Reviewed,
UniProtKB/Swiss-Prot P12046 (PUR7_BACSU)
Last modified
November 3, 2009.
Version 78.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphoribosylaminoimidazole-succinocarboxamide synthase EC=6.3.2.6 Alternative name(s): SAICAR synthetase Vegetative protein 286A Short name=VEG286A | ||||
| Gene names |
| ||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 241 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 |
| Sequence similarities | Belongs to the SAICAR synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 241 | 241 | Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137 | PRO_0000100801 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis." Ebbole D.J., Zalkin H. J. Biol. Chem. 262:8274-8287(1987) [PubMed: 3036807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis." Antelmann H., Bernhardt J., Schmid R., Mach H., Voelker U., Hecker M. Electrophoresis 18:1451-1463(1997) [PubMed: 9298659] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-14. Strain: 168 / IS58. |
Cross-references
Sequence databases | |
|---|---|
| J02732 Genomic DNA. Translation: AAA22677.1. AL009126 Genomic DNA. Translation: CAB12465.1. | |
| PIR | CEBSSC. D29326. |
| RefSeq | NP_388527.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KUT based on UniProtKB Q9X0X0. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 939389. |
| GenomeReviews | Gene locus BSU06450 in contig AL009126_GR. |
| KEGG | bsu:BSU06450. |
| NMPDR | fig|224308.1.peg.646. |
Organism-specific databases | |
| SubtiList | BG10703. purC. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P12046. |
| OMA | TAFNAQK. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU0646-MON. |
| BRENDA | 6.3.2.6. 150. |
Family and domain databases | |
| HAMAP | MF_00137. [Tree] |
| InterPro | IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. |
| PANTHER | PTHR11609. SAICAR_synt. 1 hit. |
| Pfam | PF01259. SAICAR_synt. 1 hit. [Graphical view] |
| ProDom | PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00081. purC. 1 hit. |
| PROSITE | PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR7_BACSU | ||||||||
| Accession | Primary (citable) accession number: P12046 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
