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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Tetrahymena pyriformis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111Iron (heme A axial ligand)Curated1
Metal bindingi401Copper BCurated1
Metal bindingi405Copper BCurated1
Metal bindingi450Copper BCurated1
Metal bindingi451Copper BCurated1
Metal bindingi536Iron (heme A3 axial ligand)Curated1
Metal bindingi538Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiTetrahymena pyriformis
Taxonomic identifieri5908 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Transmembranei574 – 594HelicalSequence analysisAdd BLAST21
Transmembranei613 – 633HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834251 – 698Cytochrome c oxidase subunit 1Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki401 ↔ 4051'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP11947
SMRiP11947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10, 2 hits
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
PANTHERiPTHR10422 PTHR10422, 2 hits
PfamiView protein in Pfam
PF00115 COX1, 2 hits
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 2 hits
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P11947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYIFNSFDN MWVDFIEQTK SFKVSVNNYF YYLNKIKKLF TYLNDLRKHI
60 70 80 90 100
LKKYVYTINH KRIAINYLYF SMVTGLSGAA LATMIRMELA HPESPFFKGD
110 120 130 140 150
SLRYLQVVTA HGLIMVFFVV VPILFGGFAN FLIPYHVGSK DVAYPRLNSI
160 170 180 190 200
GFWIQPCGYI LLAKIGFLRP QFWRYYDKTS FSFPFLEKMK YNQYKEYKND
210 220 230 240 250
YLFYLDFLKK EITDDHSFFW KARKVIKLPQ YSVFSFVPLK LMMWKTMINY
260 270 280 290 300
PESFWYAASR VVQSRRKKVF VTKCSARTLT TAGWTFITPF SSNIKYTGVG
310 320 330 340 350
SQDILILSVV FAGISTTISF TNLLITRRTL AMPGMRHRRV LMPFVTISIF
360 370 380 390 400
LTLRMLATIT PVLGAAVIMM AFDRHWQTTF FEYAYGGDPI LSQHLFWFFG
410 420 430 440 450
HPEVYVLIIP TFGFINMIVP HNNTRRVASK HHMIWAIYVM AYMGYLVWGH
460 470 480 490 500
HMYLVGLDHR SRTMYSTITI MISMPATIKV VNWTLSLVNG ALKVDLPFLF
510 520 530 540 550
SMSFLLLFLV AGFTGMWLSH VSLNVSMHDT FYVVAHFHIM LSGAAITGIF
560 570 580 590 600
SGFYYYFNAL FGIKFSRMFG YMHLIYYSGG QWVAFVPQFY LGFSGMPRRI
610 620 630 640 650
HDYPVVFMGW HSMSTAGHFI TLIGIMFFFL MIFDSHIERR AATSSTLGLP
660 670 680 690
RWYKRISYYI FKIRYLQHNK AKMNGIPGST VRLMLIDRHF AEFEVFKK
Length:698
Mass (Da):81,747
Last modified:October 1, 1989 - v1
Checksum:iD6B0F488A3109A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28677 Genomic DNA Translation: AAA32102.2
X06133 Genomic DNA Translation: CAB57808.1
PIRiS00742

Similar proteinsi

Entry informationi

Entry nameiCOX1_TETPY
AccessioniPrimary (citable) accession number: P11947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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