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Protein

Immunoglobulin iota chain

Gene

VPREB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169575-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin iota chain
Alternative name(s):
CD179 antigen-like family member A
Protein VPreB1
V(pre)B protein
Short name:
VpreB protein
CD_antigen: CD179a
Gene namesi
Name:VPREB1
Synonyms:VPREB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:12709. VPREB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7441.
OpenTargetsiENSG00000169575.
PharmGKBiPA37324.

Polymorphism and mutation databases

BioMutaiVPREB1.
DMDMi9911096.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001500020 – 145Immunoglobulin iota chainAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP12018.
PeptideAtlasiP12018.
PRIDEiP12018.
TopDownProteomicsiP12018.

PTM databases

iPTMnetiP12018.
PhosphoSitePlusiP12018.

Expressioni

Tissue specificityi

Only expressed by pre-B-cells.

Gene expression databases

BgeeiENSG00000169575.
CleanExiHS_VPREB1.
ExpressionAtlasiP12018. baseline and differential.
GenevisibleiP12018. HS.

Organism-specific databases

HPAiHPA055886.

Interactioni

Subunit structurei

Associates non-covalently with IGLL1.1 Publication

Protein-protein interaction databases

IntActiP12018. 2 interactors.
MINTiMINT-7241497.
STRINGi9606.ENSP00000385361.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi37 – 43Combined sources7
Beta strandi45 – 47Combined sources3
Helixi49 – 51Combined sources3
Beta strandi54 – 59Combined sources6
Beta strandi66 – 73Combined sources8
Beta strandi76 – 79Combined sources4
Beta strandi87 – 92Combined sources6
Helixi93 – 95Combined sources3
Beta strandi97 – 102Combined sources6
Helixi107 – 109Combined sources3
Beta strandi111 – 117Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70A20-145[»]
2H3NX-ray2.30A/C21-119[»]
3BJ9X-ray2.00122-121[»]
ProteinModelPortaliP12018.
SMRiP12018.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12018.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 132Ig-like V-typeAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 41Framework-1Add BLAST22
Regioni42 – 56Complementarity-determining-1Add BLAST15
Regioni57 – 70Framework-2Add BLAST14
Regioni71 – 81Complementarity-determining-2Add BLAST11
Regioni82 – 115Framework-3Add BLAST34

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IYZ1. Eukaryota.
ENOG411181I. LUCA.
GeneTreeiENSGT00780000121842.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP12018.
KOiK06553.
OMAiVYSIYWY.
OrthoDBiEOG091G0XV9.
PhylomeDBiP12018.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG
60 70 80 90 100
VYSVYWYQQR PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL
110 120 130 140
SISELQPEDE AMYYCAMGAR SSEKEERERE WEEEMEPTAA RTRVP
Length:145
Mass (Da):16,605
Last modified:December 1, 2000 - v2
Checksum:i197665B13AF64D46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → H in AAA61292 (PubMed:3258819).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450376D → N.Corresponds to variant rs1320dbSNPEnsembl.1
Natural variantiVAR_029133122S → L.Corresponds to variant rs11089979dbSNPEnsembl.1
Natural variantiVAR_029134132E → K.Corresponds to variant rs5995720dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74019 Genomic DNA. Translation: AAB32118.1.
D86992 Genomic DNA. Translation: BAA19987.1.
D88270 Genomic DNA. Translation: BAA20030.1.
CR456609 mRNA. Translation: CAG30495.1.
CH471095 Genomic DNA. Translation: EAW59498.1.
M34927 Genomic DNA. Translation: AAA61292.1.
CCDSiCCDS13798.1.
PIRiI57832.
S00258.
RefSeqiNP_009059.1. NM_007128.3.
UniGeneiHs.247979.

Genome annotation databases

EnsembliENST00000403807; ENSP00000385361; ENSG00000169575.
GeneIDi7441.
KEGGihsa:7441.
UCSCiuc002zvx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

VPREB1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74019 Genomic DNA. Translation: AAB32118.1.
D86992 Genomic DNA. Translation: BAA19987.1.
D88270 Genomic DNA. Translation: BAA20030.1.
CR456609 mRNA. Translation: CAG30495.1.
CH471095 Genomic DNA. Translation: EAW59498.1.
M34927 Genomic DNA. Translation: AAA61292.1.
CCDSiCCDS13798.1.
PIRiI57832.
S00258.
RefSeqiNP_009059.1. NM_007128.3.
UniGeneiHs.247979.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70A20-145[»]
2H3NX-ray2.30A/C21-119[»]
3BJ9X-ray2.00122-121[»]
ProteinModelPortaliP12018.
SMRiP12018.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12018. 2 interactors.
MINTiMINT-7241497.
STRINGi9606.ENSP00000385361.

PTM databases

iPTMnetiP12018.
PhosphoSitePlusiP12018.

Polymorphism and mutation databases

BioMutaiVPREB1.
DMDMi9911096.

Proteomic databases

PaxDbiP12018.
PeptideAtlasiP12018.
PRIDEiP12018.
TopDownProteomicsiP12018.

Protocols and materials databases

DNASUi7441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403807; ENSP00000385361; ENSG00000169575.
GeneIDi7441.
KEGGihsa:7441.
UCSCiuc002zvx.2. human.

Organism-specific databases

CTDi7441.
DisGeNETi7441.
GeneCardsiVPREB1.
HGNCiHGNC:12709. VPREB1.
HPAiHPA055886.
MIMi605141. gene.
neXtProtiNX_P12018.
OpenTargetsiENSG00000169575.
PharmGKBiPA37324.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZ1. Eukaryota.
ENOG411181I. LUCA.
GeneTreeiENSGT00780000121842.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP12018.
KOiK06553.
OMAiVYSIYWY.
OrthoDBiEOG091G0XV9.
PhylomeDBiP12018.
TreeFamiTF352061.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169575-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP12018.
GeneWikiiVPREB1.
GenomeRNAii7441.
PROiP12018.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169575.
CleanExiHS_VPREB1.
ExpressionAtlasiP12018. baseline and differential.
GenevisibleiP12018. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPREB_HUMAN
AccessioniPrimary (citable) accession number: P12018
Secondary accession number(s): B5MCG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.