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Protein

Immunoglobulin iota chain

Gene

VPREB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin iota chain
Alternative name(s):
CD179 antigen-like family member A
Protein VPreB1
V(pre)B protein
Short name:
VpreB protein
CD_antigen: CD179a
Gene namesi
Name:VPREB1
Synonyms:VPREB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:12709. VPREB1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 145126Immunoglobulin iota chainPRO_0000015000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 1152 PublicationsPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP12018.
PRIDEiP12018.

PTM databases

PhosphoSiteiP12018.

Expressioni

Tissue specificityi

Only expressed by pre-B-cells.

Gene expression databases

BgeeiP12018.
CleanExiHS_VPREB1.
ExpressionAtlasiP12018. baseline and differential.
GenevestigatoriP12018.

Organism-specific databases

HPAiHPA055886.

Interactioni

Subunit structurei

Associates non-covalently with IGLL1.1 Publication

Protein-protein interaction databases

IntActiP12018. 1 interaction.
MINTiMINT-7241497.
STRINGi9606.ENSP00000385361.

Structurei

Secondary structure

1
145
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 243Combined sources
Beta strandi27 – 326Combined sources
Beta strandi37 – 437Combined sources
Beta strandi45 – 473Combined sources
Helixi49 – 513Combined sources
Beta strandi54 – 596Combined sources
Beta strandi66 – 738Combined sources
Beta strandi76 – 794Combined sources
Beta strandi87 – 926Combined sources
Helixi93 – 953Combined sources
Beta strandi97 – 1026Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 1177Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70A20-145[»]
2H3NX-ray2.30A/C21-119[»]
3BJ9X-ray2.00122-121[»]
ProteinModelPortaliP12018.
SMRiP12018. Positions 21-119.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12018.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 132113Ig-like V-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4122Framework-1Add
BLAST
Regioni42 – 5615Complementarity-determining-1Add
BLAST
Regioni57 – 7014Framework-2Add
BLAST
Regioni71 – 8111Complementarity-determining-2Add
BLAST
Regioni82 – 11534Framework-3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG47424.
GeneTreeiENSGT00780000121842.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP12018.
KOiK06553.
OMAiVYSIYWY.
OrthoDBiEOG7HTHJS.
PhylomeDBiP12018.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG
60 70 80 90 100
VYSVYWYQQR PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL
110 120 130 140
SISELQPEDE AMYYCAMGAR SSEKEERERE WEEEMEPTAA RTRVP
Length:145
Mass (Da):16,605
Last modified:December 1, 2000 - v2
Checksum:i197665B13AF64D46
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101L → H in AAA61292 (PubMed:3258819).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761D → N.
Corresponds to variant rs1320 [ dbSNP | Ensembl ].
VAR_024503
Natural varianti122 – 1221S → L.
Corresponds to variant rs11089979 [ dbSNP | Ensembl ].
VAR_029133
Natural varianti132 – 1321E → K.
Corresponds to variant rs5995720 [ dbSNP | Ensembl ].
VAR_029134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74019 Genomic DNA. Translation: AAB32118.1.
D86992 Genomic DNA. Translation: BAA19987.1.
D88270 Genomic DNA. Translation: BAA20030.1.
CR456609 mRNA. Translation: CAG30495.1.
CH471095 Genomic DNA. Translation: EAW59498.1.
M34927 Genomic DNA. Translation: AAA61292.1.
CCDSiCCDS13798.1.
PIRiI57832.
S00258.
RefSeqiNP_009059.1. NM_007128.3.
UniGeneiHs.247979.

Genome annotation databases

EnsembliENST00000403807; ENSP00000385361; ENSG00000169575.
GeneIDi7441.
KEGGihsa:7441.
UCSCiuc002zvx.1. human.

Polymorphism databases

DMDMi9911096.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

VPREB1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74019 Genomic DNA. Translation: AAB32118.1.
D86992 Genomic DNA. Translation: BAA19987.1.
D88270 Genomic DNA. Translation: BAA20030.1.
CR456609 mRNA. Translation: CAG30495.1.
CH471095 Genomic DNA. Translation: EAW59498.1.
M34927 Genomic DNA. Translation: AAA61292.1.
CCDSiCCDS13798.1.
PIRiI57832.
S00258.
RefSeqiNP_009059.1. NM_007128.3.
UniGeneiHs.247979.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70A20-145[»]
2H3NX-ray2.30A/C21-119[»]
3BJ9X-ray2.00122-121[»]
ProteinModelPortaliP12018.
SMRiP12018. Positions 21-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12018. 1 interaction.
MINTiMINT-7241497.
STRINGi9606.ENSP00000385361.

PTM databases

PhosphoSiteiP12018.

Polymorphism databases

DMDMi9911096.

Proteomic databases

PaxDbiP12018.
PRIDEiP12018.

Protocols and materials databases

DNASUi7441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403807; ENSP00000385361; ENSG00000169575.
GeneIDi7441.
KEGGihsa:7441.
UCSCiuc002zvx.1. human.

Organism-specific databases

CTDi7441.
GeneCardsiGC22P022600.
HGNCiHGNC:12709. VPREB1.
HPAiHPA055886.
MIMi605141. gene.
neXtProtiNX_P12018.
PharmGKBiPA37324.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47424.
GeneTreeiENSGT00780000121842.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP12018.
KOiK06553.
OMAiVYSIYWY.
OrthoDBiEOG7HTHJS.
PhylomeDBiP12018.
TreeFamiTF352061.

Miscellaneous databases

EvolutionaryTraceiP12018.
GeneWikiiVPREB1.
GenomeRNAii7441.
NextBioi29136.
PROiP12018.
SOURCEiSearch...

Gene expression databases

BgeeiP12018.
CleanExiHS_VPREB1.
ExpressionAtlasiP12018. baseline and differential.
GenevestigatoriP12018.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain."
    Guelpa-Fonlupt V., Bossy D., Alzari P., Fumoux F., Fougereau M., Schiff C.
    Mol. Immunol. 31:1099-1108(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
    Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
    Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species."
    Bauer S.R., Kudo A., Melchers F.
    EMBO J. 7:111-116(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Structural insight into pre-B cell receptor function."
    Bankovich A.J., Raunser S., Juo Z.S., Walz T., Davis M.M., Garcia K.C.
    Science 316:291-294(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 21-119 IN COMPLEX WITH IGLL1, SUBUNIT, DISULFIDE BOND.
  9. "Engineering and characterization of a single chain surrogate light chain variable domain."
    Morstadt L., Bohm A., Yuksel D., Kumar K., Stollar B.D., Baleja J.D.
    Protein Sci. 17:458-465(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 95-108, DISULFIDE BOND.

Entry informationi

Entry nameiVPREB_HUMAN
AccessioniPrimary (citable) accession number: P12018
Secondary accession number(s): B5MCG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: March 4, 2015
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.