Reviewed,
UniProtKB/Swiss-Prot P12000 (DNLI1_SCHPO)
Last modified
June 16, 2009.
Version 74.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: DNA ligase 1 EC=6.5.1.1 Alternative name(s): DNA ligase I Polydeoxyribonucleotide synthase [ATP] 1 | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 768 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. |
| Catalytic activity | ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). |
| Cofactor | Magnesium By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the ATP-dependent DNA ligase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 768 | 768 | DNA ligase 1 | PRO_0000059585 | |||||
Regions | |||||||||
| Region | 309 – 318 | 10 | Interaction with target DNA By similarity | ||||||
| Region | 490 – 492 | 3 | Interaction with target DNA By similarity | ||||||
Sites | |||||||||
| Active site | 416 | 1 | N6-AMP-lysine intermediate By similarity | ||||||
| Metal binding | 469 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 568 | 1 | Magnesium 2 By similarity | ||||||
| Binding site | 414 | 1 | ATP By similarity | ||||||
| Binding site | 421 | 1 | ATP By similarity | ||||||
| Binding site | 437 | 1 | ATP By similarity | ||||||
| Binding site | 573 | 1 | ATP By similarity | ||||||
| Binding site | 587 | 1 | ATP By similarity | ||||||
| Binding site | 593 | 1 | ATP By similarity | ||||||
| Site | 165 | 1 | Interaction with target DNA By similarity | ||||||
| Site | 438 | 1 | Interaction with target DNA By similarity | ||||||
| Site | 619 | 1 | Interaction with target DNA By similarity | ||||||
| Site | 644 | 1 | Interaction with target DNA By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular characterisation of the DNA ligase gene, CDC17, from the fission yeast Schizosaccharomyces pombe." Barker D.G., White J.H.M., Johnston L.H. Eur. J. Biochem. 162:659-667(1987) [PubMed: 3549293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| X05107 Genomic DNA. Translation: CAA28754.1. CU329670 Genomic DNA. Translation: CAB08176.1. | |
| PIR | A29066. |
| RefSeq | NP_593318.2. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2541849. |
| KEGG | spo:SPAC20G8.01. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC20G8.01. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-001954-MON. |
| BRENDA | 6.5.1.1. 653. |
Gene expression databases | |
| ArrayExpress | P12000. |
Family and domain databases | |
| InterPro | IPR000977. DNA_ligase. IPR012309. DNA_ligase_A_C. IPR012310. DNA_ligase_A_M. IPR012308. DNA_ligase_A_N. IPR016059. DNA_ligase_CS. IPR012340. NA-bd_OB-fold. [Graphical view] |
| Gene3D | G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit. |
| Pfam | PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00574. dnl1. 1 hit. |
| PROSITE | PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DNLI1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P12000 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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