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Protein

Phosphoglycerate kinase

Gene

pgkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei173SubstrateBy similarity1
Binding sitei222ATPBy similarity1
Binding sitei315ATP; via carbonyl oxygenBy similarity1
Binding sitei346ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 378ATPBy similarity4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphoglycerate kinase activity Source: AspGD

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgkA
Synonyms:pgk
ORF Names:AN1246
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458801 – 421Phosphoglycerate kinaseAdd BLAST421

Proteomic databases

PRIDEiP11977

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00001377

Structurei

3D structure databases

ProteinModelPortaliP11977
SMRiP11977
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni66 – 69Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000227107
InParanoidiP11977
KOiK00927
OMAiDMIFDIG
OrthoDBiEOG092C2GKC

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P11977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTSKLSIT DVDLKDKRVL IRVDFNVPLD KNDNTTITNP QRIVGALPTI
60 70 80 90 100
KYAIDNGAKA VILMSHLGRP DGKKNPKYSL KPVVPKLKEL LGRDVIFTED
110 120 130 140 150
CVGPEVEETV NKASGGQVIL LENLRFHAEE EGSSKDADGN KVKADKDAVA
160 170 180 190 200
QFRKGLTALG DIYINDAFGT AHRAHSSMVG VDLPQKASGF LVKKELEYFA
210 220 230 240 250
KALEEPQRPF LAILGGSKVS DKIQLIDNLL PKVNSLIITG GMAFTFKKTL
260 270 280 290 300
ENVKIGSSLF DEAGSKIVGN IIEKAKKHNV KVVLPVDYVT ADKFAADAKT
310 320 330 340 350
GYATDEQGIP DGYMGLDVGE KSVESYKQTI AESKTILWNG PPGVFEMEPF
360 370 380 390 400
AKATKATLDA AVAAVQNGAT VIIGGGDTAT VAAKYGAEDK ISHVSTGGGA
410 420
SLELLEGKEL PGVAALSEKS K
Length:421
Mass (Da):44,909
Last modified:February 1, 1996 - v2
Checksum:iCBC948382ECE212D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27549 Genomic DNA Translation: AAA33318.1
AACD01000017 Genomic DNA Translation: EAA65839.1
BN001308 Genomic DNA Translation: CBF87861.1
PIRiA24830
RefSeqiXP_658850.1, XM_653758.1

Genome annotation databases

EnsemblFungiiCADANIAT00001377; CADANIAP00001377; CADANIAG00001377
EAA65839; EAA65839; AN1246.2
GeneIDi2877015
KEGGiani:AN1246.2

Similar proteinsi

Entry informationi

Entry nameiPGK_EMENI
AccessioniPrimary (citable) accession number: P11977
Secondary accession number(s): C8VSJ5, Q5BDY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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