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Protein

Phosphoglycerate kinase

Gene

pgkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei173SubstrateBy similarity1
Binding sitei222ATPBy similarity1
Binding sitei315ATP; via carbonyl oxygenBy similarity1
Binding sitei346ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 378ATPBy similarity4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphoglycerate kinase activity Source: ASPGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgkA
Synonyms:pgk
ORF Names:AN1246
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458801 – 421Phosphoglycerate kinaseAdd BLAST421

Proteomic databases

PRIDEiP11977.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP11977.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni66 – 69Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiP11977.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTSKLSIT DVDLKDKRVL IRVDFNVPLD KNDNTTITNP QRIVGALPTI
60 70 80 90 100
KYAIDNGAKA VILMSHLGRP DGKKNPKYSL KPVVPKLKEL LGRDVIFTED
110 120 130 140 150
CVGPEVEETV NKASGGQVIL LENLRFHAEE EGSSKDADGN KVKADKDAVA
160 170 180 190 200
QFRKGLTALG DIYINDAFGT AHRAHSSMVG VDLPQKASGF LVKKELEYFA
210 220 230 240 250
KALEEPQRPF LAILGGSKVS DKIQLIDNLL PKVNSLIITG GMAFTFKKTL
260 270 280 290 300
ENVKIGSSLF DEAGSKIVGN IIEKAKKHNV KVVLPVDYVT ADKFAADAKT
310 320 330 340 350
GYATDEQGIP DGYMGLDVGE KSVESYKQTI AESKTILWNG PPGVFEMEPF
360 370 380 390 400
AKATKATLDA AVAAVQNGAT VIIGGGDTAT VAAKYGAEDK ISHVSTGGGA
410 420
SLELLEGKEL PGVAALSEKS K
Length:421
Mass (Da):44,909
Last modified:February 1, 1996 - v2
Checksum:iCBC948382ECE212D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27549 Genomic DNA. Translation: AAA33318.1.
AACD01000017 Genomic DNA. Translation: EAA65839.1.
BN001308 Genomic DNA. Translation: CBF87861.1.
PIRiA24830.
RefSeqiXP_658850.1. XM_653758.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001377; CADANIAP00001377; CADANIAG00001377.
EAA65839; EAA65839; AN1246.2.
GeneIDi2877015.
KEGGiani:AN1246.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27549 Genomic DNA. Translation: AAA33318.1.
AACD01000017 Genomic DNA. Translation: EAA65839.1.
BN001308 Genomic DNA. Translation: CBF87861.1.
PIRiA24830.
RefSeqiXP_658850.1. XM_653758.1.

3D structure databases

ProteinModelPortaliP11977.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP11977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00001377; CADANIAP00001377; CADANIAG00001377.
EAA65839; EAA65839; AN1246.2.
GeneIDi2877015.
KEGGiani:AN1246.2.

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiP11977.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_EMENI
AccessioniPrimary (citable) accession number: P11977
Secondary accession number(s): C8VSJ5, Q5BDY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.