Reviewed, UniProtKB/Swiss-Prot P12034 (FGF5_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 5
      Short name=FGF-5
Alternative name(s):
    Heparin-binding growth factor 5
      Short name=HBGF-5
    Smag-82

Gene names

Name:

FGF5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Expressed in neonatal brain.
Developmental stage	Can transform NIH 3T3 cells.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	Signal
Molecular function	Growth factor Mitogen
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell proliferation Ref.2 Traceable author statement. Source: ProtInc cell-cell signaling Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from direct assay. Source: MGI positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Ref.2 Inferred from direct assay. Source: MGI
Cellular component	extracellular space Traceable author statement. Source: ProtInc
Molecular function	fibroblast growth factor receptor binding Inferred from direct assay. Source: MGI growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P12034-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P12034-2)

Also known as: FGF-5S;

The sequence of this isoform differs from the canonical sequence as follows:
     120-123: VLEI → QVHR
     124-268: Missing.

Note: Seems to have an antagonistic effect compared to that of the isoform Long.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 268	251	Fibroblast growth factor 5		PRO_0000008958
Regions
	Compositional bias	49 – 52	4	Poly-Ser
	Compositional bias	55 – 62	8	Poly-Ser
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	120 – 123	4	VLEI → QVHR in isoform Short.		VSP_001518
	Alternative sequence	124 – 268	145	Missing in isoform Short.		VSP_001519
	Natural variant	54	1	M → V: dbSNP rs33950145. Ref.5		VAR_025174
Experimental info
	Sequence conflict	42	1	R → I in AAB06463. Ref.1
	Sequence conflict	83 – 86	4	PSGR → LGA in AAB60699. Ref.2
	Sequence conflict	224	1	Q → QQ in AAZ67914. Ref.5
	Sequence conflict	238	1	K → N Ref.1
	Sequence conflict	238	1	K → N Ref.2
	Sequence conflict	245	1	P → S Ref.1
	Sequence conflict	245	1	P → S Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified January 24, 2006. Version 4. Checksum: 28B7268B26781BCF	FASTA	268	29,551
	10 20 30 40 50 60 MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 70 80 90 100 110 120 SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV 130 140 150 160 170 180 LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR 190 200 210 220 230 240 TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP 250 260 SPIKPKIPLS APRKNTNSVK YRLKFRFG
	Isoform Short (FGF-5S). Checksum: E77B31D2CECE1096	FASTA	123	13,006
	10 20 30 40 50 60 MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 70 80 90 100 110 120 SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSQ VHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system." Haub O., Drucker B., Goldfarb M. Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990) [PubMed: 1700424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Brain stem.
[2]	"The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors." Zhan X., Bates B., Hu X., Goldfarb M. Mol. Cell. Biol. 8:3487-3495(1988) [PubMed: 3211147] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity." Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[4]	"Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes." de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H. J. Biol. Chem. 275:23939-23947(2000) [PubMed: 10823842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Umbilical artery.
[5]	NIEHS SNPs program Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-54.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT). Tissue: Cerebellum.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37825 mRNA. Translation: AAB06463.1. M23536, M23534, M23535 Genomic DNA. Translation: AAB60699.1. M23534 Genomic DNA. Translation: AAB60698.1. Sequence problems. AB016517 mRNA. Translation: BAA33738.1. AF171928 mRNA. Translation: AAF89742.1. DQ151636 Genomic DNA. Translation: AAZ67914.1. AK312065 mRNA. Translation: BAG35001.1. CH471057 Genomic DNA. Translation: EAX05860.1.
IPI	IPI00295390. IPI00743518.
PIR	TVHUF5. A31194. B31194.
RefSeq	NP_004455.2. NP_149134.1.
UniGene	Hs.37055
3D structure databases
SMR	P12034. Positions 85-228.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4018N.
STRING	P12034.
Proteomic databases
PRIDE	P12034.
Genome annotation databases
Ensembl	ENST00000312465; ENSP00000311697; ENSG00000138675; Homo sapiens. [Genome view]
GeneID	2250.
KEGG	hsa:2250.
UCSC	uc003hmd.1. human. uc003hme.1. human.
Organism-specific databases
CTD	2250.
GeneCards	GC04P081406.
HGNC	HGNC:3683. FGF5.
HPA	CAB010313.
MIM	165190. gene.
PharmGKB	PA28122.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13725.
HOGENOM	HBG715603.
HOVERGEN	P12034.
InParanoid	P12034.
OMA	SHEANML.
OrthoDB	EOG98SKD9.
PhylomeDB	P12034.
Enzyme and pathway databases
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
ArrayExpress	P12034.
Bgee	P12034.
CleanEx	HS_FGF5.
Genevestigator	P12034.
GermOnline	ENSG00000138675. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9107.
SOURCE	Search...

Entry information

Entry name

FGF5_HUMAN

Accession

Primary (citable) accession number: P12034
Secondary accession number(s): B2R554, O75846, Q3Y8M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	January 24, 2006
Last modified:	January 19, 2010
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.