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Protein

Cytochrome c oxidase subunit 6C-2

Gene

Cox6c2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C-2
Alternative name(s):
Cytochrome c oxidase polypeptide VIc-2
Gene namesi
Name:Cox6c2
Synonyms:Cox6c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620616. Cox6c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini4 – 14Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei15 – 55HelicalBy similarityAdd BLAST41
Topological domaini56 – 76Mitochondrial intermembraneBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001913042 – 76Cytochrome c oxidase subunit 6C-2Add BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11951.
PRIDEiP11951.

PTM databases

iPTMnetiP11951.
PhosphoSitePlusiP11951.
SwissPalmiP11951.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010807.
GenevisibleiP11951. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014407.

Structurei

3D structure databases

ProteinModelPortaliP11951.
SMRiP11951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP11951.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG091G10KX.
PhylomeDBiP11951.
TreeFamiTF353619.

Family and domain databases

CDDicd00927. Cyt_c_Oxidase_VIc. 1 hit.
Gene3Di4.10.93.10. 1 hit.
InterProiView protein in InterPro
IPR004204. COX6C.
IPR034884. Cytochrome_c_oxidase_VIc/VIIs.
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiView protein in Pfam
PF02937. COX6C. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032. Cyt_c_oxidase_su6c. 1 hit.
SUPFAMiSSF81415. SSF81415. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIVGAFVV ALGVAAAYKF GVAEPRKKAY
60 70
ADFYRNYDSM KDFEEMRQAG VFQSAK
Length:76
Mass (Da):8,455
Last modified:January 23, 2007 - v3
Checksum:i988D10E1F2D387BD
GO

Sequence cautioni

The sequence AAA79270 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29V → A in AAA79270 (PubMed:2854406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20153, M20152 Genomic DNA. Translation: AAA41011.1.
M27466 mRNA. Translation: AAA79271.1.
M27467 mRNA. Translation: AAA79270.1. Different initiation.
BC058480 mRNA. Translation: AAH58480.1.
K01565 mRNA. Translation: AAA41013.1.
PIRiS00114.
RefSeqiNP_062233.2. NM_019360.2.
UniGeneiRn.846.

Genome annotation databases

EnsembliENSRNOT00000014407; ENSRNOP00000014407; ENSRNOG00000010807.
GeneIDi54322.
KEGGirno:54322.
UCSCiRGD:620616. rat.

Similar proteinsi

Entry informationi

Entry nameiCX6C2_RAT
AccessioniPrimary (citable) accession number: P11951
Secondary accession number(s): Q63703
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families