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Protein

Phosphoribulokinase 1

Gene

prkA

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate.

Enzyme regulationi

Activated by NADH and inhibited by phosphoenolpyruvate.

Pathwayi: Calvin cycle

This protein is involved in the pathway Calvin cycle, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway Calvin cycle and in Carbohydrate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20ATPSequence analysis9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Calvin cycle, Photosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribulokinase 1 (EC:2.7.1.19)
Short name:
PRK I
Short name:
PRKase 1
Alternative name(s):
Phosphopentokinase 1
Gene namesi
Name:prkA
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002019571 – 290Phosphoribulokinase 1Add BLAST290

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi349102.Rsph17025_2714.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 12Combined sources6
Helixi21 – 32Combined sources12
Beta strandi36 – 40Combined sources5
Helixi41 – 44Combined sources4
Helixi49 – 62Combined sources14
Helixi72 – 74Combined sources3
Helixi77 – 90Combined sources14
Beta strandi126 – 133Combined sources8
Helixi145 – 147Combined sources3
Beta strandi149 – 156Combined sources8
Helixi158 – 168Combined sources11
Beta strandi170 – 172Combined sources3
Helixi180 – 194Combined sources15
Helixi196 – 200Combined sources5
Beta strandi203 – 212Combined sources10
Helixi217 – 219Combined sources3
Helixi226 – 228Combined sources3
Beta strandi229 – 237Combined sources9
Helixi243 – 249Combined sources7
Beta strandi254 – 257Combined sources4
Beta strandi260 – 264Combined sources5
Helixi265 – 267Combined sources3
Helixi268 – 284Combined sources17
Turni285 – 288Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7JX-ray2.50A1-290[»]
ProteinModelPortaliP12033.
SMRiP12033.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12033.

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoribulokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CJE. Bacteria.
COG3954. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006082. PRK.
IPR006083. PRK/URK.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00478. PHRIBLKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00567. PHOSPHORIBULOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKHPIISV TGSSGAGTST VKHTFDQIFR REGVKAVSIE GDAFHRFNRA
60 70 80 90 100
DMKAELDRRY AAGDATFSHF SYEANELKEL ERVFREYGET GQGRTRTYVH
110 120 130 140 150
DDAEAARTGV APGNFTDWRD FDSDSHLLFY EGLHGAVVNS EVNIAGLADL
160 170 180 190 200
KIGVVPVINL EWIQKIHRDR ATRGYTTEAV TDVILRRMHA YVHCIVPQFS
210 220 230 240 250
QTDINFQRVP VVDTSNPFIA RWIPTADESV VVIRFRNPRG IDFPYLTSMI
260 270 280 290
HGSWMSRANS IVVPGNKLDL AMQLILTPLI DRVVRESKVA
Length:290
Mass (Da):32,664
Last modified:August 1, 1992 - v2
Checksum:i6899EFB1D780640F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64624 Genomic DNA. Translation: AAA26113.1.
M28006 Genomic DNA. Translation: AAA26153.1.
PIRiC40767. KIRFAS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64624 Genomic DNA. Translation: AAA26113.1.
M28006 Genomic DNA. Translation: AAA26153.1.
PIRiC40767. KIRFAS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7JX-ray2.50A1-290[»]
ProteinModelPortaliP12033.
SMRiP12033.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349102.Rsph17025_2714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CJE. Bacteria.
COG3954. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00116.

Miscellaneous databases

EvolutionaryTraceiP12033.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006082. PRK.
IPR006083. PRK/URK.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00478. PHRIBLKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00567. PHOSPHORIBULOKINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPPR1_RHOSH
AccessioniPrimary (citable) accession number: P12033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Is not found in cells cultured chemoheterotrophically and only low levels of activities are found in those grown photoheterotrophically on oxidized organic acids.

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.