P12002 (SIGNS_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein sigma-NS
Short name=SigmaNS

Gene names

Name:

S3

Organism

Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]

Taxonomic identifier

10885 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Reoviridae › Spinareovirinae › Orthoreovirus › Mammalian orthoreovirus › Mammalian orthoreovirus 2

Virus host

Mammalia [TaxID: 40674]

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Protein that binds to ssRNA and may be involved in genome packaging By similarity.
Subunit structure	Homomultimer By similarity. Interacts with protein mu-NS; in viral inclusions By similarity.
Sequence similarities	Belongs to the orthoreovirus sigma-NS protein family.

Ontologies

Keywords
Ligand	RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: InterPro single-stranded RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Protein sigma-NS		PRO_0000222760
Regions
	Region	1 – 11	11	Important for ssRNA-binding and formation of complexes By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12002 [UniParc]. Last modified January 1, 1990. Version 2. Checksum: EF9202C3A6FC5085	FASTA	366	41,334
	10 20 30 40 50 60 MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVNTKVVRNV VDYQIKTGGF FSCIAMLRPL 70 80 90 100 110 120 QYAKRERLLG QRNLERIAAR DVLQTRDLHS LCMPTPDAPM TNYQASTMRE LVCDHFKVDH 130 140 150 160 170 180 VDGLRYVPMD DRYSPSSLAR LFTMGMAGLH ITTEPAYKRV PIMHLAADLD CMTFALPYMI 190 200 210 220 230 240 TVDGDTVVPV APTLPAERLL DDGFKGYGCL DISYGCEVDA NNRSAGDQSM DSSRCINELY 250 260 270 280 290 300 TAETAEAICI LKTCLILNCM QFKLEMDDLA HNGFELDKVQ MMIPFSERVF RMASAFATID 310 320 330 340 350 360 VQCFRFCLLM KDKNLKIDMR ETMRLWTRAG SDDAISTSSL TISLDRGRWV AMDMNEVRLL VFPARV

References

[1]	"Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS." Wiener J.R., Joklik W.K. Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18390 Genomic RNA. Translation: AAA47282.1.
PIR	MNXRT2. B27401.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002507. Reovirus_polyG_pol. [Graphical view]
Pfam	PF01518. PolyG_pol. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIGNS_REOVJ

Accession

Primary (citable) accession number: P12002

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	January 1, 1990
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program