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Protein

Glycoprotein hormones alpha chain

Gene

Cga

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-209968. Thyroxine biosynthesis.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:Cga
Synonyms:Cga1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620436. Cga.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001165025 – 120Glycoprotein hormones alpha chainAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80N-linked (GlcNAc...)Curated1
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106N-linked (GlcNAc...)Curated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11962.

Expressioni

Gene expression databases

ExpressionAtlasiP11962. baseline and differential.
GenevisibleiP11962. RN.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

IntActiP11962. 1 interactor.
STRINGi10116.ENSRNOP00000012385.

Structurei

3D structure databases

ProteinModelPortaliP11962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP11962.
OMAiDGEFTMQ.
OrthoDBiEOG091G0TRG.
PhylomeDBiP11962.
TreeFamiTF332733.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCYRRYAAV ILVMLSMVLH ILHSLPDGDL IIQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KSFTKATVMG
110 120
NARVENHTDC HCSTCYYHKS
Length:120
Mass (Da):13,453
Last modified:October 1, 1989 - v1
Checksum:iBE0E7F3C44C69ECB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84E → Q in AAA97425 (PubMed:6177696).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00757 mRNA. Translation: AAA97425.1.
M25543, M22829 Genomic DNA. Translation: AAB04669.1.
M25544 Genomic DNA. Translation: AAB04668.1.
D00575 mRNA. Translation: BAA00453.1.
PIRiJT0408. TTRTA.
RefSeqiXP_017448612.1. XM_017593123.1.
UniGeneiRn.10589.

Genome annotation databases

EnsembliENSRNOT00000012385; ENSRNOP00000012385; ENSRNOG00000009269.
GeneIDi116700.
UCSCiRGD:620436. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00757 mRNA. Translation: AAA97425.1.
M25543, M22829 Genomic DNA. Translation: AAB04669.1.
M25544 Genomic DNA. Translation: AAB04668.1.
D00575 mRNA. Translation: BAA00453.1.
PIRiJT0408. TTRTA.
RefSeqiXP_017448612.1. XM_017593123.1.
UniGeneiRn.10589.

3D structure databases

ProteinModelPortaliP11962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11962. 1 interactor.
STRINGi10116.ENSRNOP00000012385.

Proteomic databases

PaxDbiP11962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012385; ENSRNOP00000012385; ENSRNOG00000009269.
GeneIDi116700.
UCSCiRGD:620436. rat.

Organism-specific databases

RGDi620436. Cga.

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP11962.
OMAiDGEFTMQ.
OrthoDBiEOG091G0TRG.
PhylomeDBiP11962.
TreeFamiTF332733.

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-209968. Thyroxine biosynthesis.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

PROiP11962.

Gene expression databases

ExpressionAtlasiP11962. baseline and differential.
GenevisibleiP11962. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLHA_RAT
AccessioniPrimary (citable) accession number: P11962
Secondary accession number(s): P70516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.