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P12064

- EDN2_CANFA

UniProt

P12064 - EDN2_CANFA

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Protein

Endothelin-2

Gene

EDN2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei69 – 702Cleavage; by KELBy similarity

GO - Biological processi

  1. artery smooth muscle contraction Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cytokine-mediated signaling pathway Source: Ensembl
  4. energy homeostasis Source: Ensembl
  5. inositol phosphate-mediated signaling Source: Ensembl
  6. lung alveolus development Source: Ensembl
  7. macrophage activation Source: Ensembl
  8. macrophage chemotaxis Source: Ensembl
  9. neutrophil chemotaxis Source: Ensembl
  10. positive regulation of cell proliferation Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of heart rate Source: Ensembl
  13. positive regulation of leukocyte chemotaxis Source: Ensembl
  14. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  15. positive regulation of smooth muscle contraction Source: Ensembl
  16. prostaglandin biosynthetic process Source: Ensembl
  17. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  18. regulation of vasoconstriction Source: InterPro
  19. temperature homeostasis Source: Ensembl
  20. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_246910. Peptide ligand-binding receptors.
REACT_249096. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 4622PRO_0000008084Add
BLAST
Peptidei49 – 6921Endothelin-2PRO_0000008085Add
BLAST
Propeptidei70 – 178109PRO_0000008086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 63By similarity
Disulfide bondi51 ↔ 59By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000003751.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 11116Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43933.
GeneTreeiENSGT00530000063310.
HOVERGENiHBG051441.
InParanoidiP12064.
KOiK16367.
OMAiRNIMARA.
OrthoDBiEOG7F7WBX.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12064-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAPGVHHPN TASPFLKTVA AGKGQVAAAP EHPAPSARAR GSHLRPRRCS
60 70 80 90 100
CSSWLDKECV YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPKRCECSS
110 120 130 140 150
GGDPACATFC HRRPWAEAVV VPGSRSPADV FQAGRTWTSA GELLRQLRNI
160 170
SAAKIRFPRR PQEAGRQLRP THPRRRKR
Length:178
Mass (Da):19,723
Last modified:July 19, 2004 - v2
Checksum:i5BE799BA3B9BB8AA
GO

Sequence cautioni

The sequence CAA40354.1 differs from that shown. Reason: Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 202VA → AH in CAA40354. (PubMed:2668883)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089264 mRNA. Translation: BAC56713.1.
X57038 Genomic DNA. Translation: CAA40354.1. Sequence problems.
PIRiS29563.
RefSeqiNP_001003002.1. NM_001003002.1.
UniGeneiCfa.2.

Genome annotation databases

EnsembliENSCAFT00000045204; ENSCAFP00000038061; ENSCAFG00000002579.
GeneIDi403508.
KEGGicfa:403508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089264 mRNA. Translation: BAC56713.1 .
X57038 Genomic DNA. Translation: CAA40354.1 . Sequence problems.
PIRi S29563.
RefSeqi NP_001003002.1. NM_001003002.1.
UniGenei Cfa.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000003751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000045204 ; ENSCAFP00000038061 ; ENSCAFG00000002579 .
GeneIDi 403508.
KEGGi cfa:403508.

Organism-specific databases

CTDi 1907.

Phylogenomic databases

eggNOGi NOG43933.
GeneTreei ENSGT00530000063310.
HOVERGENi HBG051441.
InParanoidi P12064.
KOi K16367.
OMAi RNIMARA.
OrthoDBi EOG7F7WBX.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_246910. Peptide ligand-binding receptors.
REACT_249096. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 20817022.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view ]
PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of dog preproendothelin-2 cDNA and quantitative method of the gene expression by real-time PCR."
    Uchide T.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Canine endothelin-2: cDNA sequence for the mature peptide."
    Itoh Y., Kimura C., Onda H., Fujino M.
    Nucleic Acids Res. 17:5389-5389(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-74.
    Tissue: Kidney.

Entry informationi

Entry nameiEDN2_CANFA
AccessioniPrimary (citable) accession number: P12064
Secondary accession number(s): Q867C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3