Reviewed,
UniProtKB/Swiss-Prot P12034 (FGF5_HUMAN)
Last modified
July 22, 2008.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fibroblast growth factor 5 Short name(s)=FGF-5 Alternative name(s): Heparin-binding growth factor 5 Short name(s)=HBGF-5 Smag-82 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 268 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase By similarity. |
| Subcellular location | SecretedPotential. |
| Tissue specificity | Expressed in neonatal brain. |
| Developmental stage | Can transform NIH 3T3 cells. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Disease | Proto-oncogene |
| Domain | Signal |
| Molecular function | Growth factor Mitogen |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | cell proliferation Ref.2 Traceable author statement. Source: ProtInc cell-cell signalingTraceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathwayTraceable author statement. Source: ProtInc nervous system developmentTraceable author statement. Source: ProtInc |
| Cellular component | extracellular space Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | |||||
| Isoform Long (identifier: P12034-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | |||||
| Isoform Short (identifier: P12034-2) Also known as: FGF-5S; The sequence of this isoform differs from the canonical sequence as follows: 120-123: VLEI → QVHR 124-268: Missing. | |||||
| Notes: Seems to have an antagonistic effect compared to that of the isoform Long. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | |||||
| Chain | 18 – 268 | 251 | Fibroblast growth factor 5 | |||||
Regions | ||||||||
| Compositional bias | 49 – 52 | 4 | Poly-Ser | |||||
| Compositional bias | 55 – 62 | 8 | Poly-Ser | |||||
Amino acid modifications | ||||||||
| Glycosylation | 110 | 1 | N-linked (GlcNAc...) Potential | |||||
Natural variations | ||||||||
| Alternative sequence | 120 – 123 | 4 | VLEI → QVHR in isoform Short. | |||||
| Alternative sequence | 124 – 268 | 145 | Missing in isoform Short. | |||||
| Natural variant | 54 | 1 | M → V: dbSNP rs33950145. | |||||
Experimental info | ||||||||
| Sequence conflict | 42 | 1 | R → I in AAB06463. Ref.1 | |||||
| Sequence conflict | 83 – 86 | 4 | PSGR → LGA in AAB60699. Ref.2 | |||||
| Sequence conflict | 224 | 1 | Q → QQ in AAZ67914. Ref.5 | |||||
| Sequence conflict | 238 | 1 | K → N Ref.1 Ref.2 | |||||
| Sequence conflict | 245 | 1 | P → S Ref.1 Ref.2 | |||||
Sequences
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References
| [1] | "Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system." Haub O., Drucker B., Goldfarb M. Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990) [PubMed: 1700424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Brain stem. |
| [2] | "The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors." Zhan X., Bates B., Hu X., Goldfarb M. Mol. Cell. Biol. 8:3487-3495(1988) [PubMed: 3211147] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity." Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). |
| [4] | "Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes." de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H. J. Biol. Chem. 275:23939-23947(2000) [PubMed: 10823842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Umbilical artery. |
| [5] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-54. |
Cross-references
Sequence databases | |
|---|---|
| M37825 mRNA. Translation: AAB06463.1. M23536, M23534, M23535 Genomic DNA. Translation: AAB60699.1. M23534 Genomic DNA. Translation: AAB60698.1. Sequence problems. AB016517 mRNA. Translation: BAA33738.1. AF171928 mRNA. Translation: AAF89742.1. DQ151636 Genomic DNA. Translation: AAZ67914.1. | |
| PIR | TVHUF5. A31194. B31194. |
| RefSeq | NP_004455.2. NP_149134.1. |
| UniGene | Hs.37055 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IJT based on UniProtKB P08620. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:4018N. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000138675. Homo sapiens. [Contig view] |
| GeneID | 2250. |
| KEGG | hsa:2250. |
Organism-specific databases | |
| HGNC | HGNC:3683. FGF5. |
| HPA | CAB010313. |
| MIM | 165190. gene. |
| PharmGKB | PA28122. |
| GenAtlas | Search... |
| GeneCards | Search... |
| GeneLynx | Search... |
Phylogenomic databases | |
| HOGENOM | P12034. |
| HOVERGEN | P12034. |
Enzyme and pathway databases | |
| Reactome | REACT_9470. Signaling by FGFR. |
Gene expression databases | |
| ArrayExpress | P12034. |
| CleanEx | HS_FGF5. |
| GermOnline | ENSG00000138675. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] |
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. |
| Pfam | PF00167. FGF. 1 hit. [Graphical view] |
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. |
| ProDom | PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00442. FGF. 1 hit. [Graphical view] |
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | FGF5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P12034 Secondary accession number(s): O75846, Q3Y8M3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


