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Protein

Cryptic beta-glucoside bgl operon antiterminator

Gene

bglG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon.

GO - Molecular functioni

  • RNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10116-MONOMER.
ECOL316407:JW3701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptic beta-glucoside bgl operon antiterminator
Gene namesi
Name:bglG
Synonyms:bglC
Ordered Locus Names:b3723, JW3701
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10116. bglG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Cryptic beta-glucoside bgl operon antiterminatorPRO_0000204244Add
BLAST

Post-translational modificationi

Phosphorylated and inactivated by BglF (eII-bgl). The degree of phosphorylation is dependent on the presence or absence of beta-glucosides which act as inducers of the operon expression. Addition of inducer result in the rapid dephosphorylation of BglG.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11989.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
dnaXP067103EBI-545674,EBI-549140
ptsHP0AA045EBI-545674,EBI-902853
ptsIP088393EBI-545674,EBI-551533
yahBP777003EBI-545674,EBI-545731

Protein-protein interaction databases

BioGridi4262138. 6 interactions.
DIPiDIP-9216N.
IntActiP11989. 14 interactions.
MINTiMINT-1240048.
STRINGi511145.b3723.

Structurei

3D structure databases

ProteinModelPortaliP11989.
SMRiP11989. Positions 3-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 171105PRD 1PROSITE-ProRule annotationAdd
BLAST
Domaini172 – 278107PRD 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PRD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CID. Bacteria.
COG3711. LUCA.
HOGENOMiHOG000223756.
InParanoidiP11989.
KOiK03488.
OMAiYPDEYAI.
OrthoDBiEOG6KT2T7.
PhylomeDBiP11989.

Family and domain databases

Gene3Di1.10.1790.10. 2 hits.
2.30.24.10. 1 hit.
InterProiIPR004341. CAT_RNA-bd_dom.
IPR011608. PRD.
IPR001550. Transcrpt_antitermin_CS.
[Graphical view]
PfamiPF03123. CAT_RBD. 1 hit.
PF00874. PRD. 2 hits.
[Graphical view]
SMARTiSM01061. CAT_RBD. 1 hit.
[Graphical view]
SUPFAMiSSF50151. SSF50151. 1 hit.
SSF63520. SSF63520. 2 hits.
PROSITEiPS00654. PRD_1. 1 hit.
PS51372. PRD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMQITKILN NNVVVVIDDQ QREKVVMGRG IGFQKRAGER INSSGIEKEY
60 70 80 90 100
ALSSHELNGR LSELLSHIPL EVMATCDRII SLAQERLGKL QDSIYISLTD
110 120 130 140 150
HCQFAIKRFQ QNVLLPNPLL WDIQRLYPKE FQLGEEALTI IDKRLGVQLP
160 170 180 190 200
KDEVGFIAMH LVSAQMSGNM EDVAGVTQLM REMLQLIKFQ FSLNYQEESL
210 220 230 240 250
SYQRLVTHLK FLSWRILEHA SINDSDESLQ QAVKQNYPQA WQCAERIAIF
260 270
IGLQYQRKIS PAEIMFLAIN IERVRKEH
Length:278
Mass (Da):32,097
Last modified:October 1, 1989 - v1
Checksum:i5ACF1A14BF438B4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16487 Genomic DNA. Translation: AAA23509.1.
L10328 Genomic DNA. Translation: AAA62074.1.
U00096 Genomic DNA. Translation: AAC76746.1.
AP009048 Genomic DNA. Translation: BAE77565.1.
M17098 Genomic DNA. Translation: AAA23512.1.
M15746 Genomic DNA. Translation: AAA83836.1. Sequence problems.
PIRiB25977.
RefSeqiNP_418179.1. NC_000913.3.
WP_001295251.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76746; AAC76746; b3723.
BAE77565; BAE77565; BAE77565.
GeneIDi948235.
KEGGiecj:JW3701.
eco:b3723.
PATRICi32122941. VBIEscCol129921_3846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16487 Genomic DNA. Translation: AAA23509.1.
L10328 Genomic DNA. Translation: AAA62074.1.
U00096 Genomic DNA. Translation: AAC76746.1.
AP009048 Genomic DNA. Translation: BAE77565.1.
M17098 Genomic DNA. Translation: AAA23512.1.
M15746 Genomic DNA. Translation: AAA83836.1. Sequence problems.
PIRiB25977.
RefSeqiNP_418179.1. NC_000913.3.
WP_001295251.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP11989.
SMRiP11989. Positions 3-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262138. 6 interactions.
DIPiDIP-9216N.
IntActiP11989. 14 interactions.
MINTiMINT-1240048.
STRINGi511145.b3723.

Proteomic databases

PaxDbiP11989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76746; AAC76746; b3723.
BAE77565; BAE77565; BAE77565.
GeneIDi948235.
KEGGiecj:JW3701.
eco:b3723.
PATRICi32122941. VBIEscCol129921_3846.

Organism-specific databases

EchoBASEiEB0114.
EcoGeneiEG10116. bglG.

Phylogenomic databases

eggNOGiENOG4105CID. Bacteria.
COG3711. LUCA.
HOGENOMiHOG000223756.
InParanoidiP11989.
KOiK03488.
OMAiYPDEYAI.
OrthoDBiEOG6KT2T7.
PhylomeDBiP11989.

Enzyme and pathway databases

BioCyciEcoCyc:EG10116-MONOMER.
ECOL316407:JW3701-MONOMER.

Miscellaneous databases

PROiP11989.

Family and domain databases

Gene3Di1.10.1790.10. 2 hits.
2.30.24.10. 1 hit.
InterProiIPR004341. CAT_RNA-bd_dom.
IPR011608. PRD.
IPR001550. Transcrpt_antitermin_CS.
[Graphical view]
PfamiPF03123. CAT_RBD. 1 hit.
PF00874. PRD. 2 hits.
[Graphical view]
SMARTiSM01061. CAT_RBD. 1 hit.
[Graphical view]
SUPFAMiSSF50151. SSF50151. 1 hit.
SSF63520. SSF63520. 2 hits.
PROSITEiPS00654. PRD_1. 1 hit.
PS51372. PRD_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Beta-glucoside (bgl) operon of Escherichia coli K-12: nucleotide sequence, genetic organization, and possible evolutionary relationship to regulatory components of two Bacillus subtilis genes."
    Schnetz K., Toloczyki C., Rak B.
    J. Bacteriol. 169:2579-2590(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "A bacterial gene involved in transcription antitermination: regulation at a rho-independent terminator in the bgl operon of E. coli."
    Mahadevan S., Wright A.
    Cell 50:485-494(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-197.
    Strain: K12.
  6. "Nucleotide sequence of bglC, the gene specifying enzymeIIbgl of the PEP:sugar phosphotransferase system in Escherichia coli K12, and overexpression of the gene product."
    Bramley H.F., Kornberg H.L.
    J. Gen. Microbiol. 133:563-573(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 264-278.
  7. "Regulation of activity of a transcriptional anti-terminator in E. coli by phosphorylation in vivo."
    Amster-Choder O., Wright A.
    Science 249:540-542(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION BY PHOSPHORYLATION.
  8. "Beta-glucoside permease represses the bgl operon of Escherichia coli by phosphorylation of the antiterminator protein and also interacts with glucose-specific enzyme III, the key element in catabolite control."
    Schnetz K., Rak B.
    Proc. Natl. Acad. Sci. U.S.A. 87:5074-5078(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION BY PHOSPHORYLATION.
  9. "Transcriptional antitermination in the bgl operon of E. coli is modulated by a specific RNA binding protein."
    Houman F., Diaz-Torre M.R., Wright A.
    Cell 62:1153-1163(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING.

Entry informationi

Entry nameiBGLG_ECOLI
AccessioniPrimary (citable) accession number: P11989
Secondary accession number(s): Q2M841, Q47078
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: January 20, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.