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P11947 (COX1_TETPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismTetrahymena pyriformis
Taxonomic identifier5908 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Protein attributes

Sequence length698 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 698698Cytochrome c oxidase subunit 1
PRO_0000183425

Regions

Transmembrane65 – 8521Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane349 – 36921Helical; Potential
Transmembrane395 – 41521Helical; Potential
Transmembrane434 – 45421Helical; Potential
Transmembrane468 – 48821Helical; Potential
Transmembrane498 – 51821Helical; Potential
Transmembrane533 – 55321Helical; Potential
Transmembrane574 – 59421Helical; Potential
Transmembrane613 – 63321Helical; Potential

Sites

Metal binding1111Iron (heme A axial ligand) Probable
Metal binding4011Copper B Probable
Metal binding4051Copper B Probable
Metal binding4501Copper B Probable
Metal binding4511Copper B Probable
Metal binding5361Iron (heme A3 axial ligand) Probable
Metal binding5381Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link401 ↔ 4051'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P11947 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: D6B0F488A3109A72

FASTA69881,747
        10         20         30         40         50         60 
MLYIFNSFDN MWVDFIEQTK SFKVSVNNYF YYLNKIKKLF TYLNDLRKHI LKKYVYTINH 

        70         80         90        100        110        120 
KRIAINYLYF SMVTGLSGAA LATMIRMELA HPESPFFKGD SLRYLQVVTA HGLIMVFFVV 

       130        140        150        160        170        180 
VPILFGGFAN FLIPYHVGSK DVAYPRLNSI GFWIQPCGYI LLAKIGFLRP QFWRYYDKTS 

       190        200        210        220        230        240 
FSFPFLEKMK YNQYKEYKND YLFYLDFLKK EITDDHSFFW KARKVIKLPQ YSVFSFVPLK 

       250        260        270        280        290        300 
LMMWKTMINY PESFWYAASR VVQSRRKKVF VTKCSARTLT TAGWTFITPF SSNIKYTGVG 

       310        320        330        340        350        360 
SQDILILSVV FAGISTTISF TNLLITRRTL AMPGMRHRRV LMPFVTISIF LTLRMLATIT 

       370        380        390        400        410        420 
PVLGAAVIMM AFDRHWQTTF FEYAYGGDPI LSQHLFWFFG HPEVYVLIIP TFGFINMIVP 

       430        440        450        460        470        480 
HNNTRRVASK HHMIWAIYVM AYMGYLVWGH HMYLVGLDHR SRTMYSTITI MISMPATIKV 

       490        500        510        520        530        540 
VNWTLSLVNG ALKVDLPFLF SMSFLLLFLV AGFTGMWLSH VSLNVSMHDT FYVVAHFHIM 

       550        560        570        580        590        600 
LSGAAITGIF SGFYYYFNAL FGIKFSRMFG YMHLIYYSGG QWVAFVPQFY LGFSGMPRRI 

       610        620        630        640        650        660 
HDYPVVFMGW HSMSTAGHFI TLIGIMFFFL MIFDSHIERR AATSSTLGLP RWYKRISYYI 

       670        680        690 
FKIRYLQHNK AKMNGIPGST VRLMLIDRHF AEFEVFKK 

« Hide

References

[1]"The cytochrome oxidase subunit I gene of Tetrahymena: a 57 amino acid NH2-terminal extension and a 108 amino acid insert."
Ziaie Z., Suyama Y.
Curr. Genet. 12:357-368(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ST.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L28677 Genomic DNA. Translation: AAA32102.2.
X06133 Genomic DNA. Translation: CAB57808.1.
PIRS00742.

3D structure databases

ProteinModelPortalP11947.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 2 hits.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 2 hits.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 2 hits.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_TETPY
AccessionPrimary (citable) accession number: P11947
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways