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Protein

Acyl-CoA-binding protein

Gene

DBI

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
DBI(32-86) has antibacterial properties.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-SSC-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Cleaved into the following chain:
Gene namesi
Name:DBI
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

Subcellular locationi

  • Endoplasmic reticulum By similarity
  • Golgi apparatus By similarity

  • Note: Golgi localization is dependent on ligand binding.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000451992 – 87Acyl-CoA-binding proteinAdd BLAST86
PeptideiPRO_000000028733 – 87DBI(32-86)Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei8N6-acetyllysine; alternateBy similarity1
Modified residuei8N6-succinyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei29PhosphotyrosineBy similarity1
Modified residuei51N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysine; alternateBy similarity1
Modified residuei55N6-malonyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysine; alternateBy similarity1
Modified residuei77N6-acetyllysine; alternateBy similarity1
Modified residuei77N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP12026.
PeptideAtlasiP12026.
PRIDEiP12026.

Expressioni

Gene expression databases

BgeeiENSSSCG00000023435.
GenevisibleiP12026. SS.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021888.

Structurei

3D structure databases

ProteinModelPortaliP12026.
SMRiP12026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiP12026.
KOiK08762.
OMAiRYKFEAW.
OrthoDBiEOG091G0NXJ.
TreeFamiTF335802.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiView protein in InterPro
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
PfamiView protein in Pfam
PF00887. ACBP. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiView protein in PROSITE
PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEFEKAA EEVKNLKTKP ADDEMLFIYS HYKQATVGDI NTERPGILDL
60 70 80
KGKAKWDAWN GLKGTSKEDA MKAYINKVEE LKKKYGI
Length:87
Mass (Da):9,896
Last modified:January 23, 2007 - v2
Checksum:i3225B53E8307DE38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019792 mRNA. Translation: BAA34531.1.
DQ885192 mRNA. Translation: ABM30147.1.
PIRiS00805. NZPG.
RefSeqiNP_999284.1. NM_214119.1.
UniGeneiSsc.55858.

Genome annotation databases

EnsembliENSSSCT00000024406; ENSSSCP00000021888; ENSSSCG00000023435.
GeneIDi397212.
KEGGissc:397212.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACBP_PIG
AccessioniPrimary (citable) accession number: P12026
Secondary accession number(s): A7YB23, Q9TSG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families