ID   CD3G_MOUSE              Reviewed;         182 AA.
AC   P11942;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   09-DEC-2015, entry version 137.
DE   RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
DE   AltName: Full=T-cell receptor T3 gamma chain;
DE   AltName: CD_antigen=CD3g;
DE   Flags: Precursor;
GN   Name=Cd3g;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3655657; DOI=10.1084/jem.166.4.1186;
RA   Haser W.G., Saito H., Koyama T., Tonegawa S.;
RT   "Cloning and sequencing of murine T3 gamma cDNA from a subtractive
RT   cDNA library.";
RL   J. Exp. Med. 166:1186-1191(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2952720;
RA   Krissansen G.W., Owen M.J., Fink P.J., Crumpton M.J.;
RT   "Molecular cloning of the cDNA encoding the T3 gamma subunit of the
RT   mouse T3/T cell antigen receptor complex.";
RL   J. Immunol. 138:3513-3518(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2827170; DOI=10.1073/pnas.84.24.9131;
RA   Saito H., Koyama T., Georgopoulos K., Clevers H., Haser W.G.,
RA   Lebien T., Tonegawa S., Terhorst C.;
RT   "Close linkage of the mouse and human CD3 gamma- and delta-chain genes
RT   suggests that their transcription is controlled by common regulatory
RT   elements.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:9131-9134(1987).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: The CD3 complex mediates signal transduction.
CC   -!- SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a
CC       TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the
CC       cell surface with the invariant subunits of CD3 labeled gamma,
CC       delta, epsilon, zeta, and eta.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 ITAM domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00379}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y00635; CAA68667.1; -; mRNA.
DR   EMBL; M58149; AAA63289.1; ALT_SEQ; mRNA.
DR   EMBL; M18227; AAA37400.1; -; Genomic_DNA.
DR   EMBL; M18222; AAA37400.1; JOINED; Genomic_DNA.
DR   EMBL; M18223; AAA37400.1; JOINED; Genomic_DNA.
DR   EMBL; M18224; AAA37400.1; JOINED; Genomic_DNA.
DR   EMBL; M18225; AAA37400.1; JOINED; Genomic_DNA.
DR   EMBL; M18226; AAA37400.1; JOINED; Genomic_DNA.
DR   EMBL; BC027528; AAH27528.1; -; mRNA.
DR   CCDS; CCDS23123.1; -.
DR   PIR; A39952; A28508.
DR   RefSeq; NP_033980.1; NM_009850.2.
DR   UniGene; Mm.335106; -.
DR   PDB; 1JBJ; NMR; -; A=22-103.
DR   PDBsum; 1JBJ; -.
DR   ProteinModelPortal; P11942; -.
DR   SMR; P11942; 22-103.
DR   STRING; 10090.ENSMUSP00000002101; -.
DR   PhosphoSite; P11942; -.
DR   MaxQB; P11942; -.
DR   PaxDb; P11942; -.
DR   PRIDE; P11942; -.
DR   Ensembl; ENSMUST00000002101; ENSMUSP00000002101; ENSMUSG00000002033.
DR   GeneID; 12502; -.
DR   KEGG; mmu:12502; -.
DR   UCSC; uc009pex.2; mouse.
DR   CTD; 917; -.
DR   MGI; MGI:88333; Cd3g.
DR   eggNOG; ENOG410IWAX; Eukaryota.
DR   eggNOG; ENOG410Y2TD; LUCA.
DR   HOGENOM; HOG000015287; -.
DR   HOVERGEN; HBG005278; -.
DR   InParanoid; P11942; -.
DR   KO; K06452; -.
DR   OMA; DRENDQY; -.
DR   OrthoDB; EOG7S4X7Q; -.
DR   PhylomeDB; P11942; -.
DR   TreeFam; TF335892; -.
DR   Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-MMU-202424; Downstream TCR signaling.
DR   Reactome; R-MMU-202427; Phosphorylation of CD3 and TCR zeta chains.
DR   Reactome; R-MMU-202430; Translocation of ZAP-70 to Immunological synapse.
DR   Reactome; R-MMU-202433; Generation of second messenger molecules.
DR   Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR   Reactome; R-MMU-389948; PD-1 signaling.
DR   EvolutionaryTrace; P11942; -.
DR   NextBio; 281454; -.
DR   PRO; PR:P11942; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; P11942; -.
DR   CleanEx; MM_CD3G; -.
DR   ExpressionAtlas; P11942; baseline and differential.
DR   Genevisible; P11942; MM.
DR   GO; GO:0042105; C:alpha-beta T cell receptor complex; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR   GO; GO:0070228; P:regulation of lymphocyte apoptotic process; ISS:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015484; CD3_esu/gsu/dsu.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR032052; Ig_4.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR   PANTHER; PTHR10570; PTHR10570; 1.
DR   Pfam; PF16680; Ig_4; 1.
DR   Pfam; PF02189; ITAM; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00077; ITAM; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS51055; ITAM_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     22
FT   CHAIN        23    182       T-cell surface glycoprotein CD3 gamma
FT                                chain.
FT                                /FTId=PRO_0000014617.
FT   TOPO_DOM     23    116       Extracellular. {ECO:0000255}.
FT   TRANSMEM    117    137       Helical. {ECO:0000255}.
FT   TOPO_DOM    138    182       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       37     94       Ig-like.
FT   DOMAIN      149    177       ITAM. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00379}.
FT   MOD_RES     145    145       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P09693}.
FT   MOD_RES     148    148       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P09693}.
FT   CARBOHYD     66     66       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     46     87       {ECO:0000250}.
FT   STRAND       16     18
FT   STRAND       37     39
FT   STRAND       41     45
FT   STRAND       47     49
FT   STRAND       53     57
FT   STRAND       73     76
FT   STRAND       82     91
FT   STRAND       93    100
SQ   SEQUENCE   182 AA;  20234 MW;  7F9D8D44A5C360D5 CRC64;
     MEQRKGLAGL FLVISLLQGT VAQTNKAKNL VQVDGSRGDG SVLLTCGLTD KTIKWLKDGS
     IISPLNATKN TWNLGNNAKD PRGTYQCQGA KETSNPLQVY YRMCENCIEL NIGTISGFIF
     AEVISIFFLA LGVYLIAGQD GVRQSRASDK QTLLQNEQLY QPLKDREYDQ YSHLQGNQLR
     KK
//