Reviewed, UniProtKB/Swiss-Prot P12034 (FGF5_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 5
      Short name(s)=FGF-5
Alternative name(s):
    Heparin-binding growth factor 5
      Short name(s)=HBGF-5
    Smag-82

Gene names

Name:

FGF5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase By similarity.
Subcellular location	SecretedPotential.
Tissue specificity	Expressed in neonatal brain.
Developmental stage	Can transform NIH 3T3 cells.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	Signal
Molecular function	Growth factor Mitogen
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell proliferation Ref.2 Traceable author statement. Source: ProtInc cell-cell signaling Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Traceable author statement. Source: ProtInc nervous system development Traceable author statement. Source: ProtInc
Cellular component	extracellular space Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P12034-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P12034-2)

Also known as: FGF-5S;

The sequence of this isoform differs from the canonical sequence as follows:
     120-123: VLEI → QVHR
     124-268: Missing.

Notes: Seems to have an antagonistic effect compared to that of the isoform Long.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 268	251	Fibroblast growth factor 5
Regions
	Compositional bias	49 – 52	4	Poly-Ser
	Compositional bias	55 – 62	8	Poly-Ser
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	120 – 123	4	VLEI → QVHR in isoform Short.
	Alternative sequence	124 – 268	145	Missing in isoform Short.
	Natural variant	54	1	M → V: dbSNP rs33950145.
Experimental info
	Sequence conflict	42	1	R → I in AAB06463. Ref.1
	Sequence conflict	83 – 86	4	PSGR → LGA in AAB60699. Ref.2
	Sequence conflict	224	1	Q → QQ in AAZ67914. Ref.5
	Sequence conflict	238	1	K → N Ref.1 Ref.2
	Sequence conflict	245	1	P → S Ref.1 Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified January 24, 2006. Version 4. Checksum: 28B7268B26781BCF	FASTA	268	29,551
	10 20 30 40 50 60 MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 70 80 90 100 110 120 SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV 130 140 150 160 170 180 LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR 190 200 210 220 230 240 TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP 250 260 SPIKPKIPLS APRKNTNSVK YRLKFRFG
	Isoform Short (FGF-5S) [UniParc]. Checksum: E77B31D2CECE1096		123	13,006
	10 20 30 40 50 60 MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 70 80 90 100 110 120 SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSQ VHR

References

[1]	"Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system." Haub O., Drucker B., Goldfarb M. Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990) [PubMed: 1700424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Brain stem.
[2]	"The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors." Zhan X., Bates B., Hu X., Goldfarb M. Mol. Cell. Biol. 8:3487-3495(1988) [PubMed: 3211147] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity." Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[4]	"Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes." de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H. J. Biol. Chem. 275:23939-23947(2000) [PubMed: 10823842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Umbilical artery.
[5]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-54.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M37825 mRNA. Translation: AAB06463.1. M23536, M23534, M23535 Genomic DNA. Translation: AAB60699.1. M23534 Genomic DNA. Translation: AAB60698.1. Sequence problems. AB016517 mRNA. Translation: BAA33738.1. AF171928 mRNA. Translation: AAF89742.1. DQ151636 Genomic DNA. Translation: AAZ67914.1.
PIR	TVHUF5. A31194. B31194.
RefSeq	NP_004455.2. NP_149134.1.
UniGene	Hs.37055
3D structure databases
HSSP	HSSP built from PDB template 1IJT based on UniProtKB P08620.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4018N.
Polymorphism databases
NIEHS-SNPs	Search...
Genome annotation databases
Ensembl	ENSG00000138675. Homo sapiens. [Contig view]
GeneID	2250.
KEGG	hsa:2250.
Organism-specific databases
HGNC	HGNC:3683. FGF5.
HPA	CAB010313.
MIM	165190. gene.
PharmGKB	PA28122.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P12034.
HOVERGEN	P12034.
Enzyme and pathway databases
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
ArrayExpress	P12034.
CleanEx	HS_FGF5.
GermOnline	ENSG00000138675. Homo sapiens.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

FGF5_HUMAN

Accession

Primary (citable) accession number: P12034
Secondary accession number(s): O75846, Q3Y8M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	January 24, 2006
Last modified:	July 22, 2008
This is version 83 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)