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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Tetrahymena pyriformis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111Iron (heme A axial ligand)Curated1
Metal bindingi401Copper BCurated1
Metal bindingi405Copper BCurated1
Metal bindingi450Copper BCurated1
Metal bindingi451Copper BCurated1
Metal bindingi536Iron (heme A3 axial ligand)Curated1
Metal bindingi538Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiTetrahymena pyriformis
Taxonomic identifieri5908 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Transmembranei574 – 594HelicalSequence analysisAdd BLAST21
Transmembranei613 – 633HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834251 – 698Cytochrome c oxidase subunit 1Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki401 ↔ 4051'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiP11947.

Structurei

3D structure databases

ProteinModelPortaliP11947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 2 hits.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 2 hits.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 2 hits.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYIFNSFDN MWVDFIEQTK SFKVSVNNYF YYLNKIKKLF TYLNDLRKHI
60 70 80 90 100
LKKYVYTINH KRIAINYLYF SMVTGLSGAA LATMIRMELA HPESPFFKGD
110 120 130 140 150
SLRYLQVVTA HGLIMVFFVV VPILFGGFAN FLIPYHVGSK DVAYPRLNSI
160 170 180 190 200
GFWIQPCGYI LLAKIGFLRP QFWRYYDKTS FSFPFLEKMK YNQYKEYKND
210 220 230 240 250
YLFYLDFLKK EITDDHSFFW KARKVIKLPQ YSVFSFVPLK LMMWKTMINY
260 270 280 290 300
PESFWYAASR VVQSRRKKVF VTKCSARTLT TAGWTFITPF SSNIKYTGVG
310 320 330 340 350
SQDILILSVV FAGISTTISF TNLLITRRTL AMPGMRHRRV LMPFVTISIF
360 370 380 390 400
LTLRMLATIT PVLGAAVIMM AFDRHWQTTF FEYAYGGDPI LSQHLFWFFG
410 420 430 440 450
HPEVYVLIIP TFGFINMIVP HNNTRRVASK HHMIWAIYVM AYMGYLVWGH
460 470 480 490 500
HMYLVGLDHR SRTMYSTITI MISMPATIKV VNWTLSLVNG ALKVDLPFLF
510 520 530 540 550
SMSFLLLFLV AGFTGMWLSH VSLNVSMHDT FYVVAHFHIM LSGAAITGIF
560 570 580 590 600
SGFYYYFNAL FGIKFSRMFG YMHLIYYSGG QWVAFVPQFY LGFSGMPRRI
610 620 630 640 650
HDYPVVFMGW HSMSTAGHFI TLIGIMFFFL MIFDSHIERR AATSSTLGLP
660 670 680 690
RWYKRISYYI FKIRYLQHNK AKMNGIPGST VRLMLIDRHF AEFEVFKK
Length:698
Mass (Da):81,747
Last modified:October 1, 1989 - v1
Checksum:iD6B0F488A3109A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28677 Genomic DNA. Translation: AAA32102.2.
X06133 Genomic DNA. Translation: CAB57808.1.
PIRiS00742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28677 Genomic DNA. Translation: AAA32102.2.
X06133 Genomic DNA. Translation: CAB57808.1.
PIRiS00742.

3D structure databases

ProteinModelPortaliP11947.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP11947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 2 hits.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 2 hits.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 2 hits.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_TETPY
AccessioniPrimary (citable) accession number: P11947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.