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P12002

- SIGNS_REOVJ

UniProt

P12002 - SIGNS_REOVJ

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Protein

Protein sigma-NS

Gene
S3
Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Protein that binds to ssRNA and may be involved in genome packaging By similarity.

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: InterPro
  2. single-stranded RNA binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sigma-NS
Short name:
SigmaNS
Gene namesi
Name:S3
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Protein sigma-NSPRO_0000222760Add
BLAST

Interactioni

Subunit structurei

Homomultimer By similarity. Interacts with protein mu-NS; in viral inclusions By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1111Important for ssRNA-binding and formation of complexes By similarityAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR002507. Reovirus_polyG_pol.
[Graphical view]
PfamiPF01518. PolyG_pol. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12002-1 [UniParc]FASTAAdd to Basket

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MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVNTKVVRNV VDYQIKTGGF    50
FSCIAMLRPL QYAKRERLLG QRNLERIAAR DVLQTRDLHS LCMPTPDAPM 100
TNYQASTMRE LVCDHFKVDH VDGLRYVPMD DRYSPSSLAR LFTMGMAGLH 150
ITTEPAYKRV PIMHLAADLD CMTFALPYMI TVDGDTVVPV APTLPAERLL 200
DDGFKGYGCL DISYGCEVDA NNRSAGDQSM DSSRCINELY TAETAEAICI 250
LKTCLILNCM QFKLEMDDLA HNGFELDKVQ MMIPFSERVF RMASAFATID 300
VQCFRFCLLM KDKNLKIDMR ETMRLWTRAG SDDAISTSSL TISLDRGRWV 350
AMDMNEVRLL VFPARV 366
Length:366
Mass (Da):41,334
Last modified:January 1, 1990 - v2
Checksum:iEF9202C3A6FC5085
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18390 Genomic RNA. Translation: AAA47282.1.
PIRiB27401. MNXRT2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18390 Genomic RNA. Translation: AAA47282.1 .
PIRi B27401. MNXRT2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002507. Reovirus_polyG_pol.
[Graphical view ]
Pfami PF01518. PolyG_pol. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS."
    Wiener J.R., Joklik W.K.
    Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiSIGNS_REOVJ
AccessioniPrimary (citable) accession number: P12002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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