Cytochrome c oxidase subunit 1 - Tetrahymena pyriformis

Preferred order of sections

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide I

Gene names

Name:

COI

Encoded on

Mitochondrion

Organism

Tetrahymena pyriformis

Taxonomic identifier

5908 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena

Protein attributes

Sequence length	698 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 698

698

Cytochrome c oxidase subunit 1

PRO_0000183425

Regions

Transmembrane

65 – 85

21

Helical; Potential

Transmembrane

113 – 133

21

Helical; Potential

Transmembrane

147 – 167

21

Helical; Potential

Transmembrane

304 – 324

21

Helical; Potential

Transmembrane

349 – 369

21

Helical; Potential

Transmembrane

395 – 415

21

Helical; Potential

Transmembrane

434 – 454

21

Helical; Potential

Transmembrane

468 – 488

21

Helical; Potential

Transmembrane

498 – 518

21

Helical; Potential

Transmembrane

533 – 553

21

Helical; Potential

Transmembrane

574 – 594

21

Helical; Potential

Transmembrane

613 – 633

21

Helical; Potential

Sites

Metal binding

111

1

Iron (heme A axial ligand) Probable

Metal binding

401

1

Copper B Probable

Metal binding

405

1

Copper B Probable

Metal binding

450

1

Copper B Probable

Metal binding

451

1

Copper B Probable

Metal binding

536

1

Iron (heme A3 axial ligand) Probable

Metal binding

538

1

Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link

401 ↔ 405

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P11947 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: D6B0F488A3109A72
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FASTA

698

81,747

        10         20         30         40         50         60 
MLYIFNSFDN MWVDFIEQTK SFKVSVNNYF YYLNKIKKLF TYLNDLRKHI LKKYVYTINH 

        70         80         90        100        110        120 
KRIAINYLYF SMVTGLSGAA LATMIRMELA HPESPFFKGD SLRYLQVVTA HGLIMVFFVV 

       130        140        150        160        170        180 
VPILFGGFAN FLIPYHVGSK DVAYPRLNSI GFWIQPCGYI LLAKIGFLRP QFWRYYDKTS 

       190        200        210        220        230        240 
FSFPFLEKMK YNQYKEYKND YLFYLDFLKK EITDDHSFFW KARKVIKLPQ YSVFSFVPLK 

       250        260        270        280        290        300 
LMMWKTMINY PESFWYAASR VVQSRRKKVF VTKCSARTLT TAGWTFITPF SSNIKYTGVG 

       310        320        330        340        350        360 
SQDILILSVV FAGISTTISF TNLLITRRTL AMPGMRHRRV LMPFVTISIF LTLRMLATIT 

       370        380        390        400        410        420 
PVLGAAVIMM AFDRHWQTTF FEYAYGGDPI LSQHLFWFFG HPEVYVLIIP TFGFINMIVP 

       430        440        450        460        470        480 
HNNTRRVASK HHMIWAIYVM AYMGYLVWGH HMYLVGLDHR SRTMYSTITI MISMPATIKV 

       490        500        510        520        530        540 
VNWTLSLVNG ALKVDLPFLF SMSFLLLFLV AGFTGMWLSH VSLNVSMHDT FYVVAHFHIM 

       550        560        570        580        590        600 
LSGAAITGIF SGFYYYFNAL FGIKFSRMFG YMHLIYYSGG QWVAFVPQFY LGFSGMPRRI 

       610        620        630        640        650        660 
HDYPVVFMGW HSMSTAGHFI TLIGIMFFFL MIFDSHIERR AATSSTLGLP RWYKRISYYI 

       670        680        690 
FKIRYLQHNK AKMNGIPGST VRLMLIDRHF AEFEVFKK

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References

[1]	"The cytochrome oxidase subunit I gene of Tetrahymena: a 57 amino acid NH2-terminal extension and a 108 amino acid insert." Ziaie Z., Suyama Y. Curr. Genet. 12:357-368(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ST.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L28677 Genomic DNA. Translation: AAA32102.2. X06133 Genomic DNA. Translation: CAB57808.1.
PIR	S00742.
3D structure databases
ProteinModelPortal	P11947.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
Gene3D	1.20.210.10. 2 hits.
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023615. Cyt_c_Oxase_su1_BS. IPR023616. Cyt_c_Oxase_su1_dom. [Graphical view]
PANTHER	PTHR10422. PTHR10422. 1 hit.
Pfam	PF00115. COX1. 2 hits. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_TETPY

Accession

Primary (citable) accession number: P11947

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents