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Protein

Chaoptin

Gene

chp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion.1 Publication

GO - Biological processi

  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • microvillus organization Source: FlyBase
  • response to stimulus Source: UniProtKB-KW
  • rhabdomere development Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Chaoptin
Alternative name(s):
Photoreceptor cell-specific membrane protein
Gene namesi
Name:chp
Synonyms:CHT
ORF Names:CG1744
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0267435. chp.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: FlyBase
  • plasma membrane Source: FlyBase
  • rhabdomere Source: FlyBase
  • rhabdomere microvillus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000002092330 – 1315ChaoptinAdd BLAST1286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) (high mannose); alternate1 Publication1
Glycosylationi77N-linked (GlcNAc...) (paucimannose); alternate1 Publication1
Glycosylationi267N-linked (GlcNAc...) (complex); alternate1 Publication1
Glycosylationi267N-linked (GlcNAc...) (paucimannose); alternate1 Publication1
Glycosylationi305N-linked (GlcNAc...) (high mannose); alternate2 Publications1
Glycosylationi305N-linked (GlcNAc...) (paucimannose); alternate2 Publications1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1
Glycosylationi361N-linked (GlcNAc...) (high mannose)1 Publication1
Glycosylationi422N-linked (GlcNAc...)1 Publication1
Glycosylationi680N-linked (GlcNAc...) (high mannose)1 Publication1
Glycosylationi692N-linked (GlcNAc...) (high mannose); alternate2 Publications1
Glycosylationi692N-linked (GlcNAc...) (paucimannose); alternate2 Publications1
Glycosylationi718N-linked (GlcNAc...) (high mannose)1 Publication1
Glycosylationi746N-linked (GlcNAc...)Sequence analysis1
Glycosylationi936N-linked (GlcNAc...) (high mannose)2 Publications1
Glycosylationi970N-linked (GlcNAc...) (paucimannose)1 Publication1
Glycosylationi1012N-linked (GlcNAc...) (complex)1 Publication1
Glycosylationi1104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1122N-linked (GlcNAc...) (high mannose)2 Publications1
Glycosylationi1152N-linked (GlcNAc...) (high mannose)1 Publication1
Glycosylationi1171N-linked (GlcNAc...) (high mannose)2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12024.
PRIDEiP12024.

Expressioni

Tissue specificityi

Expressed in photoreceptor cells and their axons in the adult retina, the ocellus and larval photoreceptor organ.1 Publication

Developmental stagei

Expressed 24 hours after initiation of photoreceptor cell differentiation, persists through development to adulthood.

Gene expression databases

BgeeiFBgn0000313.
ExpressionAtlasiP12024. baseline.
GenevisibleiP12024. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0303134.

Structurei

3D structure databases

ProteinModelPortaliP12024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 101LRR 1Add BLAST22
Repeati103 – 124LRR 2Add BLAST22
Repeati128 – 149LRR 3Add BLAST22
Repeati152 – 173LRR 4Add BLAST22
Repeati177 – 198LRR 5Add BLAST22
Repeati201 – 222LRR 6Add BLAST22
Repeati226 – 247LRR 7Add BLAST22
Repeati250 – 271LRR 8Add BLAST22
Repeati279 – 300LRR 9Add BLAST22
Repeati326 – 347LRR 10Add BLAST22
Repeati351 – 372LRR 11Add BLAST22
Repeati375 – 396LRR 12Add BLAST22
Repeati401 – 424LRR 13Add BLAST24
Repeati477 – 498LRR 14Add BLAST22
Repeati527 – 548LRR 15Add BLAST22
Repeati551 – 572LRR 16Add BLAST22
Repeati577 – 598LRR 17Add BLAST22
Repeati601 – 622LRR 18Add BLAST22
Repeati625 – 646LRR 19Add BLAST22
Repeati649 – 670LRR 20Add BLAST22
Repeati676 – 696LRR 21Add BLAST21
Repeati708 – 729LRR 22Add BLAST22
Repeati733 – 754LRR 23Add BLAST22
Repeati757 – 778LRR 24Add BLAST22
Repeati781 – 802LRR 25Add BLAST22
Repeati805 – 826LRR 26Add BLAST22
Repeati828 – 849LRR 27Add BLAST22
Repeati854 – 875LRR 28Add BLAST22
Repeati879 – 900LRR 29Add BLAST22
Repeati903 – 924LRR 30Add BLAST22
Repeati928 – 948LRR 31Add BLAST21
Repeati949 – 970LRR 32Add BLAST22
Repeati973 – 994LRR 33Add BLAST22
Repeati996 – 1017LRR 34Add BLAST22
Repeati1021 – 1044LRR 35Add BLAST24
Repeati1045 – 1066LRR 36Add BLAST22
Domaini1211 – 1274LRRCTAdd BLAST64

Sequence similaritiesi

Belongs to the chaoptin family.Curated
Contains 36 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000265621.
InParanoidiP12024.
OrthoDBiEOG091G00WB.
PhylomeDBiP12024.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000225. Armadillo.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 10 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 27 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 29 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEFFFKFG YAFLTITLMI MIWMSLARAS MFDREMEETH YPPCTYNVMC
60 70 80 90 100
TCSKSSTDLG IVHCKNVPFP ALPRMVNQSK VFMLHMENTG LREIEPYFLQ
110 120 130 140 150
STGMYRLKIS GNHLTEIPDD AFTGLERSLW ELILPQNDLV EIPSKSLRHL
160 170 180 190 200
QKLRHLDLGY NHITHIQHDS FRGLEDSLQT LILRENCISQ LMSHSFSGLL
210 220 230 240 250
ILETLDLSGN NLFEIDPNVF VDGMPRLTRL LLTDNILSEI PYDALGPLKS
260 270 280 290 300
LRTLDISHNV IWSLSGNETY EIKASTKLNL DNLHLEYNHI EVLPPNSFKY
310 320 330 340 350
FDTVNRTFFD GNPIHTLRED AFKPARIREI YMRYCGLTNI SPVAFDSLVN
360 370 380 390 400
SLQILDLSGN NLTKLHHKLF NNFDVLRVIS MRDNKIKIQK PTETFNAVHY
410 420 430 440 450
TLLKLDLSGD RNDPTNLQTL RNMTRMRNMR SLSISRLGSS SVGPEDFKDF
460 470 480 490 500
GVELEDLQIT RASLSGIQSH AFKHVRGLKR LDFSENGISS IENDAFHEIG
510 520 530 540 550
HSLISLKMSH GYSGSALPAE PLRHLTSLQE LDFSNNHISS MSDTSFHFLK
560 570 580 590 600
NLRLLELHDN RIEQVLKGTF QGDIHSKLEE ISLRFNHLTS ISQHTFFDLE
610 620 630 640 650
ALRKLHLDDN KIDKIERRAF MNLDELEYLS LRGNKINNLA DESFQNLPKL
660 670 680 690 700
EILDMAFNQL PNFNFDYFDQ VGTLSNLNVN VSHNQIRQLM YNSSWSGRNE
710 720 730 740 750
HGGMYHSNIK ILDLSHNNIS IIHPGYFRPA EISLTHLHLG YNSLMNTTRD
760 770 780 790 800
VFGNMPHLQW LDLSYNWIHE LDFDAFKNTK QLQLVFFGHN YLSDIPQDIF
810 820 830 840 850
KPVQGLRIVD FSHNHLRGLP DNLFYNGGME KLDVSHNMML KIPSSSLSSL
860 870 880 890 900
AALTLCELHL SNNFISTIHS MDLSNKFRSL RYLDISYNYL LRIDDAVFAT
910 920 930 940 950
MPKLAVLDLS HNRDLKVMDK SFMGLENSLI KLGLENISLS TVPEIRLKYL
960 970 980 990 1000
REFRLGYNEL PSIPQELAHN MSNLRMLDLS NNDLTNVPLM TQALPHLRRL
1010 1020 1030 1040 1050
MLSGNPITSL NNNSFDGVNE DLEMLDISNF RLHYFEYGCL DSLPHLRSLK
1060 1070 1080 1090 1100
LTAYSHLEHF NIPHLLRHHY NIRQLWIEAP QPFTRIVKKG SGPTQEMQTL
1110 1120 1130 1140 1150
QLGNPTDLQR EMEGHLPSKL TNITFSGPQF TNLNERILRG MRSPYLYMQL
1160 1170 1180 1190 1200
FNTSLQALPP NFFKYMGRVR NISLDIRYHN RNLKKIPNPN TGAVPYLPNS
1210 1220 1230 1240 1250
VFLTDLKMSH TDLNCDCDLG WVEFWQRKRR QYICSSQTWT DTVFRTFMNS
1260 1270 1280 1290 1300
PCQVYGRHNC DEHDDDLRET RCENKGGQQL MEALKFDLEC GWDNANCREA
1310
AFVVVMVCVA MVFWM
Length:1,315
Mass (Da):151,983
Last modified:June 20, 2001 - v2
Checksum:iD2D89A64EB46FCE5
GO

Sequence cautioni

The sequence AAA28425 differs from that shown. Reason: Frameshift at position 1123.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → V in AAA28425 (PubMed:3124963).Curated1
Sequence conflicti44C → H AA sequence (PubMed:6420071).Curated1
Sequence conflicti50C → H AA sequence (PubMed:6420071).Curated1
Sequence conflicti937I → V in AAA28425 (PubMed:3124963).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19017
, M19008, M19009, M19010, M19011, M19012, M19013, M19014, M19016 Genomic DNA. Translation: AAA28425.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF57127.1.
K03274 Genomic DNA. Translation: AAA28851.1.
PIRiA29944.
RefSeqiNP_524605.1. NM_079866.3.
UniGeneiDm.21698.

Genome annotation databases

EnsemblMetazoaiFBtr0085778; FBpp0085139; FBgn0267435.
GeneIDi43690.
KEGGidme:Dmel_CG1744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19017
, M19008, M19009, M19010, M19011, M19012, M19013, M19014, M19016 Genomic DNA. Translation: AAA28425.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF57127.1.
K03274 Genomic DNA. Translation: AAA28851.1.
PIRiA29944.
RefSeqiNP_524605.1. NM_079866.3.
UniGeneiDm.21698.

3D structure databases

ProteinModelPortaliP12024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0303134.

Proteomic databases

PaxDbiP12024.
PRIDEiP12024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085778; FBpp0085139; FBgn0267435.
GeneIDi43690.
KEGGidme:Dmel_CG1744.

Organism-specific databases

CTDi43690.
FlyBaseiFBgn0267435. chp.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000265621.
InParanoidiP12024.
OrthoDBiEOG091G00WB.
PhylomeDBiP12024.

Miscellaneous databases

ChiTaRSichp. fly.
GenomeRNAii43690.
PROiP12024.

Gene expression databases

BgeeiFBgn0000313.
ExpressionAtlasiP12024. baseline.
GenevisibleiP12024. DM.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000225. Armadillo.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 10 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 27 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 29 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHAO_DROME
AccessioniPrimary (citable) accession number: P12024
Secondary accession number(s): Q9VA01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 20, 2001
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.