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Protein

T-complex protein 1 subunit alpha

Gene

Tcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Tailless complex polypeptide 1A
Short name:
TCP-1-A
Tailless complex polypeptide 1B
Short name:
TCP-1-B
Gene namesi
Name:Tcp1
Synonyms:Cct1, Ccta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:98535 Tcp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283051 – 556T-complex protein 1 subunit alphaAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei6PhosphoserineBy similarity1
Modified residuei181PhosphotyrosineBy similarity1
Modified residuei199N6-acetyllysineBy similarity1
Modified residuei400N6-acetyllysineCombined sources1
Modified residuei494N6-acetyllysineCombined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP11983
MaxQBiP11983
PaxDbiP11983
PeptideAtlasiP11983
PRIDEiP11983

2D gel databases

REPRODUCTION-2DPAGEiIPI00459493
P11983

PTM databases

iPTMnetiP11983
PhosphoSitePlusiP11983
SwissPalmiP11983

Expressioni

Gene expression databases

BgeeiENSMUSG00000068039
CleanExiMM_TCP1
ExpressionAtlasiP11983 baseline and differential
GenevisibleiP11983 MM

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204044, 15 interactors
CORUMiP11983
DIPiDIP-32342N
IntActiP11983, 12 interactors
MINTiP11983
STRINGi10090.ENSMUSP00000116108

Structurei

3D structure databases

ProteinModelPortaliP11983
SMRiP11983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074878
HOVERGENiHBG001052
InParanoidiP11983
KOiK09493
OMAiIMRIDTL
OrthoDBiEOG091G04HL
TreeFamiTF106331

Family and domain databases

CDDicd03335 TCP1_alpha, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02340 chap_CCT_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGPLSVFGD RSTGEAVRSQ NVMAAASIAN IVKSSFGPVG LDKMLVDDIG
60 70 80 90 100
DVTITNDGAT ILKLLEVEHP AAKVLCELAD LQDKEVGDGT TSVVIIAAEL
110 120 130 140 150
LKNADELVKQ KIHPTSVISG YRLACKEAVR YINENLIINT DELGRDCLIN
160 170 180 190 200
AAKTSMSSKI IGINGDYFAN MVVDAVLAVK YTDARGQPRY PVNSVNILKA
210 220 230 240 250
HGRSQIESML INGYALNCVV GSQGMPKRIV NAKIACLDFS LQKTKMKLGV
260 270 280 290 300
QVVITDPEKL DQIRQRESDI TKERIQKILA TGANVILTTG GIDDMYLKYF
310 320 330 340 350
VEAGAMAVRR VLKRDLKHVA KASGASILST LANLEGEETF EVTMLGQAEE
360 370 380 390 400
VVQERICDDE LILIKNTKAR TSASIILRGA NDFMCDEMER SLHDALCVVK
410 420 430 440 450
RVLELKSVVP GGGAVEAALS IYLENYATSM GSREQLAIAE FARSLLVIPN
460 470 480 490 500
TLAVNAAQDS TDLVAKLRAF HNEAQVNPER KNLKWIGLDL VHGKPRDNKQ
510 520 530 540 550
AGVFEPTIVK VKSLKFATEA AITILRIDDL IKLHPESKDD KHGSYENAVH

SGALDD
Length:556
Mass (Da):60,449
Last modified:October 1, 1996 - v3
Checksum:i48F2387BE0F909A4
GO
Isoform 2 (identifier: P11983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     50-50: G → M

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):55,459
Checksum:i1E169BE37404520B
GO

Sequence cautioni

The sequence AAA40337 differs from that shown. Reason: Frameshift at position 528.Curated
The sequence AAA40338 differs from that shown. Reason: Frameshift at position 528.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17V → I in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti17V → I in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti17V → I in BAE30084 (PubMed:16141072).Curated1
Sequence conflicti36F → L in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti36F → L in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti140T → A in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti140T → A in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti149 – 151INA → TNT in AAA40337 (PubMed:3753900).Curated3
Sequence conflicti149 – 151INA → TNT in BAA14356 (PubMed:1937024).Curated3
Sequence conflicti151A → T in AAA40338 (PubMed:3753900).Curated1
Sequence conflicti177L → H in BAE31381 (PubMed:16141072).Curated1
Sequence conflicti192V → I in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti192V → I in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti217N → D in BAE39599 (PubMed:16141072).Curated1
Sequence conflicti259K → E in BAE31381 (PubMed:16141072).Curated1
Sequence conflicti296Y → C in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti296Y → C in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti318H → C in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti318H → C in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti326S → T in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti326S → T in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti378R → Q in BAE30084 (PubMed:16141072).Curated1
Sequence conflicti402V → I in BAE30407 (PubMed:16141072).Curated1
Sequence conflicti402V → I in BAE31988 (PubMed:16141072).Curated1
Sequence conflicti405L → S in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti405L → S in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti429S → N in AAA40338 (PubMed:3753900).Curated1
Sequence conflicti439A → V in BAE31381 (PubMed:16141072).Curated1
Sequence conflicti454V → M in BAE39052 (PubMed:16141072).Curated1
Sequence conflicti494K → N in BAE30407 (PubMed:16141072).Curated1
Sequence conflicti537S → C in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti537S → C in BAA14356 (PubMed:1937024).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0247341 – 49Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_02473550G → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20130 mRNA Translation: AAA40337.1 Frameshift.
M12899 mRNA Translation: AAA40338.1 Frameshift.
D90344 mRNA Translation: BAA14356.1
D10606 Genomic DNA Translation: BAA01461.1
S46763 Genomic DNA Translation: AAB23855.1
AK149611 mRNA Translation: BAE28989.1
AK149755 mRNA Translation: BAE29063.1
AK151068 mRNA Translation: BAE30084.1
AK151445 mRNA Translation: BAE30407.1
AK152641 mRNA Translation: BAE31381.1
AK153430 mRNA Translation: BAE31988.1
AK165665 mRNA Translation: BAE38327.1
AK166828 mRNA Translation: BAE39052.1
AK166966 mRNA Translation: BAE39149.1
AK167529 mRNA Translation: BAE39599.1
BC003809 mRNA Translation: AAH03809.1
CCDSiCCDS28397.1 [P11983-1]
CCDS70760.1 [P11983-2]
PIRiB24059
JC1443
RefSeqiNP_001277641.1, NM_001290712.1 [P11983-2]
NP_038714.2, NM_013686.4 [P11983-1]
UniGeneiMm.229342

Genome annotation databases

EnsembliENSMUST00000089024; ENSMUSP00000086418; ENSMUSG00000068039 [P11983-2]
ENSMUST00000151287; ENSMUSP00000116108; ENSMUSG00000068039 [P11983-1]
GeneIDi21454
KEGGimmu:21454
UCSCiuc008all.2 mouse [P11983-1]
uc008alm.2 mouse [P11983-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCPA_MOUSE
AccessioniPrimary (citable) accession number: P11983
Secondary accession number(s): P11984
, Q3TJ96, Q3TKU1, Q3U5T8, Q3U7I8, Q3UAA8, Q3UB80, Q3UE48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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