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Protein

Protein SST2

Gene

SST2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.

Miscellaneous

Present with 5980 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD

GO - Biological processi

  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
  • intracellular signal transduction Source: InterPro
  • negative regulation of signal transduction Source: UniProtKB-KW
  • signal transduction Source: SGD

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processPheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-32505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SST2
Gene namesi
Name:SST2
Ordered Locus Names:YLR452C
ORF Names:L9324.9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR452C.
SGDiS000004444. SST2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041731 – 698Protein SST2Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei539Phosphoserine; by MAPK1 Publication1
Modified residuei587PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by FUS3 and KSS1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11972.
PRIDEiP11972.

PTM databases

iPTMnetiP11972.

Expressioni

Inductioni

By exposure to pheromone.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31710. 419 interactors.
DIPiDIP-2354N.
IntActiP11972. 25 interactors.
MINTiMINT-2782980.
STRINGi4932.YLR452C.

Structurei

3D structure databases

ProteinModelPortaliP11972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini273 – 358DEPPROSITE-ProRule annotationAdd BLAST86
Domaini420 – 689RGSPROSITE-ProRule annotationAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 203Fungal-DRAdd BLAST194

Domaini

The fungal-differentiation regulator (Fungal-DR) domain is only found in fungal regulator of G-protein signaling (RGS) proteins that regulate differentiation pathways. It is required for function (By similarity).By similarity

Phylogenomic databases

HOGENOMiHOG000248349.
InParanoidiP11972.
KOiK19838.
OMAiLEWLCDF.
OrthoDBiEOG092C22MK.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000591. DEP_dom.
IPR016137. RGS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00610. DEP. 1 hit.
PF00615. RGS. 1 hit.
SMARTiView protein in SMART
SM00049. DEP. 2 hits.
SM00315. RGS. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 3 hits.
PROSITEiView protein in PROSITE
PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

P11972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDKNRTLHE LSSKNFSRTP NGLIFTNDLK TVYSIFLICL DLKEKKHSSD
60 70 80 90 100
TKSFLLTAFT KHFHFTFTYQ EAIKAMGQLE LKVDMNTTCI NVSYNIKPSL
110 120 130 140 150
ARHLLTLFMS SKLLHTPQDR TRGEPKEKVL FQPTPKGVAV LQKYVRDIGL
160 170 180 190 200
KTMPDILLSS FNSMKLFTFE RSSVTDSIIH SDYLIHILFI KMMGAKPNVW
210 220 230 240 250
SPTNADDPLP CLSSLLEYTN NDDTFTFEKS KPEQGWQAQI GNIDINDLER
260 270 280 290 300
VSPLAHRFFT NPDSESHTQY YVSNAGIRLF ENKTFGTSKK IVIKYTFTTK
310 320 330 340 350
AIWQWIMDCT DIMHVKEAVS LAALFLKTGL IVPVLLQPSR TDKKKFQISR
360 370 380 390 400
SSFFTLSKRG WDLVSWTGCK SNNIRAPNGS TIDLDFTLRG HMTVRDEKKT
410 420 430 440 450
LDDSEGFSQD MLISSSNLNK LDYVLTDPGM RYLFRRHLEK ELCVENLDVF
460 470 480 490 500
IEIKRFLKKM TILKKLIDSK HCDKKSNTST SKNNIVKTID SALMKQANEC
510 520 530 540 550
LEMAYHIYSS YIMIGSPYQL NIHHNLRQNI SDIMLHPHSP LSEHFPTNLY
560 570 580 590 600
DPSPASAESA ASSISSTEAD TLGEPPEVSL KPSKNLSNEN CSFKKQGFKH
610 620 630 640 650
QLKEYKPAPL TLAETHSPNA SVENSHTIVR YGMDNTQNDT KSVESFPATL
660 670 680 690
KVLRKLYPLF EIVSNEMYRL MNNDSFQKFT QSDVYKDASA LIEIQEKC
Length:698
Mass (Da):79,716
Last modified:April 16, 2002 - v2
Checksum:i48CF5BB6E456C11C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti616H → D in AAA35104 (PubMed:2830483).Curated1
Sequence conflicti644E → D in AAA35104 (PubMed:2830483).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18105 Genomic DNA. Translation: AAA35104.1.
U22382 Genomic DNA. Translation: AAB67534.1.
BK006945 Genomic DNA. Translation: DAA09752.1.
PIRiS55974.
RefSeqiNP_013557.1. NM_001182340.1.

Genome annotation databases

EnsemblFungiiYLR452C; YLR452C; YLR452C.
GeneIDi851173.
KEGGisce:YLR452C.

Similar proteinsi

Entry informationi

Entry nameiSST2_YEAST
AccessioniPrimary (citable) accession number: P11972
Secondary accession number(s): D6VZ86, Q06207
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 16, 2002
Last modified: September 27, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names