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Protein

Cytochrome c oxidase subunit 6C-2

Gene

Cox6c2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C-2
Alternative name(s):
Cytochrome c oxidase polypeptide VIc-2
Gene namesi
Name:Cox6c2
Synonyms:Cox6c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620616. Cox6c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini4 – 14Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei15 – 55HelicalBy similarityAdd BLAST41
Topological domaini56 – 76Mitochondrial intermembraneBy similarityAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001913042 – 76Cytochrome c oxidase subunit 6C-2Add BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11951.
PRIDEiP11951.

PTM databases

iPTMnetiP11951.
PhosphoSitePlusiP11951.
SwissPalmiP11951.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010807.
GenevisibleiP11951. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014407.

Structurei

3D structure databases

ProteinModelPortaliP11951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP11951.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG091G10KX.
PhylomeDBiP11951.
TreeFamiTF353619.

Family and domain databases

CDDicd00927. Cyt_c_Oxidase_VIc. 1 hit.
Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIVGAFVV ALGVAAAYKF GVAEPRKKAY
60 70
ADFYRNYDSM KDFEEMRQAG VFQSAK
Length:76
Mass (Da):8,455
Last modified:January 23, 2007 - v3
Checksum:i988D10E1F2D387BD
GO

Sequence cautioni

The sequence AAA79270 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29V → A in AAA79270 (PubMed:2854406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20153, M20152 Genomic DNA. Translation: AAA41011.1.
M27466 mRNA. Translation: AAA79271.1.
M27467 mRNA. Translation: AAA79270.1. Different initiation.
BC058480 mRNA. Translation: AAH58480.1.
K01565 mRNA. Translation: AAA41013.1.
PIRiS00114.
RefSeqiNP_062233.2. NM_019360.2.
UniGeneiRn.846.

Genome annotation databases

EnsembliENSRNOT00000014407; ENSRNOP00000014407; ENSRNOG00000010807.
GeneIDi54322.
KEGGirno:54322.
UCSCiRGD:620616. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20153, M20152 Genomic DNA. Translation: AAA41011.1.
M27466 mRNA. Translation: AAA79271.1.
M27467 mRNA. Translation: AAA79270.1. Different initiation.
BC058480 mRNA. Translation: AAH58480.1.
K01565 mRNA. Translation: AAA41013.1.
PIRiS00114.
RefSeqiNP_062233.2. NM_019360.2.
UniGeneiRn.846.

3D structure databases

ProteinModelPortaliP11951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014407.

PTM databases

iPTMnetiP11951.
PhosphoSitePlusiP11951.
SwissPalmiP11951.

Proteomic databases

PaxDbiP11951.
PRIDEiP11951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014407; ENSRNOP00000014407; ENSRNOG00000010807.
GeneIDi54322.
KEGGirno:54322.
UCSCiRGD:620616. rat.

Organism-specific databases

CTDi1345.
RGDi620616. Cox6c.

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP11951.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG091G10KX.
PhylomeDBiP11951.
TreeFamiTF353619.

Miscellaneous databases

PROiP11951.

Gene expression databases

BgeeiENSRNOG00000010807.
GenevisibleiP11951. RN.

Family and domain databases

CDDicd00927. Cyt_c_Oxidase_VIc. 1 hit.
Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6C2_RAT
AccessioniPrimary (citable) accession number: P11951
Secondary accession number(s): Q63703
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.