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Protein

Metallothionein-2

Gene

MtnB

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.

GO - Molecular functioni

  • copper ion binding Source: FlyBase
  • metal ion binding Source: FlyBase

GO - Biological processi

  • metal ion homeostasis Source: FlyBase
  • response to metal ion Source: FlyBase

Keywordsi

LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein B
Gene namesi
Name:MtnB
Synonyms:Mto
ORF Names:CG4312
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002869. MtnB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973551 – 43Metallothionein-2Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Blocked amino end (Met)1

Proteomic databases

PaxDbiP11956.
PRIDEiP11956.

Expressioni

Developmental stagei

Expressed predominantly in embryonic and larval stages.

Inductioni

Strongly induced by cadmium, copper and mercury.

Gene expression databases

BgeeiFBgn0002869.
ExpressionAtlasiP11956. differential.
GenevisibleiP11956. DM.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi67404. 6 interactors.
DIPiDIP-20926N.
IntActiP11956. 8 interactors.
MINTiMINT-873164.
STRINGi7227.FBpp0083298.

Structurei

3D structure databases

SMRiP11956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
InParanoidiP11956.
OrthoDBiEOG091G1AD9.
PhylomeDBiP11956.

Family and domain databases

InterProiView protein in InterPro
IPR000966. Metalthion_5.
PfamiView protein in Pfam
PF02067. Metallothio_5. 1 hit.
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

P11956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MVCKGCGTNC QCSAQKCGDN CACNKDCQCV CKNGPKDQCC SNK
Length:43
Mass (Da):4,525
Last modified:October 1, 1989 - v1
Checksum:i5EE0CF9171BD9A97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16250 mRNA. Translation: AAA28683.1.
X52098 Genomic DNA. Translation: CAA36318.1.
AE014297 Genomic DNA. Translation: AAF55768.1.
BT025813 mRNA. Translation: ABF85713.1.
PIRiS14706. SMFF2.
RefSeqiNP_001287425.1. NM_001300496.1.
NP_001287426.1. NM_001300497.1.
NP_524413.1. NM_079689.3.
UniGeneiDm.2394.

Genome annotation databases

EnsemblMetazoaiFBtr0083890; FBpp0083298; FBgn0002869.
FBtr0346152; FBpp0311980; FBgn0002869.
FBtr0346153; FBpp0311981; FBgn0002869.
GeneIDi42424.
KEGGidme:Dmel_CG4312.

Similar proteinsi

Entry informationi

Entry nameiMT2_DROME
AccessioniPrimary (citable) accession number: P11956
Secondary accession number(s): Q1ECC1, Q9VDM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 27, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families