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Protein

Cytochrome c oxidase subunit 6C-2

Gene

Cox6c2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD

GO - Biological processi

  • hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C-2
Alternative name(s):
Cytochrome c oxidase polypeptide VIc-2
Gene namesi
Name:Cox6c2
Synonyms:Cox6c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620616. Cox6c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini4 – 1411Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei15 – 5541HelicalBy similarityAdd
BLAST
Topological domaini56 – 7621Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 7675Cytochrome c oxidase subunit 6C-2PRO_0000191304Add
BLAST

Proteomic databases

PaxDbiP11951.
PRIDEiP11951.

PTM databases

iPTMnetiP11951.
PhosphoSiteiP11951.
SwissPalmiP11951.

Expressioni

Gene expression databases

GenevisibleiP11951. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014407.

Structurei

3D structure databases

ProteinModelPortaliP11951.
SMRiP11951. Positions 7-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP11951.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG73807S.
PhylomeDBiP11951.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIVGAFVV ALGVAAAYKF GVAEPRKKAY
60 70
ADFYRNYDSM KDFEEMRQAG VFQSAK
Length:76
Mass (Da):8,455
Last modified:January 23, 2007 - v3
Checksum:i988D10E1F2D387BD
GO

Sequence cautioni

The sequence AAA79270.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291V → A in AAA79270 (PubMed:2854406).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20153, M20152 Genomic DNA. Translation: AAA41011.1.
M27466 mRNA. Translation: AAA79271.1.
M27467 mRNA. Translation: AAA79270.1. Different initiation.
BC058480 mRNA. Translation: AAH58480.1.
K01565 mRNA. Translation: AAA41013.1.
PIRiS00114.
RefSeqiNP_062233.2. NM_019360.2.
UniGeneiRn.846.

Genome annotation databases

EnsembliENSRNOT00000014407; ENSRNOP00000014407; ENSRNOG00000010807.
GeneIDi54322.
KEGGirno:54322.
UCSCiRGD:620616. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20153, M20152 Genomic DNA. Translation: AAA41011.1.
M27466 mRNA. Translation: AAA79271.1.
M27467 mRNA. Translation: AAA79270.1. Different initiation.
BC058480 mRNA. Translation: AAH58480.1.
K01565 mRNA. Translation: AAA41013.1.
PIRiS00114.
RefSeqiNP_062233.2. NM_019360.2.
UniGeneiRn.846.

3D structure databases

ProteinModelPortaliP11951.
SMRiP11951. Positions 7-76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014407.

PTM databases

iPTMnetiP11951.
PhosphoSiteiP11951.
SwissPalmiP11951.

Proteomic databases

PaxDbiP11951.
PRIDEiP11951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014407; ENSRNOP00000014407; ENSRNOG00000010807.
GeneIDi54322.
KEGGirno:54322.
UCSCiRGD:620616. rat.

Organism-specific databases

CTDi1345.
RGDi620616. Cox6c.

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP11951.
KOiK02268.
OMAiARRMKFH.
OrthoDBiEOG73807S.
PhylomeDBiP11951.
TreeFamiTF353619.

Enzyme and pathway databases

ReactomeiR-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi611014.
PROiP11951.

Gene expression databases

GenevisibleiP11951. RN.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and nucleotide sequence of two chromosomal genes for rat cytochrome c oxidase subunit VIc: a structural and a processed gene."
    Suske G., Enders C., Schlerf A., Kadenbach B.
    DNA 7:163-171(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Molecular cloning and further characterization of cDNAs for rat nuclear-encoded cytochrome c oxidase subunits VIc and VIII."
    Suske G., Mengel T., Cordingley M., Kadenbach B.
    Eur. J. Biochem. 168:233-237(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Complexity of nucleus-encoded genes of mammalian cytochrome c oxidase."
    Cao X.N., Hengst L., Schlerf A., Droste M., Mengel T., Kadenbach B.
    Ann. N. Y. Acad. Sci. 550:337-347(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. "Construction of a cDNA clone for a nuclear-coded subunit of cytochrome c oxidase from rat liver."
    Parimoo S., Seelan R.S., Desai S., Buse G., Padmanaban G.
    Biochem. Biophys. Res. Commun. 118:902-909(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-76.
  6. "Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform."
    Schaegger H., Noack H., Halangk W., Brandt U., von Jagow G.
    Eur. J. Biochem. 230:235-241(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Strain: Wistar.
    Tissue: Liver.
  7. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 40-46 AND 68-76, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  8. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCX6C2_RAT
AccessioniPrimary (citable) accession number: P11951
Secondary accession number(s): Q63703
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: February 17, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.