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Protein

Glycoprotein hormones alpha chain

Gene

Cga

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-209968. Thyroxine biosynthesis.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:Cga
Synonyms:Cga1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620436. Cga.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 12096Glycoprotein hormones alpha chainPRO_0000011650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Curated
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11962.

Expressioni

Gene expression databases

ExpressionAtlasiP11962. baseline and differential.
GenevisibleiP11962. RN.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

IntActiP11962. 1 interaction.
STRINGi10116.ENSRNOP00000012385.

Structurei

3D structure databases

ProteinModelPortaliP11962.
SMRiP11962. Positions 32-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP11962.
OMAiDGEFTMQ.
OrthoDBiEOG73FQPJ.
PhylomeDBiP11962.
TreeFamiTF332733.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCYRRYAAV ILVMLSMVLH ILHSLPDGDL IIQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KSFTKATVMG
110 120
NARVENHTDC HCSTCYYHKS
Length:120
Mass (Da):13,453
Last modified:October 1, 1989 - v1
Checksum:iBE0E7F3C44C69ECB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841E → Q in AAA97425 (PubMed:6177696).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00757 mRNA. Translation: AAA97425.1.
M25543, M22829 Genomic DNA. Translation: AAB04669.1.
M25544 Genomic DNA. Translation: AAB04668.1.
D00575 mRNA. Translation: BAA00453.1.
PIRiJT0408. TTRTA.
UniGeneiRn.10589.

Genome annotation databases

EnsembliENSRNOT00000012385; ENSRNOP00000012385; ENSRNOG00000009269.
UCSCiRGD:620436. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00757 mRNA. Translation: AAA97425.1.
M25543, M22829 Genomic DNA. Translation: AAB04669.1.
M25544 Genomic DNA. Translation: AAB04668.1.
D00575 mRNA. Translation: BAA00453.1.
PIRiJT0408. TTRTA.
UniGeneiRn.10589.

3D structure databases

ProteinModelPortaliP11962.
SMRiP11962. Positions 32-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11962. 1 interaction.
STRINGi10116.ENSRNOP00000012385.

Proteomic databases

PaxDbiP11962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012385; ENSRNOP00000012385; ENSRNOG00000009269.
UCSCiRGD:620436. rat.

Organism-specific databases

RGDi620436. Cga.

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP11962.
OMAiDGEFTMQ.
OrthoDBiEOG73FQPJ.
PhylomeDBiP11962.
TreeFamiTF332733.

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-209968. Thyroxine biosynthesis.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

PROiP11962.

Gene expression databases

ExpressionAtlasiP11962. baseline and differential.
GenevisibleiP11962. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alpha subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs."
    Godine J.E., Chin W.W., Habener J.F.
    J. Biol. Chem. 257:8368-8371(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pituitary.
  2. "Isolation and characterization of the gene encoding the alpha-subunit of the rat pituitary glycoprotein hormones."
    Burnside J., Buckland P.R., Chin W.W.
    Gene 70:67-74(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Strain difference in nucleotide sequences of rat glycoprotein hormone subunit cDNAs and gene fragment."
    Kato Y., Ezashi T., Hirai T., Kato T.
    Zool. Sci. 7:877-885(1990)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar Imamichi.
    Tissue: Pituitary anterior lobe.

Entry informationi

Entry nameiGLHA_RAT
AccessioniPrimary (citable) accession number: P11962
Secondary accession number(s): P70516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 17, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.