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P12034 (FGF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 5

Short name=FGF-5
Alternative name(s):
Heparin-binding growth factor 5
Short name=HBGF-5
Smag-82
Gene names
Name:FGF5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase By similarity. Ref.10

Subunit structure

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.10

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in neonatal brain.

Developmental stage

Can transform NIH 3T3 cells.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence caution

The sequence AAB60698.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseProto-oncogene
   DomainSignal
   Molecular functionGrowth factor
Mitogen
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

cell proliferation

Traceable author statement Ref.2. Source: ProtInc

cell-cell signaling

Traceable author statement PubMed 9786939. Source: ProtInc

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Inferred from direct assay PubMed 8386828. Source: MGI

glial cell differentiation

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

nervous system development

Traceable author statement PubMed 9786939. Source: ProtInc

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from direct assay Ref.2. Source: MGI

signal transduction involved in regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Traceable author statement PubMed 9786939. Source: ProtInc

   Molecular_functionfibroblast growth factor receptor binding

Inferred from direct assay PubMed 8386828. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P12034-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P12034-2)

Also known as: FGF-5S;

The sequence of this isoform differs from the canonical sequence as follows:
     120-123: VLEI → QVHR
     124-268: Missing.
Note: Seems to have an antagonistic effect compared to that of the isoform Long.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 268248Fibroblast growth factor 5
PRO_0000008958

Regions

Compositional bias49 – 524Poly-Ser
Compositional bias55 – 628Poly-Ser

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence120 – 1234VLEI → QVHR in isoform Short.
VSP_001518
Alternative sequence124 – 268145Missing in isoform Short.
VSP_001519
Natural variant541M → V. Ref.6
Corresponds to variant rs33950145 [ dbSNP | Ensembl ].
VAR_025174

Experimental info

Sequence conflict421R → I in AAB06463. Ref.1
Sequence conflict83 – 864PSGR → LGA in AAB60699. Ref.2
Sequence conflict2241Q → QQ in AAZ67914. Ref.6
Sequence conflict2381K → N in AAB06463. Ref.1
Sequence conflict2381K → N in AAB60699. Ref.2
Sequence conflict2451P → S in AAB06463. Ref.1
Sequence conflict2451P → S in AAB60699. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified January 24, 2006. Version 4.
Checksum: 28B7268B26781BCF

FASTA26829,551
        10         20         30         40         50         60 
MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 

        70         80         90        100        110        120 
SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV 

       130        140        150        160        170        180 
LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR 

       190        200        210        220        230        240 
TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP 

       250        260 
SPIKPKIPLS APRKNTNSVK YRLKFRFG 

« Hide

Isoform Short (FGF-5S) [UniParc].

Checksum: E77B31D2CECE1096
Show »

FASTA12313,006

References

« Hide 'large scale' references
[1]"Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system."
Haub O., Drucker B., Goldfarb M.
Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
Tissue: Brain stem.
[2]"The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors."
Zhan X., Bates B., Hu X., Goldfarb M.
Mol. Cell. Biol. 8:3487-3495(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity."
Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[4]"Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes."
de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H.
J. Biol. Chem. 275:23939-23947(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Tissue: Umbilical artery.
[5]"Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas."
Hanada K.-I., Perry-Lalley D.M., Ohnmacht G.A., Bettinotti M.P., Yang J.C.
Cancer Res. 61:5511-5516(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[6]NIEHS SNPs program
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-54.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SHORT AND LONG).
Tissue: Cerebellum.
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Tissue: Lung.
[10]"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M.
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN CELL PROLIFERATION.
[11]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37825 mRNA. Translation: AAB06463.1.
M23536, M23534, M23535 Genomic DNA. Translation: AAB60699.1.
M23534 Genomic DNA. Translation: AAB60698.1. Sequence problems.
AB016517 mRNA. Translation: BAA33738.1.
AF171928 mRNA. Translation: AAF89742.1.
AF535149 mRNA. Translation: AAN04097.1.
DQ151636 Genomic DNA. Translation: AAZ67914.1.
AK291962 mRNA. Translation: BAF84651.1.
AK312065 mRNA. Translation: BAG35001.1.
CH471057 Genomic DNA. Translation: EAX05859.1.
CH471057 Genomic DNA. Translation: EAX05860.1.
BC074858 mRNA. Translation: AAH74858.1.
BC074859 mRNA. Translation: AAH74859.1.
BC131502 mRNA. Translation: AAI31503.1.
CCDSCCDS34021.1. [P12034-1]
CCDS3586.1. [P12034-2]
PIRTVHUF5. A31194.
B31194.
RefSeqNP_004455.2. NM_004464.3. [P12034-1]
NP_149134.1. NM_033143.2. [P12034-2]
UniGeneHs.37055.

3D structure databases

ProteinModelPortalP12034.
SMRP12034. Positions 87-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-4018N.
STRING9606.ENSP00000311697.

PTM databases

PhosphoSiteP12034.

Polymorphism databases

DMDM85700417.

Proteomic databases

PaxDbP12034.
PRIDEP12034.

Protocols and materials databases

DNASU2250.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312465; ENSP00000311697; ENSG00000138675. [P12034-1]
ENST00000456523; ENSP00000398353; ENSG00000138675. [P12034-2]
GeneID2250.
KEGGhsa:2250.
UCSCuc003hmd.3. human. [P12034-1]
uc003hme.3. human. [P12034-2]

Organism-specific databases

CTD2250.
GeneCardsGC04P081187.
HGNCHGNC:3683. FGF5.
HPACAB010313.
MIM165190. gene.
neXtProtNX_P12034.
PharmGKBPA28122.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247419.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP12034.
KOK04358.
OMASHEANML.
OrthoDBEOG7992S1.
PhylomeDBP12034.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP12034.
BgeeP12034.
CleanExHS_FGF5.
GenevestigatorP12034.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028240. FGF5.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF23. PTHR11486:SF23. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGF5.
GenomeRNAi2250.
NextBio9107.
PROP12034.
SOURCESearch...

Entry information

Entry nameFGF5_HUMAN
AccessionPrimary (citable) accession number: P12034
Secondary accession number(s): B2R554 expand/collapse secondary AC list , O75846, Q3Y8M3, Q8NF90
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM