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P11947

- COX1_TETPY

UniProt

P11947 - COX1_TETPY

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Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Tetrahymena pyriformis
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi111 – 1111Iron (heme A axial ligand) Inferred
Metal bindingi401 – 4011Copper B Inferred
Metal bindingi405 – 4051Copper B Inferred
Metal bindingi450 – 4501Copper B Inferred
Metal bindingi451 – 4511Copper B Inferred
Metal bindingi536 – 5361Iron (heme A3 axial ligand) Inferred
Metal bindingi538 – 5381Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiTetrahymena pyriformis
Taxonomic identifieri5908 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521Helical; Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Reviewed predictionAdd
BLAST
Transmembranei147 – 16721Helical; Reviewed predictionAdd
BLAST
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST
Transmembranei349 – 36921Helical; Reviewed predictionAdd
BLAST
Transmembranei395 – 41521Helical; Reviewed predictionAdd
BLAST
Transmembranei434 – 45421Helical; Reviewed predictionAdd
BLAST
Transmembranei468 – 48821Helical; Reviewed predictionAdd
BLAST
Transmembranei498 – 51821Helical; Reviewed predictionAdd
BLAST
Transmembranei533 – 55321Helical; Reviewed predictionAdd
BLAST
Transmembranei574 – 59421Helical; Reviewed predictionAdd
BLAST
Transmembranei613 – 63321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Cytochrome c oxidase subunit 1PRO_0000183425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki401 ↔ 4051'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP11947.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 2 hits.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 2 hits.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 2 hits.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11947-1 [UniParc]FASTAAdd to Basket

« Hide

MLYIFNSFDN MWVDFIEQTK SFKVSVNNYF YYLNKIKKLF TYLNDLRKHI    50
LKKYVYTINH KRIAINYLYF SMVTGLSGAA LATMIRMELA HPESPFFKGD 100
SLRYLQVVTA HGLIMVFFVV VPILFGGFAN FLIPYHVGSK DVAYPRLNSI 150
GFWIQPCGYI LLAKIGFLRP QFWRYYDKTS FSFPFLEKMK YNQYKEYKND 200
YLFYLDFLKK EITDDHSFFW KARKVIKLPQ YSVFSFVPLK LMMWKTMINY 250
PESFWYAASR VVQSRRKKVF VTKCSARTLT TAGWTFITPF SSNIKYTGVG 300
SQDILILSVV FAGISTTISF TNLLITRRTL AMPGMRHRRV LMPFVTISIF 350
LTLRMLATIT PVLGAAVIMM AFDRHWQTTF FEYAYGGDPI LSQHLFWFFG 400
HPEVYVLIIP TFGFINMIVP HNNTRRVASK HHMIWAIYVM AYMGYLVWGH 450
HMYLVGLDHR SRTMYSTITI MISMPATIKV VNWTLSLVNG ALKVDLPFLF 500
SMSFLLLFLV AGFTGMWLSH VSLNVSMHDT FYVVAHFHIM LSGAAITGIF 550
SGFYYYFNAL FGIKFSRMFG YMHLIYYSGG QWVAFVPQFY LGFSGMPRRI 600
HDYPVVFMGW HSMSTAGHFI TLIGIMFFFL MIFDSHIERR AATSSTLGLP 650
RWYKRISYYI FKIRYLQHNK AKMNGIPGST VRLMLIDRHF AEFEVFKK 698
Length:698
Mass (Da):81,747
Last modified:October 1, 1989 - v1
Checksum:iD6B0F488A3109A72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28677 Genomic DNA. Translation: AAA32102.2.
X06133 Genomic DNA. Translation: CAB57808.1.
PIRiS00742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28677 Genomic DNA. Translation: AAA32102.2 .
X06133 Genomic DNA. Translation: CAB57808.1 .
PIRi S00742.

3D structure databases

ProteinModelPortali P11947.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 2 hits.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 2 hits.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 2 hits.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cytochrome oxidase subunit I gene of Tetrahymena: a 57 amino acid NH2-terminal extension and a 108 amino acid insert."
    Ziaie Z., Suyama Y.
    Curr. Genet. 12:357-368(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ST.

Entry informationi

Entry nameiCOX1_TETPY
AccessioniPrimary (citable) accession number: P11947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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