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P12064

- EDN2_CANFA

UniProt

P12064 - EDN2_CANFA

Protein

Endothelin-2

Gene

EDN2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei69 – 702Cleavage; by KELBy similarity

    GO - Biological processi

    1. artery smooth muscle contraction Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cytokine-mediated signaling pathway Source: Ensembl
    4. inositol phosphate-mediated signaling Source: Ensembl
    5. macrophage activation Source: Ensembl
    6. macrophage chemotaxis Source: Ensembl
    7. neutrophil chemotaxis Source: Ensembl
    8. positive regulation of cell proliferation Source: Ensembl
    9. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    10. positive regulation of heart rate Source: Ensembl
    11. positive regulation of leukocyte chemotaxis Source: Ensembl
    12. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
    13. positive regulation of smooth muscle contraction Source: Ensembl
    14. prostaglandin biosynthetic process Source: Ensembl
    15. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    16. regulation of vasoconstriction Source: InterPro
    17. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-2
    Short name:
    ET-2
    Alternative name(s):
    Preproendothelin-2
    Short name:
    PPET2
    Gene namesi
    Name:EDN2
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 4622PRO_0000008084Add
    BLAST
    Peptidei49 – 6921Endothelin-2PRO_0000008085Add
    BLAST
    Propeptidei70 – 178109PRO_0000008086Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 63By similarity
    Disulfide bondi51 ↔ 59By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000003751.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni96 – 11116Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43933.
    GeneTreeiENSGT00530000063310.
    HOVERGENiHBG051441.
    KOiK16367.
    OMAiRNIMARA.
    OrthoDBiEOG7F7WBX.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view]
    PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12064-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAPGVHHPN TASPFLKTVA AGKGQVAAAP EHPAPSARAR GSHLRPRRCS    50
    CSSWLDKECV YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPKRCECSS 100
    GGDPACATFC HRRPWAEAVV VPGSRSPADV FQAGRTWTSA GELLRQLRNI 150
    SAAKIRFPRR PQEAGRQLRP THPRRRKR 178
    Length:178
    Mass (Da):19,723
    Last modified:July 19, 2004 - v2
    Checksum:i5BE799BA3B9BB8AA
    GO

    Sequence cautioni

    The sequence CAA40354.1 differs from that shown. Reason:

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 202VA → AH in CAA40354. (PubMed:2668883)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089264 mRNA. Translation: BAC56713.1.
    X57038 Genomic DNA. Translation: CAA40354.1. Sequence problems.
    PIRiS29563.
    RefSeqiNP_001003002.1. NM_001003002.1.
    UniGeneiCfa.2.

    Genome annotation databases

    EnsembliENSCAFT00000045204; ENSCAFP00000038061; ENSCAFG00000002579.
    GeneIDi403508.
    KEGGicfa:403508.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089264 mRNA. Translation: BAC56713.1 .
    X57038 Genomic DNA. Translation: CAA40354.1 . Sequence problems.
    PIRi S29563.
    RefSeqi NP_001003002.1. NM_001003002.1.
    UniGenei Cfa.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000003751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000045204 ; ENSCAFP00000038061 ; ENSCAFG00000002579 .
    GeneIDi 403508.
    KEGGi cfa:403508.

    Organism-specific databases

    CTDi 1907.

    Phylogenomic databases

    eggNOGi NOG43933.
    GeneTreei ENSGT00530000063310.
    HOVERGENi HBG051441.
    KOi K16367.
    OMAi RNIMARA.
    OrthoDBi EOG7F7WBX.
    TreeFami TF333184.

    Miscellaneous databases

    NextBioi 20817022.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view ]
    PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of dog preproendothelin-2 cDNA and quantitative method of the gene expression by real-time PCR."
      Uchide T.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Canine endothelin-2: cDNA sequence for the mature peptide."
      Itoh Y., Kimura C., Onda H., Fujino M.
      Nucleic Acids Res. 17:5389-5389(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-74.
      Tissue: Kidney.

    Entry informationi

    Entry nameiEDN2_CANFA
    AccessioniPrimary (citable) accession number: P12064
    Secondary accession number(s): Q867C8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3