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P12002 (SIGNS_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein sigma-NS

Short name=SigmaNS
Gene names
Name:S3
OrganismReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]
Taxonomic identifier10885 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protein that binds to ssRNA and may be involved in genome packaging By similarity.

Subunit structure

Homomultimer By similarity. Interacts with protein mu-NS; in viral inclusions By similarity.

Sequence similarities

Belongs to the orthoreovirus sigma-NS protein family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Protein sigma-NS
PRO_0000222760

Regions

Region1 – 1111Important for ssRNA-binding and formation of complexes By similarity

Sequences

Sequence LengthMass (Da)Tools
P12002 [UniParc].

Last modified January 1, 1990. Version 2.
Checksum: EF9202C3A6FC5085

FASTA36641,334
        10         20         30         40         50         60 
MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVNTKVVRNV VDYQIKTGGF FSCIAMLRPL 

        70         80         90        100        110        120 
QYAKRERLLG QRNLERIAAR DVLQTRDLHS LCMPTPDAPM TNYQASTMRE LVCDHFKVDH 

       130        140        150        160        170        180 
VDGLRYVPMD DRYSPSSLAR LFTMGMAGLH ITTEPAYKRV PIMHLAADLD CMTFALPYMI 

       190        200        210        220        230        240 
TVDGDTVVPV APTLPAERLL DDGFKGYGCL DISYGCEVDA NNRSAGDQSM DSSRCINELY 

       250        260        270        280        290        300 
TAETAEAICI LKTCLILNCM QFKLEMDDLA HNGFELDKVQ MMIPFSERVF RMASAFATID 

       310        320        330        340        350        360 
VQCFRFCLLM KDKNLKIDMR ETMRLWTRAG SDDAISTSSL TISLDRGRWV AMDMNEVRLL 


VFPARV 

« Hide

References

[1]"Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS."
Wiener J.R., Joklik W.K.
Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18390 Genomic RNA. Translation: AAA47282.1.
PIRMNXRT2. B27401.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002507. Reovirus_polyG_pol.
[Graphical view]
PfamPF01518. PolyG_pol. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIGNS_REOVJ
AccessionPrimary (citable) accession number: P12002
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families