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P12002

- SIGNS_REOVJ

UniProt

P12002 - SIGNS_REOVJ

Protein

Protein sigma-NS

Gene

S3

Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Protein that binds to ssRNA and may be involved in genome packaging.By similarity

    GO - Molecular functioni

    1. RNA-directed RNA polymerase activity Source: InterPro
    2. single-stranded RNA binding Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein sigma-NS
    Short name:
    SigmaNS
    Gene namesi
    Name:S3
    OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
    Taxonomic identifieri10885 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000006370: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Protein sigma-NSPRO_0000222760Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimer. Interacts with protein mu-NS; in viral inclusions.By similarity

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1111Important for ssRNA-binding and formation of complexesBy similarityAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002507. Reovirus_polyG_pol.
    [Graphical view]
    PfamiPF01518. PolyG_pol. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12002-1 [UniParc]FASTAAdd to Basket

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    MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVNTKVVRNV VDYQIKTGGF    50
    FSCIAMLRPL QYAKRERLLG QRNLERIAAR DVLQTRDLHS LCMPTPDAPM 100
    TNYQASTMRE LVCDHFKVDH VDGLRYVPMD DRYSPSSLAR LFTMGMAGLH 150
    ITTEPAYKRV PIMHLAADLD CMTFALPYMI TVDGDTVVPV APTLPAERLL 200
    DDGFKGYGCL DISYGCEVDA NNRSAGDQSM DSSRCINELY TAETAEAICI 250
    LKTCLILNCM QFKLEMDDLA HNGFELDKVQ MMIPFSERVF RMASAFATID 300
    VQCFRFCLLM KDKNLKIDMR ETMRLWTRAG SDDAISTSSL TISLDRGRWV 350
    AMDMNEVRLL VFPARV 366
    Length:366
    Mass (Da):41,334
    Last modified:January 1, 1990 - v2
    Checksum:iEF9202C3A6FC5085
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18390 Genomic RNA. Translation: AAA47282.1.
    PIRiB27401. MNXRT2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18390 Genomic RNA. Translation: AAA47282.1 .
    PIRi B27401. MNXRT2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002507. Reovirus_polyG_pol.
    [Graphical view ]
    Pfami PF01518. PolyG_pol. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS."
      Wiener J.R., Joklik W.K.
      Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiSIGNS_REOVJ
    AccessioniPrimary (citable) accession number: P12002
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3