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Protein

Cysteine-rich secretory protein 1

Gene

Crisp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 1
Alternative name(s):
32 kDa epididymal protein
Acidic epididymal glycoprotein
Short name:
Protein D
Short name:
Protein E
Protein IV
Sialoprotein
Sperm-coating glycoprotein
Short name:
SCP
Gene namesi
Name:Crisp1
Synonyms:Aeg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi619846 Crisp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000626320 – 246Cysteine-rich secretory protein 1Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi192 ↔ 199PROSITE-ProRule annotation
Disulfide bondi195 ↔ 204PROSITE-ProRule annotation
Disulfide bondi208 ↔ 241PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 235PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation

Post-translational modificationi

Two major variant protein D and E differ from each other by their carbohydrate side chains.
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12020

Expressioni

Tissue specificityi

Secreted by the epididymal epithelium and then becomes associated with the sperm surface.

Inductioni

By androgens.

Gene expression databases

BgeeiENSRNOG00000013496
GenevisibleiP12020 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018162

Structurei

3D structure databases

ProteinModelPortaliP12020
SMRiP12020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 172SCPAdd BLAST127
Domaini208 – 241ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000236338
HOVERGENiHBG004184
InParanoidiP12020
KOiK19919
OMAiVLKYYYV
OrthoDBiEOG091G0D4V
PhylomeDBiP12020
TreeFamiTF316148

Family and domain databases

CDDicd05383 SCP_CRISP, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMLVLLFL AAVLPPSLLQ DTTDEWDRDL ENLSTTKLSV QEEIINKHNQ
60 70 80 90 100
LRRTVSPSGS DLLRVEWDHD AYVNAQKWAN RCIYNHSPLQ HRTTTLKCGE
110 120 130 140 150
NLFMANYPAS WSSVIQDWYD ESLDFVFGFG PKKVGVKVGH YTQVVWNSTF
160 170 180 190 200
LVACGVAECP DQPLKYFYVC HYCPGGNYVG RLYSPYTEGE PCDSCPGNCE
210 220 230 240
DGLCTNSCEY EDNYSNCGDL KKMVSCDDPL LKEGCRASCF CEDKIH
Length:246
Mass (Da):27,847
Last modified:October 1, 1989 - v1
Checksum:i585207C7CF7CF9D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04643 mRNA Translation: CAA28304.1
M31173 mRNA Translation: AAB59716.1
PIRiA40918 A24609
RefSeqiNP_074050.1, NM_022859.1
XP_017452115.1, XM_017596626.1
UniGeneiRn.10102

Genome annotation databases

EnsembliENSRNOT00000018163; ENSRNOP00000018162; ENSRNOG00000013496
GeneIDi64827
KEGGirno:64827
UCSCiRGD:619846 rat

Similar proteinsi

Entry informationi

Entry nameiCRIS1_RAT
AccessioniPrimary (citable) accession number: P12020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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