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P12002

- SIGNS_REOVJ

UniProt

P12002 - SIGNS_REOVJ

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Protein

Protein sigma-NS

Gene

S3

Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Protein that binds to ssRNA and may be involved in genome packaging.By similarity

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: InterPro
  2. single-stranded RNA binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sigma-NS
Short name:
SigmaNS
Gene namesi
Name:S3
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Protein sigma-NSPRO_0000222760Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Interacts with protein mu-NS; in viral inclusions.By similarity

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1111Important for ssRNA-binding and formation of complexesBy similarityAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR002507. Reovirus_polyG_pol.
[Graphical view]
PfamiPF01518. PolyG_pol. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12002-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVNTKVVRNV VDYQIKTGGF
60 70 80 90 100
FSCIAMLRPL QYAKRERLLG QRNLERIAAR DVLQTRDLHS LCMPTPDAPM
110 120 130 140 150
TNYQASTMRE LVCDHFKVDH VDGLRYVPMD DRYSPSSLAR LFTMGMAGLH
160 170 180 190 200
ITTEPAYKRV PIMHLAADLD CMTFALPYMI TVDGDTVVPV APTLPAERLL
210 220 230 240 250
DDGFKGYGCL DISYGCEVDA NNRSAGDQSM DSSRCINELY TAETAEAICI
260 270 280 290 300
LKTCLILNCM QFKLEMDDLA HNGFELDKVQ MMIPFSERVF RMASAFATID
310 320 330 340 350
VQCFRFCLLM KDKNLKIDMR ETMRLWTRAG SDDAISTSSL TISLDRGRWV
360
AMDMNEVRLL VFPARV
Length:366
Mass (Da):41,334
Last modified:January 1, 1990 - v2
Checksum:iEF9202C3A6FC5085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18390 Genomic RNA. Translation: AAA47282.1.
PIRiB27401. MNXRT2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18390 Genomic RNA. Translation: AAA47282.1 .
PIRi B27401. MNXRT2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002507. Reovirus_polyG_pol.
[Graphical view ]
Pfami PF01518. PolyG_pol. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS."
    Wiener J.R., Joklik W.K.
    Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiSIGNS_REOVJ
AccessioniPrimary (citable) accession number: P12002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: October 1, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3