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P12034

- FGF5_HUMAN

UniProt

P12034 - FGF5_HUMAN

Protein

Fibroblast growth factor 5

Gene

FGF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 4 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase By similarity.By similarity

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. epidermal growth factor receptor signaling pathway Source: Reactome
    4. Fc-epsilon receptor signaling pathway Source: Reactome
    5. fibroblast growth factor receptor signaling pathway Source: MGI
    6. glial cell differentiation Source: Ensembl
    7. innate immune response Source: Reactome
    8. insulin receptor signaling pathway Source: Reactome
    9. nervous system development Source: ProtInc
    10. neurotrophin TRK receptor signaling pathway Source: Reactome
    11. phosphatidylinositol-mediated signaling Source: Reactome
    12. positive regulation of cell division Source: UniProtKB-KW
    13. positive regulation of cell proliferation Source: MGI
    14. signal transduction involved in regulation of gene expression Source: Ensembl

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 5
    Short name:
    FGF-5
    Alternative name(s):
    Heparin-binding growth factor 5
    Short name:
    HBGF-5
    Smag-82
    Gene namesi
    Name:FGF5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3683. FGF5.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA28122.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 268248Fibroblast growth factor 5PRO_0000008958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP12034.
    PRIDEiP12034.

    PTM databases

    PhosphoSiteiP12034.

    Expressioni

    Tissue specificityi

    Expressed in neonatal brain.

    Developmental stagei

    Can transform NIH 3T3 cells.

    Gene expression databases

    ArrayExpressiP12034.
    BgeeiP12034.
    CleanExiHS_FGF5.
    GenevestigatoriP12034.

    Organism-specific databases

    HPAiCAB010313.

    Interactioni

    Subunit structurei

    Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

    Protein-protein interaction databases

    DIPiDIP-4018N.
    IntActiP12034. 4 interactions.
    STRINGi9606.ENSP00000311697.

    Structurei

    3D structure databases

    ProteinModelPortaliP12034.
    SMRiP12034. Positions 87-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi49 – 524Poly-Ser
    Compositional biasi55 – 628Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG247419.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP12034.
    KOiK04358.
    OMAiSHEANML.
    OrthoDBiEOG7992S1.
    PhylomeDBiP12034.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028240. FGF5.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF23. PTHR11486:SF23. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P12034-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS    50
    SSAMSSSSAS SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH 100
    LQIYPDGKVN GSHEANMLSV LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL 150
    HASAKFTDDC KFRERFQENS YNTYASAIHR TEKTGREWYV ALNKRGKAKR 200
    GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP SPIKPKIPLS 250
    APRKNTNSVK YRLKFRFG 268
    Length:268
    Mass (Da):29,551
    Last modified:January 24, 2006 - v4
    Checksum:i28B7268B26781BCF
    GO
    Isoform Short (identifier: P12034-2) [UniParc]FASTAAdd to Basket

    Also known as: FGF-5S

    The sequence of this isoform differs from the canonical sequence as follows:
         120-123: VLEI → QVHR
         124-268: Missing.

    Note: Seems to have an antagonistic effect compared to that of the isoform Long.

    Show »
    Length:123
    Mass (Da):13,006
    Checksum:iE77B31D2CECE1096
    GO

    Sequence cautioni

    The sequence AAB60698.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421R → I in AAB06463. (PubMed:1700424)Curated
    Sequence conflicti83 – 864PSGR → LGA in AAB60699. (PubMed:3211147)Curated
    Sequence conflicti224 – 2241Q → QQ in AAZ67914. 1 PublicationCurated
    Sequence conflicti238 – 2381K → N in AAB06463. (PubMed:1700424)Curated
    Sequence conflicti238 – 2381K → N in AAB60699. (PubMed:3211147)Curated
    Sequence conflicti245 – 2451P → S in AAB06463. (PubMed:1700424)Curated
    Sequence conflicti245 – 2451P → S in AAB60699. (PubMed:3211147)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541M → V.1 Publication
    Corresponds to variant rs33950145 [ dbSNP | Ensembl ].
    VAR_025174

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei120 – 1234VLEI → QVHR in isoform Short. 3 PublicationsVSP_001518
    Alternative sequencei124 – 268145Missing in isoform Short. 3 PublicationsVSP_001519Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37825 mRNA. Translation: AAB06463.1.
    M23536, M23534, M23535 Genomic DNA. Translation: AAB60699.1.
    M23534 Genomic DNA. Translation: AAB60698.1. Sequence problems.
    AB016517 mRNA. Translation: BAA33738.1.
    AF171928 mRNA. Translation: AAF89742.1.
    AF535149 mRNA. Translation: AAN04097.1.
    DQ151636 Genomic DNA. Translation: AAZ67914.1.
    AK291962 mRNA. Translation: BAF84651.1.
    AK312065 mRNA. Translation: BAG35001.1.
    CH471057 Genomic DNA. Translation: EAX05859.1.
    CH471057 Genomic DNA. Translation: EAX05860.1.
    BC074858 mRNA. Translation: AAH74858.1.
    BC074859 mRNA. Translation: AAH74859.1.
    BC131502 mRNA. Translation: AAI31503.1.
    CCDSiCCDS34021.1. [P12034-1]
    CCDS3586.1. [P12034-2]
    PIRiA31194. TVHUF5.
    B31194.
    RefSeqiNP_004455.2. NM_004464.3. [P12034-1]
    NP_149134.1. NM_033143.2. [P12034-2]
    UniGeneiHs.37055.

    Genome annotation databases

    EnsembliENST00000312465; ENSP00000311697; ENSG00000138675. [P12034-1]
    ENST00000456523; ENSP00000398353; ENSG00000138675. [P12034-2]
    GeneIDi2250.
    KEGGihsa:2250.
    UCSCiuc003hmd.3. human. [P12034-1]
    uc003hme.3. human. [P12034-2]

    Polymorphism databases

    DMDMi85700417.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37825 mRNA. Translation: AAB06463.1 .
    M23536 , M23534 , M23535 Genomic DNA. Translation: AAB60699.1 .
    M23534 Genomic DNA. Translation: AAB60698.1 . Sequence problems.
    AB016517 mRNA. Translation: BAA33738.1 .
    AF171928 mRNA. Translation: AAF89742.1 .
    AF535149 mRNA. Translation: AAN04097.1 .
    DQ151636 Genomic DNA. Translation: AAZ67914.1 .
    AK291962 mRNA. Translation: BAF84651.1 .
    AK312065 mRNA. Translation: BAG35001.1 .
    CH471057 Genomic DNA. Translation: EAX05859.1 .
    CH471057 Genomic DNA. Translation: EAX05860.1 .
    BC074858 mRNA. Translation: AAH74858.1 .
    BC074859 mRNA. Translation: AAH74859.1 .
    BC131502 mRNA. Translation: AAI31503.1 .
    CCDSi CCDS34021.1. [P12034-1 ]
    CCDS3586.1. [P12034-2 ]
    PIRi A31194. TVHUF5.
    B31194.
    RefSeqi NP_004455.2. NM_004464.3. [P12034-1 ]
    NP_149134.1. NM_033143.2. [P12034-2 ]
    UniGenei Hs.37055.

    3D structure databases

    ProteinModelPortali P12034.
    SMRi P12034. Positions 87-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-4018N.
    IntActi P12034. 4 interactions.
    STRINGi 9606.ENSP00000311697.

    PTM databases

    PhosphoSitei P12034.

    Polymorphism databases

    DMDMi 85700417.

    Proteomic databases

    PaxDbi P12034.
    PRIDEi P12034.

    Protocols and materials databases

    DNASUi 2250.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312465 ; ENSP00000311697 ; ENSG00000138675 . [P12034-1 ]
    ENST00000456523 ; ENSP00000398353 ; ENSG00000138675 . [P12034-2 ]
    GeneIDi 2250.
    KEGGi hsa:2250.
    UCSCi uc003hmd.3. human. [P12034-1 ]
    uc003hme.3. human. [P12034-2 ]

    Organism-specific databases

    CTDi 2250.
    GeneCardsi GC04P081187.
    HGNCi HGNC:3683. FGF5.
    HPAi CAB010313.
    MIMi 165190. gene.
    neXtProti NX_P12034.
    PharmGKBi PA28122.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247419.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P12034.
    KOi K04358.
    OMAi SHEANML.
    OrthoDBi EOG7992S1.
    PhylomeDBi P12034.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.

    Miscellaneous databases

    GeneWikii FGF5.
    GenomeRNAii 2250.
    NextBioi 9107.
    PROi P12034.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12034.
    Bgeei P12034.
    CleanExi HS_FGF5.
    Genevestigatori P12034.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028240. FGF5.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF23. PTHR11486:SF23. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system."
      Haub O., Drucker B., Goldfarb M.
      Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Tissue: Brain stem.
    2. "The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors."
      Zhan X., Bates B., Hu X., Goldfarb M.
      Mol. Cell. Biol. 8:3487-3495(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity."
      Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    4. "Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes."
      de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H.
      J. Biol. Chem. 275:23939-23947(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Umbilical artery.
    5. "Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas."
      Hanada K.-I., Perry-Lalley D.M., Ohnmacht G.A., Bettinotti M.P., Yang J.C.
      Cancer Res. 61:5511-5516(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    6. NIEHS SNPs program
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-54.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SHORT AND LONG).
      Tissue: Cerebellum.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Lung.
    10. Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN CELL PROLIFERATION.
    11. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiFGF5_HUMAN
    AccessioniPrimary (citable) accession number: P12034
    Secondary accession number(s): B2R554
    , O75846, Q3Y8M3, Q8NF90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 140 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3