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P11972 (SST2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SST2
Gene names
Name:SST2
Ordered Locus Names:YLR452C
ORF Names:L9324.9
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length698 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.

Induction

By exposure to pheromone.

Domain

The fungal-differentiation regulator (Fungal-DR) domain is only found in fungal regulator of G-protein signaling (RGS) proteins that regulate differentiation pathways. It is required for function By similarity.

Post-translational modification

Phosphorylated by FUS3 and KSS1. Ref.4

Miscellaneous

Present with 5980 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 DEP domain.

Contains 1 RGS domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GPA1P085393EBI-18232,EBI-7376
STE2P0CI394EBI-18232,EBI-18360From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 698698Protein SST2
PRO_0000204173

Regions

Domain273 – 35886DEP
Domain420 – 689270RGS
Region10 – 203194Fungal-DR

Amino acid modifications

Modified residue2521Phosphoserine Ref.7
Modified residue4081Phosphoserine Ref.8
Modified residue5391Phosphoserine; by MAPK Ref.4
Modified residue5871Phosphoserine Ref.7 Ref.8

Experimental info

Sequence conflict6161H → D in AAA35104. Ref.1
Sequence conflict6441E → D in AAA35104. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P11972 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: 48CF5BB6E456C11C

FASTA69879,716
        10         20         30         40         50         60 
MVDKNRTLHE LSSKNFSRTP NGLIFTNDLK TVYSIFLICL DLKEKKHSSD TKSFLLTAFT 

        70         80         90        100        110        120 
KHFHFTFTYQ EAIKAMGQLE LKVDMNTTCI NVSYNIKPSL ARHLLTLFMS SKLLHTPQDR 

       130        140        150        160        170        180 
TRGEPKEKVL FQPTPKGVAV LQKYVRDIGL KTMPDILLSS FNSMKLFTFE RSSVTDSIIH 

       190        200        210        220        230        240 
SDYLIHILFI KMMGAKPNVW SPTNADDPLP CLSSLLEYTN NDDTFTFEKS KPEQGWQAQI 

       250        260        270        280        290        300 
GNIDINDLER VSPLAHRFFT NPDSESHTQY YVSNAGIRLF ENKTFGTSKK IVIKYTFTTK 

       310        320        330        340        350        360 
AIWQWIMDCT DIMHVKEAVS LAALFLKTGL IVPVLLQPSR TDKKKFQISR SSFFTLSKRG 

       370        380        390        400        410        420 
WDLVSWTGCK SNNIRAPNGS TIDLDFTLRG HMTVRDEKKT LDDSEGFSQD MLISSSNLNK 

       430        440        450        460        470        480 
LDYVLTDPGM RYLFRRHLEK ELCVENLDVF IEIKRFLKKM TILKKLIDSK HCDKKSNTST 

       490        500        510        520        530        540 
SKNNIVKTID SALMKQANEC LEMAYHIYSS YIMIGSPYQL NIHHNLRQNI SDIMLHPHSP 

       550        560        570        580        590        600 
LSEHFPTNLY DPSPASAESA ASSISSTEAD TLGEPPEVSL KPSKNLSNEN CSFKKQGFKH 

       610        620        630        640        650        660 
QLKEYKPAPL TLAETHSPNA SVENSHTIVR YGMDNTQNDT KSVESFPATL KVLRKLYPLF 

       670        680        690 
EIVSNEMYRL MNNDSFQKFT QSDVYKDASA LIEIQEKC 

« Hide

References

« Hide 'large scale' references
[1]"Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: a model for desensitization to pheromone."
Dietzel C., Kurjan J.
Mol. Cell. Biol. 7:4169-4177(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Feedback phosphorylation of an RGS protein by MAP kinase in yeast."
Garrison T.R., Zhang Y., Pausch M., Apanovitch D., Aebersold R., Dohlman H.G.
J. Biol. Chem. 274:36387-36391(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-539.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: YAL6B.
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252 AND SER-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408 AND SER-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18105 Genomic DNA. Translation: AAA35104.1.
U22382 Genomic DNA. Translation: AAB67534.1.
BK006945 Genomic DNA. Translation: DAA09752.1.
PIRS55974.
RefSeqNP_013557.1. NM_001182340.1.

3D structure databases

ProteinModelPortalP11972.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31710. 161 interactions.
DIPDIP-2354N.
IntActP11972. 11 interactions.
MINTMINT-2782980.
STRING4932.YLR452C.

Proteomic databases

PaxDbP11972.
PeptideAtlasP11972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR452C; YLR452C; YLR452C.
GeneID851173.
KEGGsce:YLR452C.

Organism-specific databases

CYGDYLR452c.
SGDS000004444. SST2.

Phylogenomic databases

eggNOGNOG270876.
HOGENOMHOG000248349.
OMAKMASERR.
OrthoDBEOG793BH8.

Enzyme and pathway databases

BioCycYEAST:G3O-32505-MONOMER.

Gene expression databases

GenevestigatorP11972.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTSM00049. DEP. 2 hits.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 3 hits.
PROSITEPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967987.

Entry information

Entry nameSST2_YEAST
AccessionPrimary (citable) accession number: P11972
Secondary accession number(s): D6VZ86, Q06207
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 16, 2002
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families