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Protein

Phosphoglycerate kinase

Gene

pgkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421SubstrateBy similarity
Binding sitei125 – 1251SubstrateBy similarity
Binding sitei173 – 1731SubstrateBy similarity
Binding sitei222 – 2221ATPBy similarity
Binding sitei315 – 3151ATP; via carbonyl oxygenBy similarity
Binding sitei346 – 3461ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi375 – 3784ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: ASPGD

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgkA
Synonyms:pgk
ORF Names:AN1246
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Phosphoglycerate kinasePRO_0000145880Add
BLAST

Proteomic databases

PRIDEiP11977.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00001377.

Structurei

3D structure databases

ProteinModelPortaliP11977.
SMRiP11977. Positions 2-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni66 – 694Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
InParanoidiP11977.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG71K6D7.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11977-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLTSKLSIT DVDLKDKRVL IRVDFNVPLD KNDNTTITNP QRIVGALPTI
60 70 80 90 100
KYAIDNGAKA VILMSHLGRP DGKKNPKYSL KPVVPKLKEL LGRDVIFTED
110 120 130 140 150
CVGPEVEETV NKASGGQVIL LENLRFHAEE EGSSKDADGN KVKADKDAVA
160 170 180 190 200
QFRKGLTALG DIYINDAFGT AHRAHSSMVG VDLPQKASGF LVKKELEYFA
210 220 230 240 250
KALEEPQRPF LAILGGSKVS DKIQLIDNLL PKVNSLIITG GMAFTFKKTL
260 270 280 290 300
ENVKIGSSLF DEAGSKIVGN IIEKAKKHNV KVVLPVDYVT ADKFAADAKT
310 320 330 340 350
GYATDEQGIP DGYMGLDVGE KSVESYKQTI AESKTILWNG PPGVFEMEPF
360 370 380 390 400
AKATKATLDA AVAAVQNGAT VIIGGGDTAT VAAKYGAEDK ISHVSTGGGA
410 420
SLELLEGKEL PGVAALSEKS K
Length:421
Mass (Da):44,909
Last modified:February 1, 1996 - v2
Checksum:iCBC948382ECE212D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27549 Genomic DNA. Translation: AAA33318.1.
AACD01000017 Genomic DNA. Translation: EAA65839.1.
BN001308 Genomic DNA. Translation: CBF87861.1.
PIRiA24830.
RefSeqiXP_658850.1. XM_653758.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001377; CADANIAP00001377; CADANIAG00001377.
GeneIDi2877015.
KEGGiani:AN1246.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27549 Genomic DNA. Translation: AAA33318.1.
AACD01000017 Genomic DNA. Translation: EAA65839.1.
BN001308 Genomic DNA. Translation: CBF87861.1.
PIRiA24830.
RefSeqiXP_658850.1. XM_653758.1.

3D structure databases

ProteinModelPortaliP11977.
SMRiP11977. Positions 2-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001377.

Proteomic databases

PRIDEiP11977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00001377; CADANIAP00001377; CADANIAG00001377.
GeneIDi2877015.
KEGGiani:AN1246.2.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
InParanoidiP11977.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG71K6D7.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcription and processing signals in the 3-phosphoglycerate kinase (PGK) gene from Aspergillus nidulans."
    Clements J.M., Roberts C.F.
    Gene 44:97-105(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiPGK_EMENI
AccessioniPrimary (citable) accession number: P11977
Secondary accession number(s): C8VSJ5, Q5BDY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.