Reviewed,
UniProtKB/Swiss-Prot P12013 (6PGD_BACSU)
Last modified
November 25, 2008.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 6-phosphogluconate dehydrogenase, decarboxylating EC=1.1.1.44 | ||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 468 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the 6-phosphogluconate dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Gluconate utilization Pentose shunt |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: InterPro |
| Molecular function | NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 468 | 468 | 6-phosphogluconate dehydrogenase, decarboxylating | PRO_0000090026 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Organization and transcription of the gluconate operon, gnt, of Bacillus subtilis." Fujita Y., Fujita T., Miwa Y., Nihashi J., Aratani Y. J. Biol. Chem. 261:13744-13753(1986) [PubMed: 3020045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Cloning and sequencing of a 36-kb region of the Bacillus subtilis genome between the gnt and iol operons." Yoshida K., Seki S., Fujimura M., Miwa Y., Fujita Y. DNA Res. 2:61-69(1995) [PubMed: 7584049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / BGSC1A1. |
| [3] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [4] | "36kb sequence between gntZ and trnY of B. subtilis genome." Kasahara Y., Nakai S., Yoshikawa H., Ogasawara N. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 460-468. Strain: 168. |
| [5] | "Analysis of the gluconate (gnt) operon of Bacillus subtilis." Reizer A., Deutscher J., Saier M.H. Jr., Reizer J. Mol. Microbiol. 5:1081-1089(1991) [PubMed: 1659648] [Abstract] Cited for: PROBABLE FUNCTION. |
Cross-references
Sequence databases | |
|---|---|
| J02584 Genomic DNA. Translation: AAA56927.1. AB005554 Genomic DNA. Translation: BAA21576.1. Z99124 Genomic DNA. Translation: CAB16045.1. D78193 Genomic DNA. Translation: BAA11267.1. | |
| PIR | D26190. |
| RefSeq | NP_391888.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2PGD based on UniProtKB P00349. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 937716. |
| GenomeReviews | Gene locus BSU40080 in contig AL009126_GR. |
| KEGG | bsu:BSU40080. |
| NMPDR | fig|224308.1.peg.4014. |
Organism-specific databases | |
| SubtiList | BG10651. gntZ. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P12013. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU4005-MON. |
Family and domain databases | |
| InterPro | IPR006183. 6-phosphogluconate_DHase. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DHase_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view] |
| PRINTS | PR00076. 6PGDHDRGNASE. |
| TIGRFAMs | TIGR00873. gnd. 1 hit. |
| PROSITE | PS00461. 6PGD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | 6PGD_BACSU | ||||||||
| Accession | Primary (citable) accession number: P12013 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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