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Protein

Larval serum protein 1 gamma chain

Gene

Lsp1gamma

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Larval serum protein 1 gamma chain
Alternative name(s):
Hexamerin-1-gamma
Gene namesi
Name:Lsp1gamma
Synonyms:Lsp1-g
ORF Names:CG6821
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0002564. Lsp1gamma.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
  • larval serum protein complex Source: FlyBase
  • lipid particle Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 772756Larval serum protein 1 gamma chainPRO_0000013335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11997.
PRIDEiP11997.

Expressioni

Tissue specificityi

Larval hemolymph.1 Publication

Gene expression databases

BgeeiFBgn0002564.
ExpressionAtlasiP11997. differential.
GenevisibleiP11997. DM.

Interactioni

Subunit structurei

Heterohexamer, composed of three subunits, alpha, beta and gamma.

Protein-protein interaction databases

STRINGi7227.FBpp0072365.

Structurei

3D structure databases

ProteinModelPortaliP11997.
SMRiP11997. Positions 23-178, 262-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hemocyanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II6Z. Eukaryota.
ENOG410XR2D. LUCA.
GeneTreeiENSGT00530000063973.
InParanoidiP11997.
OMAiYNDMEVF.
OrthoDBiEOG091G028S.
PhylomeDBiP11997.

Family and domain databases

Gene3Di1.10.1280.10. 2 hits.
1.20.1370.10. 1 hit.
2.60.40.1520. 1 hit.
InterProiIPR013788. Hemocyanin/hexamerin.
IPR000896. Hemocyanin/hexamerin_mid_dom.
IPR005203. Hemocyanin_C.
IPR005204. Hemocyanin_N.
IPR014756. Ig_E-set.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11511. PTHR11511. 2 hits.
PfamiPF03723. Hemocyanin_C. 1 hit.
PF00372. Hemocyanin_M. 1 hit.
PF03722. Hemocyanin_N. 1 hit.
[Graphical view]
PRINTSiPR00187. HAEMOCYANIN.
SUPFAMiSSF48050. SSF48050. 1 hit.
SSF48056. SSF48056. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00210. HEMOCYANIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTLVILAL VACVTAFSVP TQKVKIADKN FLEKQKFLFE IVHRIDEPLM
60 70 80 90 100
FEEWIKMGQK LITDKAQYET FDFYMEKLWE SYKLGALLPK GEFFGALVKT
110 120 130 140 150
HHKQAYGLFN FFYYAKDWET FVRNVAWARI HVNEGMFVYA LTLAVIHKPE
160 170 180 190 200
FEGLILPQIY EIFPQYFFNS KFVYAAEKFD YEVFSKLTMY EKEYKDILYK
210 220 230 240 250
DYSEFTGNFY FYTKDWKTWQ WYKMMGLDQE WYVEDKYFLR ENLSQFVNDP
260 270 280 290 300
KYVDVVKGLK KFYMPVDYTR DIDFFNDETK MTYFTEDLGW NAYWYYLNMD
310 320 330 340 350
YAFFLNGKQF GLDKDRRGEY WIYNVQQILA RYYQERLANG FGEIPEFFWY
360 370 380 390 400
KQIEYGYDPQ LIYYNGIGYS YRKNYYDFYT YGKFEMYSQI QNFFSRVYKV
410 420 430 440 450
LETGFYKTAD GQVFDLHKPE AIKIVGNYLQ GNADTFDKYF FNYYYLLAHM
460 470 480 490 500
YFADVDYNDM EVFPNVFLNF ETMLRDPFFY TFYKKFTDVF YTFKYYLKPY
510 520 530 540 550
TQKDLFYEGI TIKDVSVSKL VTYYDIVDFD VTNLLNDKMT FVDGQYIWDK
560 570 580 590 600
ALLARQARLN HKPFNFEFTI DSDKVQKGVV RVFLGPKFDE YGRVIPLDYN
610 620 630 640 650
RKNFVQIDSF VYPFIAGTNT IKRSSKEFSW TAEDRITYTE LYKYVMLASE
660 670 680 690 700
GKYDFPLDIS EPHNAFPDRL VLPKGWEQGM PMQFYFFVSP FAETYEQFSN
710 720 730 740 750
FDYTYSSGVG SGTRFVDTKP FGYPFDRQID ESDFFVPNGF FKDVKVYYVD
760 770
TFAKYFEKKY TQFGTFDYSI EY
Length:772
Mass (Da):93,408
Last modified:February 21, 2001 - v2
Checksum:iFC2BC0A7336F636D
GO

Sequence cautioni

The sequence CAA27508 differs from that shown. Reason: Frameshift at position 101. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti326 – 3283QQI → SRS in AAB71666 (PubMed:9402735).Curated
Sequence conflicti624 – 6241S → T in AAB71666 (PubMed:9402735).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47324.1.
AY069748 mRNA. Translation: AAL39893.1.
AF016033 Genomic DNA. Translation: AAB71666.1.
X03874 Genomic DNA. Translation: CAA27508.1. Frameshift.
PIRiC27144.
RefSeqiNP_523868.1. NM_079144.5.
UniGeneiDm.1973.

Genome annotation databases

EnsemblMetazoaiFBtr0072463; FBpp0072365; FBgn0002564.
GeneIDi38015.
KEGGidme:Dmel_CG6821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47324.1.
AY069748 mRNA. Translation: AAL39893.1.
AF016033 Genomic DNA. Translation: AAB71666.1.
X03874 Genomic DNA. Translation: CAA27508.1. Frameshift.
PIRiC27144.
RefSeqiNP_523868.1. NM_079144.5.
UniGeneiDm.1973.

3D structure databases

ProteinModelPortaliP11997.
SMRiP11997. Positions 23-178, 262-748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0072365.

Proteomic databases

PaxDbiP11997.
PRIDEiP11997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072463; FBpp0072365; FBgn0002564.
GeneIDi38015.
KEGGidme:Dmel_CG6821.

Organism-specific databases

CTDi38015.
FlyBaseiFBgn0002564. Lsp1gamma.

Phylogenomic databases

eggNOGiENOG410II6Z. Eukaryota.
ENOG410XR2D. LUCA.
GeneTreeiENSGT00530000063973.
InParanoidiP11997.
OMAiYNDMEVF.
OrthoDBiEOG091G028S.
PhylomeDBiP11997.

Miscellaneous databases

ChiTaRSiLsp1gamma. fly.
GenomeRNAii38015.
PROiP11997.

Gene expression databases

BgeeiFBgn0002564.
ExpressionAtlasiP11997. differential.
GenevisibleiP11997. DM.

Family and domain databases

Gene3Di1.10.1280.10. 2 hits.
1.20.1370.10. 1 hit.
2.60.40.1520. 1 hit.
InterProiIPR013788. Hemocyanin/hexamerin.
IPR000896. Hemocyanin/hexamerin_mid_dom.
IPR005203. Hemocyanin_C.
IPR005204. Hemocyanin_N.
IPR014756. Ig_E-set.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11511. PTHR11511. 2 hits.
PfamiPF03723. Hemocyanin_C. 1 hit.
PF00372. Hemocyanin_M. 1 hit.
PF03722. Hemocyanin_N. 1 hit.
[Graphical view]
PRINTSiPR00187. HAEMOCYANIN.
SUPFAMiSSF48050. SSF48050. 1 hit.
SSF48056. SSF48056. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00210. HEMOCYANIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSP1G_DROME
AccessioniPrimary (citable) accession number: P11997
Secondary accession number(s): O16162, Q9W0V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.