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P12018

- VPREB_HUMAN

UniProt

P12018 - VPREB_HUMAN

Protein

Immunoglobulin iota chain

Gene

VPREB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin iota chain
    Alternative name(s):
    CD179 antigen-like family member A
    Protein VPreB1
    V(pre)B protein
    Short name:
    VpreB protein
    CD_antigen: CD179a
    Gene namesi
    Name:VPREB1
    Synonyms:VPREB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:12709. VPREB1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37324.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 145126Immunoglobulin iota chainPRO_0000015000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 1152 PublicationsPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP12018.
    PRIDEiP12018.

    PTM databases

    PhosphoSiteiP12018.

    Expressioni

    Tissue specificityi

    Only expressed by pre-B-cells.

    Gene expression databases

    ArrayExpressiP12018.
    BgeeiP12018.
    CleanExiHS_VPREB1.
    GenevestigatoriP12018.

    Organism-specific databases

    HPAiHPA055886.

    Interactioni

    Subunit structurei

    Associates non-covalently with IGLL1.1 Publication

    Protein-protein interaction databases

    IntActiP12018. 1 interaction.
    MINTiMINT-7241497.
    STRINGi9606.ENSP00000385361.

    Structurei

    Secondary structure

    1
    145
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 243
    Beta strandi27 – 326
    Beta strandi37 – 437
    Beta strandi45 – 473
    Helixi49 – 513
    Beta strandi54 – 596
    Beta strandi66 – 738
    Beta strandi76 – 794
    Beta strandi87 – 926
    Helixi93 – 953
    Beta strandi97 – 1026
    Helixi107 – 1093
    Beta strandi111 – 1177

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2H32X-ray2.70A20-145[»]
    2H3NX-ray2.30A/C21-119[»]
    3BJ9X-ray2.00122-121[»]
    ProteinModelPortaliP12018.
    SMRiP12018. Positions 21-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12018.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 132113Ig-like V-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 4122Framework-1Add
    BLAST
    Regioni42 – 5615Complementarity-determining-1Add
    BLAST
    Regioni57 – 7014Framework-2Add
    BLAST
    Regioni71 – 8111Complementarity-determining-2Add
    BLAST
    Regioni82 – 11534Framework-3Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG47424.
    HOGENOMiHOG000059537.
    HOVERGENiHBG018013.
    InParanoidiP12018.
    KOiK06553.
    OMAiVYSIYWY.
    OrthoDBiEOG7HTHJS.
    PhylomeDBiP12018.
    TreeFamiTF352061.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12018-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG    50
    VYSVYWYQQR PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL 100
    SISELQPEDE AMYYCAMGAR SSEKEERERE WEEEMEPTAA RTRVP 145
    Length:145
    Mass (Da):16,605
    Last modified:December 1, 2000 - v2
    Checksum:i197665B13AF64D46
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101L → H in AAA61292. (PubMed:3258819)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti76 – 761D → N.
    Corresponds to variant rs1320 [ dbSNP | Ensembl ].
    VAR_024503
    Natural varianti122 – 1221S → L.
    Corresponds to variant rs11089979 [ dbSNP | Ensembl ].
    VAR_029133
    Natural varianti132 – 1321E → K.
    Corresponds to variant rs5995720 [ dbSNP | Ensembl ].
    VAR_029134

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S74019 Genomic DNA. Translation: AAB32118.1.
    D86992 Genomic DNA. Translation: BAA19987.1.
    D88270 Genomic DNA. Translation: BAA20030.1.
    CR456609 mRNA. Translation: CAG30495.1.
    CH471095 Genomic DNA. Translation: EAW59498.1.
    M34927 Genomic DNA. Translation: AAA61292.1.
    CCDSiCCDS13798.1.
    PIRiI57832.
    S00258.
    RefSeqiNP_009059.1. NM_007128.2.
    UniGeneiHs.247979.

    Genome annotation databases

    EnsembliENST00000403807; ENSP00000385361; ENSG00000169575.
    GeneIDi7441.
    KEGGihsa:7441.
    UCSCiuc002zvx.1. human.

    Polymorphism databases

    DMDMi9911096.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    VPREB1

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S74019 Genomic DNA. Translation: AAB32118.1 .
    D86992 Genomic DNA. Translation: BAA19987.1 .
    D88270 Genomic DNA. Translation: BAA20030.1 .
    CR456609 mRNA. Translation: CAG30495.1 .
    CH471095 Genomic DNA. Translation: EAW59498.1 .
    M34927 Genomic DNA. Translation: AAA61292.1 .
    CCDSi CCDS13798.1.
    PIRi I57832.
    S00258.
    RefSeqi NP_009059.1. NM_007128.2.
    UniGenei Hs.247979.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2H32 X-ray 2.70 A 20-145 [» ]
    2H3N X-ray 2.30 A/C 21-119 [» ]
    3BJ9 X-ray 2.00 1 22-121 [» ]
    ProteinModelPortali P12018.
    SMRi P12018. Positions 21-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P12018. 1 interaction.
    MINTi MINT-7241497.
    STRINGi 9606.ENSP00000385361.

    PTM databases

    PhosphoSitei P12018.

    Polymorphism databases

    DMDMi 9911096.

    Proteomic databases

    PaxDbi P12018.
    PRIDEi P12018.

    Protocols and materials databases

    DNASUi 7441.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000403807 ; ENSP00000385361 ; ENSG00000169575 .
    GeneIDi 7441.
    KEGGi hsa:7441.
    UCSCi uc002zvx.1. human.

    Organism-specific databases

    CTDi 7441.
    GeneCardsi GC22P022600.
    HGNCi HGNC:12709. VPREB1.
    HPAi HPA055886.
    MIMi 605141. gene.
    neXtProti NX_P12018.
    PharmGKBi PA37324.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47424.
    HOGENOMi HOG000059537.
    HOVERGENi HBG018013.
    InParanoidi P12018.
    KOi K06553.
    OMAi VYSIYWY.
    OrthoDBi EOG7HTHJS.
    PhylomeDBi P12018.
    TreeFami TF352061.

    Miscellaneous databases

    EvolutionaryTracei P12018.
    GeneWikii VPREB1.
    GenomeRNAii 7441.
    NextBioi 29136.
    PROi P12018.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12018.
    Bgeei P12018.
    CleanExi HS_VPREB1.
    Genevestigatori P12018.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain."
      Guelpa-Fonlupt V., Bossy D., Alzari P., Fumoux F., Fougereau M., Schiff C.
      Mol. Immunol. 31:1099-1108(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
      Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
      Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species."
      Bauer S.R., Kudo A., Melchers F.
      EMBO J. 7:111-116(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structural insight into pre-B cell receptor function."
      Bankovich A.J., Raunser S., Juo Z.S., Walz T., Davis M.M., Garcia K.C.
      Science 316:291-294(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 21-119 IN COMPLEX WITH IGLL1, SUBUNIT, DISULFIDE BOND.
    9. "Engineering and characterization of a single chain surrogate light chain variable domain."
      Morstadt L., Bohm A., Yuksel D., Kumar K., Stollar B.D., Baleja J.D.
      Protein Sci. 17:458-465(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 95-108, DISULFIDE BOND.

    Entry informationi

    Entry nameiVPREB_HUMAN
    AccessioniPrimary (citable) accession number: P12018
    Secondary accession number(s): B5MCG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3