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P12018 (VPREB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin iota chain
Alternative name(s):
CD179 antigen-like family member A
Protein VPreB1
V(pre)B protein
Short name=VpreB protein
CD_antigen=CD179a
Gene names
Name:VPREB1
Synonyms:VPREB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

Subunit structure

Associates non-covalently with IGLL1. Ref.8

Tissue specificity

Only expressed by pre-B-cells.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 145126Immunoglobulin iota chain
PRO_0000015000

Regions

Domain20 – 132113Ig-like V-type
Region20 – 4122Framework-1
Region42 – 5615Complementarity-determining-1
Region57 – 7014Framework-2
Region71 – 8111Complementarity-determining-2
Region82 – 11534Framework-3

Amino acid modifications

Disulfide bond41 ↔ 115 Ref.8 Ref.9

Natural variations

Natural variant761D → N.
Corresponds to variant rs1320 [ dbSNP | Ensembl ].
VAR_024503
Natural variant1221S → L.
Corresponds to variant rs11089979 [ dbSNP | Ensembl ].
VAR_029133
Natural variant1321E → K.
Corresponds to variant rs5995720 [ dbSNP | Ensembl ].
VAR_029134

Experimental info

Sequence conflict101L → H in AAA61292. Ref.6

Secondary structure

.......................... 145
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P12018 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 197665B13AF64D46

FASTA14516,605
        10         20         30         40         50         60 
MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG VYSVYWYQQR 

        70         80         90        100        110        120 
PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL SISELQPEDE AMYYCAMGAR 

       130        140 
SSEKEERERE WEEEMEPTAA RTRVP 

« Hide

References

« Hide 'large scale' references
[1]"The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain."
Guelpa-Fonlupt V., Bossy D., Alzari P., Fumoux F., Fougereau M., Schiff C.
Mol. Immunol. 31:1099-1108(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species."
Bauer S.R., Kudo A., Melchers F.
EMBO J. 7:111-116(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Structural insight into pre-B cell receptor function."
Bankovich A.J., Raunser S., Juo Z.S., Walz T., Davis M.M., Garcia K.C.
Science 316:291-294(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 21-119 IN COMPLEX WITH IGLL1, SUBUNIT, DISULFIDE BOND.
[9]"Engineering and characterization of a single chain surrogate light chain variable domain."
Morstadt L., Bohm A., Yuksel D., Kumar K., Stollar B.D., Baleja J.D.
Protein Sci. 17:458-465(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 95-108, DISULFIDE BOND.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S74019 Genomic DNA. Translation: AAB32118.1.
D86992 Genomic DNA. Translation: BAA19987.1.
D88270 Genomic DNA. Translation: BAA20030.1.
CR456609 mRNA. Translation: CAG30495.1.
CH471095 Genomic DNA. Translation: EAW59498.1.
M34927 Genomic DNA. Translation: AAA61292.1.
CCDSCCDS13798.1.
PIRI57832.
S00258.
RefSeqNP_009059.1. NM_007128.2.
UniGeneHs.247979.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70A20-145[»]
2H3NX-ray2.30A/C21-119[»]
3BJ9X-ray2.00122-121[»]
ProteinModelPortalP12018.
SMRP12018. Positions 21-119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP12018. 1 interaction.
MINTMINT-7241497.
STRING9606.ENSP00000385361.

PTM databases

PhosphoSiteP12018.

Polymorphism databases

DMDM9911096.

Proteomic databases

PaxDbP12018.
PRIDEP12018.

Protocols and materials databases

DNASU7441.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000403807; ENSP00000385361; ENSG00000169575.
GeneID7441.
KEGGhsa:7441.
UCSCuc002zvx.1. human.

Organism-specific databases

CTD7441.
GeneCardsGC22P022600.
HGNCHGNC:12709. VPREB1.
HPAHPA055886.
MIM605141. gene.
neXtProtNX_P12018.
PharmGKBPA37324.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47424.
HOGENOMHOG000059537.
HOVERGENHBG018013.
InParanoidP12018.
KOK06553.
OMAVYSIYWY.
OrthoDBEOG7HTHJS.
PhylomeDBP12018.
TreeFamTF352061.

Gene expression databases

ArrayExpressP12018.
BgeeP12018.
CleanExHS_VPREB1.
GenevestigatorP12018.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP12018.
GeneWikiVPREB1.
GenomeRNAi7441.
NextBio29136.
PROP12018.
SOURCESearch...

Entry information

Entry nameVPREB_HUMAN
AccessionPrimary (citable) accession number: P12018
Secondary accession number(s): B5MCG2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries