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Protein

Chaoptin

Gene

chp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion.1 Publication

GO - Biological processi

  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • microvillus organization Source: FlyBase
  • response to stimulus Source: UniProtKB-KW
  • rhabdomere development Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Biological processCell adhesion, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Chaoptin
Alternative name(s):
Photoreceptor cell-specific membrane protein
Gene namesi
Name:chp
Synonyms:CHT
ORF Names:CG1744
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0267435 chp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000002092330 – 1315ChaoptinAdd BLAST1286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) (high mannose) asparagine; alternate1 Publication1
Glycosylationi77N-linked (GlcNAc...) (paucimannose) asparagine; alternate1 Publication1
Glycosylationi267N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi267N-linked (GlcNAc...) (paucimannose) asparagine; alternate1 Publication1
Glycosylationi305N-linked (GlcNAc...) (high mannose) asparagine; alternate2 Publications1
Glycosylationi305N-linked (GlcNAc...) (paucimannose) asparagine; alternate2 Publications1
Glycosylationi361N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi422N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi680N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi692N-linked (GlcNAc...) (high mannose) asparagine; alternate2 Publications1
Glycosylationi692N-linked (GlcNAc...) (paucimannose) asparagine; alternate2 Publications1
Glycosylationi718N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi936N-linked (GlcNAc...) (high mannose) asparagine2 Publications1
Glycosylationi970N-linked (GlcNAc...) (paucimannose) asparagine1 Publication1
Glycosylationi1012N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi1122N-linked (GlcNAc...) (high mannose) asparagine2 Publications1
Glycosylationi1152N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi1171N-linked (GlcNAc...) (high mannose) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12024
PRIDEiP12024

PTM databases

iPTMnetiP12024

Expressioni

Tissue specificityi

Expressed in photoreceptor cells and their axons in the adult retina, the ocellus and larval photoreceptor organ.1 Publication

Developmental stagei

Expressed 24 hours after initiation of photoreceptor cell differentiation, persists through development to adulthood.

Gene expression databases

BgeeiFBgn0267435
ExpressionAtlasiP12024 differential
GenevisibleiP12024 DM

Interactioni

Protein-protein interaction databases

BioGridi68535, 2 interactors
STRINGi7227.FBpp0303134

Structurei

3D structure databases

ProteinModelPortaliP12024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 101LRR 1Add BLAST22
Repeati103 – 124LRR 2Add BLAST22
Repeati128 – 149LRR 3Add BLAST22
Repeati152 – 173LRR 4Add BLAST22
Repeati177 – 198LRR 5Add BLAST22
Repeati201 – 222LRR 6Add BLAST22
Repeati226 – 247LRR 7Add BLAST22
Repeati250 – 271LRR 8Add BLAST22
Repeati279 – 300LRR 9Add BLAST22
Repeati326 – 347LRR 10Add BLAST22
Repeati351 – 372LRR 11Add BLAST22
Repeati375 – 396LRR 12Add BLAST22
Repeati401 – 424LRR 13Add BLAST24
Repeati477 – 498LRR 14Add BLAST22
Repeati527 – 548LRR 15Add BLAST22
Repeati551 – 572LRR 16Add BLAST22
Repeati577 – 598LRR 17Add BLAST22
Repeati601 – 622LRR 18Add BLAST22
Repeati625 – 646LRR 19Add BLAST22
Repeati649 – 670LRR 20Add BLAST22
Repeati676 – 696LRR 21Add BLAST21
Repeati708 – 729LRR 22Add BLAST22
Repeati733 – 754LRR 23Add BLAST22
Repeati757 – 778LRR 24Add BLAST22
Repeati781 – 802LRR 25Add BLAST22
Repeati805 – 826LRR 26Add BLAST22
Repeati828 – 849LRR 27Add BLAST22
Repeati854 – 875LRR 28Add BLAST22
Repeati879 – 900LRR 29Add BLAST22
Repeati903 – 924LRR 30Add BLAST22
Repeati928 – 948LRR 31Add BLAST21
Repeati949 – 970LRR 32Add BLAST22
Repeati973 – 994LRR 33Add BLAST22
Repeati996 – 1017LRR 34Add BLAST22
Repeati1021 – 1044LRR 35Add BLAST24
Repeati1045 – 1066LRR 36Add BLAST22
Domaini1211 – 1274LRRCTAdd BLAST64

Sequence similaritiesi

Belongs to the chaoptin family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118777
HOGENOMiHOG000265621
InParanoidiP12024
OrthoDBiEOG091G00WB
PhylomeDBiP12024

Family and domain databases

Gene3Di3.80.10.10, 7 hits
InterProiView protein in InterPro
IPR000225 Armadillo
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 10 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 27 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 29 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEFFFKFG YAFLTITLMI MIWMSLARAS MFDREMEETH YPPCTYNVMC
60 70 80 90 100
TCSKSSTDLG IVHCKNVPFP ALPRMVNQSK VFMLHMENTG LREIEPYFLQ
110 120 130 140 150
STGMYRLKIS GNHLTEIPDD AFTGLERSLW ELILPQNDLV EIPSKSLRHL
160 170 180 190 200
QKLRHLDLGY NHITHIQHDS FRGLEDSLQT LILRENCISQ LMSHSFSGLL
210 220 230 240 250
ILETLDLSGN NLFEIDPNVF VDGMPRLTRL LLTDNILSEI PYDALGPLKS
260 270 280 290 300
LRTLDISHNV IWSLSGNETY EIKASTKLNL DNLHLEYNHI EVLPPNSFKY
310 320 330 340 350
FDTVNRTFFD GNPIHTLRED AFKPARIREI YMRYCGLTNI SPVAFDSLVN
360 370 380 390 400
SLQILDLSGN NLTKLHHKLF NNFDVLRVIS MRDNKIKIQK PTETFNAVHY
410 420 430 440 450
TLLKLDLSGD RNDPTNLQTL RNMTRMRNMR SLSISRLGSS SVGPEDFKDF
460 470 480 490 500
GVELEDLQIT RASLSGIQSH AFKHVRGLKR LDFSENGISS IENDAFHEIG
510 520 530 540 550
HSLISLKMSH GYSGSALPAE PLRHLTSLQE LDFSNNHISS MSDTSFHFLK
560 570 580 590 600
NLRLLELHDN RIEQVLKGTF QGDIHSKLEE ISLRFNHLTS ISQHTFFDLE
610 620 630 640 650
ALRKLHLDDN KIDKIERRAF MNLDELEYLS LRGNKINNLA DESFQNLPKL
660 670 680 690 700
EILDMAFNQL PNFNFDYFDQ VGTLSNLNVN VSHNQIRQLM YNSSWSGRNE
710 720 730 740 750
HGGMYHSNIK ILDLSHNNIS IIHPGYFRPA EISLTHLHLG YNSLMNTTRD
760 770 780 790 800
VFGNMPHLQW LDLSYNWIHE LDFDAFKNTK QLQLVFFGHN YLSDIPQDIF
810 820 830 840 850
KPVQGLRIVD FSHNHLRGLP DNLFYNGGME KLDVSHNMML KIPSSSLSSL
860 870 880 890 900
AALTLCELHL SNNFISTIHS MDLSNKFRSL RYLDISYNYL LRIDDAVFAT
910 920 930 940 950
MPKLAVLDLS HNRDLKVMDK SFMGLENSLI KLGLENISLS TVPEIRLKYL
960 970 980 990 1000
REFRLGYNEL PSIPQELAHN MSNLRMLDLS NNDLTNVPLM TQALPHLRRL
1010 1020 1030 1040 1050
MLSGNPITSL NNNSFDGVNE DLEMLDISNF RLHYFEYGCL DSLPHLRSLK
1060 1070 1080 1090 1100
LTAYSHLEHF NIPHLLRHHY NIRQLWIEAP QPFTRIVKKG SGPTQEMQTL
1110 1120 1130 1140 1150
QLGNPTDLQR EMEGHLPSKL TNITFSGPQF TNLNERILRG MRSPYLYMQL
1160 1170 1180 1190 1200
FNTSLQALPP NFFKYMGRVR NISLDIRYHN RNLKKIPNPN TGAVPYLPNS
1210 1220 1230 1240 1250
VFLTDLKMSH TDLNCDCDLG WVEFWQRKRR QYICSSQTWT DTVFRTFMNS
1260 1270 1280 1290 1300
PCQVYGRHNC DEHDDDLRET RCENKGGQQL MEALKFDLEC GWDNANCREA
1310
AFVVVMVCVA MVFWM
Length:1,315
Mass (Da):151,983
Last modified:June 20, 2001 - v2
Checksum:iD2D89A64EB46FCE5
GO

Sequence cautioni

The sequence AAA28425 differs from that shown. Reason: Frameshift at position 1123.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → V in AAA28425 (PubMed:3124963).Curated1
Sequence conflicti44C → H AA sequence (PubMed:6420071).Curated1
Sequence conflicti50C → H AA sequence (PubMed:6420071).Curated1
Sequence conflicti937I → V in AAA28425 (PubMed:3124963).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19017
, M19008, M19009, M19010, M19011, M19012, M19013, M19014, M19016 Genomic DNA Translation: AAA28425.1 Frameshift.
AE014297 Genomic DNA Translation: AAF57127.1
K03274 Genomic DNA Translation: AAA28851.1
PIRiA29944
RefSeqiNP_524605.1, NM_079866.3
UniGeneiDm.21698

Genome annotation databases

EnsemblMetazoaiFBtr0085778; FBpp0085139; FBgn0267435
GeneIDi43690
KEGGidme:Dmel_CG1744

Similar proteinsi

Entry informationi

Entry nameiCHAO_DROME
AccessioniPrimary (citable) accession number: P12024
Secondary accession number(s): Q9VA01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 20, 2001
Last modified: May 23, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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