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P11966

- ODPB_BOVIN

UniProt

P11966 - ODPB_BOVIN

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Protein
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Gene
PDHB
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891Thiamine pyrophosphate By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
  2. pyruvate dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. acetyl-CoA biosynthetic process from pyruvate Source: UniProtKB
  2. glucose metabolic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiREACT_204177. Regulation of pyruvate dehydrogenase (PDH) complex.
REACT_226374. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Name:PDHB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. pyruvate dehydrogenase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030Mitochondrion1 Publication
Add
BLAST
Chaini31 – 359329Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
PRO_0000162216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Phosphotyrosine By similarity
Modified residuei354 – 3541N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11966.
PRIDEiP11966.

Interactioni

Subunit structurei

Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028958.

Structurei

3D structure databases

ProteinModelPortaliP11966.
SMRiP11966. Positions 30-359.

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0022.
GeneTreeiENSGT00530000063423.
HOGENOMiHOG000281450.
HOVERGENiHBG000917.
InParanoidiP11966.
KOiK00162.
OMAiNVKVPMV.
OrthoDBiEOG7KSX8S.
TreeFamiTF105674.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PANTHERiPTHR11624:SF56. PTHR11624:SF56. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11966-1 [UniParc]FASTAAdd to Basket

« Hide

MAVVAVLVRK PLEQVSGLLR RRFHRTAPAA LQVTVREAIN QGMDEELERD    50
EKVFLLGEEV AQYDGAYKVS RGLWKKYGDK RIIDTPISEM GFAGIAVGAA 100
MAGLRPICEF MTFNFSMQAI DQVINSAAKT YYMSGGLQSV PIVFRGPNGA 150
SAGVAAQHSQ CFAAWYGHCP GLKVVSPWSS EDAKGLIKSA IRDNNPVVVL 200
ENELMYGVPF ELPSEAQSKD FLIPIGKAKI ERQGTHVTIV AHSRPVGHCL 250
EAATVLSKEG IECEVINLRT IRPMDIETIE GSVMKTNHLV TVEGGWPQFG 300
VGAEICARIM EGPAFNFLDA PAVRVTGADV PMPYAKILED NSVPQVKDII 350
FAIKKTLNI 359
Length:359
Mass (Da):39,126
Last modified:October 17, 2006 - v2
Checksum:i584B86D36A233EFC
GO

Sequence cautioni

The sequence AAX46758.1 differs from that shown. Reason: Frameshift at position 201.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021911 mRNA. Translation: AAX46758.1. Frameshift.
BC150020 mRNA. Translation: AAI50021.1.
PIRiB27712.
RefSeqiNP_001030512.2. NM_001035435.3.
UniGeneiBt.49794.

Genome annotation databases

EnsembliENSBTAT00000028958; ENSBTAP00000028958; ENSBTAG00000021724.
GeneIDi613610.
KEGGibta:613610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021911 mRNA. Translation: AAX46758.1 . Frameshift.
BC150020 mRNA. Translation: AAI50021.1 .
PIRi B27712.
RefSeqi NP_001030512.2. NM_001035435.3.
UniGenei Bt.49794.

3D structure databases

ProteinModelPortali P11966.
SMRi P11966. Positions 30-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000028958.

Proteomic databases

PaxDbi P11966.
PRIDEi P11966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000028958 ; ENSBTAP00000028958 ; ENSBTAG00000021724 .
GeneIDi 613610.
KEGGi bta:613610.

Organism-specific databases

CTDi 5162.

Phylogenomic databases

eggNOGi COG0022.
GeneTreei ENSGT00530000063423.
HOGENOMi HOG000281450.
HOVERGENi HBG000917.
InParanoidi P11966.
KOi K00162.
OMAi NVKVPMV.
OrthoDBi EOG7KSX8S.
TreeFami TF105674.

Enzyme and pathway databases

Reactomei REACT_204177. Regulation of pyruvate dehydrogenase (PDH) complex.
REACT_226374. Pyruvate metabolism.

Miscellaneous databases

NextBioi 20898665.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProi IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view ]
PANTHERi PTHR11624:SF56. PTHR11624:SF56. 1 hit.
Pfami PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  3. "Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex."
    Ho L., Javed A.A., Pepin R.A., Thekkumkara T.J., Raefsky C., Mole J.E., Caliendo A.M., Kwon M.S., Kerr D.S., Patel M.S.
    Biochem. Biophys. Res. Commun. 150:904-908(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-54.

Entry informationi

Entry nameiODPB_BOVIN
AccessioniPrimary (citable) accession number: P11966
Secondary accession number(s): A6QQW6, Q58CN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

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