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P11947

- COX1_TETPY

UniProt

P11947 - COX1_TETPY

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Tetrahymena pyriformis
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi111 – 1111Iron (heme A axial ligand)Curated
Metal bindingi401 – 4011Copper BCurated
Metal bindingi405 – 4051Copper BCurated
Metal bindingi450 – 4501Copper BCurated
Metal bindingi451 – 4511Copper BCurated
Metal bindingi536 – 5361Iron (heme A3 axial ligand)Curated
Metal bindingi538 – 5381Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiTetrahymena pyriformis
Taxonomic identifieri5908 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Cytochrome c oxidase subunit 1PRO_0000183425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki401 ↔ 4051'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP11947.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST
Transmembranei468 – 48821HelicalSequence AnalysisAdd
BLAST
Transmembranei498 – 51821HelicalSequence AnalysisAdd
BLAST
Transmembranei533 – 55321HelicalSequence AnalysisAdd
BLAST
Transmembranei574 – 59421HelicalSequence AnalysisAdd
BLAST
Transmembranei613 – 63321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 2 hits.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 2 hits.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 2 hits.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11947-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYIFNSFDN MWVDFIEQTK SFKVSVNNYF YYLNKIKKLF TYLNDLRKHI
60 70 80 90 100
LKKYVYTINH KRIAINYLYF SMVTGLSGAA LATMIRMELA HPESPFFKGD
110 120 130 140 150
SLRYLQVVTA HGLIMVFFVV VPILFGGFAN FLIPYHVGSK DVAYPRLNSI
160 170 180 190 200
GFWIQPCGYI LLAKIGFLRP QFWRYYDKTS FSFPFLEKMK YNQYKEYKND
210 220 230 240 250
YLFYLDFLKK EITDDHSFFW KARKVIKLPQ YSVFSFVPLK LMMWKTMINY
260 270 280 290 300
PESFWYAASR VVQSRRKKVF VTKCSARTLT TAGWTFITPF SSNIKYTGVG
310 320 330 340 350
SQDILILSVV FAGISTTISF TNLLITRRTL AMPGMRHRRV LMPFVTISIF
360 370 380 390 400
LTLRMLATIT PVLGAAVIMM AFDRHWQTTF FEYAYGGDPI LSQHLFWFFG
410 420 430 440 450
HPEVYVLIIP TFGFINMIVP HNNTRRVASK HHMIWAIYVM AYMGYLVWGH
460 470 480 490 500
HMYLVGLDHR SRTMYSTITI MISMPATIKV VNWTLSLVNG ALKVDLPFLF
510 520 530 540 550
SMSFLLLFLV AGFTGMWLSH VSLNVSMHDT FYVVAHFHIM LSGAAITGIF
560 570 580 590 600
SGFYYYFNAL FGIKFSRMFG YMHLIYYSGG QWVAFVPQFY LGFSGMPRRI
610 620 630 640 650
HDYPVVFMGW HSMSTAGHFI TLIGIMFFFL MIFDSHIERR AATSSTLGLP
660 670 680 690
RWYKRISYYI FKIRYLQHNK AKMNGIPGST VRLMLIDRHF AEFEVFKK
Length:698
Mass (Da):81,747
Last modified:October 1, 1989 - v1
Checksum:iD6B0F488A3109A72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28677 Genomic DNA. Translation: AAA32102.2.
X06133 Genomic DNA. Translation: CAB57808.1.
PIRiS00742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28677 Genomic DNA. Translation: AAA32102.2 .
X06133 Genomic DNA. Translation: CAB57808.1 .
PIRi S00742.

3D structure databases

ProteinModelPortali P11947.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 2 hits.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 2 hits.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 2 hits.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cytochrome oxidase subunit I gene of Tetrahymena: a 57 amino acid NH2-terminal extension and a 108 amino acid insert."
    Ziaie Z., Suyama Y.
    Curr. Genet. 12:357-368(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ST.

Entry informationi

Entry nameiCOX1_TETPY
AccessioniPrimary (citable) accession number: P11947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3