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Protein

Chaoptin

Gene

chp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion.1 Publication

GO - Biological processi

  • compound eye photoreceptor development Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • microvillus organization Source: FlyBase
  • response to stimulus Source: UniProtKB-KW
  • rhabdomere development Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Chaoptin
Alternative name(s):
Photoreceptor cell-specific membrane protein
Gene namesi
Name:chp
Synonyms:CHT
ORF Names:CG1744
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0267435. chp.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: FlyBase
  • plasma membrane Source: FlyBase
  • rhabdomere Source: FlyBase
  • rhabdomere microvillus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 13151286ChaoptinPRO_0000020923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...) (high mannose); alternate1 Publication
Glycosylationi77 – 771N-linked (GlcNAc...) (low mannose); alternate1 Publication
Glycosylationi267 – 2671N-linked (GlcNAc...) (complex); alternate1 Publication
Glycosylationi267 – 2671N-linked (GlcNAc...) (low mannose); alternate1 Publication
Glycosylationi305 – 3051N-linked (GlcNAc...) (high mannose); alternate2 Publications
Glycosylationi305 – 3051N-linked (GlcNAc...) (low mannose); alternate2 Publications
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence analysis
Glycosylationi361 – 3611N-linked (GlcNAc...) (high mannose)1 Publication
Glycosylationi422 – 4221N-linked (GlcNAc...)1 Publication
Glycosylationi680 – 6801N-linked (GlcNAc...) (high mannose)1 Publication
Glycosylationi692 – 6921N-linked (GlcNAc...) (high mannose); alternate2 Publications
Glycosylationi692 – 6921N-linked (GlcNAc...) (low mannose); alternate2 Publications
Glycosylationi718 – 7181N-linked (GlcNAc...) (high mannose)1 Publication
Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence analysis
Glycosylationi936 – 9361N-linked (GlcNAc...) (high mannose)2 Publications
Glycosylationi970 – 9701N-linked (GlcNAc...) (low mannose)1 Publication
Glycosylationi1012 – 10121N-linked (GlcNAc...) (complex)1 Publication
Glycosylationi1104 – 11041N-linked (GlcNAc...)Sequence analysis
Glycosylationi1122 – 11221N-linked (GlcNAc...) (high mannose)2 Publications
Glycosylationi1152 – 11521N-linked (GlcNAc...) (high mannose)1 Publication
Glycosylationi1171 – 11711N-linked (GlcNAc...) (high mannose)2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12024.
PRIDEiP12024.

Expressioni

Tissue specificityi

Expressed in photoreceptor cells and their axons in the adult retina, the ocellus and larval photoreceptor organ.1 Publication

Developmental stagei

Expressed 24 hours after initiation of photoreceptor cell differentiation, persists through development to adulthood.

Gene expression databases

BgeeiP12024.
ExpressionAtlasiP12024. differential.
GenevisibleiP12024. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0303134.

Structurei

3D structure databases

ProteinModelPortaliP12024.
SMRiP12024. Positions 49-1122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati80 – 10122LRR 1Add
BLAST
Repeati103 – 12422LRR 2Add
BLAST
Repeati128 – 14922LRR 3Add
BLAST
Repeati152 – 17322LRR 4Add
BLAST
Repeati177 – 19822LRR 5Add
BLAST
Repeati201 – 22222LRR 6Add
BLAST
Repeati226 – 24722LRR 7Add
BLAST
Repeati250 – 27122LRR 8Add
BLAST
Repeati279 – 30022LRR 9Add
BLAST
Repeati326 – 34722LRR 10Add
BLAST
Repeati351 – 37222LRR 11Add
BLAST
Repeati375 – 39622LRR 12Add
BLAST
Repeati401 – 42424LRR 13Add
BLAST
Repeati477 – 49822LRR 14Add
BLAST
Repeati527 – 54822LRR 15Add
BLAST
Repeati551 – 57222LRR 16Add
BLAST
Repeati577 – 59822LRR 17Add
BLAST
Repeati601 – 62222LRR 18Add
BLAST
Repeati625 – 64622LRR 19Add
BLAST
Repeati649 – 67022LRR 20Add
BLAST
Repeati676 – 69621LRR 21Add
BLAST
Repeati708 – 72922LRR 22Add
BLAST
Repeati733 – 75422LRR 23Add
BLAST
Repeati757 – 77822LRR 24Add
BLAST
Repeati781 – 80222LRR 25Add
BLAST
Repeati805 – 82622LRR 26Add
BLAST
Repeati828 – 84922LRR 27Add
BLAST
Repeati854 – 87522LRR 28Add
BLAST
Repeati879 – 90022LRR 29Add
BLAST
Repeati903 – 92422LRR 30Add
BLAST
Repeati928 – 94821LRR 31Add
BLAST
Repeati949 – 97022LRR 32Add
BLAST
Repeati973 – 99422LRR 33Add
BLAST
Repeati996 – 101722LRR 34Add
BLAST
Repeati1021 – 104424LRR 35Add
BLAST
Repeati1045 – 106622LRR 36Add
BLAST
Domaini1211 – 127464LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the chaoptin family.Curated
Contains 36 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000265621.
InParanoidiP12024.
OrthoDBiEOG744T88.
PhylomeDBiP12024.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000225. Armadillo.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 9 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 27 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 29 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEFFFKFG YAFLTITLMI MIWMSLARAS MFDREMEETH YPPCTYNVMC
60 70 80 90 100
TCSKSSTDLG IVHCKNVPFP ALPRMVNQSK VFMLHMENTG LREIEPYFLQ
110 120 130 140 150
STGMYRLKIS GNHLTEIPDD AFTGLERSLW ELILPQNDLV EIPSKSLRHL
160 170 180 190 200
QKLRHLDLGY NHITHIQHDS FRGLEDSLQT LILRENCISQ LMSHSFSGLL
210 220 230 240 250
ILETLDLSGN NLFEIDPNVF VDGMPRLTRL LLTDNILSEI PYDALGPLKS
260 270 280 290 300
LRTLDISHNV IWSLSGNETY EIKASTKLNL DNLHLEYNHI EVLPPNSFKY
310 320 330 340 350
FDTVNRTFFD GNPIHTLRED AFKPARIREI YMRYCGLTNI SPVAFDSLVN
360 370 380 390 400
SLQILDLSGN NLTKLHHKLF NNFDVLRVIS MRDNKIKIQK PTETFNAVHY
410 420 430 440 450
TLLKLDLSGD RNDPTNLQTL RNMTRMRNMR SLSISRLGSS SVGPEDFKDF
460 470 480 490 500
GVELEDLQIT RASLSGIQSH AFKHVRGLKR LDFSENGISS IENDAFHEIG
510 520 530 540 550
HSLISLKMSH GYSGSALPAE PLRHLTSLQE LDFSNNHISS MSDTSFHFLK
560 570 580 590 600
NLRLLELHDN RIEQVLKGTF QGDIHSKLEE ISLRFNHLTS ISQHTFFDLE
610 620 630 640 650
ALRKLHLDDN KIDKIERRAF MNLDELEYLS LRGNKINNLA DESFQNLPKL
660 670 680 690 700
EILDMAFNQL PNFNFDYFDQ VGTLSNLNVN VSHNQIRQLM YNSSWSGRNE
710 720 730 740 750
HGGMYHSNIK ILDLSHNNIS IIHPGYFRPA EISLTHLHLG YNSLMNTTRD
760 770 780 790 800
VFGNMPHLQW LDLSYNWIHE LDFDAFKNTK QLQLVFFGHN YLSDIPQDIF
810 820 830 840 850
KPVQGLRIVD FSHNHLRGLP DNLFYNGGME KLDVSHNMML KIPSSSLSSL
860 870 880 890 900
AALTLCELHL SNNFISTIHS MDLSNKFRSL RYLDISYNYL LRIDDAVFAT
910 920 930 940 950
MPKLAVLDLS HNRDLKVMDK SFMGLENSLI KLGLENISLS TVPEIRLKYL
960 970 980 990 1000
REFRLGYNEL PSIPQELAHN MSNLRMLDLS NNDLTNVPLM TQALPHLRRL
1010 1020 1030 1040 1050
MLSGNPITSL NNNSFDGVNE DLEMLDISNF RLHYFEYGCL DSLPHLRSLK
1060 1070 1080 1090 1100
LTAYSHLEHF NIPHLLRHHY NIRQLWIEAP QPFTRIVKKG SGPTQEMQTL
1110 1120 1130 1140 1150
QLGNPTDLQR EMEGHLPSKL TNITFSGPQF TNLNERILRG MRSPYLYMQL
1160 1170 1180 1190 1200
FNTSLQALPP NFFKYMGRVR NISLDIRYHN RNLKKIPNPN TGAVPYLPNS
1210 1220 1230 1240 1250
VFLTDLKMSH TDLNCDCDLG WVEFWQRKRR QYICSSQTWT DTVFRTFMNS
1260 1270 1280 1290 1300
PCQVYGRHNC DEHDDDLRET RCENKGGQQL MEALKFDLEC GWDNANCREA
1310
AFVVVMVCVA MVFWM
Length:1,315
Mass (Da):151,983
Last modified:June 20, 2001 - v2
Checksum:iD2D89A64EB46FCE5
GO

Sequence cautioni

The sequence AAA28425.1 differs from that shown. Reason: Frameshift at position 1123. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → V in AAA28425 (PubMed:3124963).Curated
Sequence conflicti44 – 441C → H AA sequence (PubMed:6420071).Curated
Sequence conflicti50 – 501C → H AA sequence (PubMed:6420071).Curated
Sequence conflicti937 – 9371I → V in AAA28425 (PubMed:3124963).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19017
, M19008, M19009, M19010, M19011, M19012, M19013, M19014, M19016 Genomic DNA. Translation: AAA28425.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF57127.1.
K03274 Genomic DNA. Translation: AAA28851.1.
PIRiA29944.
RefSeqiNP_524605.1. NM_079866.3.
UniGeneiDm.21698.

Genome annotation databases

EnsemblMetazoaiFBtr0085778; FBpp0085139; FBgn0267435.
GeneIDi43690.
KEGGidme:Dmel_CG1744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19017
, M19008, M19009, M19010, M19011, M19012, M19013, M19014, M19016 Genomic DNA. Translation: AAA28425.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF57127.1.
K03274 Genomic DNA. Translation: AAA28851.1.
PIRiA29944.
RefSeqiNP_524605.1. NM_079866.3.
UniGeneiDm.21698.

3D structure databases

ProteinModelPortaliP12024.
SMRiP12024. Positions 49-1122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0303134.

Proteomic databases

PaxDbiP12024.
PRIDEiP12024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085778; FBpp0085139; FBgn0267435.
GeneIDi43690.
KEGGidme:Dmel_CG1744.

Organism-specific databases

CTDi43690.
FlyBaseiFBgn0267435. chp.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000265621.
InParanoidiP12024.
OrthoDBiEOG744T88.
PhylomeDBiP12024.

Miscellaneous databases

ChiTaRSichp. fly.
GenomeRNAii43690.
PROiP12024.

Gene expression databases

BgeeiP12024.
ExpressionAtlasiP12024. differential.
GenevisibleiP12024. DM.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000225. Armadillo.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 9 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 27 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 29 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human."
    Reinke R., Krantz D.E., Yen D., Zipursky S.L.
    Cell 52:291-301(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Head.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "From monoclonal antibody to gene for a neuron-specific glycoprotein in Drosophila."
    Zipursky S.L., Venkatesh T.R., Benzer S.
    Proc. Natl. Acad. Sci. U.S.A. 82:1855-1859(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-50.
    Tissue: Head.
  5. "Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes."
    Zipursky S.L., Venkatesh T.R., Teplow D.B., Benzer S.
    Cell 36:15-26(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-50, TISSUE SPECIFICITY.
    Strain: Canton-S.
    Tissue: Head.
  6. "Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster."
    Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L., Panin V.
    Glycobiology 17:1388-1403(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-305; ASN-692; ASN-936; ASN-1122 AND ASN-1171, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Oregon-R.
    Tissue: Head.
  7. "Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometry."
    Kanie Y., Yamamoto-Hino M., Karino Y., Yokozawa H., Nishihara S., Ueda R., Goto S., Kanie O.
    PLoS ONE 4:E5434-E5434(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-77; ASN-267; ASN-305; ASN-361; ASN-422; ASN-680; ASN-692; ASN-718; ASN-936; ASN-970; ASN-1012; ASN-1122; ASN-1152 AND ASN-1171, FUNCTION.

Entry informationi

Entry nameiCHAO_DROME
AccessioniPrimary (citable) accession number: P12024
Secondary accession number(s): Q9VA01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 20, 2001
Last modified: June 8, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.