Reviewed,
UniProtKB/Swiss-Prot P11966 (ODPB_BOVIN)
Last modified
June 16, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Short name=PDHE1-B EC=1.2.4.1 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). |
| Catalytic activity | Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. |
| Cofactor | Thiamine pyrophosphate. |
| Subunit structure | Tetramer of 2 alpha and 2 beta subunits. |
| Subcellular location | |
| Sequence caution | The sequence AAX46758.1 differs from that shown. Reason: Frameshift at position 201. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Pyruvate Thiamine pyrophosphate |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 30 | 30 | Mitochondrion Ref.3 | ||||||
| Chain | 31 – 359 | 329 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | PRO_0000162216 | |||||
Sites | |||||||||
| Binding site | 89 | 1 | Thiamine pyrophosphate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 67 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle. |
| [3] | "Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex." Ho L., Javed A.A., Pepin R.A., Thekkumkara T.J., Raefsky C., Mole J.E., Caliendo A.M., Kwon M.S., Kerr D.S., Patel M.S. Biochem. Biophys. Res. Commun. 150:904-908(1988) [PubMed: 2829898] [Abstract] Cited for: PROTEIN SEQUENCE OF 31-54. |
Cross-references
Sequence databases | |
|---|---|
| BT021911 mRNA. Translation: AAX46758.1. Frameshift. BC150020 mRNA. Translation: AAI50021.1. | |
| IPI | IPI00703729. |
| PIR | B27712. |
| RefSeq | NP_001030512.2. |
| UniGene | Bt.49794 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NI4 based on UniProtKB P11177. |
| SMR | P11966. Positions 30-359. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000021724. Bos taurus. [Contig view] |
| GeneID | 613610. |
| KEGG | bta:613610. |
Phylogenomic databases | |
| HOVERGEN | P11966. |
| OMA | P11966. AAKMHYM. |
Enzyme and pathway databases | |
| BRENDA | 1.2.4.1. 251. |
Family and domain databases | |
| InterPro | IPR005476. Transketo_C. IPR015941. Transketolase_C-like. IPR005475. Transketolase_central-reg. [Graphical view] |
| Gene3D | G3DSA:3.40.50.920. Transketo_C_like. 1 hit. |
| Pfam | PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ODPB_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P11966 Secondary accession number(s): A6QQW6, Q58CN6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


