPAPSARAR GSHLRPRRCS
60 70 80 90 100
CSSWLDKECV YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPKRCECSS
110 120 130 140 150
GGDPACATFC HRRPWAEAVV VPGSRSPADV FQAGRTWTSA GELLRQLRNI
160 170
SAAKIRFPRR PQEAGRQLRP THPRRRKR
Length:178
Mass (Da):19,723
Last modified:July 19, 2004 - v2
Checksum:i5BE799BA3B9BB8AA
GO

Sequence cautioni

The sequence CAA40354 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 20VA → AH in CAA40354 (PubMed:2668883).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089264 mRNA. Translation: BAC56713.1.
X57038 Genomic DNA. Translation: CAA40354.1. Sequence problems.
PIRiS29563.
RefSeqiNP_001003002.1. NM_001003002.1.
UniGeneiCfa.2.

Genome annotation databases

EnsembliENSCAFT00000045204; ENSCAFP00000038061; ENSCAFG00000002579.
GeneIDi403508.
KEGGicfa:403508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089264 mRNA. Translation: BAC56713.1.
X57038 Genomic DNA. Translation: CAA40354.1. Sequence problems.
PIRiS29563.
RefSeqiNP_001003002.1. NM_001003002.1.
UniGeneiCfa.2.

3D structure databases

ProteinModelPortaliP12064.
SMRiP12064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038061.

Proteomic databases

PaxDbiP12064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000045204; ENSCAFP00000038061; ENSCAFG00000002579.
GeneIDi403508.
KEGGicfa:403508.

Organism-specific databases

CTDi1907.

Phylogenomic databases

eggNOGiENOG410J1XQ. Eukaryota.
ENOG410YUMW. LUCA.
GeneTreeiENSGT00530000063310.
HOVERGENiHBG051441.
InParanoidiP12064.
KOiK16367.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF9. PTHR13874:SF9. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDN2_CANLF
AccessioniPrimary (citable) accession number: P12064
Secondary accession number(s): Q867C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.