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P12064 (EDN2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-2

Short name=ET-2
Alternative name(s):
Preproendothelin-2
Short name=PPET2
Gene names
Name:EDN2
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular location

Secreted.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Sequence caution

The sequence CAA40354.1 differs from that shown. Reason:

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processartery smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

calcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

inositol phosphate-mediated signaling

Inferred from electronic annotation. Source: Ensembl

macrophage activation

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin-endoperoxide synthase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

prostaglandin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by endothelin

Inferred from electronic annotation. Source: Ensembl

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vein smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 4622
PRO_0000008084
Peptide49 – 6921Endothelin-2
PRO_0000008085
Propeptide70 – 178109
PRO_0000008086

Regions

Region96 – 11116Endothelin-like

Sites

Site69 – 702Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond49 ↔ 63 By similarity
Disulfide bond51 ↔ 59 By similarity

Experimental info

Sequence conflict19 – 202VA → AH in CAA40354. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P12064 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 5BE799BA3B9BB8AA

FASTA17819,723
        10         20         30         40         50         60 
MPAPGVHHPN TASPFLKTVA AGKGQVAAAP EHPAPSARAR GSHLRPRRCS CSSWLDKECV 

        70         80         90        100        110        120 
YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPKRCECSS GGDPACATFC HRRPWAEAVV 

       130        140        150        160        170 
VPGSRSPADV FQAGRTWTSA GELLRQLRNI SAAKIRFPRR PQEAGRQLRP THPRRRKR 

« Hide

References

[1]"Cloning of dog preproendothelin-2 cDNA and quantitative method of the gene expression by real-time PCR."
Uchide T.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Canine endothelin-2: cDNA sequence for the mature peptide."
Itoh Y., Kimura C., Onda H., Fujino M.
Nucleic Acids Res. 17:5389-5389(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-74.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB089264 mRNA. Translation: BAC56713.1.
X57038 Genomic DNA. Translation: CAA40354.1. Sequence problems.
PIRS29563.
RefSeqNP_001003002.1. NM_001003002.1.
UniGeneCfa.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000003751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000045204; ENSCAFP00000038061; ENSCAFG00000002579.
GeneID403508.
KEGGcfa:403508.

Organism-specific databases

CTD1907.

Phylogenomic databases

eggNOGNOG43933.
GeneTreeENSGT00530000063310.
HOVERGENHBG051441.
KOK16367.
OrthoDBEOG7F7WBX.
TreeFamTF333184.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERPTHR13874:SF4. PTHR13874:SF4. 1 hit.
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817022.

Entry information

Entry nameEDN2_CANFA
AccessionPrimary (citable) accession number: P12064
Secondary accession number(s): Q867C8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families